{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:25:17Z","timestamp":1789989917817,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.exppara.2017.07.009","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T07:18:18Z","timestamp":1501571898000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Activity of rosuvastatin in tachyzoites of Toxoplasma gondii (RH strain) in HeLa cells"],"prefix":"10.1016","volume":"181","author":[{"given":"Raquel Arruda","family":"Sanfelice","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00eds Fernanda","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Rodrigues","family":"Bosqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Menegazzo","family":"Miranda-Sapla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Tomiotto-Pellissier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"de Alc\u00e2ntara Dalevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dielle","family":"Ioris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Fonseca","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Aparecido","family":"Panagio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italmar Teodorico","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliano","family":"Bordignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivete","family":"Conchon-Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wander Rog\u00e9rio","family":"Pavanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Sergio","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idessania Nazareth","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2017.07.009_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1359-6446(04)03308-2","article-title":"Targeting DHFR in parasitic protozoa","volume":"10","author":"Anderson","year":"2005","journal-title":"Drug. Discov. Today"},{"key":"10.1016\/j.exppara.2017.07.009_bib2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.7883\/yoken.JJID.2014.422","article-title":"Severe toxoplasmic hepatitis in an immunocompetent patient","volume":"68","author":"Atilla","year":"2015","journal-title":"Jpn. J. Infect. Dis."},{"key":"10.1016\/j.exppara.2017.07.009_bib3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.vetpar.2011.12.039","article-title":"Enrofloxacina is able to control Toxoplasma gondii infection in both in\u00a0vitro and in\u00a0vivo experimental models","volume":"187","author":"Barbosa","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2017.07.009_bib4","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.4049\/jimmunol.153.10.4583","article-title":"Enhancement of intracellular replication of Toxoplasma gondii by IL -6. Interactions with IFN-\u0263 and TNF-\u03b1","volume":"153","author":"Beaman","year":"1994","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.exppara.2017.07.009_bib5","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.2353\/ajpath.2006.050636","article-title":"Toxoplasma gondii infection reveals a novel regulatory role for Galectin-3 in the interface of innate and adaptive immunity","volume":"168","author":"Bernardes","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exppara.2017.07.009_bib6","doi-asserted-by":"crossref","first-page":"24223","DOI":"10.1074\/jbc.M100951200","article-title":"Microarray analysis reveals previously unknown changes in Toxoplasma gondii infected human cells","volume":"276","author":"Blader","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.exppara.2017.07.009_bib7","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1089\/fpd.2010.0795","article-title":"Toxoplasma in animals, food, and humans: an old parasite of new concern","volume":"8","author":"Cenci-Goga","year":"2011","journal-title":"Foodborne Pathog. Dis."},{"key":"10.1016\/j.exppara.2017.07.009_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13041-014-0085-7","article-title":"Statin treatment affects cytokine release and phagocytic activity in primary cultured microglia througt two separable mechanisms","volume":"7","author":"Churchwad","year":"2014","journal-title":"Mol. Brain"},{"key":"10.1016\/j.exppara.2017.07.009_bib9","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nrmicro3139","article-title":"Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies","volume":"11","author":"Coppens","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.exppara.2017.07.009_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2016.02.012","article-title":"Rosuvastatin: beyond the cholesterol-lowering effect","volume":"107","author":"Cortese","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.exppara.2017.07.009_bib11","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijantimicag.2008.07.026","article-title":"Statins inhibit Toxoplasma gondii multiplication in macrophages in\u00a0vitro","volume":"33","author":"Cortez","year":"2009","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.exppara.2017.07.009_bib12","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1600-0854.2012.01335.x","article-title":"Apicoplast Targeting of a Toxoplasma gondii transmembrane protein requires a cytosolic tyrosine-based motif","volume":"13","author":"De Rocher","year":"2012","journal-title":"Traffic"},{"key":"10.1016\/j.exppara.2017.07.009_bib13","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1007\/s00436-015-4618-5","article-title":"Antileishmanial effect of mevastatin is due to interference with sterol metabolism","volume":"114","author":"Dinesh","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2017.07.009_bib14","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.ijpara.2008.03.007","article-title":"Toxoplasma gondii infection in humans and animals in the United States","volume":"38","author":"Dubey","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2017.07.009_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.puhe.2007.08.009","article-title":"Congenital toxoplasmosis: priorities for further health promotion action","volume":"122","author":"Elsheikha","year":"2008","journal-title":"Public Health"},{"key":"10.1016\/j.exppara.2017.07.009_bib16","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0022-2275(20)41379-3","article-title":"The Discovery and development of HMG-CoA reductase inhibitors","volume":"33","author":"Endo","year":"1992","journal-title":"J.\u00a0Lipid. Res."},{"key":"10.1016\/j.exppara.2017.07.009_bib17","first-page":"9","article-title":"Pharmacokinetics of statins","volume":"85","author":"Fonseca","year":"2005","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.exppara.2017.07.009_bib18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/sj.icb.7100038","article-title":"Cytokine regulation of immunopathology in toxoplasmosis","volume":"85","author":"Gaddi","year":"2007","journal-title":"Immunol. Cell. Biol."},{"key":"10.1016\/j.exppara.2017.07.009_bib19","first-page":"102","article-title":"Pharmacological actions of statins: a critical appraisal in the management of cancer","volume":"64","author":"Gazzerro","year":"2012","journal-title":"Am. Soc. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.exppara.2017.07.009_bib20","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.farma.2011.02.010","article-title":"Consideraciones espec\u00edficas enlaprescripci\u00f3n e intercambio terap\u00e9utico de estatinas","volume":"36","author":"Garc\u00eda-Sabina","year":"2012","journal-title":"Farm. Hosp."},{"key":"10.1016\/j.exppara.2017.07.009_bib22","series-title":"Princ\u00edpios de Farmacologia: a Base Fisiopatol\u00f3gica da Farmacoterapia","author":"Golan","year":"2009"},{"key":"10.1016\/j.exppara.2017.07.009_bib23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1086\/653738","article-title":"Interleukin 17 receptor signaling is deleterious during Toxoplasma gondii infection in susceptible BL6 mice","volume":"202","author":"Guiton","year":"2010","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.exppara.2017.07.009_bib24","series-title":"Farmacologia B\u00e1sica & Cl\u00ednica","first-page":"546","author":"Katzung","year":"2006"},{"key":"10.1016\/j.exppara.2017.07.009_bib25","doi-asserted-by":"crossref","first-page":"e55497","DOI":"10.1371\/journal.pone.0055497","article-title":"Trypanosoma cruzi response to sterol biosynthesis inhibitors: morphophysiological alterations leading to cell death","volume":"8","author":"Kesller","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.exppara.2017.07.009_bib26","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1126\/science.275.5305.1485","article-title":"A\u00a0plastid of probable green algal origin in Apicomplexan parasites","volume":"275","author":"K\u00f6hler","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.exppara.2017.07.009_bib27","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.exppara.2010.12.003","article-title":"Influence of long-term treatment with pravastatin on the survival, evolution of cutaneous lesion and weight of animals infected by Leishmania amazonensis","volume":"127","author":"K\u00fcckelhaus","year":"2013","journal-title":"Exp. Parasitol."},{"issue":"9","key":"10.1016\/j.exppara.2017.07.009_bib28","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/j.bbamem.2016.06.010","article-title":"Statin induced chronic cholesterol depletion inhibits Leishmania donovani infection: relevance of optimum host membrane cholesterol","volume":"1858","author":"Kumar","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.exppara.2017.07.009_bib29","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.biopha.2007.06.005","article-title":"Immunomodulation by statin: inhibition of cholesterol vs. isoprenoid biosynthesis","volume":"61","author":"Kuipers","year":"2007","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exppara.2017.07.009_bib30","doi-asserted-by":"crossref","first-page":"e1003665","DOI":"10.1371\/journal.ppat.1003665","article-title":"Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatin","volume":"9","author":"Li","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.exppara.2017.07.009_bib31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.amjcard.2006.09.018","article-title":"Molecular basis of differences among statins and a comparison with antioxidant vitamins","volume":"98","author":"Mason","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.exppara.2017.07.009_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.exppara.2017.07.009_bib33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1600-065X.2010.00992.x","article-title":"Immunology of Toxoplasma gondii","volume":"240","author":"Munoz","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.exppara.2017.07.009_bib34","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1084\/jem.20110039","article-title":"Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii","volume":"208","author":"Nair","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.exppara.2017.07.009_bib35","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1292\/jvms.10-0496","article-title":"Host cholesterol synthesis contributes to growth of intracellular Toxoplasma gondii in macrophages","volume":"73","author":"Nishikawa","year":"2011","journal-title":"J.Vet. Med. Sci."},{"key":"10.1016\/j.exppara.2017.07.009_bib36","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1128\/IAI.00386-05","article-title":"cDNA microarray analysis of host-pathogen interactions in a porcine in\u00a0vitro model for Toxoplasma gondii infection","volume":"74","author":"Okomo-Adhiambo","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exppara.2017.07.009_bib37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.parint.2015.11.001","article-title":"Atorvastatin and metformin administration modulates experimental Trichinella spiralis infection","volume":"65","author":"Othman","year":"2016","journal-title":"Parasitol. Inter"},{"key":"10.1016\/j.exppara.2017.07.009_bib38","series-title":"Farmacologia Integrada","first-page":"302","author":"Page","year":"2004"},{"key":"10.1016\/j.exppara.2017.07.009_bib39","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.4049\/jimmunol.0901843","article-title":"IL-6 promotes NK cell production of IL-17 during toxoplasmosis","volume":"184","author":"Passos","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.exppara.2017.07.009_bib41","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pt.2011.03.009","article-title":"Innate responses to Toxoplasma gondii in mice and humans","volume":"27","author":"Pifer","year":"2001","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.exppara.2017.07.009_bib42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1747-0285.2012.01389.x","article-title":"Antimalarial drugs and drug targets specific to fatty acid metabolic pathway of Plasmodium falciparum","volume":"80","author":"Qidwai","year":"2012","journal-title":"Chem. Biol. Drug. Des."},{"key":"10.1016\/j.exppara.2017.07.009_bib43","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.actatropica.2016.12.006","article-title":"Pravastatin and simvastatin inhibit the adhesion, replication and proliferation of Toxoplasma gondii (RH strain) in HeLa cells","volume":"167","author":"Sanfelice","year":"2017","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2017.07.009_bib46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1937-6448(10)81005-6","article-title":"Metabolic pathways in the apicoplast of apicomplexa","volume":"281","author":"Seeber","year":"2010","journal-title":"Int. Rev. Cell. Mol. Biol."},{"key":"10.1016\/j.exppara.2017.07.009_bib47","author":"Serrano"},{"issue":"4","key":"10.1016\/j.exppara.2017.07.009_bib48","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1590\/S0074-02762012000400012","article-title":"Short-term therapy with simvastatin reduces inflammatory mediators and heart inflammation during the acute phase of experimental Chagas disease","volume":"107","author":"Silva","year":"2012","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2017.07.009_bib50","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans","volume":"12","author":"Tenter","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2017.07.009_bib51","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1128\/AAC.01469-08","article-title":"Statins as potential antimalarial drugs: low relative potency and lack of synergy with conventional antimalarial drugs","volume":"53","author":"Wong","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.exppara.2017.07.009_bib52","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nature01158","article-title":"The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease","volume":"6911","author":"Youssef","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.exppara.2017.07.009_bib53","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1182\/blood-2007-08-106005","article-title":"Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th2 polarization while sparing graft-versus-leukemia activity","volume":"110","author":"Zeiser","year":"2007","journal-title":"Blood"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489417301662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489417301662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T19:54:30Z","timestamp":1692906870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489417301662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":48,"alternative-id":["S0014489417301662"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2017.07.009","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activity of rosuvastatin in tachyzoites of Toxoplasma gondii (RH strain) in HeLa cells","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2017.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}