{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:10:02Z","timestamp":1788340202552,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["475782\/2012-7"],"award-info":[{"award-number":["475782\/2012-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["CBB-PPM00196\/13"],"award-info":[{"award-number":["CBB-PPM00196\/13"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["00610\/15"],"award-info":[{"award-number":["00610\/15"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UNICEF\/UNDP\/World Bank\/WHO (TDR)"},{"name":"P3D-Programa de descoberta e desenvolvimento de drogas","award":["PROEP\/CNPq\/FIOCRUZ 401988\/2012-0"],"award-info":[{"award-number":["PROEP\/CNPq\/FIOCRUZ 401988\/2012-0"]}]},{"name":"RIPAg-Rede para Identifica\u00e7\u00e3o, Produ\u00e7\u00e3o e Avalia\u00e7\u00e3o de Ant\u00edgenos","award":["PROEP\/CNPq\/FIOCRUZ 402010\/2012-4"],"award-info":[{"award-number":["PROEP\/CNPq\/FIOCRUZ 402010\/2012-4"]}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["140435\/2013"],"award-info":[{"award-number":["140435\/2013"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.exppara.2016.08.006","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T08:18:18Z","timestamp":1472545098000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Molecular characterization of lipoamide dehydrogenase gene in Trypanosoma cruzi populations susceptible and resistant to benznidazole"],"prefix":"10.1016","volume":"170","author":[{"given":"Paula F.","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas S.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio H.","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.O.","family":"Volpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jer\u00f4nimo C.","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro J.","family":"Romanha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvane M.F.","family":"Murta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2016.08.006_bib1","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/bioinformatics\/bti263","article-title":"ProtTest: selection of best-fit models of protein evolution","volume":"21","author":"Abascal","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exppara.2016.08.006_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0166-6851(94)90075-2","article-title":"Molecular characterization and overexpression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma cruzi","volume":"65","author":"Allen","year":"1994","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.exppara.2016.08.006_bib3","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exppara.2016.08.006_bib4","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1021\/pr700659m","article-title":"Proteomic analysis of Trypanosoma cruzi resistance to Benznidazole","volume":"7","author":"Andrade","year":"2008","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.exppara.2016.08.006_bib5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00239-004-0078-8","article-title":"The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions","volume":"60","author":"Annoura","year":"2005","journal-title":"J.\u00a0Mol. Evol."},{"key":"10.1016\/j.exppara.2016.08.006_bib6","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1073\/pnas.0610618104","article-title":"Cryptic proteolytic activity of dihydrolipoamide dehydrogenase","volume":"104","author":"Babady","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exppara.2016.08.006_bib7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A\u00a0rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.exppara.2016.08.006_bib8","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.actatropica.2009.02.007","article-title":"Characterization of a gene encoding alcohol dehydrogenase in benznidazole-susceptible and -resistant populations of Trypanosoma cruzi","volume":"111","author":"Campos","year":"2009","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2016.08.006_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S0036-46652002000100006","article-title":"Long term evaluation of etiological treatment of chagas disease with benznidazole","volume":"44","author":"Can\u00e7ado","year":"2002","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.exppara.2016.08.006_bib10","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1093\/bioinformatics\/btp348","article-title":"TrimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses","volume":"25","author":"Capella-Gutierrez","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exppara.2016.08.006_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00208309","article-title":"Identification and purification of a distinct dihydrolipoamide dehydrogenase from pea chloroplasts","volume":"200","author":"Conner","year":"1996","journal-title":"Planta"},{"key":"10.1016\/j.exppara.2016.08.006_bib12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1042\/bj2430661","article-title":"Dihydrolipoamide dehydrogenase from Trypanosoma brucei. Characterization and cellular location","volume":"243","author":"Danson","year":"1987","journal-title":"Biochem. J."},{"key":"10.1016\/j.exppara.2016.08.006_bib13","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1007\/BF01941187","article-title":"Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi","volume":"44","author":"Diaz de Toranzo","year":"1988","journal-title":"Experientia"},{"key":"10.1016\/j.exppara.2016.08.006_bib14","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.jprot.2011.05.001","article-title":"Differential expression of Trypanosoma cruzi I associated with clinical forms of Chagas disease: overexpression of oxidative stress proteins in acute patient isolate","volume":"74","author":"Diaz","year":"2011","journal-title":"J.\u00a0Proteomics"},{"key":"10.1016\/j.exppara.2016.08.006_bib15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1360-1385(01)01892-1","article-title":"The glycine decarboxylase system: a fascinating complex","volume":"6","author":"Douce","year":"2001","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.exppara.2016.08.006_bib16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.1112631","article-title":"The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease","volume":"309","author":"El-Sayed","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.exppara.2016.08.006_bib17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1432-1033.1993.tb17678.x","article-title":"Cloning, sequencing, and expression of Trypanosoma brucei dihydrolipoamide dehydrogenase","volume":"212","author":"Else","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.exppara.2016.08.006_bib18","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0005-2744(74)90503-8","article-title":"Lipoamide dehydrogenase of the phytopathogenic fungi Pythium ultimum and Phytophthora erythroseptica. Differences in conformation and kinetics","volume":"350","author":"Fehrmann","year":"1974","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exppara.2016.08.006_bib19","series-title":"Phylip","author":"Felsenstein","year":"2009"},{"key":"10.1016\/j.exppara.2016.08.006_bib20","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0035-9203(87)90020-4","article-title":"Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease","volume":"81","author":"Filardi","year":"1987","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2016.08.006_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1475-9292-2-11","article-title":"Evolution of energy metabolism and its compartmentation in Kinetoplastida","volume":"2","author":"Hannaert","year":"2003","journal-title":"Kinetoplastid Biol. Dis."},{"key":"10.1016\/j.exppara.2016.08.006_bib22","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.febslet.2004.05.024","article-title":"Dihydrolipoamide dehydrogenase from porcine heart catalyzes NADH-dependent scavenging of nitric oxide","volume":"568","author":"Igamberdiev","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exppara.2016.08.006_bib23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/nar\/gkf436","article-title":"MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform","volume":"30","author":"Katoh","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exppara.2016.08.006_bib24","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.fgb.2010.06.005","article-title":"Roles of dihydrolipoamide dehydrogenase Lpd1 in Candida albicans filamentation","volume":"47","author":"Kim","year":"2010","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.exppara.2016.08.006_bib25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S1473-3099(13)70002-1","article-title":"Global economic burden of Chagas disease: a computational simulation model","volume":"13","author":"Lee","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.exppara.2016.08.006_bib26","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1432-1033.1990.tb19480.x","article-title":"Purification and characterization of lipoamide dehydrogenase from Trypanosoma cruzi","volume":"194","author":"Lohrer","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.exppara.2016.08.006_bib27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/bj2150133","article-title":"Dual role of a single multienzyme complex in the oxidative decarboxylation of pyruvate and branched-chain 2-oxo acids in Bacillus subtilis","volume":"215","author":"Lowe","year":"1983","journal-title":"Biochem. J."},{"key":"10.1016\/j.exppara.2016.08.006_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0014-5793(00)02116-5","article-title":"Molecular evidence of a unique lipoamide dehydrogenase in plastids: analysis of plastidic lipoamide dehydrogenase from Arabidopsis thaliana","volume":"484","author":"Lutziger","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exppara.2016.08.006_bib29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1104\/pp.010321","article-title":"Characterization of two cDNAs encoding mitochondrial lipoamide dehydrogenase from Arabidopsis","volume":"127","author":"Lutziger","year":"2001","journal-title":"Plant Physiol."},{"key":"10.1016\/j.exppara.2016.08.006_bib30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0969-2126(96)00032-9","article-title":"Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase","volume":"4","author":"Mande","year":"1996","journal-title":"Structure"},{"key":"10.1016\/j.exppara.2016.08.006_bib31","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cbpa.2006.03.004","article-title":"Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host","volume":"146","author":"Maya","year":"2007","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.exppara.2016.08.006_bib32","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj2330737","article-title":"Resolution of branched-chain oxo acid dehydrogenase complex of Pseudomonas aeruginosa PAO","volume":"233","author":"McCully","year":"1986","journal-title":"Biochem. J."},{"key":"10.1016\/j.exppara.2016.08.006_bib33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2958.2004.04398.x","article-title":"The human malaria parasite Plasmodium falciparum possesses two distinct dihydrolipoamide dehydrogenases","volume":"55","author":"McMillan","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.exppara.2016.08.006_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0166-6851(98)00037-1","article-title":"Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox","volume":"93","author":"Murta","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.exppara.2016.08.006_bib35","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.molbiopara.2005.12.001","article-title":"Deletion of copies of the gene encoding old yellow enzyme (TcOYE), a NAD(P)H flavin oxidoreductase, associates with in\u00a0vitro-induced benznidazole resistance in Trypanosoma cruzi","volume":"146","author":"Murta","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.exppara.2016.08.006_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.actatropica.2008.04.011","article-title":"Differential gene expression in Trypanosoma cruzi populations susceptible and resistant to benznidazole","volume":"107","author":"Murta","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2016.08.006_bib37","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1017\/S0031182097002084","article-title":"In\u00a0vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole","volume":"116","author":"Murta","year":"1998","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2016.08.006_bib38","first-page":"1239","article-title":"Drug-resistant epimastigotes of Trypanosoma cruzi and persistence of this phenotype after differentiation into amastigotes","volume":"318","author":"Nird\u00e9","year":"1995","journal-title":"C\u00a0R. Acad. Sci. III."},{"key":"10.1016\/j.exppara.2016.08.006_bib39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.actatropica.2006.10.004","article-title":"Increased expression of iron-containing superoxide dismutase-A (TcFeSOD-A) enzyme in Trypanosoma cruzi population with in\u00a0vitro-induced resistance to benznidazole","volume":"100","author":"Nogueira","year":"2006","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2016.08.006_bib40","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1590\/S0074-02762012000400009","article-title":"The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide","volume":"107","author":"Nogueira","year":"2012","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2016.08.006_bib41","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s00436-008-1264-1","article-title":"Molecular characterization of cytosolic and mitochondrial tryparedoxin peroxidase in Trypanosoma cruzi populations susceptible and resistant to benznidazole","volume":"104","author":"Nogueira","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2016.08.006_bib42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/biof.5520180206","article-title":"Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase","volume":"18","author":"Nordman","year":"2003","journal-title":"Biofactors"},{"key":"10.1016\/j.exppara.2016.08.006_bib43","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0014-5793(99)00363-4","article-title":"Ubiquinone is reduced by lipoamide dehydrogenase and this reaction is potently stimulated by zinc","volume":"448","author":"Olsson","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.exppara.2016.08.006_bib44","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.pt.2007.08.002","article-title":"Horizontal gene transfer in trypanosomatids","volume":"23","author":"Opperdoes","year":"2007","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.exppara.2016.08.006_bib45","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/jac\/dkp357","article-title":"Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis","volume":"64","author":"Perez-Molina","year":"2009","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.exppara.2016.08.006_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1989.tb14983.x","article-title":"2-Oxo acid dehydrogenase multienzyme complexes: domains, dynamics and design","volume":"573","author":"Perham","year":"1989","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.exppara.2016.08.006_bib47","doi-asserted-by":"crossref","first-page":"46403","DOI":"10.1074\/jbc.M305291200","article-title":"Reduction of Fe(III) ions complexed to physiological ligands by lipoyl dehydrogenase and other flavoenzymes in\u00a0vitro: implications for an enzymatic reduction of Fe(III) ions of the labile iron pool","volume":"278","author":"Petrat","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exppara.2016.08.006_bib48","first-page":"147","article-title":"Lipoamide dehydrogenase from Trypanosoma cruzi: some properties and cellular localization","volume":"24","author":"Portela","year":"1991","journal-title":"Biochem. Int."},{"key":"10.1016\/j.exppara.2016.08.006_bib49","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2958.2011.07721.x","article-title":"Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei","volume":"81","author":"Rold\u00e1n","year":"2011","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.exppara.2016.08.006_bib50","first-page":"925","article-title":"Cloning and characterization of the gene encoding lipoamide dehydrogenase in Saccharomyces cerevisiae","volume":"133","author":"Roy","year":"1987","journal-title":"J.\u00a0Gen. Microbiol."},{"key":"10.1016\/j.exppara.2016.08.006_bib51","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/bioinformatics\/16.10.944","article-title":"Artemis: sequence visualization and annotation","volume":"16","author":"Rutherford","year":"2000","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exppara.2016.08.006_bib52","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1756-3305-5-161","article-title":"Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi","volume":"5","author":"Santos","year":"2012","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.exppara.2016.08.006_bib53","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1432-1033.1997.00739.x","article-title":"Cloning, sequencing and functional expression of dihydrolipoamide dehydrogenase from the human pathogen Trypanosoma cruzi","volume":"243","author":"Sch\u00f6neck","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.exppara.2016.08.006_bib54","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1046\/j.1365-2958.2002.02883.x","article-title":"Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection","volume":"44","author":"Smith","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.exppara.2016.08.006_bib55","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/0006-291X(81)91932-X","article-title":"Isolation of two lipoamide dehydrogenases from Pseudomonas putida grown on valine","volume":"100","author":"Sokatch","year":"1981","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exppara.2016.08.006_bib56","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/jac\/dkh224","article-title":"Effects of specific treatment on parasitological and histopathological parameters in mice infected with different Trypanosoma cruzi clonal genotypes","volume":"53","author":"Toledo","year":"2004","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.exppara.2016.08.006_bib57","doi-asserted-by":"crossref","first-page":"e2844","DOI":"10.1371\/journal.pntd.0002844","article-title":"Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics","volume":"8","author":"Trochine","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.exppara.2016.08.006_bib58","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.molbiopara.2010.05.002","article-title":"YCF45 protein, usually associated with plastids, is targeted into the mitochondrion of Trypanosoma brucei","volume":"173","author":"T\u00fdc","year":"2010","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.exppara.2016.08.006_bib59","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.chom.2010.12.004","article-title":"Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes","volume":"9","author":"Venugopal","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.exppara.2016.08.006_bib60","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.exppara.2004.07.001","article-title":"Lack of correlation between in\u00a0vitro susceptibility to Benznidazole and phylogenetic diversity of Trypanosoma cruzi, the agent of Chagas disease","volume":"108","author":"Villarreal","year":"2004","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2016.08.006_bib61","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1128\/AAC.49.7.2701-2709.2005","article-title":"Differential gene expression in benznidazole-resistant Trypanosoma cruzi parasites","volume":"49","author":"Villarreal","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.exppara.2016.08.006_bib62","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/S0021-9258(17)35920-3","article-title":"Glycine decarboxylase multienzyme complex. Purification and partial characterization from pea leaf mitochondria","volume":"261","author":"Walker","year":"1986","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exppara.2016.08.006_bib63","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1073\/pnas.0711014105","article-title":"A\u00a0mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes","volume":"105","author":"Wilkinson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exppara.2016.08.006_bib64","first-page":"121","article-title":"Lipoamide dehydrogenase, glutathione reductase, thioredoxin reductase, and mercuric ion reductase \u2013 a family of flavoenzyme transhydrogenases","volume":"vol. III","author":"Williams","year":"1992"},{"key":"10.1016\/j.exppara.2016.08.006_bib65","series-title":"Chagas Disease (American Trypanosomiasis). Fact Sheet N\u00b0340","author":"World Health Organization (WHO)","year":"2016"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489416301643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489416301643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T09:17:53Z","timestamp":1657185473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489416301643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":65,"alternative-id":["S0014489416301643"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2016.08.006","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characterization of lipoamide dehydrogenase gene in Trypanosoma cruzi populations susceptible and resistant to benznidazole","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2016.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}