{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:08:50Z","timestamp":1762150130994,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560334","U1303121"],"award-info":[{"award-number":["81560334","U1303121"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.exppara.2022.108280","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T21:26:08Z","timestamp":1652822768000},"page":"108280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["In vitro protoscolicidal effects of lithocholic acid on protoscoleces of Echinococcus granulosus and its mechanism"],"prefix":"10.1016","volume":"239","author":[{"given":"Ya","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Qing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2022.108280_bib1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fmicb.2018.00089","article-title":"Bile salt hydrolase activities: a novel target to screen anti-giardia lactobacilli?","volume":"9","author":"Allain","year":"2018","journal-title":"Front. Microbiol."},{"issue":"9","key":"10.1016\/j.exppara.2022.108280_bib2","doi-asserted-by":"crossref","first-page":"16522","DOI":"10.3390\/ijms150916522","article-title":"Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid","volume":"15","author":"Arlia-Ciommo","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.exppara.2022.108280_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mrrev.2004.08.001","article-title":"Bile acids as carcinogens in human gastrointestinal cancers","volume":"589","author":"Bernstein","year":"2005","journal-title":"Mutat. Res."},{"issue":"6","key":"10.1016\/j.exppara.2022.108280_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1155\/1998\/78170","article-title":"Scolicidal agents in hydatid cyst surgery","volume":"10","author":"Besim","year":"1998","journal-title":"HPB Surg."},{"key":"10.1016\/j.exppara.2022.108280_bib5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fnagi.2019.00177","article-title":"The precursor to glutathione (GSH), gamma-glutamylcysteine (GGC), can ameliorate oxidative damage and neuroinflammation induced by Abeta40 oligomers in human astrocytes","volume":"11","author":"Braidy","year":"2019","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.exppara.2022.108280_bib6","doi-asserted-by":"crossref","first-page":"15876","DOI":"10.1038\/s41598-019-52456-3","article-title":"Unraveling oxidative stress response in the cestode parasite Echinococcus granulosus","volume":"9","author":"Cancela","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.exppara.2022.108280_bib7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00436-009-1483-0","article-title":"Enzymatic antioxidant systems in helminth parasites","volume":"105","author":"Chiumiento","year":"2009","journal-title":"Parasitol. Res."},{"issue":"4","key":"10.1016\/j.exppara.2022.108280_bib8","first-page":"447","article-title":"The effects of some drugs--pentamidine, stibocaptate, Hoechst 33258, F 151, compound 'E' and Nifurtimox--on Onchocerca volvulus in chimpanzees","volume":"28","author":"Duke","year":"1977","journal-title":"Tropenmed. Parasitol."},{"issue":"6","key":"10.1016\/j.exppara.2022.108280_bib9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1159\/000008610","article-title":"Effect of albendazole sulfoxide solution on the scolices and the hepatobiliary system","volume":"30","author":"Erzurumlu","year":"1998","journal-title":"Eur. Surg. Res."},{"key":"10.1016\/j.exppara.2022.108280_bib10","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.7717\/peerj.122","article-title":"Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells","volume":"1","author":"Goldberg","year":"2013","journal-title":"PeerJ"},{"issue":"5","key":"10.1016\/j.exppara.2022.108280_bib11","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s10495-007-0747-3","article-title":"The permeability transition pore in cell death","volume":"12","author":"Grimm","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.exppara.2022.108280_bib12","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.steroids.2017.06.009","article-title":"The synthesis and antitumor activity of lithocholic acid and its derivatives","volume":"125","author":"He","year":"2017","journal-title":"Steroids"},{"issue":"2","key":"10.1016\/j.exppara.2022.108280_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0166-6851(01)00252-3","article-title":"Antioxidant enzyme families in parasitic nematodes","volume":"114","author":"Henkle-Duhrsen","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"issue":"3","key":"10.1016\/j.exppara.2022.108280_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3347\/kjp.2006.44.3.239","article-title":"In vitro protoscolicidal effects of hypertonic glucose on protoscolices of hydatid cyst","volume":"44","author":"Hosseini","year":"2006","journal-title":"Kor. J. Parasitol."},{"issue":"5","key":"10.1016\/j.exppara.2022.108280_bib15","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1074\/jbc.M805804200","article-title":"Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines","volume":"284","author":"Katona","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.exppara.2022.108280_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11091255","article-title":"Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer","volume":"11","author":"Kovacs","year":"2019","journal-title":"Cancers"},{"issue":"11","key":"10.1016\/j.exppara.2022.108280_bib17","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s00018-011-0895-z","article-title":"Cytochrome c: the Achilles' heel in apoptosis","volume":"69","author":"Kulikov","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.exppara.2022.108280_bib18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/trstmh\/try112","article-title":"Epidemiology, diagnosis, treatment and follow-up of cystic echinococcosis in asymptomatic carriers","volume":"113","author":"Larrieu","year":"2019","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2022.108280_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.gene.2003.10.027","article-title":"Functional expression and characterization of Echinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage","volume":"326","author":"Li","year":"2004","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.exppara.2022.108280_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s13402-017-0353-5","article-title":"Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells","volume":"41","author":"Luu","year":"2018","journal-title":"Cell. Oncol."},{"issue":"2","key":"10.1016\/j.exppara.2022.108280_bib21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3347\/kjp.2013.51.2.255","article-title":"In vitro effects of SB202190 on Echinococcus granulosus","volume":"51","author":"Lv","year":"2013","journal-title":"Kor. J. Parasitol."},{"issue":"28","key":"10.1016\/j.exppara.2022.108280_bib22","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4254\/wjh.v8.i28.1169","article-title":"Current status of diagnosis and treatment of hepatic echinococcosis","volume":"8","author":"Mihmanli","year":"2016","journal-title":"World J. Hepatol."},{"issue":"8820","key":"10.1016\/j.exppara.2022.108280_bib23","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/0140-6736(92)92180-N","article-title":"Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness","volume":"340","author":"Milord","year":"1992","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.exppara.2022.108280_bib24","first-page":"185","article-title":"Clearing the final hurdles to mitochondrial apoptosis: regulation post cytochrome C release","volume":"34","author":"Monian","year":"2012","journal-title":"Exp. Oncol."},{"issue":"11","key":"10.1016\/j.exppara.2022.108280_bib25","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/AAC.00578-06","article-title":"In vitro metacestodicidal activities of genistein and other isoflavones against Echinococcus multilocularis and Echinococcus granulosus","volume":"50","author":"Naguleswaran","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"issue":"8","key":"10.1016\/j.exppara.2022.108280_bib26","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/abbs\/gmx067","article-title":"Effects of trigonelline inhibition of the Nrf2 transcription factor in vitro on Echinococcus granulosus","volume":"49","author":"Qin","year":"2017","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"4","key":"10.1016\/j.exppara.2022.108280_bib27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.mehy.2013.07.003","article-title":"Using specific synthetic peptide (p176) derived AgB 8\/1-kDa accompanied by modified patient's sera: a novel hypothesis to follow-up of Cystic echinococcosis after surgery","volume":"81","author":"Rouhani","year":"2013","journal-title":"Med. Hypotheses"},{"issue":"27","key":"10.1016\/j.exppara.2022.108280_bib28","doi-asserted-by":"crossref","first-page":"25039","DOI":"10.1074\/jbc.M302930200","article-title":"BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization","volume":"278","author":"Ruffolo","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.exppara.2022.108280_bib29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1006\/expr.1998.4339","article-title":"Echinococcus granulosus: cloning of a thioredoxin peroxidase","volume":"90","author":"Salinas","year":"1998","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2022.108280_bib30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exppara.2016.05.004","article-title":"Protoscolicidal effects of chenodeoxycholic acid on protoscoleces of Echinococcus granulosus","volume":"167","author":"Shi","year":"2016","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2022.108280_bib31","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s13071-019-3653-y","article-title":"First description of Echinococcus ortleppi infection in China","volume":"12","author":"Shi","year":"2019","journal-title":"Parasites Vectors"},{"issue":"6","key":"10.1016\/j.exppara.2022.108280_bib32","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.cell.2008.11.029","article-title":"Bcl-2 proteins and apoptosis: choose your partner","volume":"135","author":"Shore","year":"2008","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.exppara.2022.108280_bib33","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1039\/C4MD00223G","article-title":"Synthesis, structure-activity relationship, and mechanistic investigation of lithocholic acid amphiphiles for colon cancer therapy","volume":"6","author":"Singh","year":"2015","journal-title":"Medchemcomm"},{"issue":"9","key":"10.1016\/j.exppara.2022.108280_bib34","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1046\/j.1365-2168.1998.00823.x","article-title":"Efficacy of cetrimide-chlorhexidine combination in surgery for hydatid cyst","volume":"85","author":"Sonisik","year":"1998","journal-title":"Br. J. Surg."},{"issue":"2","key":"10.1016\/j.exppara.2022.108280_bib35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/AAC.47.2.467-474.2003","article-title":"In vitro parasiticidal effect of Nitazoxanide against Echinococcus multilocularis metacestodes","volume":"47","author":"Stettler","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.exppara.2022.108280_bib36","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/s13071-014-0522-6","article-title":"Echinococcus granulosus infection reduces airway inflammation of mice likely through enhancing IL-10 and down-regulation of IL-5 and IL-17A","volume":"7","author":"Wang","year":"2014","journal-title":"Parasites Vectors"},{"issue":"6","key":"10.1016\/j.exppara.2022.108280_bib37","first-page":"3195","article-title":"Effect of lithocholic acid on biologically active alpha,beta-unsaturated aldehydes induced by H2O2 in glioma mitochondria for use in glioma treatment","volume":"41","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"2","key":"10.1016\/j.exppara.2022.108280_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00075-18","article-title":"Echinococcosis: advances in the 21st century","volume":"32","author":"Wen","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"issue":"9","key":"10.1016\/j.exppara.2022.108280_bib39","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/j.1440-1746.2005.03843.x","article-title":"Results of alcohol and albendazole injections in hepatic hydatidosis: experimental study","volume":"20","author":"Yetim","year":"2005","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"Pt B","key":"10.1016\/j.exppara.2022.108280_bib40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.actatropica.2014.03.014","article-title":"Epidemiology and control of echinococcosis in central Asia, with particular reference to the People's Republic of China","volume":"141","author":"Zhang","year":"2015","journal-title":"Acta Trop."},{"issue":"5","key":"10.1016\/j.exppara.2022.108280_bib41","first-page":"478","author":"\u725b\u5c11\u96c4","year":"2007","journal-title":"CT\u5728\u56ca\u578b\u809d\u5305\u866b\u6d3b\u6027\u5224\u65ad\u4e2d\u7684\u5e94\u7528\u4ef7\u503c. \u533b\u5b66\u5f71\u50cf\u5b66\u6742\u5fd7"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489422000741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489422000741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:04:22Z","timestamp":1762149862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489422000741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":41,"alternative-id":["S0014489422000741"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108280","relation":{},"ISSN":["0014-4894"],"issn-type":[{"type":"print","value":"0014-4894"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro protoscolicidal effects of lithocholic acid on protoscoleces of Echinococcus granulosus and its mechanism","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108280"}}