{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:11:14Z","timestamp":1777525874509,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["Pict-O-ANLIS-2011"],"award-info":[{"award-number":["Pict-O-ANLIS-2011"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2016\\u20132693"],"award-info":[{"award-number":["PICT 2016\\u20132693"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PIP 2014"],"award-info":[{"award-number":["PIP 2014"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011778","name":"Universidad Abierta Interamericana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.exppara.2020.108044","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T11:03:04Z","timestamp":1606474984000},"page":"108044","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Trypanosoma cruzi infection in Cyclophilin D deficient mice"],"prefix":"10.1016","volume":"220","author":[{"given":"Natalia","family":"Milduberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L.","family":"Bustos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina E.","family":"Perrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Postan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Bua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7033","key":"10.1016\/j.exppara.2020.108044_bib1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.exppara.2020.108044_bib2","doi-asserted-by":"crossref","first-page":"18558","DOI":"10.1074\/jbc.C500089200","article-title":"Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D","volume":"280","author":"Basso","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.exppara.2020.108044_bib3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00395-013-0363-z","article-title":"Endoplasmic reticulum stress contributes to heart protection induced by cyclophilin D inhibition","volume":"108","author":"Belaidi","year":"2013","journal-title":"Basic Res. Cardiol."},{"issue":"3","key":"10.1016\/j.exppara.2020.108044_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijpara.2005.11.003","article-title":"Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action","volume":"36","author":"Bell","year":"2006","journal-title":"Int. J. Parasitol."},{"issue":"2","key":"10.1016\/j.exppara.2020.108044_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF02110643","article-title":"The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal","volume":"28","author":"Bernardi","year":"1996","journal-title":"J. Bioenerg. Biomembr."},{"issue":"18","key":"10.1016\/j.exppara.2020.108044_bib6","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1016\/j.bmcl.2004.07.003","article-title":"In vitro anti-parasitic activity of Cyclosporin A analogs on Trypanosoma cruzi","volume":"14","author":"Bua","year":"2004","journal-title":"Bioorg. Med. Chem. Lett"},{"issue":"10","key":"10.1016\/j.exppara.2020.108044_bib7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.trstmh.2012.03.015","article-title":"Vertical transmission of Trypanosoma cruzi infection: quantification of parasite burden in mothers and their children by parasite DNA amplification","volume":"106","author":"Bua","year":"2012","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"4","key":"10.1016\/j.exppara.2020.108044_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4049\/immunohorizons.2000016","article-title":"Cyclophilin D regulates antiviral CD8+ T cell survival in a cell-extrinsic manner","volume":"4","author":"Condotta","year":"2020","journal-title":"Immunohorizons"},{"issue":"1","key":"10.1016\/j.exppara.2020.108044_bib9","first-page":"357","article-title":"Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress","volume":"255","author":"Crompton","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.exppara.2020.108044_bib10","article-title":"Antiproliferative, ultrastructural, and physiological effects of amiodarone on promastigote and amastigote forms of Leishmania amazonensis","author":"de Macedo-Silva","year":"2011","journal-title":"Mol. Biol. Int."},{"issue":"10","key":"10.1016\/j.exppara.2020.108044_bib11","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nm.1868","article-title":"Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease","volume":"14","author":"Du","year":"2008","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.exppara.2020.108044_bib12","first-page":"1101","article-title":"Determination of enzymatic catalysis for the cis-trans- isomerization of peptide binding in proline-containing peptides","volume":"43","author":"Fischer","year":"1984","journal-title":"Biomed. Biochim. Acta"},{"issue":"6206","key":"10.1016\/j.exppara.2020.108044_bib13","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/337476a0","article-title":"Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins","volume":"337","author":"Fischer","year":"1989","journal-title":"Nature"},{"issue":"18","key":"10.1016\/j.exppara.2020.108044_bib14","doi-asserted-by":"crossref","first-page":"7558","DOI":"10.1073\/pnas.0702228104","article-title":"Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis","volume":"104","author":"Forte","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"22","key":"10.1016\/j.exppara.2020.108044_bib15","doi-asserted-by":"crossref","first-page":"10214","DOI":"10.1073\/pnas.0914209107","article-title":"Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency","volume":"107","author":"Fujimoto","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"20","key":"10.1016\/j.exppara.2020.108044_bib16","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1007\/s00018-010-0437-0","article-title":"Molecular aspects of cyclophilins mediating therapeutic actions of their ligands","volume":"67","author":"Galat","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.exppara.2020.108044_bib17","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1086\/428906","article-title":"Enhancement of antimycobacterial activity of macrophages by stabilization of inner mitochondrial membrane potential","volume":"191","author":"Gan","year":"2005","journal-title":"J. Infect. Dis."},{"issue":"Pt 3","key":"10.1016\/j.exppara.2020.108044_bib18","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1042\/BJ20040356","article-title":"Gene expression analysis in mitochondria from chagasic mice: alterations in specific metabolic pathways","volume":"381","author":"Garg","year":"2004","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.exppara.2020.108044_bib19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ceca.2016.09.001","article-title":"Involvement of mitochondrial permeability transition pore (mPTP) in cardiac arrhythmias: evidence from cyclophilin D knockout mice","volume":"60","author":"Gordan","year":"2016","journal-title":"Cell Calcium"},{"issue":"10","key":"10.1016\/j.exppara.2020.108044_bib20","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.freeradbiomed.2009.08.008","article-title":"Trypanosoma cruzi infection disturbs mitochondrial membrane potential and ROS production rate in cardiomyocytes","volume":"47","author":"Gupta","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"4674","key":"10.1016\/j.exppara.2020.108044_bib21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1126\/science.6238408","article-title":"Cyclophilin: a specific cytosolic binding protein for cyclosporin A","volume":"226","author":"Handschumacher","year":"1984","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.exppara.2020.108044_bib22","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/cvr\/cvq113","article-title":"Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning","volume":"88","author":"Hausenloy","year":"2010","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.exppara.2020.108044_bib23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/0976-500X.72351","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"1","author":"Kilkenny","year":"2010","journal-title":"J. Pharmacol. Pharmacother."},{"issue":"1\u20132","key":"10.1016\/j.exppara.2020.108044_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0005-2728(98)00112-1","article-title":"The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy","volume":"1366","author":"Lemasters","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.exppara.2020.108044_bib25","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nm1736","article-title":"Genetic and pharmacologic inhibition of mitochondrial- dependent necrosis attenuates muscular dystrophy","volume":"14","author":"Millay","year":"2008","journal-title":"Nat. Med."},{"issue":"7033","key":"10.1016\/j.exppara.2020.108044_bib26","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nature03317","article-title":"Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death","volume":"434","author":"Nakagawa","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.exppara.2020.108044_bib27","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fcimb.2017.00430","article-title":"Inactive trans-sialidase expression in iTS-null Trypanosoma cruzi generates virulent trypomastigotes","volume":"7","author":"Pascuale","year":"2017","journal-title":"Front. Cell Infect. Microbiol."},{"issue":"34","key":"10.1016\/j.exppara.2020.108044_bib28","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1073\/pnas.0505294102","article-title":"Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia","volume":"102","author":"Schinzel","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"10.1016\/j.exppara.2020.108044_bib29","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0008-6363(96)88617-2","article-title":"Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines","volume":"29","author":"Shindo","year":"1995","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.exppara.2020.108044_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0155709","article-title":"Cyclophilin D knock-out mice show enhanced resistance to osteoporosis and to metabolic changes observed in aging bone","volume":"11","author":"Shum","year":"2016","journal-title":"PloS One"},{"issue":"12","key":"10.1016\/j.exppara.2020.108044_bib31","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1586\/14779072.2015.1103648","article-title":"Developments in the management of Chagas cardiomyopathy","volume":"13","author":"Tanowitz","year":"2015","journal-title":"Expert Rev. Cardiovasc Ther."},{"issue":"23","key":"10.1016\/j.exppara.2020.108044_bib32","doi-asserted-by":"crossref","first-page":"eaar4135","DOI":"10.1126\/sciimmunol.aar4135","article-title":"Mitochondrial cyclophilin D regulates T cell metabolic responses and disease tolerance to tuberculosis","volume":"3","author":"Tzelepis","year":"2018","journal-title":"Sci. Immunol."},{"issue":"11","key":"10.1016\/j.exppara.2020.108044_bib33","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/1357-2725(95)00073-X","article-title":"Energetics of heart mitochondria during acute phase of Trypanosoma cruzi infection in rats","volume":"27","author":"Uyemura","year":"1995","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"16","key":"10.1016\/j.exppara.2020.108044_bib34","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.2174\/0929867033457160","article-title":"Cyclophilin D as a drug target","volume":"10","author":"Waldmeier","year":"2003","journal-title":"Curr. Med. Chem."},{"issue":"5","key":"10.1016\/j.exppara.2020.108044_bib35","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/cdd.2014.165","article-title":"E2F1-regulated miR-30b suppresses cyclophilin D and protects heart from ischemia\/reperfusion injury and necrotic cell death","volume":"22","author":"Wang","year":"2015","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.exppara.2020.108044_bib36","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/hep.29788","article-title":"Cyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis","volume":"68","author":"Wang","year":"2018","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"2","key":"10.1016\/j.exppara.2020.108044_bib37","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.freeradbiomed.2006.04.009","article-title":"Increased oxidative stress is correlated with mitochondrial dysfunction in chagasic patients","volume":"41","author":"Wen","year":"2006","journal-title":"Free Radic. Biol. Med."},{"issue":"10\u201311","key":"10.1016\/j.exppara.2020.108044_bib38","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.micinf.2008.06.013","article-title":"Tissue-specific oxidative imbalance and mitochondrial dysfunction during Trypanosoma cruzi infection in mice","volume":"10","author":"Wen","year":"2008","journal-title":"Microb. Infect."},{"key":"10.1016\/j.exppara.2020.108044_bib39","series-title":"Chagas Disease (American Trypanosomiasis)","year":"2020"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489420305695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489420305695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:27:38Z","timestamp":1777393658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489420305695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":39,"alternative-id":["S0014489420305695"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2020.108044","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trypanosoma cruzi infection in Cyclophilin D deficient mice","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2020.108044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108044"}}