{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T06:52:49Z","timestamp":1771915969977,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.exppara.2021.108096","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T18:04:05Z","timestamp":1616004245000},"page":"108096","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Generation and application of a monoclonal antibody against the 18-kDa oncosphere antigen of Taenia pisiformis"],"prefix":"10.1016","volume":"224","author":[{"given":"Ze-Xiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai-Dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Hui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4583-0369","authenticated-orcid":false,"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.exppara.2021.108096_bib1","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1021\/acs.bioconjchem.7b00389","article-title":"Peptide dendrons as thermal-stability amplifiers for immunoglobulin G1 monoclonal antibody biotherapeutics","volume":"28","author":"Bansal","year":"2017","journal-title":"Bioconjugate Chem."},{"issue":"5","key":"10.1016\/j.exppara.2021.108096_bib2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nri2747","article-title":"Strategies and challenges for the next generation of therapeutic antibodies","volume":"10","author":"Beck","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"17","key":"10.1016\/j.exppara.2021.108096_bib3","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1016\/j.vaccine.2012.02.022","article-title":"Effective protection induced by three different versions of the porcine S3Pvac anticysticercosis vaccine against rabbit experimental Taenia pisiformis cysticercosis","volume":"30","author":"Betancourt","year":"2012","journal-title":"Vaccine"},{"issue":"4","key":"10.1016\/j.exppara.2021.108096_bib4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0020-7519(92)90148-E","article-title":"A monoclonal antibody-based ELISA for the detection of circulating excretory-secretory antigens in Taenia saginata cysticercosis","volume":"22","author":"Brandt","year":"1992","journal-title":"Int. J. Parasitol."},{"issue":"3","key":"10.1016\/j.exppara.2021.108096_bib5","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.4238\/2014.February.13.14","article-title":"Protection against Taenia pisiformis larval infection induced by a recombinant oncosphere antigen vaccine","volume":"13","author":"Chen","year":"2014","journal-title":"Genet. Mol. Res."},{"issue":"3\u20134","key":"10.1016\/j.exppara.2021.108096_bib6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.vetpar.2014.05.021","article-title":"Evaluation of a novel Dot-ELISA assay utilizing a recombinant protein for the effective diagnosis of Taenia pisiformis larval infections","volume":"204","author":"Chen","year":"2014","journal-title":"Vet. Parasitol."},{"issue":"5","key":"10.1016\/j.exppara.2021.108096_bib7","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1177\/31.5.6341459","article-title":"Monoclonal antibody storage conditions, and concentration effects on immunohistochemical specificity","volume":"31","author":"Ciocca","year":"1983","journal-title":"J. Histochem. Cytochem."},{"issue":"Pt 1","key":"10.1016\/j.exppara.2021.108096_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1017\/S0031182000001177","article-title":"Circulating antigens, antibodies and immune complexes in experimental Taenia pisiformis infections of rabbits","volume":"89","author":"Craig","year":"1984","journal-title":"Parasitology"},{"issue":"5","key":"10.1016\/j.exppara.2021.108096_bib9","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ijpara.2008.10.012","article-title":"Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis","volume":"39","author":"Deckers","year":"2009","journal-title":"Int. J. Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2021.108096_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4161\/19420862.2015.989042","article-title":"The therapeutic monoclonal antibody market","volume":"7","author":"Ecker","year":"2015","journal-title":"mAbs"},{"key":"10.1016\/j.exppara.2021.108096_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.leukres.2016.07.009","article-title":"New monoclonal antibodies for the treatment of acute lymphoblastic leukemia","volume":"49","author":"Farhadfar","year":"2016","journal-title":"Leuk. Res."},{"issue":"8","key":"10.1016\/j.exppara.2021.108096_bib12","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.trstmh.2005.02.003","article-title":"Oncospheral peptide-based ELISAs as potential seroepidemiological tools for Taenia solium cysticercosis\/neurocysticercosis in Venezuela","volume":"99","author":"Ferrer","year":"2005","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"3","key":"10.1016\/j.exppara.2021.108096_bib13","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00436-007-0507-x","article-title":"Evaluation of recombinant HP6-Tsag, an 18 kDa Taenia saginata oncospheral adhesion protein, for the diagnosis of cysticercosis","volume":"101","author":"Ferrer","year":"2007","journal-title":"Parasitol. Res."},{"issue":"5","key":"10.1016\/j.exppara.2021.108096_bib14","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0020-7519(98)00034-4","article-title":"A Taenia solium oncosphere protein homologous to host-protective Taenia ovis and Taenia saginata 18 kDa antigens","volume":"28","author":"Gauci","year":"1998","journal-title":"Int. J. Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2021.108096_bib15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.molbiopara.2005.10.014","article-title":"Conservation of the vaccine antigen gene, TSOL18, among genetically variant isolates of Taenia solium","volume":"146","author":"Gauci","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"issue":"4","key":"10.1016\/j.exppara.2021.108096_bib16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0022-1759(80)90230-6","article-title":"Antibody production by hybridomas","volume":"39","author":"Goding","year":"1980","journal-title":"J. Immunol. Methods"},{"issue":"6","key":"10.1016\/j.exppara.2021.108096_bib17","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00436-007-0673-x","article-title":"The Taenia saginata homologue of the major surface antigen of Echinococcus spp. is immunogenic and 97% identical to its Taenia solium homologue","volume":"101","author":"Gonz\u00e1lez","year":"2007","journal-title":"Parasitol. Res."},{"issue":"5","key":"10.1016\/j.exppara.2021.108096_bib18","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00436-010-1786-1","article-title":"Mapping of Taenia solium TSOL18 antigenic epitopes by phage display library","volume":"106","author":"Guo","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2021.108096_bib19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.vetpar.2016.09.015","article-title":"Taenia pisiformis cysticercosis induces decreased prolificacy and increased progesterone levels in rabbits","volume":"229","author":"Hallal-Calleros","year":"2016","journal-title":"Vet. Parasitol."},{"issue":"2","key":"10.1016\/j.exppara.2021.108096_bib20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0020-7519(95)00097-6","article-title":"Identification and cDNA cloning of two novel low molecular weight host-protective antigens from Taenia ovis oncospheres","volume":"26","author":"Harrison","year":"1996","journal-title":"Int. J. Parasitol."},{"issue":"Suppl. l","key":"10.1016\/j.exppara.2021.108096_bib21","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.parint.2005.11.049","article-title":"Phylogeny of Taenia: species definitions and origins of human parasites","volume":"55","author":"Hoberg","year":"2006","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.exppara.2021.108096_bib22","first-page":"119","article-title":"Generation of murine monoclonal antibodies by hybridoma technology","volume":"2","author":"Holzl\u00f6hner","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.exppara.2021.108096_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/1475-2875-13-277","article-title":"Production and characterization of specific monoclonal antibodies binding the Plasmodium falciparum diagnostic biomarker, histidine-rich protein 2","volume":"13","author":"Leow","year":"2014","journal-title":"Malar. J."},{"issue":"3","key":"10.1016\/j.exppara.2021.108096_bib24","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1128\/JCM.42.3.1082-1088.2004","article-title":"Molecular cloning, expression, and serological evaluation of an 8-kilodalton subunit of antigen B from Echinococcus multilocularis","volume":"42","author":"Mamuti","year":"2004","journal-title":"J. Clin. Microbiol."},{"issue":"38","key":"10.1016\/j.exppara.2021.108096_bib25","doi-asserted-by":"crossref","first-page":"8089","DOI":"10.1039\/C5CC01877C","article-title":"Inhibited fragmentation of mAbs in buffered ionic liquids","volume":"51","author":"Mazid","year":"2015","journal-title":"Chem. Commun."},{"issue":"4","key":"10.1016\/j.exppara.2021.108096_bib26","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/1087057114557781","article-title":"High-throughput screening of formulations to optimize the thermal stability of a therapeutic monoclonal antibody","volume":"20","author":"Niedziela-Majka","year":"2014","journal-title":"J. Biomol. Screen"},{"issue":"5","key":"10.1016\/j.exppara.2021.108096_bib27","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00436-007-0853-8","article-title":"TSOL18\/HP6-Tsol, an immunogenic Taenia solium oncospheral adhesion protein and potential protective antigen","volume":"102","author":"Parkhouse","year":"2008","journal-title":"Parasitol. Res."},{"issue":"1\u20132","key":"10.1016\/j.exppara.2021.108096_bib28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijpharm.2012.06.063","article-title":"Long-term stability of diluted solutions of the monoclonal antibody rituximab","volume":"436","author":"Paul","year":"2012","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.exppara.2021.108096_bib29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0014-4894(85)90087-6","article-title":"Taenia pisiformis: protective immunization of rabbits with solubilized oncospheral antigens","volume":"59","author":"Rajasekariah","year":"1985","journal-title":"Exp. Parasitol."},{"issue":"14","key":"10.1016\/j.exppara.2021.108096_bib30","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S1286-4579(02)00025-4","article-title":"Protective immunity against Taenia crassiceps murine cysticercosis induced by DNA vaccination with a Taenia saginata tegument antigen","volume":"4","author":"Rosas","year":"2002","journal-title":"Microb. Infect."},{"issue":"2","key":"10.1016\/j.exppara.2021.108096_bib31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0020-7519(91)90007-T","article-title":"Immunodiagnosis of angiostrongyliasis with monoclonal antibodies recognizing a circulating antigen of mol. wt 91,000 from Angiostrongylus cantonensis","volume":"21","author":"Shih","year":"1991","journal-title":"Int. J. Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2021.108096_bib32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00436-013-3625-7","article-title":"Occurrence of gastrointestinal parasites in slaughter rabbits","volume":"113","author":"Szkucik","year":"2014","journal-title":"Parasitol. Res."},{"issue":"4","key":"10.1016\/j.exppara.2021.108096_bib33","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.exppara.2010.06.010","article-title":"Taenia saginata: production and characterization of monoclonal antibodies against Taenia saginata metacestode antigens","volume":"126","author":"Vicentini-Oliveira","year":"2010","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2021.108096_bib34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00436-010-1857-3","article-title":"Production and immunoanalytical application of 32 monoclonal antibodies against metacestode somatic antigens of Echinococcus multilocularis","volume":"107","author":"Wang","year":"2010","journal-title":"Parasitol. Res."},{"issue":"4","key":"10.1016\/j.exppara.2021.108096_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032283","article-title":"Annotation of the transcriptome from Taenia pisiformis and its comparative analysis with three Taeniidae species","volume":"7","author":"Yang","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.exppara.2021.108096_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1051\/parasite\/2013053","article-title":"Expression and immunolocalisation of TpFABP as a candidate antigen for the serodiagnosis of rabbit Taenia pisiformis cysticercosis","volume":"20","author":"Yang","year":"2013","journal-title":"Parasite"},{"key":"10.1016\/j.exppara.2021.108096_bib37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.actatropica.2015.01.007","article-title":"Identification and functional characterization of alpha-enolase from Taenia pisiformis metacestode","volume":"144","author":"Zhang","year":"2015","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2021.108096_bib38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.exppara.2016.03.011","article-title":"Generation and characterization of monoclonal antibodies specific for 18 kDa antigen from Taenia solium cysticerci","volume":"166","author":"Zhang","year":"2016","journal-title":"Exp. Parasitol."},{"issue":"7","key":"10.1016\/j.exppara.2021.108096_bib39","doi-asserted-by":"crossref","first-page":"271","DOI":"10.6026\/97320630006271","article-title":"Immunoinformatics prediction of linear epitopes from Taenia solium TSOL18","volume":"6","author":"Zimic","year":"2011","journal-title":"Bioinformation"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489421000333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489421000333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:03:02Z","timestamp":1762149782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489421000333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":39,"alternative-id":["S0014489421000333"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2021.108096","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation and application of a monoclonal antibody against the 18-kDa oncosphere antigen of Taenia pisiformis","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2021.108096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108096"}}