{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:00:47Z","timestamp":1793487647261,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2010CB530000"],"award-info":[{"award-number":["2010CB530000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.exppara.2014.12.008","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T05:37:34Z","timestamp":1419313054000},"page":"47-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Investigation of infectivity of neonates and adults from different rat strains to Toxoplasma gondii Prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection"],"prefix":"10.1016","volume":"149","author":[{"given":"Jiang-Mei","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5503-8477","authenticated-orcid":false,"given":"Si-Qi","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Qing","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Long","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Li","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff","family":"Hide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Hua","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Rong","family":"Lun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2014.12.008_bib0010","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.4049\/jimmunol.144.7.2725","article-title":"Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine","volume":"144","author":"Adams","year":"1990","journal-title":"J. Immunol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0015","first-page":"47","article-title":"Susceptibility to toxoplasmosis: correlation between macrophage function, brain cyst formation and mortality in rats","volume":"19","author":"Benedetto","year":"1996","journal-title":"New Microbiol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0020","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1128\/IAI.55.4.990-994.1987","article-title":"Protective immunity in toxoplasmosis: correlation between antibody response, brain cyst formation, T-cell activation, and survival in normal and B-cell-deficient mice bearing the H-2k haplotype","volume":"55","author":"Brinkmann","year":"1987","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.12.008_bib0025","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1073\/pnas.0506643103","article-title":"The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms","volume":"103","author":"Cavaill\u00e8s","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.exppara.2014.12.008_bib0030","first-page":"273","article-title":"Natural adaptation of the white rat to Toxoplasma gondii","volume":"29","author":"Chinchilla","year":"1981","journal-title":"Rev. Biol. Trop"},{"key":"10.1016\/j.exppara.2014.12.008_bib0035","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0923-2494(05)80091-4","article-title":"Experimental models of toxoplasmosis","volume":"144","author":"Darcy","year":"1993","journal-title":"Res. Immunol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0040","doi-asserted-by":"crossref","first-page":"e186","DOI":"10.1371\/journal.ppat.0030186","article-title":"Mechanism of inducible nitric oxide synthase exclusion from mycobacterial phagosomes","volume":"3","author":"Davis","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.exppara.2014.12.008_bib0045","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0195-5616(87)50008-0","article-title":"Toxoplasmosis","volume":"17","author":"Dubey","year":"1987","journal-title":"Vet. Clin. North Am. Small Anim. Pract"},{"key":"10.1016\/j.exppara.2014.12.008_bib0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.vetpar.2004.09.005","article-title":"Toxoplasmosis \u2013 a waterborne zoonosis","volume":"126","author":"Dubey","year":"2004","journal-title":"Vet. Parasitol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0055","series-title":"Toxoplasmosis of Animals and Man","first-page":"220","author":"Dubey","year":"1988"},{"key":"10.1016\/j.exppara.2014.12.008_bib0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.vetpar.2006.03.023","article-title":"Characterization of Toxoplasma gondii isolates in free-range chickens from Chile, South America","volume":"140","author":"Dubey","year":"2006","journal-title":"Vet. Parasitol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0065","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1017\/S0031182012000765","article-title":"Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology","volume":"139","author":"Dubey","year":"2012","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2014.12.008_bib0070","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ni.1671","article-title":"Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens","volume":"9","author":"EI Kasmi","year":"2008","journal-title":"Nat. Immunol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0075","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1590\/S0074-02762001000100011","article-title":"Vertical toxoplasmosis in a murine model. Protection after immunization with antigens of T. gondii incorporated into liposomes","volume":"96","author":"Elsaid","year":"2001","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2014.12.008_bib0080","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbi.2013.11.012","article-title":"Patterns of Toxoplasma gondii cyst distribution in the forebrain associate with individual variation in predator odor avoidance and anxiety-related behavior in male Long-Evans rats","volume":"37","author":"Evans","year":"2014","journal-title":"Brain Behav. Immun"},{"key":"10.1016\/j.exppara.2014.12.008_bib0085","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1128\/JCM.41.10.4826-4828.2003","article-title":"Diagnosis of congenital toxoplasmosis: comparison of targets for detection of Toxoplasma gondii by PCR","volume":"41","author":"Filisetti","year":"2003","journal-title":"J. Clin. Microbiol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0090","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7883\/yoken1952.36.343","article-title":"Species and strain differences in sensitivity to Toxoplasma infections among laboratory rodents","volume":"36","author":"Fujii","year":"1983","journal-title":"Jpn. J. Med. Sci. Biol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S0031182011001880","article-title":"Toxoplasma gondii infection in pregnant women in China","volume":"139","author":"Gao","year":"2012","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2014.12.008_bib0100","first-page":"1529","article-title":"Diagnosis of toxoplasmic encephalitis in HIV-infected patients","volume":"11","author":"Gianotti","year":"1997","journal-title":"AIDS"},{"key":"10.1016\/j.exppara.2014.12.008_bib0105","first-page":"27","article-title":"Age influence in the natural resistance of white rat and mice to the protozoan Toxoplasma gondii","volume":"43","author":"Guerrero","year":"1995","journal-title":"Rev. Biol. Trop"},{"key":"10.1016\/j.exppara.2014.12.008_bib0110","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0020-7519(99)00170-8","article-title":"Identication of a 200- to 300-fold repetitive 529 bp DNA fragment in Toxoplasma gondii, and its use for diagnostic and quantitative PCR","volume":"30","author":"Homan","year":"2000","journal-title":"Int. J. Parasitol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0115","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1128\/MMBR.59.4.533-547.1995","article-title":"Role of nitric oxide in parasitic infections","volume":"59","author":"James","year":"1995","journal-title":"Microbiol. Rev"},{"key":"10.1016\/j.exppara.2014.12.008_bib0120","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2307\/3284036","article-title":"Preimmune resistance to Toxoplasma gondii in aged and young adult mice","volume":"6","author":"Johnson","year":"1995","journal-title":"J. Parasitol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0125","doi-asserted-by":"crossref","first-page":"582","DOI":"10.3201\/eid1204.051081","article-title":"Recently acquired Toxoplasma gondii infection, Brazil","volume":"12","author":"Jones","year":"2006","journal-title":"Emerg. Infect. Dis"},{"key":"10.1016\/j.exppara.2014.12.008_bib0130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s004300050085","article-title":"Different manifestations of Toxoplasma gondii infection in F344 and LEW rats","volume":"187","author":"Kempf","year":"1999","journal-title":"Med. Microbiol. Immunol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0135","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1128\/IAI.71.11.6615-6619.2003","article-title":"Vaccination with T. gondii SAG-1 protein is protective against congenital toxoplasmosis in BALB\/c mice but not in CBA\/J mice","volume":"71","author":"Letscher-Bru","year":"2003","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.12.008_bib0140","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0014-4894(58)90040-7","article-title":"Acquisition of immunity to toxoplasmosis by the newborn rat","volume":"7","author":"Lewis","year":"1958","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0145","doi-asserted-by":"crossref","first-page":"e35834","DOI":"10.1371\/journal.pone.0035834","article-title":"Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection","volume":"7","author":"Li","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.exppara.2014.12.008_bib0150","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1645\/0022-3395(2001)087[1491:IOGASH]2.0.CO;2","article-title":"Importance of gender and sex hormones in regulation of susceptibility of the small intestine to peroral infection with Toxoplasma gondii tissue cysts","volume":"87","author":"Liesenfeld","year":"2001","journal-title":"J. Parasitol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0155","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2302\/kjm.9.217","article-title":"A preliminary report of a comparison of the survival of high virulent RH strain and cyst-producing Beverley strain of Toxoplasma in rats","volume":"9","author":"Nakayama","year":"1960","journal-title":"Keio J. Med"},{"key":"10.1016\/j.exppara.2014.12.008_bib0160","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.ijpara.2009.04.003","article-title":"Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis","volume":"39","author":"Pappas","year":"2009","journal-title":"Int. J. Parasitol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0165","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.pt.2005.08.001","article-title":"Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host","volume":"21","author":"Saeij","year":"2005","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0170","first-page":"297","article-title":"Infection of the athymic rat by Toxoplasma gondii","volume":"304","author":"Santoro","year":"1987","journal-title":"C. R. Acad. Sci. III"},{"key":"10.1016\/j.exppara.2014.12.008_bib0175","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-3024.2008.01029.x","article-title":"Control of Toxoplasma gondii infection by athymic LEW-Whnrnu rats","volume":"30","author":"Sepulveda-Arias","year":"2008","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0180","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1128\/IAI.73.10.6990-6997.2005","article-title":"Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cells","volume":"73","author":"Sergent","year":"2005","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.12.008_bib0185","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/359082a0","article-title":"Virulent strains of Toxoplasma gondii comprise a single clonal lineage","volume":"359","author":"Sibley","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.exppara.2014.12.008_bib0190","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0303-8467(97)00101-7","article-title":"Toxoplasma encephalitis in a HIV patient: unusual involvement of the corpus callosum","volume":"99","author":"Supiot","year":"1997","journal-title":"Clin. Neurol. Neurosurg"},{"key":"10.1016\/j.exppara.2014.12.008_bib0195","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.3201\/eid0911.030143","article-title":"Toxoplasma gondii and schizophrenia","volume":"9","author":"Torrey","year":"2003","journal-title":"Emerg. Infect. Dis"},{"key":"10.1016\/j.exppara.2014.12.008_bib0200","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/schbul\/sbl050","article-title":"Antibodies to Toxoplasma gondii in patients with schizophrenia: a meta-analysis","volume":"33","author":"Torrey","year":"2007","journal-title":"Schizophr. Bull"},{"key":"10.1016\/j.exppara.2014.12.008_bib0205","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1128\/IAI.00983-10","article-title":"Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron","volume":"79","author":"Von Bargen","year":"2011","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.12.008_bib0210","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1128\/IAI.65.3.1119-1121.1997","article-title":"Innate immunity to Toxoplasma gondii is influenced by gender and is associated with differences in interleukin-12 and gamma interferon production","volume":"65","author":"Walker","year":"1997","journal-title":"Infect. Immun"},{"key":"10.1016\/j.exppara.2014.12.008_bib0215","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00436-013-3661-3","article-title":"Toxoplasma gondii infection in the peritoneal macrophages of rats treated with glucocorticoids","volume":"113","author":"Wang","year":"2014","journal-title":"Parasitol. Res"},{"key":"10.1016\/j.exppara.2014.12.008_bib0220","doi-asserted-by":"crossref","first-page":"e1003535","DOI":"10.1371\/journal.ppat.1003535","article-title":"MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice","volume":"9","author":"Woods","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.exppara.2014.12.008_bib0225","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1006\/expr.1998.4301","article-title":"Toxoplasma gondii: kinetics of the dissemination in the host tissues during the acute phase of infection of mice and rats","volume":"90","author":"Zenner","year":"1998","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0230","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0344-0338(99)80051-X","article-title":"Infection with Toxoplasma gondii RH and Prugniaudgniaud strains in mice, rats and nude rats: kinetics of infection in blood and tissues related to pathology in acute and chronic infection","volume":"195","author":"Zenner","year":"1999","journal-title":"Pathol. Res. Pract"},{"key":"10.1016\/j.exppara.2014.12.008_bib0235","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1365-3024.1999.00229.x","article-title":"Protective immunity in the rat model of congenital toxoplasmosis and the potential of excreted-secreted antigens as vaccine components","volume":"21","author":"Zenner","year":"1999","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.exppara.2014.12.008_bib0240","doi-asserted-by":"crossref","first-page":"e63650","DOI":"10.1371\/journal.pone.0063650","article-title":"Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS ONE"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489414002872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489414002872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T21:54:58Z","timestamp":1690754098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489414002872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":47,"alternative-id":["S0014489414002872"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2014.12.008","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of infectivity of neonates and adults from different rat strains to Toxoplasma gondii Prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2014.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}