{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:37:10Z","timestamp":1762324630851,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008223","name":"Universidade Federal do Paran\u00e1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008223","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["DT 303733\/2016-0","PVE 401355\/2014-4"],"award-info":[{"award-number":["DT 303733\/2016-0","PVE 401355\/2014-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.exppara.2020.107830","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T01:22:34Z","timestamp":1578360154000},"page":"107830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Targeting epimastigotes of Trypanosoma cruzi with a peptide isolated from a phage display random library"],"prefix":"10.1016","volume":"210","author":[{"given":"Jos\u00e9 L.","family":"S\u00e1enz-Garcia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel B.","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisandro A.","family":"Pacheco-Lugo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana S.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily S.","family":"C\u00f3rneo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo A.","family":"Machado-de-\u00c1vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana F.","family":"De Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanderson D.","family":"DaRocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2020.107830_bib1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.toxicon.2013.03.011","article-title":"Melittin peptide kills Trypanosoma cruzi parasites by inducing different cell death pathways","volume":"69","author":"Adade","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.exppara.2020.107830_bib2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.exppara.2020.107830_bib3","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ibmb.2011.12.006","article-title":"Intestinal aspartate proteases TiCatD and TiCatD2 of the haematophagous bug Triatoma infestans (Reduviidae): sequence characterisation, expression pattern and characterisation of proteolytic activity","volume":"42","author":"Balczun","year":"2012","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.exppara.2020.107830_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.ento.47.091201.145144","article-title":"Bacterial symbionts of the triatominae and their potential use in control of Chagas disease transmission","volume":"47","author":"Beard","year":"2002","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.exppara.2020.107830_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143541","article-title":"Inhibition of Plasmodium berghei development in mosquitoes by effector proteins secreted from Asaia sp. bacteria using a novel native secretion signal","volume":"10","author":"Bongio","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exppara.2020.107830_bib6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1006\/jmbi.1996.0284","article-title":"Probing the basis of antibody reactivity with a panel of constrained peptide libraries displayed by filamentous phage","volume":"258","author":"Bonnycastle","year":"1996","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.exppara.2020.107830_bib7","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.vaccine.2015.01.044","article-title":"Efficacy of a trans-sialidase-ISCOMATRIX subunit vaccine candidate to protect against experimental Chagas disease","volume":"33","author":"Bontempi","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2020.107830_bib8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.exppara.2005.09.008","article-title":"Trypanosoma cruzi: effects of infection on cathepsin D activity in the midgut of Rhodnius prolixus","volume":"112","author":"Borges","year":"2006","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2020.107830_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004792","article-title":"Over six thousand Trypanosoma cruzi strains classified into discrete typing units (DTUs): attempt at an inventory. Debrabant A, editor","volume":"10","author":"Breni\u00e8re","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2020.107830_bib10","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1002\/anie.200705435","article-title":"A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors","volume":"47","author":"Buchini","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.exppara.2020.107830_bib11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0166-6851(85)90073-8","article-title":"In vitro differentiation of Trypanosoma cruzi under chemically defined conditions","volume":"16","author":"Contreras","year":"1985","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.exppara.2020.107830_bib12","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1021\/pr800887u","article-title":"Proteomic analysis of detergent-solubilized membrane proteins from insect-developmental forms of Trypanosoma cruzi \u2020","volume":"8","author":"Cordero","year":"2009","journal-title":"J. Proteome Res."},{"issue":"Suppl. 1","key":"10.1016\/j.exppara.2020.107830_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1590\/S0074-02762007005000092","article-title":"Southern Cone Initiative for the elimination of domestic populations of Triatoma infestans and the interruption of transfusional Chagas disease. Historical aspects, present situation, and perspectives","volume":"102","author":"Dias","year":"2007","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2020.107830_bib14","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1073\/pnas.94.7.3274","article-title":"Prevention of insect-borne disease: an approach using transgenic symbiotic bacteria","volume":"94","author":"Durvasula","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exppara.2020.107830_bib15","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.1112631","article-title":"The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease","volume":"309","author":"El-Sayed","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.exppara.2020.107830_bib16","first-page":"9","article-title":"The lipocalin protein family: structural and sequence overview","volume":"1482","author":"Flower","year":"2000","journal-title":"Biochim Biophys Acta BBA - Protein Struct Mol Enzymol."},{"key":"10.1016\/j.exppara.2020.107830_bib17","doi-asserted-by":"crossref","first-page":"13278","DOI":"10.1073\/pnas.241491198","article-title":"Targeting Plasmodium ligands on mosquito salivary glands and midgut with a phage display peptide library","volume":"98","author":"Ghosh","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.exppara.2020.107830_bib18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/hdy.2011.71","article-title":"Genetics and evolution of triatomines: from phylogeny to vector control","volume":"108","author":"Gourbi\u00e8re","year":"2012","journal-title":"Heredity"},{"key":"10.1016\/j.exppara.2020.107830_bib19","first-page":"95","article-title":"BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume":"41","author":"Hall","year":"1999","journal-title":"Nucleic Acids Symp. Ser."},{"key":"10.1016\/j.exppara.2020.107830_bib20","series-title":"Peptide Antibodies","first-page":"33","article-title":"Fmoc solid-phase peptide synthesis","author":"Hansen","year":"2015"},{"key":"10.1016\/j.exppara.2020.107830_bib21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.actatropica.2017.06.022","article-title":"Salivary gland transcripts of the kissing bug, Panstrongylus chinai, a vector of Chagas disease","volume":"174","author":"Kato","year":"2017","journal-title":"Acta Trop."},{"issue":"1","key":"10.1016\/j.exppara.2020.107830_bib22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00436-014-4172-6","article-title":"Prokineticin receptor identified by phage display is an entry receptor for Trypanosoma cruzi into mammalian cells","volume":"114","author":"Khusal","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2020.107830_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005511","article-title":"Transcriptome remodeling in Trypanosoma cruzi and human cells during intracellular infection. Clayton C","volume":"12","author":"Li","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.exppara.2020.107830_bib24","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jconrel.2012.05.023","article-title":"Defeating Leishmania resistance to Miltefosine (hexadecylphosphocholine) by peptide-mediated drug smuggling: a proof of mechanism for trypanosomatid chemotherapy","volume":"161","author":"Luque-Ortega","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.exppara.2020.107830_bib25","doi-asserted-by":"crossref","first-page":"W597","DOI":"10.1093\/nar\/gkt376","article-title":"Analysis tool web services from the EMBL-EBI","volume":"41","author":"McWilliam","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.exppara.2020.107830_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.toxicon.2017.02.031","article-title":"Evaluation of the antichagasic activity of batroxicidin, a cathelicidin-related antimicrobial peptide found in Bothrops atrox venom gland","volume":"130","author":"Mello","year":"2017","journal-title":"Toxicon"},{"key":"10.1016\/j.exppara.2020.107830_bib27","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1056\/NEJMoa1507574","article-title":"Randomized trial of benznidazole for chronic Chagas' cardiomyopathy","volume":"373","author":"Morillo","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exppara.2020.107830_bib28","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1021\/pr400110h","article-title":"Comprehensive proteomic analysis of trypanosoma cruzi epimastigote cell surface proteins by two complementary methods","volume":"12","author":"Queiroz","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.exppara.2020.107830_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.actatropica.2016.03.018","article-title":"Targeting Leishmania major parasite with peptides derived from a combinatorial phage display library","volume":"159","author":"Rhaiem","year":"2016","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2020.107830_bib30","doi-asserted-by":"crossref","first-page":"e2358","DOI":"10.1371\/journal.pntd.0002358","article-title":"Epidemiology of and impact of insecticide spraying on Chagas disease in communities in the Bolivian Chaco","volume":"7","author":"Samuels","year":"2013","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2020.107830_bib31","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1016\/j.vaccine.2014.04.026","article-title":"A synthetic peptide from Trypanosoma cruzi mucin-like associated surface protein as candidate for a vaccine against Chagas disease","volume":"32","author":"Serna","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2020.107830_bib32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.tibtech.2013.01.001","article-title":"Genetic approaches to interfere with malaria transmission by vector mosquitoes","volume":"31","author":"Wang","year":"2013","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.exppara.2020.107830_bib33","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1590\/S0074-02762009000700021","article-title":"A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI","volume":"104","author":"Zingales","year":"2009","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2020.107830_bib34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00232-016-9940-z","article-title":"Progress in research and application of HIV-1 TAT-derived cell-penetrating peptide","volume":"250","author":"Zou","year":"2017","journal-title":"J. Membr. Biol."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489419304461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489419304461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:02:18Z","timestamp":1762149738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489419304461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":34,"alternative-id":["S0014489419304461"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2020.107830","relation":{},"ISSN":["0014-4894"],"issn-type":[{"type":"print","value":"0014-4894"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting epimastigotes of Trypanosoma cruzi with a peptide isolated from a phage display random library","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2020.107830","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107830"}}