{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:14:55Z","timestamp":1790810095365,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Universidade Estadual de Maring\u00e1"},{"DOI":"10.13039\/501100004842","name":"Universidade Paranaense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.exppara.2016.02.009","type":"journal-article","created":{"date-parts":[[2016,2,21]],"date-time":"2016-02-21T02:15:30Z","timestamp":1456020930000},"page":"56-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Chronic infection with Toxoplasma gondii induces death of submucosal enteric neurons and damage in the colonic mucosa of rats"],"prefix":"10.1016","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0822-8440","authenticated-orcid":false,"given":"Marcelo Biondaro","family":"G\u00f3is","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catchia","family":"Hermes-Uliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00edsa Cristina","family":"Barreto Zago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline Nelisis","family":"Zanoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristeu Vieira","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc\u00edlio Hubner","family":"de Miranda-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Jos\u00e9 de","family":"Almeida Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora de Mello Gon\u00e7ales","family":"Sant\u2019Ana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2016.02.009_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1179\/147683010X12611460763841","article-title":"Immunohistochemical study of vasoactive intestinal peptide (VIP) enteric neurons in diabetic rats supplemented with L-glutamine","volume":"13","author":"Alves","year":"2010","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.exppara.2016.02.009_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0305-0491(99)00140-6","article-title":"Effect of turkey (Meleagridis gallopavo) breeder hen age and egg size on poult development. 2. Intestinal villus growth, enterocyte migration, and proliferation of the turkey poult","volume":"124","author":"Applegate","year":"1999","journal-title":"Comp. Biochem. Physiol."},{"issue":"16","key":"10.1016\/j.exppara.2016.02.009_bib3","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.3748\/wjg.v21.i16.4829","article-title":"Toxoplasma gondii causes death and plastic alteration in the jejunal myenteric plexus","volume":"21","author":"Ara\u00fajo","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.exppara.2016.02.009_bib4","series-title":"BioEstat: Aplica\u00e7\u00f5es Estat\u00edsticas nas \u00c1reas das Ci\u00eancias Biol\u00f3gicas e M\u00e9dicas","author":"Ayres","year":"2007"},{"key":"10.1016\/j.exppara.2016.02.009_bib5","first-page":"257","article-title":"The organization of the enteric nervous system in the submucous and mucous layers of the small intestine of the pig studied by VIP and neurofilament protein immunohistochemistry","volume":"192","author":"Balemba","year":"1998","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.exppara.2016.02.009_bib6","first-page":"95","article-title":"T\u00e9cnica histol\u00f3gica para g\u00e2nglios nervosos intramurais em preparados espessos","volume":"11","author":"Barbosa","year":"1978","journal-title":"Rev. Bras. Pesq. M\u00e9d. Biol."},{"key":"10.1016\/j.exppara.2016.02.009_bib7","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S0966-842X(03)00205-1","article-title":"Migration of Toxoplasma gondii across biological barriers","volume":"11","author":"Barragan","year":"2003","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.exppara.2016.02.009_bib8","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1128\/IAI.00093-07","article-title":"Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen","volume":"76","author":"Bergstrom","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exppara.2016.02.009_bib9","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1590\/S0100-736X2010000900013","article-title":"Effects of infection with Toxoplasma gondii oocysts on the intestinal wall and the myenteric plexus of chicken (Gallus gallus)","volume":"30","author":"Bonapaz","year":"2010","journal-title":"Pesq. Vet. Bras."},{"key":"10.1016\/j.exppara.2016.02.009_bib10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1590\/S0102-09352011000200011","article-title":"Infec\u00e7\u00e3o toxopl\u00e1smica causa hipertrofia da parede do c\u00f3lon de frangos","volume":"63","author":"Braga","year":"2011","journal-title":"Arq. Bras. Med. Vet. Zoot"},{"key":"10.1016\/j.exppara.2016.02.009_bib11","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.pt.2006.08.002","article-title":"Toxoplasma gondii and subversion of the immune system","volume":"22","author":"Buzoni-Gatel","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.exppara.2016.02.009_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2011.00001","article-title":"The differential effect of Toxoplasma gondii infection on the stability of BCL2-family members involves multiple activities","volume":"2","author":"Carmen","year":"2011","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.exppara.2016.02.009_bib13","series-title":"C\u00e9lulas: uma Abordagem Multidisciplinar","first-page":"340","author":"Carvalho","year":"2005"},{"key":"10.1016\/j.exppara.2016.02.009_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.immunol.22.012703.104522","article-title":"Starting at the beginning: new perspectives on the biology of mucosal T cells","volume":"22","author":"Cheroutre","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.exppara.2016.02.009_bib15","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/mi.2014.25","article-title":"Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii","volume":"7","author":"Cohen","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.exppara.2016.02.009_bib16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.exppara.2013.03.010","article-title":"Toxoplasma gondii invasion and replication within neonate mouse astrocytes and changes in apoptosis related molecules","volume":"134","author":"Contreras-Ochoa","year":"2013","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2016.02.009_bib17","first-page":"269","article-title":"\u201cEnteric tears\u201d: chloride secretion and its neural regulation","volume":"13","author":"Cooke","year":"1998","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.exppara.2016.02.009_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00493164","article-title":"Immunohistochemical localization of polypeptides in peripheral autonomic nerves using whole mount","volume":"65","author":"Costa","year":"1980","journal-title":"Histochemi."},{"key":"10.1016\/j.exppara.2016.02.009_bib19","first-page":"55","article-title":"The effects of the infection caused by Toxoplasma gondii on the cat duodenal wall","volume":"19","author":"Da Silva","year":"2010","journal-title":"Rev. Bras. Parasitol. Vet."},{"key":"10.1016\/j.exppara.2016.02.009_bib20","doi-asserted-by":"crossref","first-page":"1131S","DOI":"10.1093\/ajcn\/73.6.1131S","article-title":"Microbial modulation of innate defense: goblet cells and the intestinal mucus layer","volume":"73","author":"Deplancke","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.exppara.2016.02.009_bib21","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1128\/JCM.11.6.562-568.1980","article-title":"Direct agglutination test for diagnosis of Toxoplasma infection: method of increasing sensitivity and specificity","volume":"11","author":"Desmonts","year":"1980","journal-title":"J.\u00a0Clin. Microbiol."},{"issue":"3","key":"10.1016\/j.exppara.2016.02.009_bib22","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2307\/3283823","article-title":"Duration of immunity to shedding of Toxoplasma gondii oocysts by cats","volume":"81","author":"Dubey","year":"1995","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.exppara.2016.02.009_bib23","series-title":"Toxoplasmosis of Animals and Humans","author":"Dubey","year":"2010"},{"key":"10.1016\/j.exppara.2016.02.009_bib24","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.coi.2010.04.008","article-title":"Monocytes mediate mucosal immunity to Toxoplasma gondii","volume":"22","author":"Dunay","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.exppara.2016.02.009_bib25","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/icb.2011.93","article-title":"Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger","volume":"90","author":"Egan","year":"2012","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.exppara.2016.02.009_bib26","series-title":"The Enteric Nervous System","first-page":"340","author":"Furness","year":"2006"},{"key":"10.1016\/j.exppara.2016.02.009_bib27","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1053\/j.gastro.2008.09.071","article-title":"Cholera toxin induces sustained hyperexcitability in submucosal secretomotor neurons in Guinea pig jejunum","volume":"136","author":"Gwynne","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.exppara.2016.02.009_bib28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1462-5822.2006.00767.x","article-title":"Inverted topology of the Toxoplasma gondii ROP5 rhoptry protein provides new insights into the association of the ROP2 protein family with the parasitophorous vacuole membrane","volume":"9","author":"Hajj","year":"2007","journal-title":"Cell Microbiol."},{"issue":"452","key":"10.1016\/j.exppara.2016.02.009_bib29","article-title":"Gastrointestinal parasites and the neural control of gut functions","volume":"9","author":"Halliez","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.exppara.2016.02.009_bib30","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s10620-013-2993-2","article-title":"Is L-glutathione more effective than L-glutamine in preventing enteric diabetic neuropathy?","volume":"59","author":"Hermes-Uliana","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.exppara.2016.02.009_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autneu.2010.09.003","article-title":"Chronic infection with Toxoplasma gondii causes myenteric neuroplasticity of the jejunum in rats","volume":"160","author":"Hermes-Uliana","year":"2011","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.exppara.2016.02.009_bib32","first-page":"7","article-title":"Neuronal populations in the submucous plexus of the human colon","volume":"166","author":"Hoyle","year":"1989","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.exppara.2016.02.009_bib33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11894-010-0131-2","article-title":"Intestinal goblet cells and mucins in health and disease: recent insights and progress","volume":"12","author":"Kim","year":"2010","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.exppara.2016.02.009_bib34","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-065X.2006.00475.x","article-title":"Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine","volume":"215","author":"Kunisawa","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.exppara.2016.02.009_bib35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0016-5085(03)00903-X","article-title":"CCR5 mediates specific migration of Toxoplasma gondii-primed CD8 lymphocytes to inflammatory intestinal epithelial cells","volume":"125","author":"Luangsay","year":"2003","journal-title":"Gastroenterol."},{"key":"10.1016\/j.exppara.2016.02.009_bib36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1128\/CMR.19.2.315-337.2006","article-title":"The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides and microbiota","volume":"19","author":"Moal","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.exppara.2016.02.009_bib37","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/iep.12049","article-title":"Moderate physical exercise reduces parasitaemia and protects colonic myenteric neurons in mice infected with Trypanosoma cruzi","volume":"94","author":"Moreira","year":"2013","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.exppara.2016.02.009_bib38","series-title":"Theory and Practice of Histological Techniques","first-page":"161","article-title":"Carbohydrates","author":"Myers","year":"2008"},{"key":"10.1016\/j.exppara.2016.02.009_bib39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrgastro.2012.221","article-title":"The digestive neuronal\u2013glial\u2013epithelial unit: a new actor in gut health and disease","volume":"10","author":"Neunlist","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.exppara.2016.02.009_bib40","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.autneu.2010.01.012","article-title":"Quantitative and morphometric changes of subpopulations of myenteric neurons in Swines with toxoplasmosis","volume":"155","author":"Odorizzi","year":"2010","journal-title":"Auton. Neurosci."},{"issue":"37","key":"10.1016\/j.exppara.2016.02.009_bib41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/pim.12157","article-title":"Toxoplasma gondii-induced neuronal alterations","volume":"2015","author":"Parlog","year":"2015","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.exppara.2016.02.009_bib42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0301-6226(97)00057-2","article-title":"Factors influencing the structure and function of the small intestine in the weaned pig: a review","volume":"51","author":"Pluske","year":"1997","journal-title":"Livest. Prod. Sci."},{"key":"10.1016\/j.exppara.2016.02.009_bib43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.exppara.2015.06.002","article-title":"Pathological changes in acute experimental toxoplasmosis with Toxoplasma gondii strains obtained from human cases of congenital disease","volume":"156","author":"Pinheiro","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2016.02.009_bib44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0167-0115(02)00290-2","article-title":"Differential effects of VIP and PACAP on survival of cultured adult rat myenteric neurons","volume":"111","author":"Sandgren","year":"2003","journal-title":"Regul. Pept."},{"key":"10.1016\/j.exppara.2016.02.009_bib45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2613.2012.00824.x","article-title":"Intraepithelial lymphocytes, goblet cells and VIP-IR submucosal neurons of jejunum rats infected with Toxoplasma gondii","volume":"93","author":"Sant\u2019Ana","year":"2012","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.exppara.2016.02.009_bib46","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1590\/S0103-84782009000700030","article-title":"An\u00e1lise morfom\u00e9trica da parede intestinal e din\u00e2mica de mucinas secretadas no \u00edleo de frangos infectados por Toxoplasma gondii","volume":"39","author":"Shiraishi","year":"2009","journal-title":"Ci\u00eancia Rural."},{"key":"10.1016\/j.exppara.2016.02.009_bib47","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.exppara.2010.03.004","article-title":"Toxoplasma gondii: a morphometric analysis of the wall and epithelial cells of pigs intestine","volume":"125","author":"Silva","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2016.02.009_bib48","series-title":"Parasitologia Cl\u00ednica Veterin\u00e1ria","first-page":"198","author":"Sloss","year":"1999"},{"key":"10.1016\/j.exppara.2016.02.009_bib49","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1017\/S0031182097001959","article-title":"Ultrastructure of early stages of infections in mice fed Toxoplasma gondii oocysts","volume":"116","author":"Speer","year":"1998","journal-title":"Parasitol."},{"key":"10.1016\/j.exppara.2016.02.009_bib50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/216173a0","article-title":"Fixation of ejaculated spermatozoa for electron microscopy","volume":"216","author":"Stefanini","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.exppara.2016.02.009_bib51","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbrc.2004.03.033","article-title":"Vasoactive intestinal peptide induces IL-8 production in human colonic epithelial cells via MAP kinase-dependent and PKA-independent pathways","volume":"317","author":"Toumi","year":"2004","journal-title":"Biochem. Biophis. Res. Commun."},{"key":"10.1016\/j.exppara.2016.02.009_bib52","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.peptides.2012.09.011","article-title":"Antioxidant activity of vasoactive intestinal peptide in HK2 human renal cells","volume":"38","author":"Vacas","year":"2012","journal-title":"Pept."},{"key":"10.1016\/j.exppara.2016.02.009_bib53","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.exppara.2015.05.007","article-title":"Oral dependent-dose toxoplasmic infection model induced by oocysts in rats: myenteric plexus and jejunal wall changes","volume":"156","author":"Vicentino-Vieira","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2016.02.009_bib54","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1590\/S0102-86502007000300012","article-title":"Anesthetic experimental device for small animal","volume":"22","author":"Vivas","year":"2007","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.exppara.2016.02.009_bib55","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1469-7793.2001.00741.x","article-title":"Neural components of distension-evoked secretory responses in the Guinea-Pig distal colon","volume":"536","author":"Weber","year":"2001","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.exppara.2016.02.009_bib56","first-page":"752","article-title":"Toxoplasma Gondii: the Model Apicomplexan. Perspectives and Methods","author":"Weiss","year":"2007"},{"key":"10.1016\/j.exppara.2016.02.009_bib57","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1292\/jvms.67.311","article-title":"Murine goblet cell hypoplasia during Eimeria pragensis infection is ameliorated by clindamycin treatment","volume":"67","author":"Yunus","year":"2005","journal-title":"J.\u00a0Vet. Med. Sci."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489416300236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489416300236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T22:15:29Z","timestamp":1600208129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489416300236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":57,"alternative-id":["S0014489416300236"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2016.02.009","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic infection with Toxoplasma gondii induces death of submucosal enteric neurons and damage in the colonic mucosa of rats","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2016.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}