{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:34:13Z","timestamp":1789882453903,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.exppara.2015.03.013","type":"journal-article","created":{"date-parts":[[2015,4,2]],"date-time":"2015-04-02T07:16:18Z","timestamp":1427958978000},"page":"75-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Development of novel valerolactam-benzimidazole hybrids anthelmintic derivatives: Diffusion and biotransformation studies in helminth parasites"],"prefix":"10.1016","volume":"153","author":[{"given":"Beatriz","family":"Mungu\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-6108","authenticated-orcid":false,"given":"Mauricio","family":"Michelena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Melian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Salda\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximena","family":"Ures","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Manta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2015.03.013_bib0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jmgm.2013.07.008","article-title":"Molecular basis for benzimidazoles resistance from a novel \u03b2-tubulin binding site model","volume":"45","author":"Aguayo-Ortiz","year":"2013","journal-title":"J. Mol. Graph. Model"},{"key":"10.1016\/j.exppara.2015.03.013_bib0015","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pt.2007.01.003","article-title":"Drug transfer into target helminth parasites","volume":"23","author":"Alvarez","year":"2007","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0020","first-page":"42","article-title":"Resistencia antihelm\u00edntica en ovinos","author":"Bonino","year":"2003","journal-title":"Rev. Plan Agropec"},{"key":"10.1016\/j.exppara.2015.03.013_bib0025","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.vetpar.2007.10.010","article-title":"Biotransformation of flubendazole and selected model xenobiotics in Haemonchus contortus","volume":"151","author":"Cvilink","year":"2008","journal-title":"Vet. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0030","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/03602530802602880","article-title":"Xenobiotic metabolizing enzymes and metabolism of anthelminthics in helminths","volume":"41","author":"Cvilink","year":"2009","journal-title":"Drug Metab. Rev"},{"key":"10.1016\/j.exppara.2015.03.013_bib0035","first-page":"697","article-title":"Bioavailability comparison between albendazole and albendazole sulphoxide in rats and man","volume":"50","author":"Dom\u00ednguez","year":"1995","journal-title":"Farmaco"},{"key":"10.1016\/j.exppara.2015.03.013_bib0040","first-page":"160","article-title":"Use of L4 larvae of Nippostrongylus brasiliensis for the in vivo screening of anthelmintic drugs","volume":"64","author":"Dom\u00ednguez","year":"2000","journal-title":"Can. J. Vet. Res"},{"key":"10.1016\/j.exppara.2015.03.013_bib0045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.pt.2004.08.003","article-title":"The changing landscape of antiparasitic drug discovery for veterinary medicine","volume":"20","author":"Geary","year":"2004","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0166-6851(90)90178-O","article-title":"Biophysical transport properties of the cuticle of Ascaris suum","volume":"41","author":"Ho","year":"1990","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0166-6851(92)90031-E","article-title":"Mechanistic studies in the transcuticular delivery of antiparasitic drugs II: ex vivo\/in vitro correlation of solute transport by Ascaris suum","volume":"52","author":"Ho","year":"1992","journal-title":"Mol. Biochem. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0060","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.pt.2009.04.004","article-title":"Drug resistance mechanisms in helminths: is it survival of the fittest?","volume":"25","author":"James","year":"2009","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0065","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2307\/3280351","article-title":"Isolation and partial biochemical characterization of the brush border plasma membrane from the cestode Hyminolepis diminuta","volume":"65","author":"Knowles","year":"1979","journal-title":"J. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.vetpar.2005.11.001","article-title":"Synergism of rotenone by piperonyl butoxide in Haemonchus contortus and Trichostrongylus colubriformis in vitro: potential for drug-synergism through inhibition of nematode oxidative detoxification pathways","volume":"136","author":"Kotze","year":"2006","journal-title":"Vet. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0075","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0014-4894(75)90078-8","article-title":"Surface ultrastructure and cytochemistry of parasitic helmints","volume":"37","author":"Lumsden","year":"1975","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0080","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ar7000843","article-title":"Hybrid molecules with a dual mode of action: dream or reality?","volume":"41","author":"Meunier","year":"2008","journal-title":"Acc. Chem. Res"},{"key":"10.1016\/j.exppara.2015.03.013_bib0085","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.exppara.2005.12.004","article-title":"Drug transport mechanism in helminth parasites: passive diffusion of benzimidazole anthelmintics","volume":"113","author":"Mottier","year":"2006","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-4894(03)00060-2","article-title":"Transtegumental diffusion of benzimidazole antihelmintics into Moniezia benedeni: correlation with their octanol- water partition coefficients","volume":"103","author":"Mottier","year":"2003","journal-title":"Exp. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0095","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.2174\/15701808113109990028","article-title":"Synthesis and anthelmintic evaluation of novel valerolactam- benzimidazole hybrids","volume":"10","author":"Mungu\u00eda","year":"2013","journal-title":"Lett. Drug Des. Discov"},{"key":"10.1016\/j.exppara.2015.03.013_bib0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1079\/ASC41010023","article-title":"Costs of the major endemic diseases of sheep in Great Britain and the potential benefits of reduction in disease impact","volume":"81","author":"Neiuwhoff","year":"2005","journal-title":"Anim. Sci"},{"key":"10.1016\/j.exppara.2015.03.013_bib0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/PL00008579","article-title":"In vitro taurocholate- induced segmentation and clustering of Mesocestoides vogae (syn. Corti) tetrathyridea (Cestoda) \u2013 inhibition by cestocidal drugs","volume":"87","author":"Salda\u00f1a","year":"2001","journal-title":"Parasitol. Res"},{"key":"10.1016\/j.exppara.2015.03.013_bib0110","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00436-002-0801-6","article-title":"The toxicity of praziquantel against Mesocestoides vogae (syn. Corti) tetrathyridia can be assessed using a novel in vitro system","volume":"89","author":"Salda\u00f1a","year":"2003","journal-title":"Parasitol. Res"},{"key":"10.1016\/j.exppara.2015.03.013_bib0115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vetpar.2010.06.013","article-title":"Multiple resistance of gastrointestinal nematodes to nine different drugs in a sheep flock in southern Brazil","volume":"173","author":"Skrebsky","year":"2010","journal-title":"Vet. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0120","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.exppara.2015.03.013_bib0125","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/PL00008578","article-title":"Comparative metabolism of albendazole and albendazole sulphoxide by different helminth parasites","volume":"87","author":"Solana","year":"2001","journal-title":"Parasitol. Res"},{"key":"10.1016\/j.exppara.2015.03.013_bib0130","series-title":"Biochemistry and Molecular Biology of Parasites","first-page":"203","article-title":"The structure and function of helminth surfaces","author":"Thompson","year":"1995"},{"key":"10.1016\/j.exppara.2015.03.013_bib0135","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0169-4758(93)90162-9","article-title":"Mechanistic approaches to quantitate anthelmintic absorption by gastrointestinal nematodes","volume":"9","author":"Thompson","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.exppara.2015.03.013_bib0140","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.vetpar.2012.03.037","article-title":"Anthelmintic resistance in sheep farms: update of the situation in the American continent","volume":"189","author":"Torres-Acosta","year":"2012","journal-title":"Vet. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0145","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1017\/S003118200800543X","article-title":"Molecular detection of benzimidazole resistance in Haemonchus contortus using real-time PCR and pyrosequencing","volume":"136","author":"von Samson-Himmelstjerna","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2015.03.013_bib0150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.vetpar.2013.03.018","article-title":"Biotransformation of albendazole and activities of selected detoxification enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics","volume":"196","author":"Vok\u0159\u00e1l","year":"2013","journal-title":"Vet. Parasitol"},{"key":"10.1016\/j.exppara.2015.03.013_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2006.02.036","article-title":"From discovery to development: current industry perspectives for the development of novel methods of helminth control in livestock","volume":"139","author":"Waller","year":"2006","journal-title":"Vet. Parasitol"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489415000752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489415000752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:01:54Z","timestamp":1762149714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489415000752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":30,"alternative-id":["S0014489415000752"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2015.03.013","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of novel valerolactam-benzimidazole hybrids anthelmintic derivatives: Diffusion and biotransformation studies in helminth parasites","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2015.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}