{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:18:50Z","timestamp":1762064330402,"version":"build-2065373602"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:00:00Z","timestamp":1693612800000},"content-version":"am","delay-in-days":336,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.exppara.2022.108354","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:09:52Z","timestamp":1661299792000},"page":"108354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The effect of atovaquone on the mitochondrial membrane potential of Babesia gibsoni"],"prefix":"10.1016","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4698-7037","authenticated-orcid":false,"given":"Aiko","family":"Iguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiro","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reeko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2022.108354_bib1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1128\/AAC.46.5.1163-1173.2002","article-title":"Antiparasitic agent atovaquone","volume":"46","author":"Baggish","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.exppara.2022.108354_bib7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/CMR.13.3.451","article-title":"Babesiosis","volume":"13","author":"Homer","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.exppara.2022.108354_bib5","first-page":"145","article-title":"Development of in vitro atovaquone-resistant Babesia gibsoni with a single-nucleotide polymorphism in cyt b","volume":"185","author":"Iguchi","year":"2012","journal-title":"Vet. Pract."},{"issue":"9","key":"10.1016\/j.exppara.2022.108354_bib6","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1292\/jvms.14-0139","article-title":"Efficacy of Malarone\u00ae in dogs naturally infected with Babesia gibsoni","volume":"76","author":"Iguchi","year":"2014","journal-title":"J. Vet. Med. Sci."},{"issue":"3\u20134","key":"10.1016\/j.exppara.2022.108354_bib4","first-page":"527","article-title":"The in vitro interactions and in vivo efficacy of atovaquone and proguanil against Babesia gibsoni infection in dogs","volume":"197","author":"Iguchi","year":"2013","journal-title":"Vet. Pract."},{"issue":"6","key":"10.1016\/j.exppara.2022.108354_bib2","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1128\/JCM.42.6.2465-2469.2004","article-title":"Molecular evidence of infections with Babesia gibsoni parasites in Japan and evaluation of the diagnostic potential of a loop-mediated isothermal amplification method","volume":"42","author":"Ikadai","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.exppara.2022.108354_bib8","first-page":"9","article-title":"Efficacy of atovaquone against Babesia gibsoni in vivo and in vitro","volume":"124","author":"Matsuu","year":"2004","journal-title":"Vet. Pract."},{"issue":"1\u20132","key":"10.1016\/j.exppara.2022.108354_bib9","first-page":"1","article-title":"In vitro evaluation of the growth inhibitory activities of 15 drugs against Babesia gibsoni (Aomori strain)","volume":"157","author":"Matsuu","year":"2008","journal-title":"Vet. Pract."},{"issue":"7","key":"10.1016\/j.exppara.2022.108354_bib10","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1074\/jbc.272.7.3961","article-title":"Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite","volume":"272","author":"Srivastava","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.exppara.2022.108354_bib3","first-page":"1334","article-title":"A mechanism for the synergistic antimalarial action of atovaquone and proguanil","volume":"43","author":"Srivastava","year":"1999","journal-title":"Anti. Agent. Chem."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489422001485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489422001485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T06:30:33Z","timestamp":1758004233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489422001485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":10,"alternative-id":["S0014489422001485"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108354","relation":{},"ISSN":["0014-4894"],"issn-type":[{"type":"print","value":"0014-4894"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of atovaquone on the mitochondrial membrane potential of Babesia gibsoni","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108354","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108354"}}