{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:25:04Z","timestamp":1790810704986,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Human Science Frontiers Program","award":["RGY0078\/2015"],"award-info":[{"award-number":["RGY0078\/2015"]}]},{"name":"European projects (KJP)","award":["316304"],"award-info":[{"award-number":["316304"]}]},{"name":"European project"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.exppara.2018.06.009","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T22:57:45Z","timestamp":1530140265000},"page":"55-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Evaluating rodent experimental models for studies of Blastocystis ST1"],"prefix":"10.1016","volume":"191","author":[{"given":"Ji\u0159ina","family":"R\u016f\u017ekov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Kv\u011bto\u0148ov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Jirk\u016f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Lhotsk\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1417-7048","authenticated-orcid":false,"given":"Christen Rune","family":"Stensvold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Wegener","family":"Parfrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5411-6082","authenticated-orcid":false,"given":"Kate\u0159ina","family":"Jirk\u016f Pomajb\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2018.06.009_bib1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1550-7408.2012.00644.x","article-title":"The revised classification of eukaryotes","volume":"59","author":"Adl","year":"2012","journal-title":"J. Eukaryot. Microbiol."},{"key":"10.1016\/j.exppara.2018.06.009_bib2","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.parint.2016.05.007","article-title":"Pathogenic mechanisms in Blastocystis spp. \u2013 interpreting results from in vitro and in vivo studies","volume":"65","author":"Ajjampur","year":"2016","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.exppara.2018.06.009_bib3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.protis.2013.05.003","article-title":"Genetic diversity of Blastocystis in livestock and zoo animals","volume":"164","author":"Alfellani","year":"2013","journal-title":"Protist"},{"key":"10.1016\/j.exppara.2018.06.009_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.actatropica.2012.12.011","article-title":"Variable geographic distribution of Blastocystis subtypes and its potential implications","volume":"126","author":"Alfellani","year":"2013","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2018.06.009_bib5","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1017\/S0031182013000255","article-title":"Diversity and distribution of Blastocystis sp. subtypes in non-human primates","volume":"140","author":"Alfellani","year":"2013","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2018.06.009_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/femsec\/fiv072","article-title":"A retrospective metagenomics approach to studying Blastocystis","volume":"91","author":"Andersen","year":"2015","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.exppara.2018.06.009_bib7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1128\/JCM.02520-15","article-title":"Blastocystis in health and disease: are we moving from a clinical to a public health perspective?","volume":"54","author":"Andersen","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.exppara.2018.06.009_bib8","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s10096-016-2680-2","article-title":"Associations between common intestinal parasites and bacteria in humans as revealed by qPCR","volume":"35","author":"Andersen","year":"2016","journal-title":"Eur. J. Clin. Microbiol."},{"key":"10.1016\/j.exppara.2018.06.009_bib9","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2307\/3282084","article-title":"Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic percoll gradients","volume":"73","author":"Arrowood","year":"1987","journal-title":"J. Parasitol."},{"key":"10.1016\/j.exppara.2018.06.009_bib10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/srep25255","article-title":"Colonization with the enteric protozoa Blastocystis is associated with increased diversity of human gut bacterial microbiota","volume":"6","author":"Audebert","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exppara.2018.06.009_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134116","article-title":"The evolution of stomach acidity and its relevance to the human microbiome","volume":"10","author":"Beasley","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exppara.2018.06.009_bib12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1756-3305-1-40","article-title":"Oh my aching gut: irritable bowel syndrome, Blastocystis, and asymptomatic infection","volume":"1","author":"Boorom","year":"2008","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.exppara.2018.06.009_bib13","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.pt.2017.08.005","article-title":"Gut protozoa: friends or foes of the human gut microbiota?","volume":"33","author":"Chab\u00e9","year":"2017","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.exppara.2018.06.009_bib14","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s00436-010-1825-y","article-title":"Urinary hyaluronidase activity in rats infected with Blastocystis hominis-evidence for invasion?","volume":"106","author":"Chandramathi","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2018.06.009_bib15","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1017\/S0031182009991351","article-title":"High levels of oxidative stress in rats infected with Blastocystis hominis","volume":"137","author":"Chandramathi","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2018.06.009_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094567","article-title":"Stress exacerbates infectivity and pathogenicity of Blastocystis hominis: in vitro and in vivo evidences","volume":"9","author":"Chandramathi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exppara.2018.06.009_bib17","first-page":"91","article-title":"A survey of Blastocystis sp. in rodents","volume":"47","author":"Chen","year":"1997","journal-title":"Lab. Anim. Sci."},{"key":"10.1016\/j.exppara.2018.06.009_bib18","series-title":"Advances in Parasitology","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-407706-5.00001-0","article-title":"Recent developments in Blastocystis research","author":"Clark","year":"2013"},{"key":"10.1016\/j.exppara.2018.06.009_bib19","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3389\/fcimb.2017.00238","article-title":"Translational rodent models for research on parasitic protozoa \u2013 a review of confounders and possibilities","volume":"7","author":"Ehret","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.exppara.2018.06.009_bib20","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00436-014-3787-y","article-title":"Blastocystis tropism in the pig intestine","volume":"113","author":"Fayer","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2018.06.009_bib21","article-title":"Blastocystis sp. infection mimicking Clostridium difficile colitis","author":"Gill","year":"2016","journal-title":"Case. Rep. Infect. Dis."},{"key":"10.1016\/j.exppara.2018.06.009_bib22","article-title":"Extreme genome diversity in hyper-prevalent parasitic eukaryote Blastocystis","volume":"11","author":"Gentekaki","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.exppara.2018.06.009_bib23","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00436-007-0833-z","article-title":"Pathophysiological variability of different genotypes of human Blastocystis hominis Egyptian isolates in experimentally infected rats","volume":"102","author":"Hussein","year":"2008","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2018.06.009_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.parint.2006.12.004","article-title":"Infectivity of different genotypes of human Blastocystis hominis isolates in chickens and rats","volume":"56","author":"Iguchi","year":"2007","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.exppara.2018.06.009_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00436-009-1373-5","article-title":"Expression of interferon gamma and proinflammatory cytokines in the cecal mucosa of rats experimentally infected with Blastocystis strain RN94-9","volume":"105","author":"Iguchi","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2018.06.009_bib26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.cgh.2014.07.065","article-title":"The prevalence of intestinal parasites is not greater among individuals with Irritable Bowel Syndrome: a population-based case-control study","volume":"13","author":"Krogsgaard","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.exppara.2018.06.009_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183097","article-title":"Exacerbation of colon carcinogenesis by Blastocystis sp","volume":"12","author":"Kumarasamy","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.exppara.2018.06.009_bib28","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1179\/000349802125002275","article-title":"In-vitro cultivation: a sensitive method for detecting Blastocystis hominis","volume":"96","author":"Leelayoova","year":"2002","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.exppara.2018.06.009_bib29","first-page":"107","article-title":"Parasitism, commensalism, and mutualism: exploring the many shades of symbioses","volume":"58","author":"Leung","year":"2008","journal-title":"Vie Milieu"},{"key":"10.1016\/j.exppara.2018.06.009_bib30","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1007\/s00436-013-3536-7","article-title":"A rat model to study Blastocytis subtype 1 infections","volume":"112","author":"Li","year":"2013","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2018.06.009_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005039","article-title":"Are human intestinal eukaryotes beneficial or commensals?","volume":"11","author":"Luke\u0161","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.exppara.2018.06.009_bib32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s004360050256","article-title":"Experimental Blastocystis hominis infection in laboratory mice","volume":"83","author":"Moe","year":"1997","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2018.06.009_bib33","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00007-18","article-title":"Asymptomatic intestinal colonization with protist Blastocystis is strongly associated with distinct microbiome ecological patterns","volume":"3","author":"Nieves-Ram\u00edrez","year":"2018","journal-title":"mSystem"},{"key":"10.1016\/j.exppara.2018.06.009_bib34","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1590\/S0036-46652015000600002","article-title":"Pathogenicity of Blastocystis sp. to the gastrointestinal tract of mice: relationship between inoculum size and period of infection","volume":"57","author":"Pavanelli","year":"2015","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.exppara.2018.06.009_bib35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fmicb.2014.00298","article-title":"Communities of microbial eukaryotes in the mammalian gut within the context of environmental eukaryotic diversity","volume":"5","author":"Parfrey","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.exppara.2018.06.009_bib36","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3109\/00365521.2013.780094","article-title":"Active ulcerative colitis associated with low prevalence of Blastocystis and Dientamoeba fragilis infection","volume":"48","author":"Petersen","year":"2013","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.exppara.2018.06.009_bib37","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1371\/journal.ppat.1002545","article-title":"New insights into Blastocystis spp.: a potential link with irritable bowel syndrome","volume":"8","author":"Poirier","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.exppara.2018.06.009_bib38","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1645\/GE-2433.1","article-title":"Discrepancies in the occurrence of Balantidium coli between wild and captive African great apes","volume":"96","author":"Pomajb\u00edkov\u00e1","year":"2010","journal-title":"J. Parasitol."},{"key":"10.1016\/j.exppara.2018.06.009_bib39","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10096-012-1746-z","article-title":"Subtype distribution of Blastocystis isolates identified in a Sydney population and pathogenic potential of Blastocystis","volume":"32","author":"Roberts","year":"2013","journal-title":"Eur. J. Clin. Microbiol."},{"key":"10.1016\/j.exppara.2018.06.009_bib40","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s10096-015-2312-2","article-title":"Low prevalence of Blastocystis sp. in active ulcerative colitis patients","volume":"34","author":"Rossen","year":"2015","journal-title":"Eur. J. Clin. Microbiol."},{"key":"10.1016\/j.exppara.2018.06.009_bib41","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.pt.2013.08.006","article-title":"Blastocystis: getting to grips with our guileful guest","volume":"29","author":"Scanlan","year":"2013","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.exppara.2018.06.009_bib42","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/1574-6941.12396","article-title":"The microbial eukaryote Blastocystis is a prevalent and diverse member of the healthy human gut microbiota","volume":"90","author":"Scanlan","year":"2014","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/j.exppara.2018.06.009_bib43","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.protis.2005.12.001","article-title":"DNA barcoding of Blastocystis","volume":"157","author":"Scicluna","year":"2006","journal-title":"Protist"},{"key":"10.1016\/j.exppara.2018.06.009_bib44","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/BF00931510","article-title":"Elucidation of the life-cycle of the intestinal protozoan Blastocystis hominis","volume":"81","author":"Singh","year":"1995","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2018.06.009_bib45","first-page":"565","article-title":"Effect of various external factors on encystment and excystment of Balantidium coli","volume":"30","author":"Skotarczak","year":"1984","journal-title":"Wiad. Parazytol."},{"key":"10.1016\/j.exppara.2018.06.009_bib46","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ijpara.2008.07.006","article-title":"Subytpe distribution of Blastocystis isolates from synanthropic and zoo animals and identification of a new subtype","volume":"39","author":"Stensvold","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2018.06.009_bib47","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4269\/ajtmh.2011.11-0005","article-title":"Blastocystis sp. subtype 4 is common in Danish Blastocystis-positive patients presenting with acute diarrhea","volume":"84","author":"Stensvold","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2018.06.009_bib48","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1128\/CMR.9.4.563","article-title":"Blastocysts hominis revisited","volume":"9","author":"Stenzel","year":"1996","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.exppara.2018.06.009_bib49","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1128\/CMR.00022-08","article-title":"New insights on classification, identification, and clinical relevance of Blastocystis spp","volume":"21","author":"Tan","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"issue":"8","key":"10.1016\/j.exppara.2018.06.009_bib1a","article-title":"Location and pathogenic potential of blastocystis in the porcine intestine","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exppara.2018.06.009_bib50","first-page":"165","article-title":"Blastocystis, an unrecognized parasite: an overview of pathogenesis and diagnosis","volume":"1","author":"Wawrzyniak","year":"2013","journal-title":"Ther. Adv. Infect Dis."},{"key":"10.1016\/j.exppara.2018.06.009_bib51","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00436-004-1230-5","article-title":"Fecal-oral transmission of the cyst form of Blastocystis hominis in rats","volume":"94","author":"Yoshikawa","year":"2004","journal-title":"Parasitol. Res."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489418301784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489418301784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T22:40:53Z","timestamp":1571524853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489418301784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":52,"alternative-id":["S0014489418301784"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2018.06.009","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating rodent experimental models for studies of Blastocystis ST1","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2018.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}