{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:17:10Z","timestamp":1784809030786,"version":"3.55.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.exppara.2020.107849","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T02:15:09Z","timestamp":1580696109000},"page":"107849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["The potential of live attenuated vaccines against Cutaneous Leishmaniasis"],"prefix":"10.1016","volume":"210","author":[{"given":"A.","family":"Zabala-Pe\u00f1afiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Todd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Daneshvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Burchmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.exppara.2020.107849_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004349","article-title":"A historical overview of the classification, evolution, and dispersion of Leishmania parasites and sandflies","volume":"10","author":"Akhoundi","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"5924","key":"10.1016\/j.exppara.2020.107849_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.1169464","article-title":"Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector","volume":"324","author":"Akopyants","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.exppara.2020.107849_bib3","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.4049\/jimmunol.161.12.6794","article-title":"Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a TH1 response","volume":"161","author":"Alexander","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.exppara.2020.107849_bib4","doi-asserted-by":"crossref","first-page":"B244","DOI":"10.1016\/j.vaccine.2012.11.080","article-title":"Case study for a vaccine against Leishmaniasis","volume":"31","author":"Alvar","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2020.107849_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.exppara.2020.107849_bib6","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1590\/S0074-02762002000700019","article-title":"Study of the safety, immunogenicity and efficacy of attenuated and killed Leishmania (Leishmania) major vaccines in a rhesus monkey (Macaca mulatta) model of the human disease","volume":"97","author":"Amaral","year":"2002","journal-title":"Memorias Do Instituto Oswaldo Cruz"},{"issue":"10","key":"10.1016\/j.exppara.2020.107849_bib7","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2003-4-10-r64","article-title":"The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism","volume":"4","author":"Aravind","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.exppara.2020.107849_bib8","doi-asserted-by":"crossref","first-page":"170095","DOI":"10.1098\/rsos.170095","article-title":"A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids","volume":"4","author":"Beneke","year":"2017","journal-title":"R. Soc. Open Sci."},{"key":"10.1016\/j.exppara.2020.107849_bib9","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.micinf.2004.10.004","article-title":"Dendritic cells in Leishmania infection","volume":"6","author":"Brandonisio","year":"2004","journal-title":"Microb. Infect."},{"issue":"1485","key":"10.1016\/j.exppara.2020.107849_bib10","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1098\/rspb.2001.1821","article-title":"An unlikely partnership: parasites, concomitant immunity and host defence","volume":"268","author":"Brown","year":"2001","journal-title":"Proc. Biol. Sci."},{"issue":"9","key":"10.1016\/j.exppara.2020.107849_bib11","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1017\/S0031182011002368","article-title":"Strategies to dissect parasite proteomes","volume":"139","author":"Burgess","year":"2012","journal-title":"Parasitology"},{"issue":"10","key":"10.1016\/j.exppara.2020.107849_bib12","article-title":"Leishmania infantum HSP70-II null mutant as candidate vaccine against Leishmaniasis: a preliminary evaluation","volume":"4","author":"Carrion","year":"2011","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.exppara.2020.107849_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0001-706X(94)90103-1","article-title":"Clinical and immunopathological aspects of disseminated cutaneous Leishmaniasis","volume":"56","author":"Carvalho","year":"1994","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2020.107849_bib14","first-page":"9","article-title":"Vaccines for the Leishmaniases: proposals for a research agenda","volume":"5","author":"Costa","year":"2011","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2020.107849_bib15","doi-asserted-by":"crossref","first-page":"7170","DOI":"10.1073\/pnas.88.16.7170","article-title":"Double targeted gene replacement for creating NULL mutants","volume":"88","author":"Cruz","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exppara.2020.107849_bib16","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1017\/S0031182009990679","article-title":"Leishmania major H-line attenuated under pressure of gentamicin, induces a Th1 response which protects susceptible BALB\/c mice against infection with virulent L. major","volume":"136","author":"Daneshvar","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2020.107849_bib17","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1086\/374783","article-title":"Leishmania mexicana and Leishmania major: attenuation of wild-type parasites and vaccination with the attenuated lines","volume":"187","author":"Daneshvar","year":"2003","journal-title":"JID (J. Infect. Dis.)"},{"key":"10.1016\/j.exppara.2020.107849_bib18","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.0141-9838.2004.00671.x","article-title":"Leishmania mexicana H-line attenuated under pressure of gentamicin, potentiates a Th1 response and control of cutaneous Leishmaniasis in BALB\/c mice","volume":"25","author":"Daneshvar","year":"2003","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.exppara.2020.107849_bib19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.vetimm.2008.12.002","article-title":"Gentamicin-attenuated Leishmania infantum: a clinicopathological study in dogs","volume":"129","author":"Daneshvar","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.exppara.2020.107849_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1371\/journal.pntd.0002757","article-title":"Gentamicin-attenuated Leishmania infantum vaccine: protection of dogs against canine visceral Leishmaniosis in endemic area of Southeast of Iran","volume":"8","author":"Daneshvar","year":"2014","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"5","key":"10.1016\/j.exppara.2020.107849_bib21","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jprot.2011.11.018","article-title":"Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism","volume":"75","author":"Daneshvar","year":"2012","journal-title":"J. Proteomics"},{"key":"10.1016\/j.exppara.2020.107849_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fimmu.2016.00151","article-title":"Cutaneous leishmaniasis vaccination: a matter of quality","volume":"7","author":"De Luca","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exppara.2020.107849_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1574-6968.2004.tb09571.x","article-title":"Generation of Leishmania mutants lacking antibiotic resistance genes using a versatile hit-and-run targeting strategy","volume":"235","author":"Denise","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.exppara.2020.107849_bib24","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.4049\/jimmunol.1202801","article-title":"Live attenuated Leishmania donovani p27 gene knockout parasites are nonpathogenic and elicit long-term protective immunity in BALB\/c mice","volume":"190","author":"Dey","year":"2013","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.exppara.2020.107849_bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2958.2010.07214.x","article-title":"Characterization of a Leishmania stage specific mitochondrial membrane protein that enhances the activity of cytochrome C oxidase and its role in virulence","volume":"77","author":"Dey","year":"2010","journal-title":"Mol. Microbiol."},{"issue":"3","key":"10.1016\/j.exppara.2020.107849_bib26","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/mmi.12478","article-title":"An Alba-domain protein contributes to the stage- regulated stability of amastin transcripts in Leishmania","volume":"91","author":"Dupe","year":"2014","journal-title":"Mol. Microbiol."},{"issue":"9","key":"10.1016\/j.exppara.2020.107849_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0137243","article-title":"Differential subcellular localization of Leishmania alba-domain proteins throughout the parasite development","volume":"10","author":"Dupe","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.exppara.2020.107849_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2018.07.002","article-title":"Development of a new live attenuated Leishmania major p27 gene knockout: safety and Immunogenicity evaluation in BALB\/c mice","author":"Elikaee","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.exppara.2020.107849_bib29","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1016\/j.vaccine.2019.04.068","article-title":"Leishmania major p27 gene knockout as a novel live attenuated vaccine candidate: protective immunity and efficacy evaluation against cutaneous and visceral Leishmaniasis in BALB\/c mice","volume":"37","author":"Elikaee","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2020.107849_bib30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.vaccine.2014.11.039","article-title":"Vaccination using live attenuated Leishmania donovani centrin deleted parasites induces protection in dogs against Leishmania infantum","volume":"33","author":"Fiuza","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2020.107849_bib31","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.vaccine.2013.01.048","article-title":"Induction of immunogenicity by live attenuated Leishmania donovani centrin deleted parasites in dogs","volume":"31","author":"Fiuza","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2020.107849_bib32","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1016\/j.vaccine.2015.12.071","article-title":"Status of vaccine research and development of vaccines for Leishmaniasis","volume":"34","author":"Gillespie","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2020.107849_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2016.07.010","article-title":"Memory T cells in cutaneous Leishmaniasis","author":"Glennie","year":"2016","journal-title":"Cell. Immunol."},{"issue":"94","key":"10.1016\/j.exppara.2020.107849_bib34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0008-8749(85)90081-4","article-title":"Immunization of Susceptible BALB\/c mice against Leishmania braziliensis","author":"Gorczynski","year":"1985","journal-title":"Cell. Immunol."},{"issue":"5","key":"10.1016\/j.exppara.2020.107849_bib35","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.bbapap.2016.02.015","article-title":"The Alba protein family: structure and function","volume":"1864","author":"Goyal","year":"2016","journal-title":"Biochim. Biophys. Acta Protein Proteonomics"},{"issue":"10","key":"10.1016\/j.exppara.2020.107849_bib36","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1128\/MCB.16.10.5655","article-title":"Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major","volume":"16","author":"Gueiros-Filho","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.exppara.2020.107849_bib37","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1073\/pnas.0900226106","article-title":"Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps","volume":"106","author":"Guimaraes-Costa","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"10.1016\/j.exppara.2020.107849_bib38","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jaad.2014.08.051","article-title":"Cutaneous and mucocutaneous Leishmaniasis: clinical perspectives","volume":"73","author":"Handler","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.exppara.2020.107849_bib39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1128\/CMR.14.2.229-243.2001","article-title":"Leishmaniasis: current status of vaccine development","volume":"14","author":"Handman","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"issue":"2","key":"10.1016\/j.exppara.2020.107849_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192723","article-title":"CRISPR\/Cas9 in Leishmania mexicana: a case study of LmxBTN1","volume":"13","author":"Ishemgulova","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.exppara.2020.107849_bib41","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.4161\/hv.7.11.17752","article-title":"Leishmaniasis","volume":"7","author":"Kedzierski","year":"2011","journal-title":"Hum. Vaccine"},{"key":"10.1016\/j.exppara.2020.107849_bib42","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1017\/S0031182006001831","article-title":"Leishmania vaccines: progress and problems","volume":"133","author":"Kedzierski","year":"2006","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2020.107849_bib43","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1128\/iai.61.12.5205-5213.1993","article-title":"AN avirulent lipophosphoglycan-deficient leishmania-major clone induces CD4(+) T-cells WHICH protect susceptible BALB\/C mice against infection with virulent L-major","volume":"61","author":"Kimsey","year":"1993","journal-title":"Infect. Immun."},{"issue":"9","key":"10.1016\/j.exppara.2020.107849_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005098","article-title":"Hybridization in parasites: consequences for adaptive evolution, pathogenesis, and public health in a changing world","volume":"11","author":"King","year":"2015","journal-title":"PLoS Pathog."},{"issue":"3\u20134","key":"10.1016\/j.exppara.2020.107849_bib85","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.imbio.2007.11.010","article-title":"Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: apoptosis as infection-promoting factor","volume":"213","author":"Laskay","year":"2008","journal-title":"Immunobiology"},{"key":"10.1016\/j.exppara.2020.107849_bib45","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0966-842X(03)00075-1","article-title":"Neutrophil granulocytes-Trojan horses for Leishmania major and other intracellular microbes?","volume":"11","author":"Laskay","year":"2003","journal-title":"Trends Microbiol."},{"issue":"2","key":"10.1016\/j.exppara.2020.107849_bib46","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0167-5699(89)90302-2","article-title":"Functional heterogeneity of CD4+ T cells in Leishmaniasis","volume":"10","author":"Liew","year":"1989","journal-title":"Immunol. Today"},{"issue":"83","key":"10.1016\/j.exppara.2020.107849_bib47","article-title":"The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response","volume":"2","author":"Liu","year":"2012","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.exppara.2020.107849_bib48","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1128\/IAI.01447-08","article-title":"Leishmania major phosphoglycans influence the host early immune response by modulating dendritic cell functions","volume":"77","author":"Liu","year":"2009","journal-title":"Infect. Immun."},{"issue":"17","key":"10.1016\/j.exppara.2020.107849_bib49","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.vaccine.2016.11.097","article-title":"The origins of the vaccine cold chain and a glimpse of the future","volume":"35","author":"Lloyd","year":"2017","journal-title":"Vaccine"},{"issue":"6","key":"10.1016\/j.exppara.2020.107849_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0004811","article-title":"Concomitant immunity induced by persistent Leishmania major does not preclude secondary Re-infection: implications for genetic exchange, diversity and vaccination","volume":"10","author":"Mandell","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2020.107849_bib51","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1159\/000364945","article-title":"M1 and M2 macrophages: the chicken and the egg of immunity","volume":"6","author":"Mills","year":"2014","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.exppara.2020.107849_bib52","series-title":"Research on Control Strategies for the Leishmaniases","article-title":"Future Leishmania vaccine development","author":"Mitchell","year":"1987"},{"key":"10.1016\/j.exppara.2020.107849_bib53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3347\/kjp.2006.44.1.43","article-title":"Identification of novel Leishmania major antigens that elicit IgG2a response in resistant and susceptible mice","volume":"44","author":"Mohammadi","year":"2006","journal-title":"Kor. J. Parasitol."},{"key":"10.1016\/j.exppara.2020.107849_bib54","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1073\/pnas.93.12.6008","article-title":"Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors","volume":"93","author":"Mottram","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exppara.2020.107849_bib55","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)67629-5","article-title":"Advances in leishmaniasis","volume":"366","author":"Murray","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.exppara.2020.107849_bib56","series-title":"Research on Control Strategies for the Leishmaniases. Otawa","article-title":"Leishmanization in the Islamic Republic of Iran","author":"Nadim","year":"1988"},{"key":"10.1016\/j.exppara.2020.107849_bib57","first-page":"377","article-title":"Effectiveness of leishmanization in the control of cutaneous Leishmaniasis","volume":"76","author":"Nadim","year":"1983","journal-title":"Bulletin De La Societe De Pathologie Exotique Filiales"},{"key":"10.1016\/j.exppara.2020.107849_bib58","doi-asserted-by":"crossref","first-page":"8088","DOI":"10.4049\/jimmunol.0803720","article-title":"Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection","volume":"183","author":"Novais","year":"2009","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.exppara.2020.107849_bib59","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4103\/0974-777X.62876","article-title":"Immunological perspectives of leishmaniasis","volume":"2","author":"Nyl\u00e9n","year":"2010","journal-title":"J. Global Infect. Dis."},{"key":"10.1016\/j.exppara.2020.107849_bib60","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/CMR.18.2.293-305.2005","article-title":"Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view","volume":"18","author":"Olivier","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"issue":"4\u20135","key":"10.1016\/j.exppara.2020.107849_bib61","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.drup.2004.07.002","article-title":"Leishmaniasis: drugs in the clinic, resistance and new developments","volume":"7","author":"Ouellette","year":"2004","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.exppara.2020.107849_bib62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.actatropica.2016.10.019","article-title":"The new situation of cutaneous Leishmaniasis after Syrian civil war in Gaziantep city, Southeastern region of Turkey","volume":"166","author":"\u00d6zkeklik\u00e7i","year":"2017","journal-title":"Acta Trop."},{"issue":"12","key":"10.1016\/j.exppara.2020.107849_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006052","article-title":"Drug resistance and treatment failure in Leishmaniasis: a 21st century challenge","volume":"11","author":"Ponte-Sucre","year":"2017","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"24","key":"10.1016\/j.exppara.2020.107849_bib64","doi-asserted-by":"crossref","first-page":"14173","DOI":"10.1021\/acs.analchem.8b02517","article-title":"Mix-and-Match proteomics: using advanced iodoacetyl tandem mass tag multiplexing to investigate cysteine oxidation changes with respect to protein expression","volume":"90","author":"Prakash","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.exppara.2020.107849_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00134","article-title":"Live vaccination tactics: possible approaches for controlling visceral leishmaniasis","volume":"5","author":"Saljoughian","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exppara.2020.107849_bib66","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1016\/j.vaccine.2005.05.045","article-title":"Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models","volume":"24","author":"Saravia","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.exppara.2020.107849_bib67","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri.2016.72","article-title":"Cutaneous Leishmaniasis: immune responses in protection and pathogenesis","volume":"16","author":"Scott","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.exppara.2020.107849_bib68","doi-asserted-by":"crossref","first-page":"25703","DOI":"10.1074\/jbc.M402794200","article-title":"Centrin gene disruption impairs stage-specific basal body duplication and cell cycle progression in Leishmania","volume":"279","author":"Selvapandiyan","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exppara.2020.107849_bib69","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.4049\/jimmunol.0900276","article-title":"Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasis","volume":"183","author":"Selvapandiyan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.exppara.2020.107849_bib70","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00005-008-0010-9","article-title":"Live attenuated Leishmania vaccines: a potential strategic alternative","volume":"56","author":"Silvestre","year":"2008","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.exppara.2020.107849_bib71","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3389\/fmicb.2018.01279","article-title":"Genome plasticity in cultured Leishmania donovani: comparison of early and late passages","volume":"9","author":"Sinha","year":"2018","journal-title":"Front. Microbiol."},{"issue":"10","key":"10.1016\/j.exppara.2020.107849_bib72","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/cmi.12456","article-title":"Fisrt efficient CRISPR-Cas9-mediated genome editing in Leishmania parasites","volume":"17","author":"Sollelis","year":"2015","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.exppara.2020.107849_bib73","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0166-6851(94)90057-4","article-title":"Null mutants for the LMCPA cysteine proteinase gene IN leishmania-mexicana","volume":"63","author":"Souza","year":"1994","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.exppara.2020.107849_bib74","doi-asserted-by":"crossref","first-page":"9258","DOI":"10.1073\/pnas.160257897","article-title":"Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major","volume":"97","author":"Sp\u00e4th","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exppara.2020.107849_bib75","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1126\/science.1087499","article-title":"Persistence without pathology in phosphoglycan-deficient Leishmania major","volume":"301","author":"Sp\u00e4th","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.exppara.2020.107849_bib76","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1128\/IAI.72.6.3622-3627.2004","article-title":"Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies","volume":"72","author":"Sp\u00e4th","year":"2004","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.exppara.2020.107849_bib77","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-016-1553-y","article-title":"Possibilities and challenges for developing a successful vaccine for Leishmaniasis","volume":"9","author":"Srivastava","year":"2016","journal-title":"Parasites Vectors"},{"issue":"1","key":"10.1016\/j.exppara.2020.107849_bib78","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2958.2012.08185.x","article-title":"Novel insights into genome plasticity in Eukaryotes: mosaic aneuploidy in Leishmania","volume":"86","author":"Sterkers","year":"2012","journal-title":"Mol. Microbiol."},{"issue":"8","key":"10.1016\/j.exppara.2020.107849_bib79","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1128\/IAI.73.8.4714-4722.2005","article-title":"Conditions influencing the efficacy of vaccination with live organisms against Leishmania major infection","volume":"73","author":"Tabbara","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exppara.2020.107849_bib80","doi-asserted-by":"crossref","first-page":"10267","DOI":"10.1073\/pnas.92.22.10267","article-title":"Development of a safe live Leishmania vaccine line by gene replacement","volume":"92","author":"Titus","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exppara.2020.107849_bib81","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.gene.2005.06.047","article-title":"Targeted disruption of cytosolic SIR2 deacetylase discloses its essential role in Leishmania survival and proliferation","volume":"363","author":"Vergnes","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.exppara.2020.107849_bib82","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S1367-5931(99)00028-9","article-title":"Aminoglycoside - RNA interactions","volume":"3","author":"Walter","year":"1999","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.exppara.2020.107849_bib83","author":"WHO"},{"issue":"4","key":"10.1016\/j.exppara.2020.107849_bib84","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00861-15","article-title":"CRISPR-Cas9-Mediated genome editing in Leishmania donovani","volume":"6","author":"Zhang","year":"2015","journal-title":"mBio"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489419304448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489419304448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T06:26:50Z","timestamp":1758004010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489419304448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":85,"alternative-id":["S0014489419304448"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2020.107849","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potential of live attenuated vaccines against Cutaneous Leishmaniasis","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2020.107849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107849"}}