{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:32:04Z","timestamp":1784259124677,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.exppara.2015.10.010","type":"journal-article","created":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T01:54:31Z","timestamp":1446861271000},"page":"49-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["In\u00a0vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs"],"prefix":"10.1016","volume":"160","author":[{"given":"Mar\u00eda Victoria","family":"Solana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Mera y Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Scarcella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Neira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Daniel","family":"Solana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2015.10.010_bib1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2460\/javma.2001.218.669","article-title":"2000 report of the A.V.M.A panel on Euthanasia","volume":"218","author":"A.V.M.A","year":"2001","journal-title":"J.\u00a0Am. Vet. Med. Assoc."},{"key":"10.1016\/j.exppara.2015.10.010_bib2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1017\/S0022149X00016667","article-title":"Morphological variability in Fasciola hepatica eggs in ruminants, rodents and lagomorphs","volume":"72","author":"Abrous","year":"1998","journal-title":"J.\u00a0Helminthol."},{"key":"10.1016\/j.exppara.2015.10.010_bib3","series-title":"Disease of Domestic Animals Caused by Flukes (Rome, FAO)","first-page":"1","author":"Boray","year":"1994"},{"key":"10.1016\/j.exppara.2015.10.010_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/vr.113.14.315","article-title":"Treatment of immature and mature Fasciola hepatica infections in sheep with triclabendazole","volume":"113","author":"Boray","year":"1983","journal-title":"Vet. Rec."},{"key":"10.1016\/j.exppara.2015.10.010_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.vetpar.2005.11.019","article-title":"The detection of anthelmintic resistance in nematodes of veterinary importance","volume":"136","author":"Coles","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2015.10.010_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/ps.2780020307","article-title":"A\u00a0possible biochemical mode of action of the fasciolicides nitroxynil, hexachlorophene and oxyclozanide","volume":"2","author":"Corbett","year":"1971","journal-title":"Pestic. Sci."},{"key":"10.1016\/j.exppara.2015.10.010_bib7","first-page":"108","article-title":"Investigations on excretion time of liver fluke eggs after killing the parasite","volume":"14","author":"Chowaniec","year":"1970","journal-title":"Bull. Vet. Inst. Pulaway"},{"key":"10.1016\/j.exppara.2015.10.010_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2010.12.011","article-title":"Liver fluke isolates: a question of provenance","volume":"176","author":"Fairweather","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2015.10.010_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetpar.2010.12.011","article-title":"Liver fluke isolates: a question of provenance","volume":"176","author":"Fairweather","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2015.10.010_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.vetpar.2011.05.034","article-title":"Reducing the future threat from (liver) fluke: realistic prospect or quixotic fantasy?","volume":"180","author":"Fairweather","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2015.10.010_bib12","series-title":"Mechanisms of Fasciolicide Action and Drug Resistance in Fasciola Hepatica","first-page":"225","year":"1999"},{"key":"10.1016\/j.exppara.2015.10.010_bib13","series-title":"Congreso Internacional de Zoonosis y Enfermedades Emergentes y VII Congreso Argentino de Zoonosis","first-page":"149","article-title":"An\u00e1lisis morfom\u00e9trico de huevos de Fasciola hepatica en hu\u00e9spedes dom\u00e9sticos del oeste argentino","author":"Fantozzi","year":"2011"},{"key":"10.1016\/j.exppara.2015.10.010_bib14","series-title":"XI European Multicolloquium of Parasitology","first-page":"518","article-title":"Phenotypic analysis of eggs of Fasciola hepatica recovered from Creole goats, in western Argentina","author":"Fantozzi","year":"2012"},{"key":"10.1016\/j.exppara.2015.10.010_bib15","doi-asserted-by":"crossref","first-page":"e16126","DOI":"10.1371\/journal.pone.0016126","article-title":"Predicting impacts of climate change on Fasciola hepatica risk","volume":"6","author":"Fox","year":"2011","journal-title":"Plos One"},{"key":"10.1016\/j.exppara.2015.10.010_bib16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.vetpar.2006.06.025","article-title":"The effect of a parenteral ivermectin\/closantel injection on the growth and reproductive development of early immature Fasciola hepatica in cattle","volume":"142","author":"Hanna","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2015.10.010_bib17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.vetpar.2014.11.016","article-title":"Fasciola hepatica: a comparative survey of adult fluke resistance to triclabendazole, nitroxynil and closantel on selected upland and lowland sheep farms in Northern Ireland using faecal egg counting, coproantigen ELISA testing and fluke histology","volume":"207","author":"Hanna","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2015.10.010_bib18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0166-6851(80)90052-3","article-title":"Metabolic studies on the new fasciolicidal drug, closantel","volume":"1","author":"Kane","year":"1980","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.exppara.2015.10.010_bib19","series-title":"XVII Reuni\u00f3n Cient\u00edfico T\u00e9cnica de la Asociaci\u00f3n Argentina de Veterinarios de Laboratorios de Diagn\u00f3stico","article-title":"Morfolog\u00eda y viabilidad de los huevos de Fasciola hepatica en distintos hospedadores en Patagonia","author":"Larroza","year":"2008"},{"key":"10.1016\/j.exppara.2015.10.010_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0034-5288(18)30845-2","article-title":"Flukicidal action of closantel against immature and mature Fasciola hepatica in experimentally infected rats and sheep","volume":"44","author":"Maes","year":"1988","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.exppara.2015.10.010_bib21","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2460\/ajvr.1984.45.05.851","article-title":"Efficacy of clorsulon for treatment of mature naturally acquired and 8-week-old experimentally induced Fasciola hepatica infections in cattle","volume":"45","author":"Malone","year":"1984","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.exppara.2015.10.010_bib22","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.ijpara.2010.02.009","article-title":"The development of linear regression models using environmental variables to explain the spatial distribution of Fasciola hepatica infection in dairy herds in England and Wales","volume":"40","author":"McCann","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2015.10.010_bib23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/03602538708998307","article-title":"The metabolism and fate of closantel (Flukiver) in sheep and cattle","volume":"18","author":"Michiels","year":"1987","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.exppara.2015.10.010_bib24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.vetpar.2010.12.047","article-title":"Resistance of Fasciola hepatica against triclabendazole in cattle in Patagonia (Argentina)","volume":"178","author":"Olaechea","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2015.10.010_bib26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1751-0813.1995.tb03546.x","article-title":"Resistance of Fasciola hepatica to triclabendazole","volume":"22","author":"Overend","year":"1995","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.exppara.2015.10.010_bib27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0031182096008372","article-title":"Egg production in adult trematodes: adaptation or constraint?","volume":"114","author":"Poulin","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2015.10.010_bib28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/PL00008578","article-title":"Comparative metabolism of albendazole and albendazole sulphoxide by different helminth parasites","volume":"87","author":"Solana","year":"2001","journal-title":"Parasitol. Res."},{"issue":"1","key":"10.1016\/j.exppara.2015.10.010_bib600","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.vetpar.2010.11.032","article-title":"Disruption of egg formation by Fasciola hepatica following treatment in vivo with triclabendazole in the sheep host","volume":"177","author":"Toner","year":"2011","journal-title":"Veterinary parasitology"},{"key":"10.1016\/j.exppara.2015.10.010_bib29","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00436-011-2341-4","article-title":"Fasciola hepatica: time-dependent disruption of spermatogenesis following in\u00a0vivo treatment with triclabendazole","volume":"109","author":"Toner","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2015.10.010_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0304-4017(01)00499-X","article-title":"Relationships between host species and morphometric patterns in Fasciola hepatica adults and eggs from the northern Bolivian Altiplano hyperendemic region","volume":"102","author":"Valero","year":"2001","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2015.10.010_bib31","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00436-009-1466-1","article-title":"Standardization of the egg hatch test for the detection of benzimidazole resistance in parasitic nematodes","volume":"105","author":"von Samson-Himmelstjerna","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2015.10.010_bib32","series-title":"Report of the WHO Informal Meeting on Use of Triclabendazole in Fascioliasis Control","first-page":"17","author":"WHO","year":"2006"},{"key":"10.1016\/j.exppara.2015.10.010_bib33","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.158.3809.1694","article-title":"Salicylanilides: a new group of active uncouplers of oxidative phosphorylation","volume":"158","author":"Williamson","year":"1967","journal-title":"Science"},{"key":"10.1016\/j.exppara.2015.10.010_bib34","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0304-4017(95)00806-2","article-title":"World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) Second edition of guidelines for evaluating the efficacy of anthelmintics in ruminants (bovine, ovine, caprine)","volume":"58","author":"Wood","year":"1995","journal-title":"Vet. Parasitol."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489415300576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489415300576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T10:22:49Z","timestamp":1748686969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489415300576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":33,"alternative-id":["S0014489415300576"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2015.10.010","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0vivo assessment of closantel ovicidal activity in Fasciola hepatica eggs","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2015.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}