{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:17:43Z","timestamp":1778926663489,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00537-17"],"award-info":[{"award-number":["APQ-00537-17"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["152652\/2016?"],"award-info":[{"award-number":["152652\/2016?"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient&amp;#x00ED;fico e Tecnol&amp;#x00F3;gico","doi-asserted-by":"publisher","award":["304815-2017-9"],"award-info":[{"award-number":["304815-2017-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient&amp;#x00ED;fico e Tecnol&amp;#x00F3;gico","doi-asserted-by":"publisher","award":["152652\/2016\\u20137"],"award-info":[{"award-number":["152652\/2016\\u20137"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.exppara.2020.108006","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T14:13:31Z","timestamp":1601302411000},"page":"108006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Toxoplasma gondii: Cytokine responses in mice reinfected with atypical strains"],"prefix":"10.1016","volume":"218","author":[{"given":"Julia Gatti Ladeia","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Velozo","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon Castro de Araujo","family":"Baraviera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan Michael","family":"Geiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio Sobreira","family":"Silva Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olindo Assis","family":"Martins-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Wagner Almeida","family":"Vitor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2020.108006_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075138","article-title":"Toxoplasma gondii soluble tachyzoite antigen triggers protective mechanisms against fatal intestinal pathology in oral infection of C57BL\/6 mice","volume":"8","author":"Benevides","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.exppara.2020.108006_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1590\/S0074-02762009000200017","article-title":"Experimental reinfection of BALB\/c mice with different recombinant type I\/III strains of Toxoplasma gondii: involvement of IFN-gamma and IL-10","volume":"104","author":"Brand\u00e3o","year":"2009","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.exppara.2020.108006_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1051\/parasite\/2006132143","article-title":"Characterization of Toxoplasma gondii from domestic animals from Minas Gerais, Brazil","volume":"13","author":"Brand\u00e3o","year":"2006","journal-title":"Parasite"},{"key":"10.1016\/j.exppara.2020.108006_bib4","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3201\/eid1504.081306","article-title":"Severe acquired toxoplasmosis caused by wild cycle of Toxoplasma gondii, French Guiana","volume":"15","author":"Carme","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.exppara.2020.108006_bib5","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1128\/JCM.02502-12","article-title":"Genetic characterization of Toxoplasma gondii revealed highly diverse genotypes for isolates from newborns with congenital toxoplasmosis in southeastern Brazil","volume":"51","author":"Carneiro","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.exppara.2020.108006_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.exppara.2017.11.003","article-title":"Kinetics of parasite distribution after reinfection with genetically distinct strains of Toxoplasma gondii","volume":"184","author":"Costa","year":"2018","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2020.108006_bib7","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1128\/CMR.11.4.569","article-title":"Regulation and function of T cell-mediated immunity during Toxoplasma gondii infection","volume":"11","author":"Denkers","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.exppara.2020.108006_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182011001673","article-title":"Oral oocyst-induced mouse of toxoplasmosis: effect of infection with Toxoplasma gondii strains of different genotypes, dose, and mouse strains (transgenic, out-bred, in-bred) on pathogenesis and mortality","volume":"139","author":"Dubey","year":"2012","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2020.108006_bib9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.vetpar.2013.11.001","article-title":"Genotyping Toxoplasma gondii from wildlife in Pennsylvania and identification of natural recombinants virulent to mice","volume":"200","author":"Dubey","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2020.108006_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1051\/parasite\/2001082099","article-title":"Virulence for BALB\/c mice and antigenic diversity of eight Toxoplasma gondii strains isolated from animals and humans in Brasil","volume":"8","author":"Ferreira","year":"2001","journal-title":"Parasite"},{"key":"10.1016\/j.exppara.2020.108006_bib11","first-page":"71","article-title":"Immune response to Toxoplasma gondii","volume":"40","author":"Filisetti","year":"2004","journal-title":"Ann. Ist. Super Sanita"},{"key":"10.1016\/j.exppara.2020.108006_bib12","first-page":"1","article-title":"Calomys callosus chronically infected by Toxoplasma gondii clonal type II strain and reinfected by Brazilian strains is not able to prevent vertical transmission","volume":"181","author":"Franco","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.exppara.2020.108006_bib13","first-page":"127","article-title":"Role of macrophage-derived cytokines in the induction and regulation of cell-mediated immunity to Toxoplasma gondii","volume":"219","author":"Gazzinelli","year":"1996","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.exppara.2020.108006_bib14","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1073\/pnas.90.13.6115","article-title":"Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts","volume":"90","author":"Gazzinelli","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.exppara.2020.108006_bib15","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1371\/journal.pntd.0000277","article-title":"Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe","volume":"13","author":"Gilbert","year":"2008","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2020.108006_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02280-14","article-title":"Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5\/ROP18 allelic combination","volume":"6","author":"Jensen","year":"2015","journal-title":"mBio"},{"key":"10.1016\/j.exppara.2020.108006_bib17","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1084\/jem.20090900","article-title":"Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17","volume":"206","author":"Mu\u00f1oz","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exppara.2020.108006_bib18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.ijpara.2007.09.004","article-title":"Population structure and mouse-virulence of Toxoplasma gondii","volume":"38","author":"Pena","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2020.108006_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.vetpar.2017.09.015","article-title":"Association of ROP18 and ROP5 was efficient as a marker of virulence in atypical isolates of Toxoplasma gondii obtained from pigs and goats in Piau\u00ed, Brazil","volume":"247","author":"R\u00eago","year":"2017","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2020.108006_bib20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1017\/S0031182013001844","article-title":"Geographical patterns of Toxoplasma gondii genetic diversity revealed by multilocus PCR-RFLP genotyping","volume":"141","author":"Shwab","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2020.108006_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijpara.2015.10.005","article-title":"The ROP18 and ROP5 gene allele types are highly predictive of virulence in mice across globally distributed strains of Toxoplasma gondii","volume":"46","author":"Shwab","year":"2016","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2020.108006_bib22","article-title":"Overlapping Toxoplasma gondii genotypes circulating in domestic animals and humans in southeastern Brazil","volume":"9","author":"Silva","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.exppara.2020.108006_bib23","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1126\/science.1133643","article-title":"A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii","volume":"314","author":"Taylor","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.exppara.2020.108006_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0037-86822002000100001","article-title":"Prenatal toxoplasmosis diagnosis from amniotic fluid by PCR","volume":"35","author":"Vidigal","year":"2002","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.exppara.2020.108006_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nri3598","article-title":"Innate immunity to Toxoplasma gondii infection","volume":"14","author":"Yarovinsky","year":"2014","journal-title":"Nat. Rev. Immunol."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489420300977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489420300977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:51:16Z","timestamp":1778633476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489420300977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":25,"alternative-id":["S0014489420300977"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2020.108006","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxoplasma gondii: Cytokine responses in mice reinfected with atypical strains","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2020.108006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108006"}}