{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:51:22Z","timestamp":1777413082263,"version":"3.51.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["BSC0114"],"award-info":[{"award-number":["BSC0114"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.exppara.2016.09.010","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T17:55:52Z","timestamp":1474566952000},"page":"135-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Recombinant Leishmania Rab6 (rLdRab6) is recognized by sera from visceral leishmaniasis patients"],"prefix":"10.1016","volume":"170","author":[{"given":"Indira Singh","family":"Chauhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rantidev","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shagun","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savita","family":"Sekhri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umesh","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabitha","family":"Baby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiranjib","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Imran","family":"Siddiqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Sundar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6627-7449","authenticated-orcid":false,"given":"Neeloo","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2016.09.010_bib1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.biochi.2011.09.026","article-title":"The PE\/PPE multigene family codes for virulence factors and is a possible source of mycobacterial antigenic variation: perhaps more?","volume":"94","author":"Akhter","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.exppara.2016.09.010_bib2","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/infdis\/173.3.758","article-title":"rK39: a cloned antigen of Leishmania chagasi that predicts active visceral leishmaniasis","volume":"173","author":"Badaro","year":"1996","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.exppara.2016.09.010_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.4269\/ajtmh.2000.63.153","article-title":"Use of the recombinant K39 dipstick test and the direct agglutination test in a setting endemic for visceral leishmaniasis in Nepal","volume":"63","author":"Bern","year":"2000","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2016.09.010_bib4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1073\/pnas.90.2.775","article-title":"Molecular characterization of a kinesin-related antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis","volume":"90","author":"Burns","year":"1993","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.exppara.2016.09.010_bib5","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1099\/jmm.0.47565-0","article-title":"Characterization of T-cell immunogenicity of two PE\/PPE proteins of Mycobacterium tuberculosis","volume":"57","author":"Chaitra","year":"2008","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.exppara.2016.09.010_bib6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12862-015-0538-3","article-title":"Evolutionary comparison of prenylation pathway in kinetoplastid Leishmania and its sister Leptomonas","volume":"15","author":"Chauhan","year":"2015","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.exppara.2016.09.010_bib7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.bbrc.2006.01.005","article-title":"Identification of a new developmentally regulated Leishmania major large RAB GTPase","volume":"341","author":"Chenik","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.exppara.2016.09.010_bib8","first-page":"45","article-title":"Amino acid sequence","volume":"47","author":"Chou","year":"2009","journal-title":"Adv. Enzym. Relat. Areas Mol. Biol."},{"key":"10.1016\/j.exppara.2016.09.010_bib9","doi-asserted-by":"crossref","first-page":"12658","DOI":"10.1074\/jbc.M413140200","article-title":"Monastrol inhibition of the mitotic kinesin Eg5","volume":"280","author":"Cochran","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exppara.2016.09.010_bib10","doi-asserted-by":"crossref","first-page":"e0003992","DOI":"10.1371\/journal.pntd.0003992","article-title":"Over-expression of cysteine leucine rich protein is related to SAG resistance in clinical isolates of Leishmania donovani","volume":"9","author":"Das","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.exppara.2016.09.010_bib11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0166-6851(02)00133-0","article-title":"Leishmania RAB7: characterisation of terminal endocytic stages in an intracellular parasite","volume":"123","author":"Denny","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.exppara.2016.09.010_bib12","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.279.5350.580","article-title":"Interaction of a golgi-associated kinesin-like protein with Rab6","volume":"279","author":"Echard","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.exppara.2016.09.010_bib13","doi-asserted-by":"crossref","first-page":"e86073","DOI":"10.1371\/journal.pone.0086073","article-title":"Characterization of glycolytic enzymes-rAldolase and rEnolase of Leishmania donovani, identified as Th1 stimulatory proteins, for their immunogenicity and immunoprophylactic efficacies against experimental visceral leishmaniasis","volume":"9","author":"Gupta","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.exppara.2016.09.010_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00251-008-0341-z","article-title":"NetMHCpan, a method for MHC class I binding prediction beyond humans","volume":"61","author":"Hoof","year":"2009","journal-title":"Immunogenetics"},{"key":"10.1016\/j.exppara.2016.09.010_bib15","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1042\/BST0391202","article-title":"Rab GTPases and microtubule motors","volume":"39","author":"Horgan","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.exppara.2016.09.010_bib16","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1086\/382077","article-title":"Combating tropical infectious diseases: report of the disease control priorities in developing countries project","volume":"38","author":"Hotez","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.exppara.2016.09.010_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1152\/physrev.00059.2009","article-title":"Role of Rab GTPases in membrane traffic and cell physiology","volume":"91","author":"Hutagalung","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.exppara.2016.09.010_bib18","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/jac\/dks507","article-title":"A\u00a0member of the Ras oncogene family, RAP1A, mediates antileishmanial activity of monastrol","volume":"68","author":"Kaur","year":"2013","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.exppara.2016.09.010_bib19","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1093\/jac\/dkq189","article-title":"Molecular docking, structure\u2013activity relationship and biological evaluation of the anticancer drug monastrol as a pteridine reductase inhibitor in a clinical isolate of Leishmania donovani","volume":"65","author":"Kaur","year":"2010","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.exppara.2016.09.010_bib20","first-page":"190","article-title":"Gene regulation of pteridine reductase 1 in Leishmania promastigotes and amastigotes using a full-length antisense construct","volume":"8","author":"Kheirandish","year":"2013","journal-title":"Iran. J. Parasitol."},{"key":"10.1016\/j.exppara.2016.09.010_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pep.2005.10.002","article-title":"Prokaryotic expression, purification, and polyclonal antibody production against a novel drug resistance gene of Leishmania donovani clinical isolate","volume":"45","author":"Kothari","year":"2006","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.exppara.2016.09.010_bib22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.pep.2004.08.015","article-title":"Overexpression in Escherichia coli and purification of pteridine reductase (PTR1) from a clinical isolate of Leishmania donovani","volume":"38","author":"Kumar","year":"2004","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.exppara.2016.09.010_bib23","doi-asserted-by":"crossref","first-page":"13253","DOI":"10.1016\/S0021-9258(18)90686-1","article-title":"Synthesis of a model protein of defined secondary and quaternary structure. Effect of chain length on the stabilization and formation of two-stranded alpha-helical coiled-coils","volume":"259","author":"Lau","year":"1984","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exppara.2016.09.010_bib24","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/bioinformatics\/btn128","article-title":"Accurate approximation method for prediction of class I MHC affinities for peptides of length 8, 10 and 11 using prediction tools trained on 9mers","volume":"24","author":"Lundegaard","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.exppara.2016.09.010_bib25","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s00299-007-0367-y","article-title":"Perinuclear and nuclear envelope localizations of Arabidopsis Ran proteins","volume":"26","author":"Ma","year":"2007","journal-title":"Plant cell Rep."},{"key":"10.1016\/j.exppara.2016.09.010_bib26","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1574-6976.2006.00041.x","article-title":"Comparative genomics of metabolic pathways in Mycobacterium species: gene duplication, gene decay and lateral gene transfer","volume":"30","author":"Marri","year":"2006","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.exppara.2016.09.010_bib27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4137\/DTI.S10219","article-title":"Drug target exploitable structural features of adenylyl cyclase activity in Schistosoma mansoni","volume":"6","author":"Mbah","year":"2012","journal-title":"Drug Target Insights"},{"issue":"50","key":"10.1016\/j.exppara.2016.09.010_bib28","doi-asserted-by":"crossref","first-page":"29993","DOI":"10.1074\/jbc.M115.670018","article-title":"Functional characterization of monomeric GTPase Rab1 in the secretory pathway of Leishmania","volume":"290","author":"Mukhopadhyay","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exppara.2016.09.010_bib29","series-title":"The World Health Report: 2000: Health Systems: Improving Performance","author":"Organization","year":"2000"},{"key":"10.1016\/j.exppara.2016.09.010_bib30","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1073\/pnas.0800404105","article-title":"Leishmania requires Rab7-mediated degradation of endocytosed hemoglobin for their growth","volume":"105","author":"Patel","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.exppara.2016.09.010_bib31","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1006\/jmbi.2000.4010","article-title":"The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily","volume":"301","author":"Pereira-Leal","year":"2000","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.exppara.2016.09.010_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-6-132","article-title":"Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method","volume":"6","author":"Peters","year":"2005","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.exppara.2016.09.010_bib33","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1073\/pnas.93.5.1759","article-title":"A\u00a0quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells","volume":"93","author":"Rosa","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.exppara.2016.09.010_bib34","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1242\/jcs.044651","article-title":"Ancient Leishmania coronin (CRN12) is involved in microtubule remodeling during cytokinesis","volume":"122","author":"Sahasrabuddhe","year":"2009","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.exppara.2016.09.010_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/497203","article-title":"Mycobacterial PE\/PPE proteins at the host-pathogen interface","volume":"2011","author":"Sampson","year":"2011","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.exppara.2016.09.010_bib36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.chom.2012.03.003","article-title":"Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion-encoded PE-PPE proteins predicts vaccine potential","volume":"11","author":"Sayes","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.exppara.2016.09.010_bib37","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1093\/emboj\/cdg557","article-title":"Rab5-mediated endosome\u2013endosome fusion regulates hemoglobin endocytosis in Leishmania donovani","volume":"22","author":"Singh","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.exppara.2016.09.010_bib38","first-page":"951","article-title":"Laboratory diagnosis of visceral leishmaniasis","volume":"9","author":"Sundar","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.exppara.2016.09.010_bib39","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1469-0691.2011.03540.x","article-title":"Evaluation of rK28 antigen for serodiagnosis of visceral Leishmaniasis in India","volume":"18","author":"Vaish","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.exppara.2016.09.010_bib40","doi-asserted-by":"crossref","first-page":"e40890","DOI":"10.1371\/journal.pone.0040890","article-title":"Conserved immune recognition hierarchy of mycobacterial PE\/PPE proteins during infection in natural hosts","volume":"7","author":"Vordermeier","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.exppara.2016.09.010_bib41","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1083\/jcb.147.4.743","article-title":"Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells","volume":"147","author":"White","year":"1999","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.exppara.2016.09.010_bib42","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1128\/CDLI.5.5.717-720.1998","article-title":"rK39 enzyme-linked immunosorbent assay for diagnosis of Leishmania donovani infection","volume":"5","author":"Zijlstra","year":"1998","journal-title":"Clin. Diagn. Lab. Immunol."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489416301990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489416301990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T16:43:42Z","timestamp":1616517822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489416301990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":42,"alternative-id":["S0014489416301990"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2016.09.010","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant Leishmania Rab6 (rLdRab6) is recognized by sera from visceral leishmaniasis patients","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2016.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}