{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:46:04Z","timestamp":1777484764469,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.exppara.2019.02.017","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T21:54:08Z","timestamp":1551477248000},"page":"52-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Oxfendazole kinetics in pigs: In vivo assessment of its pattern of accumulation in Ascaris suum"],"prefix":"10.1016","volume":"199","author":[{"given":"Laura","family":"Ceballos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candela","family":"Canton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Cadenazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Virkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Lanusse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2019.02.017_bib1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pt.2007.01.003","article-title":"Drug transfer into target helminth parasites","volume":"23","author":"Alvarez","year":"2007","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.exppara.2019.02.017_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vetpar.2013.01.003","article-title":"Efficacy of a single high oxfendazole dose against gastrointestinal nematodes in naturally infected pigs","volume":"194","author":"Alvarez","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2019.02.017_bib3","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2460\/javma.2001.218.669","article-title":"Report of the AVMA panel on euthanasia","volume":"218","author":"AVMA","year":"2001","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.exppara.2019.02.017_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1017\/S003118200000648X","article-title":"Animal models of intestinal nematode infections of humans","volume":"121","author":"Boes","year":"2000","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2019.02.017_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0169-4758(90)90231-R","article-title":"Benzirnidazoles veterinary uses","volume":"6","author":"Campbell","year":"1990","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.exppara.2019.02.017_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0304-4017(02)00080-8","article-title":"Helminth infections in Danish organic swine herds","volume":"26","author":"Carstensen","year":"2002","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2019.02.017_bib7","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.parint.2009.07.006","article-title":"Flubendazole in cystic echinococcosis therapy: pharmaco-parasitological evaluation in mice","volume":"58","author":"Ceballos","year":"2009","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.exppara.2019.02.017_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1074\/jbc.M005561200","article-title":"Glutathione S-transferase Mu modulates the stress-activated signals by suppressing apoptosis signal regulating Kinase 1","volume":"276","author":"Cho","year":"2001","journal-title":"Biol. Chem."},{"key":"10.1016\/j.exppara.2019.02.017_bib9","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.micinf.2010.09.012","article-title":"Ascaris and ascariasis","volume":"13","author":"Dold","year":"2010","journal-title":"Microb. Infect."},{"key":"10.1016\/j.exppara.2019.02.017_bib10","series-title":"Pharmacokinetics","article-title":"Pharmacokinetics","author":"Gibaldi","year":"1982"},{"key":"10.1016\/j.exppara.2019.02.017_bib11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4269\/ajtmh.1996.54.391","article-title":"Effective, single-dose treatment of porcine cysticercosis with oxfendazole","volume":"54","author":"Gonzalez","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2019.02.017_bib12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0076-6879(81)77029-0","article-title":"Glutathione S-transferases (rat and human)","volume":"77","author":"Habig","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.exppara.2019.02.017_bib13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijpddr.2014.03.003","article-title":"Uptake of benzimidazoles by Trichuris suis in vivo in pigs","volume":"8","author":"Hansen","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.exppara.2019.02.017_bib14","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ijpddr.2017.11.002","article-title":"Pathway of oxfendazole from the host into the worm: Trichuris suis in pigs","volume":"7","author":"Hansen","year":"2017","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.exppara.2019.02.017_bib15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0169-4758(93)90232-5","article-title":"Pharmacokinetic disposition of benzimidazole drugs in the ruminant gastrointestinal tract","volume":"9","author":"Hennessy","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.exppara.2019.02.017_bib16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0001-706X(94)90066-3","article-title":"Biochemistry of benzimidazole resistance","volume":"56","author":"Lacey","year":"1994","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2019.02.017_bib17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/03602539308993977","article-title":"Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants","volume":"25","author":"Lanusse","year":"1993","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.exppara.2019.02.017_bib18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1365-2885.1995.tb00578.x","article-title":"Comparative plasma disposition kinetics of albendazole, fenbendazole, oxfendazole and their metabolites in adult sheep","volume":"18","author":"Lanusse","year":"1995","journal-title":"Vet. Pharmacol. Therap."},{"key":"10.1016\/j.exppara.2019.02.017_bib19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0166-6851(94)90021-3","article-title":"Molecular cloning and expression of a cDNA encoding glutathione S-transferase from Ascaris suum","volume":"63","author":"Liebau","year":"1994","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.exppara.2019.02.017_bib20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/03602538808994138","article-title":"Intracellular binding and transport of hormones and xenobiotics by glutathione S-transferase","volume":"19","author":"Listowsky","year":"1988","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.exppara.2019.02.017_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exppara.2019.02.017_bib22","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bcp.2008.07.002","article-title":"Hepatic and extra-hepatic metabolic pathways involved in flubendazole biotransformation in sheep","volume":"76","author":"Mat\u00e9","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exppara.2019.02.017_bib23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1365-2885.1990.tb00773.x","article-title":"The benzimidazole anthelmintic agents \u2013 a review","volume":"13","author":"McKellar","year":"1990","journal-title":"J. Vet. Pharmacol. Therapeut."},{"key":"10.1016\/j.exppara.2019.02.017_bib24","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1016\/j.fct.2012.07.023","article-title":"A high oxfendazole dose to control porcine cysticercosis: pharmacokinetics and tissue residue profiles","volume":"50","author":"Moreno","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.exppara.2019.02.017_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-4894(03)00060-2","article-title":"Transtegumental difusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol\u2013water partition coefcients","volume":"103","author":"Mottier","year":"2003","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2019.02.017_bib26","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0020-7519(99)00048-X","article-title":"Parasitic helminths of the pig: factors influencing transmission and infection levels","volume":"29","author":"Nansen","year":"1999","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2019.02.017_bib27","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2460\/ajvr.1997.58.04.384","article-title":"Efficacy of fenbendazole for treatment of giardiasis in calves","volume":"58","author":"O'Handley","year":"1997","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.exppara.2019.02.017_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.actatropica.2014.03.024","article-title":"Oxfendazole flukicidal activity in pigs","volume":"136","author":"Ortiz","year":"2014","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2019.02.017_bib29","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0020-7519(97)00104-5","article-title":"A new in vitro assay of benzimidazole activity against adult Oesophagostomum dentatum","volume":"27","author":"Petersen","year":"1997","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2019.02.017_bib30","first-page":"156","volume":"vol. 5","author":"Precious","year":"1989"},{"key":"10.1016\/j.exppara.2019.02.017_bib31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1071\/AR9500099","article-title":"Methods for egg counts and larval cultures for strongyles infesting the gastrointestinal tract of cattle","volume":"1","author":"Roberts","year":"1950","journal-title":"Crop Pasture Sci."},{"key":"10.1016\/j.exppara.2019.02.017_bib32","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.2527\/jas1988.6661548x","article-title":"Losses to internal parasites in swine production","volume":"66","author":"Stewart","year":"1988","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.exppara.2019.02.017_bib33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0169-4758(93)90162-9","article-title":"Mechanistic approaches to quantitate anthelmintic absorption by gastrointestinal nematodes","volume":"9","author":"Thompson","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.exppara.2019.02.017_bib34","series-title":"Soil Transmitted Helminth Infections","author":"WHO","year":"2018"},{"key":"10.1016\/j.exppara.2019.02.017_bib35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0304-4017(94)00701-D","article-title":"Comparative efficacy of levamisole, thiabendazole and fenbendazole against cattle gastrointestinal nematodes","volume":"58","author":"Williams","year":"1994","journal-title":"Vet. Parasitol."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489418304843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489418304843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T06:25:02Z","timestamp":1758003902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489418304843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":35,"alternative-id":["S0014489418304843"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2019.02.017","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxfendazole kinetics in pigs: In vivo assessment of its pattern of accumulation in Ascaris suum","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2019.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}