{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T13:18:17Z","timestamp":1761311897852,"version":"3.44.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.exppara.2022.108317","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T13:45:09Z","timestamp":1656423909000},"page":"108317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Different panel of toll-like receptors expression during chronic Schistosoma mansoni infection in experimental animals"],"prefix":"10.1016","volume":"239","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4125-1650","authenticated-orcid":false,"given":"Abeer E.","family":"Saad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia S.","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman M.","family":"Osman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.exppara.2022.108317_bib1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.vaccine.2016.12.057","article-title":"Nanoformulation of synergistic TLR ligands to enhance vaccination against Entamoeba histolytica","volume":"35","author":"Abhyankar","year":"2017","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0952-7915(02)00013-4","article-title":"Mammalian toll-like receptors","volume":"15","author":"Akira","year":"2003","journal-title":"Curr. Opin. Immunol."},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1074\/jbc.M411223200","article-title":"Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells","volume":"280","author":"Aksoy","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.exppara.2022.108317_bib4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri2992","article-title":"Diversity and dialogue in immunity to helminths","volume":"11","author":"Allen","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.exppara.2022.108317_bib5","article-title":"Schistosoma species detection by environmental DNA assays in African freshwaters [published correction appears in PLoS","volume":"14","author":"Alzaylaee","year":"2020","journal-title":"Negl. Trop. Dis."},{"issue":"6","key":"10.1016\/j.exppara.2022.108317_bib6","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jare.2014.08.004","article-title":"Upregulation of Toll-like receptor 2 and nuclear factor-kappa B expression in experimental colonic schistosomiasis","volume":"6","author":"Ashour","year":"2015","journal-title":"J. Adv. Res."},{"issue":"6","key":"10.1016\/j.exppara.2022.108317_bib7","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1586\/1744666X.2015.1037286","article-title":"Toll-like receptor signaling in parasitic infections","volume":"11","author":"Ashour","year":"2015","journal-title":"Expet Rev. Clin. Immunol."},{"key":"10.1016\/j.exppara.2022.108317_bib8","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.4049\/jimmunol.175.2.1170","article-title":"Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation","volume":"175","author":"Babu","year":"2005","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.exppara.2022.108317_bib9","first-page":"1109","article-title":"The involvement of the spleen during chronic phase of Schistosoma mansoni infection in galectin-3-\/- mice","volume":"27","author":"Brand","year":"2012","journal-title":"Histol. Histopathol."},{"issue":"2","key":"10.1016\/j.exppara.2022.108317_bib10","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4049\/jimmunol.159.2.777","article-title":"IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis","volume":"159","author":"Brunet","year":"1997","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.exppara.2022.108317_bib11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1177\/1753425919840424","article-title":"Expression of TLR2, TLR3, TLR4, and TLR7 on pulmonary lymphocytes of Schistosoma japonicum-infected C57BL\/6 mice","volume":"25","author":"Chen","year":"2019","journal-title":"Innate Immun."},{"issue":"3","key":"10.1016\/j.exppara.2022.108317_bib12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.actatropica.2013.05.012","article-title":"A study of immunomodulatory genes responses to macrophages of Schistosoma japonicum infection during different stages by microarray analysis","volume":"127","author":"Cheng","year":"2013","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2022.108317_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/intimm\/dxl136","article-title":"TLR9 ligand enhances proliferation of rat CD4+ T cell and modulates suppressive activity mediated by CD4+ CD25+ T cell","volume":"19","author":"Chiffoleau","year":"2007","journal-title":"Int. Immunol."},{"issue":"5","key":"10.1016\/j.exppara.2022.108317_bib14","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1074\/jbc.M109.060368","article-title":"Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3","volume":"285","author":"Donnelly","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exppara.2022.108317_bib15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0171-2985(98)80063-6","article-title":"Experimental murine schistosomiasis mansoni: modulation of the B-1 lymphocyte distribution and phenotype expression","volume":"199","author":"El-Cheikh","year":"1998","journal-title":"Immunobiology"},{"issue":"4","key":"10.1016\/j.exppara.2022.108317_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1600-0463.2010.02585.x","article-title":"Homing of transplanted bone marrow cells in livers of Schistosoma mansoni-infected mice","volume":"118","author":"Elkhafif","year":"2010","journal-title":"APMIS"},{"key":"10.1016\/j.exppara.2022.108317_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.754299","article-title":"Roles of TLR7 in Schistosoma japonicum infection-induced hepatic pathological changes in C57BL\/6 mice","volume":"11","author":"Feng","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1189\/jlb.0908559","article-title":"Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells","volume":"87","author":"Forward","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.exppara.2022.108317_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1477-3155-12-17","article-title":"A nanoliposome delivery system to synergistically trigger TLR4 AND TLR7","volume":"12","author":"Fox","year":"2014","journal-title":"J. Nanobiotechnol."},{"issue":"4","key":"10.1016\/j.exppara.2022.108317_bib20","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.4049\/jimmunol.180.4.2117","article-title":"TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages","volume":"180","author":"Gantier","year":"2008","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.exppara.2022.108317_bib21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cellimm.2011.10.007","article-title":"Deficiency in TLR2 but not in TLR4 impairs dendritic cells derived IL-10 responses to schistosome antigens","volume":"272","author":"Gao","year":"2012","journal-title":"Cell. Immunol."},{"issue":"2","key":"10.1016\/j.exppara.2022.108317_bib22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1080\/09168451.2016.1254534","article-title":"Expression of TLR2 and TLR4 in murine small intestine during postnatal development","volume":"81","author":"Inoue","year":"2017","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"12","key":"10.1016\/j.exppara.2022.108317_bib23","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1164\/rccm.200906-0892OC","article-title":"Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation","volume":"180","author":"Ito","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"11","key":"10.1016\/j.exppara.2022.108317_bib24","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1093\/intimm\/dxh319","article-title":"Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and -independent pathways","volume":"17","author":"Jenkins","year":"2005","journal-title":"Int. Immunol."},{"issue":"12","key":"10.1016\/j.exppara.2022.108317_bib25","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1002\/eji.200838629","article-title":"TLR3 modulates immunopathology during a Schistosoma mansoni egg-driven Th2 response in the lung","volume":"38","author":"Joshi","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.exppara.2022.108317_bib26","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1128\/IAI.00497-08","article-title":"Schistosoma mansoni egg antigen\u2013mediated modulation of Toll-like receptor (TLR)\u2013induced activation occurs independently of TLR2, TLR4, and MyD88","volume":"76","author":"Kane","year":"2008","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.exppara.2022.108317_bib27","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molimm.2012.03.020","article-title":"Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation","volume":"51","author":"Kuijk","year":"2012","journal-title":"Mol. Immunol."},{"issue":"9","key":"10.1016\/j.exppara.2022.108317_bib28","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1128\/IAI.71.9.4996-5004.2003","article-title":"Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis","volume":"71","author":"La Flamme","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exppara.2022.108317_bib29","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/eji.200737063","article-title":"Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2","volume":"37","author":"Layland","year":"2007","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib30","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1645\/GE-2195.1","article-title":"Toll-like receptor 2 and Muc2 expression on human intestinal epithelial cells by Gymnophalloides seoi adult antigen","volume":"96","author":"Lee","year":"2010","journal-title":"J. Parasitol."},{"issue":"2","key":"10.1016\/j.exppara.2022.108317_bib31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1365-2249.2010.04091.x","article-title":"Modulation of immune responses through direct activation of Toll-like receptors to T cells","volume":"160","author":"Liu","year":"2010","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s13287-020-01735-2","article-title":"Immunopathology in schistosomiasis is regulated by TLR2,4- and IFN-\u03b3-activated MSC through modulating Th1\/Th2 responses","volume":"11","author":"Liu","year":"2020","journal-title":"Stem Cell Res. Ther."},{"issue":"9","key":"10.1016\/j.exppara.2022.108317_bib33","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1086\/656477","article-title":"Schistosomal\u2010derived lysophosphatidylcholine are involved in eosinophil activation and recruitment through Toll\u2010like receptor-2-dependent mechanisms","volume":"202","author":"Magalh\u00e3es","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.exppara.2022.108317_bib34","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/S0188-4409(00)00199-5","article-title":"Lipophosphopeptidoglycan of Entamoeba histolytica induces an antiinflammatory innate immune response and downregulation of Toll-like receptor 2 (TLR-2) gene expression in human monocytes","volume":"31","author":"Maldonado","year":"2000","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.exppara.2022.108317_bib35","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1590\/s1678-9946201759008","article-title":"Synthesis and biological evaluation of novel imidazolidine derivatives as candidates to schistosomicidal agents","volume":"59","author":"Matos-Rocha","year":"2017","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"issue":"8","key":"10.1016\/j.exppara.2022.108317_bib36","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1136\/gutjnl-2013-305929","article-title":"An apPEAling new therapeutic for ulcerative colitis?","volume":"63","author":"McKernan","year":"2014","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib37","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1128\/CMR.00046-07","article-title":"Current status of vaccines for schistosomiasis","volume":"21","author":"McManus","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.exppara.2022.108317_bib38","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.exppara.2011.05.005","article-title":"Schistosoma mansoni egg glycoproteins and C-type lectins of host immune cells: molecular partners that shape immune responses","volume":"132","author":"Meevissen","year":"2012","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/gut.53.1.99","article-title":"Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced colitis in rats","volume":"53","author":"Moreels","year":"2004","journal-title":"Gut"},{"issue":"12","key":"10.1016\/j.exppara.2022.108317_bib40","doi-asserted-by":"crossref","first-page":"6712","DOI":"10.4049\/jimmunol.163.12.6712","article-title":"Induction of Th2 responses and IgE is largely due to carbohydrates functioning as adjuvants on Schistosoma mansoni egg antigens","volume":"163","author":"Okano","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.exppara.2022.108317_bib41","doi-asserted-by":"crossref","first-page":"442","DOI":"10.4049\/jimmunol.167.1.442","article-title":"Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response","volume":"167","author":"Okano","year":"2001","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/MNH.0000000000000377","article-title":"The role of toll-like receptors in diabetic kidney disease","volume":"27","author":"Panchapakesan","year":"2018","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"7","key":"10.1016\/j.exppara.2022.108317_bib43","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.exppara.2022.108317_bib44","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/infdis\/jiy049","article-title":"Interleukin 1\u03b1 (IL-1\u03b1) promotes pathogenic immature Myeloid cells and IL-1\u03b2 favors protective mature Myeloid cells during acute lung infection","volume":"217","author":"Periasamy","year":"2018","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.exppara.2022.108317_bib45","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3389\/fimmu.2017.01075","article-title":"The toll for trafficking: toll-like receptor 7 delivery to the endosome","volume":"8","author":"Petes","year":"2017","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.exppara.2022.108317_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005513","article-title":"A novel toll-like receptor (TLR) influences compatibility between the gastropod Biomphalaria glabrata, and the digenean trematode Schistosoma mansoni","volume":"12","author":"Pila","year":"2016","journal-title":"PLoS Pathog."},{"issue":"10","key":"10.1016\/j.exppara.2022.108317_bib47","doi-asserted-by":"crossref","first-page":"5799","DOI":"10.1128\/IAI.72.10.5799-5806.2004","article-title":"Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract","volume":"72","author":"Pioli","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exppara.2022.108317_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7519856","article-title":"TLR3 modulates the response of NK cells against Schistosoma japonicum","volume":"2018","author":"Qu","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.exppara.2022.108317_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6865789","article-title":"TLR specific immune responses against helminth infections","volume":"2017","author":"Rajasekaran","year":"2017","journal-title":"J. Parasitol. Res."},{"key":"10.1016\/j.exppara.2022.108317_bib50","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/09680519040100060801","article-title":"Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruzi","volume":"10","author":"Ropert","year":"2004","journal-title":"J. Endotoxin Res."},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib51","first-page":"35","article-title":"The immunomodulatory effect of bone-marrow Mesenchymal stem cells on expression of TLR3 and TLR9 in mice dendritic cells","volume":"8","author":"Sadeghi","year":"2017","journal-title":"Int. J. Organ. Transplant. Med."},{"issue":"3","key":"10.1016\/j.exppara.2022.108317_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005443","article-title":"Protective immune responses against Schistosoma mansoni infection by immunization with functionally active gut-derived cysteine peptidases alone and in combination with glyceraldehyde 3-phosphate dehydrogenase","volume":"11","author":"Tallima","year":"2017","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"11","key":"10.1016\/j.exppara.2022.108317_bib53","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.4049\/jimmunol.171.11.5837","article-title":"Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism","volume":"171","author":"Thomas","year":"2003","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.exppara.2022.108317_bib54","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00595-005-3144-y","article-title":"The expression patterns of Toll-like receptors in the ileal pouch mucosa of postoperative ulcerative colitis patients","volume":"36","author":"Toiyama","year":"2006","journal-title":"Surg. Today"},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib55","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0952-7915(01)00304-1","article-title":"Toll-like receptors: key mediators of microbe detection","volume":"14","author":"Underhill","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.exppara.2022.108317_bib56","doi-asserted-by":"crossref","first-page":"48122","DOI":"10.1074\/jbc.M206941200","article-title":"A novel hostparasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization","volume":"277","author":"van der Kleij","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exppara.2022.108317_bib57","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.micinf.2007.09.013","article-title":"Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathology","volume":"9","author":"Vanhoutte","year":"2007","journal-title":"Microb. Infect."},{"issue":"6","key":"10.1016\/j.exppara.2022.108317_bib58","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jhep.2006.06.017","article-title":"Critical role of toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury","volume":"45","author":"Velayudham","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.exppara.2022.108317_bib59","doi-asserted-by":"crossref","first-page":"36068","DOI":"10.1074\/jbc.M205584200","article-title":"Induction of bacterial lipoprotein tolerance is associated with suppression of Toll-like receptor 2 expression","volume":"277","author":"Wang","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.exppara.2022.108317_bib60","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/jcmm.12991","article-title":"Inhibition of cytokine response to TLR stimulation and alleviation of collagen-induced arthritis in mice by Schistosoma japonicum peptide SJMHE1","volume":"21","author":"Wang","year":"2017","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.exppara.2022.108317_bib61","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.exppara.2013.02.014","article-title":"Systemic cytokine profiles and splenic toll-like receptor expression during Trichinella spiralis infection","volume":"134","author":"Yu","year":"2013","journal-title":"Exp. Parasitol."},{"issue":"4","key":"10.1016\/j.exppara.2022.108317_bib62","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-3024.2010.01265.x","article-title":"Toll-like receptor (TLR) 2 and TLR4 deficiencies exert differential in vivo effects against Schistosoma japonicum","volume":"33","author":"Zhang","year":"2011","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.exppara.2022.108317_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00061","article-title":"T lymphocyte-mediated liver immunopathology of schistosomiasis","volume":"11","author":"Zheng","year":"2020","journal-title":"Front. Immunol."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489422001114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489422001114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T06:31:36Z","timestamp":1758004296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489422001114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":63,"alternative-id":["S0014489422001114"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108317","relation":{},"ISSN":["0014-4894"],"issn-type":[{"type":"print","value":"0014-4894"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Different panel of toll-like receptors expression during chronic Schistosoma mansoni infection in experimental animals","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108317","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108317"}}