{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:39:53Z","timestamp":1787063993696,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100008781","name":"Pomorski Uniwersytet Medyczny W Szczecinie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.exppara.2018.09.002","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T05:53:46Z","timestamp":1536299626000},"page":"58-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Relationship between antioxidant defense in Acanthamoeba spp. infected lungs and host immunological status"],"prefix":"10.1016","volume":"193","author":[{"given":"N.","family":"\u0141anocha-Arendarczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Baranowska-Bosiacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Gutowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Metryka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.I.","family":"Kosik-Bogacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2018.09.002_bib1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0891-5849(99)00242-7","article-title":"Oxidative stress and gene regulation","volume":"28","author":"Allen","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exppara.2018.09.002_bib2","first-page":"682","article-title":"Pulmonary cryptosporidiosis: role of COX2 and NF-\u03baB","volume":"114","author":"Asaad","year":"2006","journal-title":"AMPIS"},{"key":"10.1016\/j.exppara.2018.09.002_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12941-017-0224-y","article-title":"Parasitological and biochemical studies on cutaneous leishmaniasis in Shara'b District, Taiz","volume":"16","author":"Asmaa","year":"2017","journal-title":"Yemen. Ann. Clin. Microbiol. Antimicrob"},{"key":"10.1016\/j.exppara.2018.09.002_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3347\/kjp.2016.54.3.247","article-title":"Oxidative stress in the heart of rats infected with Trypanosoma evansi","volume":"54","author":"Baldissera","year":"2016","journal-title":"Kor. J. Parasitol."},{"key":"10.1016\/j.exppara.2018.09.002_bib5","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.rmed.2009.04.014","article-title":"Oxidative stress in the pathogenesis of diffuse lung diseases: a review","volume":"103","author":"Bargagli","year":"2009","journal-title":"Respir. Med."},{"key":"10.1016\/j.exppara.2018.09.002_bib6","series-title":"Another Aspect of Oxygen. Free Radicals in Nature","author":"Bartosz","year":"2003"},{"key":"10.1016\/j.exppara.2018.09.002_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative stress and antioxidant defense","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ. J."},{"key":"10.1016\/j.exppara.2018.09.002_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/351289","article-title":"Oxidative stress control by apicomplexan parasites","volume":"2015","author":"Bosch","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"72","key":"10.1016\/j.exppara.2018.09.002_bib9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"1976","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.exppara.2018.09.002_bib10","article-title":"Influence of organic zinc supplementation on the antioxidant status and immune responses of broilers challenged with Eimeria tenella","volume":"90","author":"Bun","year":"2011","journal-title":"Int. J. Poultry Sci."},{"key":"10.1016\/j.exppara.2018.09.002_bib11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1017\/S0031182009991351","article-title":"High levels of oxidative stress in rats infected with Blastocystis hominis","volume":"137","author":"Chandramathi","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2018.09.002_bib12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.rvsc.2007.09.001","article-title":"Erythrocytic antioxidant defense, lipid peroxides level and blood iron, zinc and copper concentrations in dogs naturally infected with Babesia gibsoni","volume":"85","author":"Chaudhuri","year":"2008","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.exppara.2018.09.002_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/874021","article-title":"Parasitic pneumonia and lung involvement","volume":"2014","author":"Cheepsattayakorn","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.exppara.2018.09.002_bib14","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.parint.2010.06.007","article-title":"Thai Acanthamoeba isolate (T4) induced apoptotic death in neuroblastoma cells via the Bax-mediated pathway","volume":"59","author":"Chusattayanond","year":"2010","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.exppara.2018.09.002_bib15","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00491.2001","article-title":"Antioxidant responses to oxidant-mediated lung diseases","volume":"283","author":"Comhair","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.exppara.2018.09.002_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/ajcp\/43.4_ts.383","article-title":"The isolation of additional strains FF pathogenic Hartmanella sp. (Acanthamoeba): proposed culture method for application to biological material","volume":"43","author":"Culbertson","year":"1965","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.exppara.2018.09.002_bib17","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1007\/s00436-017-5656-y","article-title":"Characterization of extracellular proteases of Acanthamoeba genotype T4 isolated from different sources in Iran","volume":"116","author":"Mahdavi Poor","year":"2017","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2018.09.002_bib18","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/path.2975","article-title":"NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease","volume":"225","author":"Dhiman","year":"2011","journal-title":"J. Pathol."},{"key":"10.1016\/j.exppara.2018.09.002_bib19","first-page":"1","article-title":"Role of acanthamoeba in granulomatous encephalitis: a review","volume":"1","author":"Duggal","year":"2017","journal-title":"J. Infect. Dis. Immunol. Ther"},{"key":"10.1016\/j.exppara.2018.09.002_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1017\/S0031182096008037","article-title":"Anti-oxidant enzymes in Cryptosporidium parvum oocysts","volume":"114","author":"Entrala","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2018.09.002_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/1475-2875-12-315","article-title":"Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice","volume":"10","author":"Fabbri","year":"2013","journal-title":"Malar. J."},{"key":"10.1016\/j.exppara.2018.09.002_bib22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/ars.2011.4198","article-title":"Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities","volume":"17","author":"Fitzpatrick","year":"2012","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.exppara.2018.09.002_bib23","first-page":"8","article-title":"Oxidative stress in Chagas disease","volume":"190354","author":"Gupta","year":"2009","journal-title":"Interdiscip. Perspect. Infect. Dis. D"},{"key":"10.1016\/j.exppara.2018.09.002_bib24","first-page":"197","article-title":"Proteolytic enzymes of pathogenic and non-pathogenic strains of Acanthamoeba spp","volume":"44","author":"Hada\u015b","year":"1993","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.exppara.2018.09.002_bib25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.exppara.2004.01.011","article-title":"Molecular cloning and characterization of a cDNA encoding a laminin-binding protein (AhLBP) from Acanthamoeba healyi","volume":"106","author":"Hong","year":"2004","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2018.09.002_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/203818","article-title":"Reactive oxygen species and nitric oxide in cutaneous leishmaniasis","volume":"2012","author":"Horta","year":"2012","journal-title":"J. Parasitol. Res."},{"key":"10.1016\/j.exppara.2018.09.002_bib27","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1165\/rcmb.2008-0330OC","article-title":"Respiratory syncytial virus induces oxidative stress by modulating antioxidant enzymes","volume":"41","author":"Hosakote","year":"2009","journal-title":"Am. J. Respir. Cell. Mol."},{"issue":"22","key":"10.1016\/j.exppara.2018.09.002_bib28","article-title":"Pathogenic Acanthamoeba castellanii secretes the extracellular aminopeptidase M20\/M25\/M40 Family protein to target cells for phagocytosis by disruption","volume":"18","author":"Huang","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.exppara.2018.09.002_bib29","first-page":"60","article-title":"Induction of oxidative stress in skin and lung of infected BALB\/C mice with Iranian strain of Leishmania major (MRHO\/IR\/75\/ER)","volume":"1","author":"Jafari","year":"2014","journal-title":"Iran. J. Parasitol."},{"key":"10.1016\/j.exppara.2018.09.002_bib30","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s12639-014-0431-9","article-title":"Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis","volume":"4","author":"Kamel","year":"2015","journal-title":"J. Parasit. Dis."},{"key":"10.1016\/j.exppara.2018.09.002_bib31","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1017\/S0031182013001832","article-title":"Characterization of biochemical properties of a selenium-independent glutathione peroxidase of Cryptosporidium parvum","volume":"141","author":"Kang","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2018.09.002_bib32","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s00436-012-3006-7","article-title":"Functional expression and characterization of an iron-containing superoxide dismutase of Acanthamoeba castellanii","volume":"111","author":"Kim","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2018.09.002_bib33","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1164\/rccm.200212-1479SO","article-title":"Superoxide dismutases in the lung and human lung diseases","volume":"167","author":"Kinnula","year":"2003","journal-title":"Am. J. Respir. Crit"},{"key":"10.1016\/j.exppara.2018.09.002_bib34","doi-asserted-by":"crossref","first-page":"639","DOI":"10.18388\/abp.2014_1825","article-title":"Cyclooxygenase pathways","volume":"61","author":"Korbecki","year":"2014","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.exppara.2018.09.002_bib35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.exppara.2011.02.026","article-title":"Hymenolepis diminuta: activity of anti-oxidant enzymes in different parts of rat gastrointestinal tract","volume":"128","author":"Kosik-Bogacka","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2018.09.002_bib36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.exppara.2016.07.009","article-title":"The inflammatory effect of infection with Hymenolepis diminuta via the increased expression and activity of COX-1 and COX-2 in the rat jejunum and colon","volume":"169","author":"Kosik-Bogacka","year":"2016","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2018.09.002_bib37","doi-asserted-by":"crossref","first-page":"48389","DOI":"10.1074\/jbc.M409935200","article-title":"A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages","volume":"279","author":"Kumagai","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exppara.2018.09.002_bib38","first-page":"271","article-title":"The occurrence Acanthamoeba (free living amoeba) in environmental and respiratory samples in Poland","volume":"48","author":"Lanocha","year":"2009","journal-title":"Acta Protozool."},{"key":"10.1016\/j.exppara.2018.09.002_bib39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/ijms19010121","article-title":"Expression and activity of COX-1 and COX-2 in Acanthamoeba spp.-Infected lungs according to the host immunological status","volume":"19","author":"\u0141anocha-Arendarczyk","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exppara.2018.09.002_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3409\/fb_66-1.04","article-title":"Biochemical profile, liver and kidney selenium (Se) status during acanthamoebiasis in a mouse model","volume":"1","author":"\u0141anocha-Arendarczyk","year":"2018","journal-title":"Folia Biol."},{"key":"10.1016\/j.exppara.2018.09.002_bib41","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"13","author":"Liguori","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.exppara.2018.09.002_bib42","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1051\/parasite\/2015010","article-title":"An update on Acanthamoeba keratitis: diagnosis, pathogenesis and treatment","volume":"22","author":"Lorenzo-Morales","year":"2015","journal-title":"Parasite"},{"key":"10.1016\/j.exppara.2018.09.002_bib43","doi-asserted-by":"crossref","DOI":"10.4172\/2165-7831.1000128","article-title":"Oxidants in acute and chronic lung disease","volume":"4","author":"Mannam","year":"2014","journal-title":"J. Blood Lymph"},{"key":"10.1016\/j.exppara.2018.09.002_bib44","first-page":"733","article-title":"Experimental Acanthamoeba infections in mice pretreated with methylprednisolone or tetracycline","volume":"92","author":"Markowitz","year":"1978","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.exppara.2018.09.002_bib45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S1542-0124(12)70071-X","article-title":"Pathogenesis of acanthamoeba keratitis","volume":"8","author":"Panjwani","year":"2010","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.exppara.2018.09.002_bib46","article-title":"Acanthamoeba protease activity promotes allergic airway inflammation via protease-activated receptor 2","volume":"9","author":"Park","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.exppara.2018.09.002_bib47","doi-asserted-by":"crossref","first-page":"16346","DOI":"10.3390\/ijms131216346","article-title":"Oxidative stress in malaria","volume":"13","author":"Perc\u00e1rio","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exppara.2018.09.002_bib48","first-page":"299","article-title":"Regulatory antioxidant enzymes","volume":"108","author":"Pippenger","year":"1998","journal-title":"Meth. Mol. Biol."},{"key":"10.1016\/j.exppara.2018.09.002_bib49","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1034\/j.1399-3003.2000.016003534.x","article-title":"Oxidative stress and regulation of glutathione in lung inflammation","volume":"16","author":"Rahman","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.exppara.2018.09.002_bib50","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.exppara.2018.09.002_bib51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S2222-1808(15)60856-8","article-title":"Superoxide dismutase activity in patients of cerebral malaria","volume":"5","author":"Raza","year":"2015","journal-title":"Asian. Pac. J. Trop. Dis"},{"key":"10.1016\/j.exppara.2018.09.002_bib52","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/jbt.10071","article-title":"Changes in expression and activity of glutathione S-transferase in different organs of Schistosoma haematobium-infected hamster","volume":"17","author":"Sheweita","year":"2003","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.exppara.2018.09.002_bib53","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-3305-5-6","article-title":"Biology and pathogenesis of acanthamoeba","volume":"5","author":"Siddiqui","year":"2012","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.exppara.2018.09.002_bib54","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0891-5849(96)00550-3","article-title":"Reduced superoxide dismutase in lung cells of patients with asthma","volume":"22","author":"Smith","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exppara.2018.09.002_bib55","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1590\/S1806-37132014000300006","article-title":"Effects of acute and chronic administration of methylprednisolone on oxidative stress in rat lungs","volume":"40","author":"Torres","year":"2014","journal-title":"J. Bras. Pneumol."},{"key":"10.1016\/j.exppara.2018.09.002_bib56","first-page":"10","article-title":"The effects of dexamethasone on oxidant\/antioxidant status in kidneys of rats administered mercuric chloride","volume":"113","author":"Turgay","year":"2012","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.exppara.2018.09.002_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.exppara.2018.09.002_bib58","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-444-53490-3.00010-8","article-title":"Infections with free-living amebae","volume":"114","author":"Visvesvara","year":"2013","journal-title":"Handb. Clin. Neurol."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489418302959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489418302959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T06:24:26Z","timestamp":1758003866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489418302959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":58,"alternative-id":["S0014489418302959"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2018.09.002","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationship between antioxidant defense in Acanthamoeba spp. infected lungs and host immunological status","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2018.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}