{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:54:10Z","timestamp":1791226450940,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:00:00Z","timestamp":1692403200000},"content-version":"am","delay-in-days":291,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015313","name":"National Wildlife Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.exppara.2022.108355","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T23:17:10Z","timestamp":1660864630000},"page":"108355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Evaluation of the mechanism of action of albendazole on adult rat lungworm (Angiostrongylus cantonensis)"],"prefix":"10.1016","volume":"242","author":[{"given":"John","family":"Jacob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Afjalus","family":"Siraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argon","family":"Steel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghee","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Jarvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2022.108355_bib1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1017\/S0031182020001262","article-title":"Guidelines for the diagnosis and treatment of neuroangiostrongyliasis: updated recommendations","volume":"148","author":"Ansdell","year":"2021","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2022.108355_bib2","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1017\/S0031182016000652","article-title":"Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen","volume":"143","author":"Barratt","year":"2016","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2022.108355_bib3","first-page":"72","article-title":"Why do cells cycle with a 24 hour period? Genome informatics","volume":"17","author":"Bernard","year":"2006","journal-title":"International Conference on Genome Informatics"},{"key":"10.1016\/j.exppara.2022.108355_bib4","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/jac\/dkl492","article-title":"Biochemical and pathological evaluation of albendazole\/thalidomide co-therapy against eosinophilic meningitis or meningoencephalitis induced by Angiostrongylus cantonensis","volume":"59","author":"Chen","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.exppara.2022.108355_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0020-7519(89)90024-6","article-title":"Colorimetric quantitation of filarial viability","volume":"19","author":"Comley","year":"1989","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2022.108355_bib6","series-title":"Biology, Systematics, Life Cycle, and Distribution of Angiostrongylus Cantonensis, the Cause of Rat Lungworm Disease","author":"Cowie","year":"2013"},{"key":"10.1016\/j.exppara.2022.108355_bib7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2307\/3275961","article-title":"Therapeutic effect of thiabendazole on Angiostrongylus cantonensis infection in rats","volume":"51","author":"Cuckler","year":"1965","journal-title":"J. Parasitol."},{"key":"10.1016\/j.exppara.2022.108355_bib8","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/0006-2952(84)90515-X","article-title":"A comparison of the interaction of anthelmintic benzimidazole with tubulin isolated from mammalian tissue and the parasitic nematode Ascaridia galli","volume":"33","author":"Dawson","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.exppara.2022.108355_bib9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.neuro.31.061307.090711","article-title":"Role of axonal transport in neurodegenerative diseases","volume":"31","author":"de Vos","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.exppara.2022.108355_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0020-7519(90)90096-6","article-title":"Effect of benzimidazole drugs on tubulin in benzimidazole resistant and susceptible strains of Caenorhabditis elegans","volume":"20","author":"Enos","year":"1990","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2022.108355_bib11","first-page":"575","article-title":"Studies on chemotherapy of parasitic helminths (XIV) anthelmintic effect of mebendazole on Angiostrongylus cantonensis in rats","volume":"31","author":"Hayashi","year":"1982","journal-title":"Jpn. J. Parasitol."},{"key":"10.1016\/j.exppara.2022.108355_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4269\/ajtmh.1988.39.191","article-title":"Larvicidal effect of albendazole against Angiostrongylus cantonensis in mice","volume":"39","author":"Hwang","year":"1988","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2022.108355_bib13","article-title":"Clinical efficacy and safety of albendazole and other benzimidazole anthelmintics for rat lungworm disease (neuroangiostrongyliasis): a systematic analysis of clinical reports and animal studies","author":"Jacob","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.exppara.2022.108355_bib14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1017\/S0031182020001146","article-title":"In vitro efficacy of anthelmintics on Angiostrongylus cantonensis L3 larvae","volume":"148","author":"Jacob","year":"2021","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2022.108355_bib15","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00436-007-0572-1","article-title":"A rapid colorimetric assay for the quantitation of the viability of free-living larvae of nematodes in vitro","volume":"101","author":"James","year":"2007","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2022.108355_bib16","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1017\/S0031182019000908","article-title":"Validation of a death assay for Angiostrongylus cantonensis larvae (L3) using propidium iodide in a rat model (Rattus norvegicus)","volume":"146","author":"Jarvi","year":"2019","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2022.108355_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-3305-3-99","article-title":"Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes","volume":"3","author":"Johnston","year":"2010","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.exppara.2022.108355_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00002826-199012000-00008","article-title":"Plasma and CSF levels of albendazole and praziquantel in patients with neurocysticercosis","volume":"13","author":"Jung","year":"1990","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.exppara.2022.108355_bib19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/j.1552-4604.1992.tb03783.x","article-title":"Clinical pharmacokinetics of albendazole in patients with brain cysticercosis","volume":"32","author":"Jung","year":"1992","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.exppara.2022.108355_bib20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1159\/000238533","article-title":"Larvicidal effect of perbendazole on experimental infection of Angiostrongylus cantonensis in mice","volume":"33","author":"Kamath","year":"1987","journal-title":"Chemotherapy"},{"key":"10.1016\/j.exppara.2022.108355_bib21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0166-6851(91)90155-Y","article-title":"Beta-tubulin and benzimidazole resistance in the sheep nematode Haemonchus contortus","volume":"47","author":"Lubega","year":"1991","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.exppara.2022.108355_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1071\/ZO9550001","article-title":"The life history of the rat lung-worm, Angiostrongylus cantonensis (Chen) (Nematoda: metastrongylidae)","volume":"3","author":"Mackerras","year":"1955","journal-title":"Aust. J. Zool."},{"key":"10.1016\/j.exppara.2022.108355_bib23","doi-asserted-by":"crossref","first-page":"512","DOI":"10.2307\/3281499","article-title":"Studies on anthelmintic effects of flubendazole and mebendazole on the rat lungworm Angiostrongylus cantonensis in mice and rats","volume":"72","author":"Maki","year":"1986","journal-title":"J. Parasitol."},{"key":"10.1016\/j.exppara.2022.108355_bib24","first-page":"5","article-title":"Morphometrics of third-stage larvae of the rat lungworm (Angiostrongylus cantonensis) in Hawai'i","volume":"10","author":"Marahatta","year":"2020","journal-title":"Pacific agriculture and natural resources"},{"key":"10.1016\/j.exppara.2022.108355_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"Journal of lmmunological Methods"},{"key":"10.1016\/j.exppara.2022.108355_bib26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000220405","article-title":"Experimental studies on the chemotherapy of rat lungworm, Angiostrongylus cantonensis, in rats","volume":"10","author":"Nishimura","year":"1965","journal-title":"Chemotherapia"},{"key":"10.1016\/j.exppara.2022.108355_bib27","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1590\/S0001-37652011000200024","article-title":"Cross-disciplinary approaches for measuring parasitic helminth viability and phenotype","volume":"83","author":"Peak","year":"2011","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.exppara.2022.108355_bib28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0188-4409(01)00259-4","article-title":"In vitro effects of Albendazole and its metabolites on the cell proliferation kinetics and micronuclei frequency of stimulated human lymphocytes","volume":"32","author":"Ram\u00edrez","year":"2001","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.exppara.2022.108355_bib29","doi-asserted-by":"crossref","first-page":"e1594","DOI":"10.1093\/cid\/ciaa1791","article-title":"AcanR3990 qPCR: a novel, highly sensitive, bioinformatically-informed assay to detect Angiostrongylus cantonensis infections","volume":"73","author":"Sears","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.exppara.2022.108355_bib30","first-page":"78","article-title":"Effect of dimethyl sulfoxide on in vitro proliferation of skin fibroblast cells","volume":"8","author":"Singh","year":"2017","journal-title":"J. Bio. Technol. Res."},{"key":"10.1016\/j.exppara.2022.108355_bib31","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1644\/10-MAMM-F-355.1","article-title":"Guidelines of the American society of mammalogists for the use of wild mammals in research","volume":"92","author":"Sikes","year":"2011","journal-title":"J. Mammal."},{"key":"10.1016\/j.exppara.2022.108355_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.yexcr.2013.11.007","article-title":"The control of cell growth and body size in Caenorhabditis elegans","volume":"321","author":"Tuck","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.exppara.2022.108355_bib33","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1473-3099(08)70229-9","article-title":"Human angiostrongyliasis","volume":"8","author":"Wang","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.exppara.2022.108355_bib34","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0603704103","article-title":"Insights into the mechanism of microtubule stabilization by Taxol","volume":"103","author":"Xiao","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exppara.2022.108355_bib35","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3892\/etm.2016.3992","article-title":"Anthelmintic drug albendazole arrests human gastric cancer cells at the mitotic phase and induces apoptosis","volume":"13","author":"Zhang","year":"2017","journal-title":"Exp. Ther. Med."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489422001497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489422001497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:04:06Z","timestamp":1762149846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489422001497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":35,"alternative-id":["S0014489422001497"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108355","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the mechanism of action of albendazole on adult rat lungworm (Angiostrongylus cantonensis)","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108355","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108355"}}