{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:23:44Z","timestamp":1782332624824,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["7502016\/6\/15"],"award-info":[{"award-number":["7502016\/6\/15"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.exppara.2021.108151","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T11:05:36Z","timestamp":1629371136000},"page":"108151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Evaluation of curcumin and CM11 peptide alone and in combination against amastigote form of Iranian strain of L. major (MRHO\/IR75\/ER) in vitro"],"prefix":"10.1016","volume":"229","author":[{"given":"G.","family":"Aqeele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Shayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ebrahimzade Abkooh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mohebali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.exppara.2021.108151_bib1","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.peptides.2008.05.008","article-title":"Isolation, characterization and molecular cloning of new temporins from the skin of the North African ranid Pelophylax saharica","volume":"29","author":"Abbassi","year":"2008","journal-title":"peptides"},{"issue":"1\/A","key":"10.1016\/j.exppara.2021.108151_bib2","first-page":"363","article-title":"Anticancer potential of curcumin: preclinical and clinical studies","volume":"23","author":"Aggarwal","year":"2003","journal-title":"Anticancer Res."},{"issue":"5","key":"10.1016\/j.exppara.2021.108151_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.exppara.2021.108151_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1248\/bpb.26.453","article-title":"In vitro antiproliferative effects of several diaryl derivatives on Leishmania spp","volume":"26","author":"Alves","year":"2003","journal-title":"Biol. Pharm. Bull."},{"issue":"10","key":"10.1016\/j.exppara.2021.108151_bib5","doi-asserted-by":"crossref","first-page":"940","DOI":"10.2174\/0929866522666150728115439","article-title":"In vitro synergistic effect of the CM11 antimicrobial peptide in combination with common antibiotics against clinical isolates of six species of multidrug-resistant pathogenic bacteria","volume":"22","author":"Amani","year":"2015","journal-title":"Protein Pept. Lett."},{"issue":"No. 4","key":"10.1016\/j.exppara.2021.108151_bib6","first-page":"413","article-title":"Determination of the effective dose of curcumin alone and in combination with antimicrobial peptide CM11 on promastigote forms of Iranian strain of L. major (MRHO\/IR\/75\/ER)","volume":"74","author":"Aqeele","year":"2019","journal-title":"Archives of Razi Institute"},{"issue":"3","key":"10.1016\/j.exppara.2021.108151_bib7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1645\/GE-1031R.1","article-title":"Sensitivity of Leishmania braziliensis promastigotes to meglumine antimoniate (glucantime) is higher than that of other Leishmania species and correlates with response to therapy in American tegumentary leishmaniasis","volume":"93","author":"Azeredo-Coutinho","year":"2007","journal-title":"J. Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2021.108151_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007843","article-title":"Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasis","volume":"14","author":"Badirzadeh","year":"2020","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"266","key":"10.1016\/j.exppara.2021.108151_bib9","article-title":"A potential acetyltransferase involved in Leishmania major metacaspase-dependent cell death","volume":"12","author":"Basmaciyan","year":"2019","journal-title":"Parasites Vectors"},{"issue":"3","key":"10.1016\/j.exppara.2021.108151_bib10","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1158\/0008-5472.CAN-08-2367","article-title":"Curcumin disrupts the Mammalian target of rapamycin-raptor complex","volume":"69","author":"Beevers","year":"2009","journal-title":"Canc. Res."},{"issue":"9","key":"10.1016\/j.exppara.2021.108151_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107514","article-title":"Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT","volume":"9","author":"Buhrmann","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.exppara.2021.108151_bib12","doi-asserted-by":"crossref","first-page":"100339","DOI":"10.1016\/j.hermed.2020.100339","article-title":"Significant decrease in the viability and tumor stem cell marker expression in tumor cell lines treated with curcumin","author":"Buhrmann","year":"2020","journal-title":"J. Herb. Med."},{"issue":"1","key":"10.1016\/j.exppara.2021.108151_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.eujim.2014.12.007","article-title":"Building WHO's global strategy for traditional medicine","volume":"7","author":"Burton","year":"2015","journal-title":"European Journal of Integrative Medicine"},{"issue":"5","key":"10.1016\/j.exppara.2021.108151_bib14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.parint.2018.06.004","article-title":"Chemoprevention of Leishmaniasis: in-vitro antiparasitic activity of dibenzalacetone, a synthetic curcumin analog leads to apoptotic cell death in Leishmania donovani","volume":"67","author":"Chauhan","year":"2018","journal-title":"Parasitol. Int."},{"issue":"8","key":"10.1016\/j.exppara.2021.108151_bib15","first-page":"868","article-title":"Antimicrobial peptides for leishmaniasis","volume":"11","author":"Cobb","year":"2010","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"10.1016\/j.exppara.2021.108151_bib16","first-page":"1","article-title":"Potential of the natural products against leishmaniasis in Old World-a review of in-vitro studies","author":"Cortes","year":"2020","journal-title":"Pathog. Glob. Health"},{"issue":"10","key":"10.1016\/j.exppara.2021.108151_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002491","article-title":"Human neutrophil peptide-1 (HNP-1): a new anti-leishmanial drug candidate","volume":"7","author":"Dabirian","year":"2013","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2021.108151_bib18","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s10495-008-0224-7","article-title":"Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani","volume":"13","author":"Das","year":"2008","journal-title":"Apoptosis"},{"key":"10.1016\/j.exppara.2021.108151_bib19","article-title":"Anti-proliferative and apoptosis induction activities of curcumin on Leishmania major","author":"Elamin","year":"2021","journal-title":"Rev. Argent. Microbiol."},{"key":"10.1016\/j.exppara.2021.108151_bib21","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fmicb.2013.00353","article-title":"Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance","volume":"4","author":"Guilhelmelli","year":"2013","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.exppara.2021.108151_bib22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10555-010-9235-2","article-title":"Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals","volume":"29","author":"Gupta","year":"2010","journal-title":"Canc. Metastasis Rev."},{"issue":"9","key":"10.1016\/j.exppara.2021.108151_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0966-842X(00)01823-0","article-title":"The role of cationic antimicrobial peptides in innate host defences","volume":"8","author":"Hancock","year":"2000","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.exppara.2021.108151_bib24","series-title":"Veterinary Research Forum","first-page":"323","article-title":"Antimicrobial activity of an antimicrobial peptide against amastigote forms of Leishmania major","volume":"vol. 9","author":"Khalili","year":"2018"},{"key":"10.1016\/j.exppara.2021.108151_bib25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.exppara.2018.11.006","article-title":"Investigation of the antimicrobial activity of a short cationic peptide against promastigote and amastigote forms of Leishmania major (MHRO\/IR\/75\/ER): an in vitro study","volume":"196","author":"Khalili","year":"2019","journal-title":"Exp. Parasitol."},{"issue":"18","key":"10.1016\/j.exppara.2021.108151_bib26","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1007\/s00253-019-09990-x","article-title":"Curcumin-loaded self-emulsifying drug delivery system (cu-SEDDS): a promising approach for the control of primary pathogen and secondary bacterial infections in cutaneous leishmaniasis","volume":"103","author":"Khan","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.exppara.2021.108151_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13104-018-3446-y","article-title":"In vitro s creening of known drugs identified by scaffold hopping techniques shows promising leishmanicidal activity for suramin and netilmicin","volume":"11","author":"Khanra","year":"2018","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.exppara.2021.108151_bib28","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.3389\/fmicb.2017.01907","article-title":"Analytical performance of four polymerase chain reaction (PCR) and real time PCR (qPCR) assays for the detection of six Leishmania species DNA in Colombia","volume":"8","author":"Le\u00f3n","year":"2017","journal-title":"Front. Microbiol."},{"issue":"5","key":"10.1016\/j.exppara.2021.108151_bib29","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1128\/AAC.02804-15","article-title":"A new antileishmanial preparation of combined solamargine and solasonine heals cutaneous leishmaniasis through different immunochemical pathways","volume":"60","author":"Lezama-D\u00e1vila","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.exppara.2021.108151_bib30","doi-asserted-by":"crossref","first-page":"e1141","DOI":"10.1371\/journal.pntd.0001141","article-title":"Effect of BMAP-28 antimicrobial peptides on Leishmania major promastigote and amastigote growth: role of leishmanolysin in parasite survival","volume":"5","author":"Lynn","year":"2011","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"5","key":"10.1016\/j.exppara.2021.108151_bib31","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.coph.2006.04.006","article-title":"Anti-bacterial peptides for therapeutic use: obstacles and realistic outlook","volume":"6","author":"Marr","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"issue":"5","key":"10.1016\/j.exppara.2021.108151_bib32","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s11274-013-1575-y","article-title":"Investigation of the anti-bacterial activity of a short cationic peptide against multidrug-resistant Klebsiella pneumoniae and Salmonella typhimurium strains and its cytotoxicity on eukaryotic cells","volume":"30","author":"Moghaddam","year":"2014","journal-title":"World J. Microbiol. Biotechnol."},{"issue":"2","key":"10.1016\/j.exppara.2021.108151_bib33","first-page":"27","article-title":"Phytomedicine: an ancient approach turning into future potential source of therapeutics","volume":"3","author":"Mukeshwar","year":"2011","journal-title":"J. Pharmacogn. Phytotherapy"},{"key":"10.1016\/j.exppara.2021.108151_bib34","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fphys.2014.00026","article-title":"The emerging roles of ribosome biogenesis in craniofacial development","volume":"5","author":"Ross","year":"2014","journal-title":"Front. Physiol."},{"issue":"25","key":"10.1016\/j.exppara.2021.108151_bib35","first-page":"265","article-title":"Global leishmaniasis surveillance, 2017-2018, and first report on 5 additional indicators\/Surveillance mondiale de la leishmaniose, 2017-2018, et premier rapport sur 5 indicateurs supplementaires","volume":"95","author":"Ruiz-Postigo","year":"2020","journal-title":"Wkly. Epidemiol. Rec."},{"issue":"3","key":"10.1016\/j.exppara.2021.108151_bib36","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1248\/bpb.25.386","article-title":"Latent activity of curcumin against leishmaniasis in vitro","volume":"25","author":"Saleheen","year":"2002","journal-title":"Biol. Pharm. Bull."},{"issue":"41","key":"10.1016\/j.exppara.2021.108151_bib37","doi-asserted-by":"crossref","first-page":"32376","DOI":"10.1039\/C5RA02669E","article-title":"Antileishmanial drug discovery: comprehensive review of the last 10 years","volume":"5","author":"Sangshetti","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.exppara.2021.108151_bib38","series-title":"Curcumin: Biosynthesis, Medicinal Uses and Health Benefits","year":"2012"},{"issue":"2","key":"10.1016\/j.exppara.2021.108151_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057218","article-title":"Curcumin enhances the effect of chemotherapy against colorectal cancer cells by inhibition of NF-\u03baB and Src protein kinase signaling pathways","volume":"8","author":"Shakibaei","year":"2013","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.exppara.2021.108151_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085397","article-title":"Curcumin chemosensitizes 5-fluorouracil resistant MMR-deficient human colon cancer cells in high density cultures","volume":"9","author":"Shakibaei","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.exppara.2021.108151_bib41","first-page":"250","article-title":"Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer","volume":"15","author":"Shakibaei","year":"2015","journal-title":"BioMed Central (BMC)"},{"issue":"3","key":"10.1016\/j.exppara.2021.108151_bib42","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01169-16","article-title":"Nanotized curcumin and miltefosine, a potential combination for treatment of experimental visceral leishmaniasis","volume":"61","author":"Tiwari","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.exppara.2021.108151_bib43","author":"Who"},{"issue":"5","key":"10.1016\/j.exppara.2021.108151_bib44","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1017\/S1461145713001661","article-title":"Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats","volume":"17","author":"Zhang","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489421000886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489421000886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:03:11Z","timestamp":1762149791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489421000886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":43,"alternative-id":["S0014489421000886"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2021.108151","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of curcumin and CM11 peptide alone and in combination against amastigote form of Iranian strain of L. major (MRHO\/IR75\/ER) in vitro","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2021.108151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108151"}}