{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T09:19:56Z","timestamp":1774171196849,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2015\/001674"],"award-info":[{"award-number":["EMR\/2015\/001674"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["PDF\/2016\/001437"],"award-info":[{"award-number":["PDF\/2016\/001437"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.exppara.2022.108365","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T22:00:42Z","timestamp":1661205642000},"page":"108365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Host P2X7R-p38MAPK axis mediated intra-macrophage leishmanicidal activity of Spergulin-A"],"prefix":"10.1016","volume":"241","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3240-7641","authenticated-orcid":false,"given":"Niladri","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saswati","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sk. Abdul","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarun","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sriparna","family":"Datta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Das Saha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2022.108365_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.exppara.2022.108365_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004188","article-title":"Pulmonary infection with hypervirulent Mycobacteria reveals a crucial role for the P2X7 receptor in aggressive forms of tuberculosis","volume":"10","author":"Amaral","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.exppara.2022.108365_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.compbiolchem.2017.01.004","article-title":"Pharmacoinformatics study of piperolactam a from Piper beetle root as new lead for nonsteroidal anti fertility drug development","volume":"67","author":"Amin","year":"2017","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.exppara.2022.108365_bib4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2174\/1570180813666160916153017","article-title":"Possible binding mode analysis of pyrazolo-triazole hybrids as potential anticancer agents through validated molecular docking and 3D-QSAR modeling approaches","volume":"14","author":"Amin","year":"2017","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.exppara.2022.108365_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/srep22335","article-title":"Attenuated Leishmania induce pro-inflammatory mediators and influence leishmanicidal activity by p38 MAPK dependent phagosome maturation in Leishmania donovani co-infected macrophages","volume":"6","author":"Banerjee","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exppara.2022.108365_bib7","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.2147\/IDR.S211721","article-title":"Intracellular anti-leishmanial effect of Spergulin-A, a triterpenoid saponin of Glinus oppositifolius","volume":"12","author":"Banerjee","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.exppara.2022.108365_bib8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/1062936X.2019.1615545","article-title":"Insight into structural features of phenyltetrazole derivatives as ABCG2 inhibitors for the treatment of multidrug resistance in cancer","volume":"30","author":"Bhardwaj","year":"2019","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.exppara.2022.108365_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148084","article-title":"The role of nitric oxide and reactive oxygen species in the killing of Leishmania braziliensis by monocytes from patients with cutaneous leishmaniasis","volume":"11","author":"Carneiro","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.exppara.2022.108365_bib10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1097-2765(01)00189-7","article-title":"The stress induced MAP kinase p38 regulates endocytic trafficking via GDI:Rab5 complex","author":"Cavalli","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.exppara.2022.108365_bib11","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.micinf.2009.05.001","article-title":"Modulation of P2X7 purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination","volume":"11","author":"Chaves","year":"2009","journal-title":"Microb. Infect."},{"key":"10.1016\/j.exppara.2022.108365_bib12","unstructured":"Chem 3D Pro Version 8.0 And CHem Draw Ultra Version 8.0 Are Software Programs Developed by Cambridge Soft Corporation. USA."},{"key":"10.1016\/j.exppara.2022.108365_bib13","doi-asserted-by":"crossref","first-page":"e466","DOI":"10.1097\/CCM.0b013e31829a8246","article-title":"P2X7 receptor antagonism inhibits p38 MAPK activation and ameliorates neuronal apoptosis after subarachnoid hemorrhage in the rat","volume":"41","author":"Chen","year":"2013","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.exppara.2022.108365_bib14","doi-asserted-by":"crossref","first-page":"55684","DOI":"10.18632\/oncotarget.18264","article-title":"The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells","author":"Corre","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.exppara.2022.108365_bib15","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.micinf.2012.05.009","article-title":"Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites","volume":"14","author":"Coutinho-Silva","year":"2012","journal-title":"Microb. Infect."},{"key":"10.1016\/j.exppara.2022.108365_bib16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1074-7613(03)00235-8","article-title":"Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation","volume":"19","author":"Coutinho-Silva","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.exppara.2022.108365_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005641","article-title":"Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress","volume":"11","author":"Deep","year":"2017","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2022.108365_bib18","series-title":"(DS 3.0)","year":"2015"},{"key":"10.1016\/j.exppara.2022.108365_bib19","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.3390\/ijms21144833","article-title":"Is p38 MAPK associated to drugs of abuse-induced abnormal behaviors?","volume":"21","author":"El Rawas","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exppara.2022.108365_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11302-016-9544-1","article-title":"The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control","volume":"13","author":"Figliuolo","year":"2017","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.exppara.2022.108365_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s11302-013-9392-1","article-title":"Natural compounds with P2X7 receptor-modulating properties","volume":"10","author":"Fischer","year":"2014","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.exppara.2022.108365_bib22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fimmu.2016.00153","article-title":"The contribution of immune evasive mechanisms to parasite persistence in visceral leishmaniasis","volume":"7","author":"Freitas","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exppara.2022.108365_bib23","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1189\/jlb.0907612","article-title":"The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells","volume":"84","author":"Gavala","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.exppara.2022.108365_bib24","series-title":"2019\u20132020, a Baseline for the 2030 Roadmap","year":"2020"},{"key":"10.1016\/j.exppara.2022.108365_bib25","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/cyto.2002.0894","article-title":"Inhibition of TNF-alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells","author":"Jeong","year":"2002","journal-title":"Cytokine"},{"key":"10.1016\/j.exppara.2022.108365_bib26","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1128\/IAI.70.9.5026-5035.2002","article-title":"Activation of p38 mitogen-activated protein kinase attenuates Leishmania donovani infection in macrophages","volume":"70","author":"Junghae","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exppara.2022.108365_bib27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fimmu.2013.00156","article-title":"Interferon gamma in leishmaniasis","volume":"4","author":"Kima","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exppara.2022.108365_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6509212","article-title":"Fucofuroeckol-A from Eisenia bicyclis inhibits inflammation in lipopolysaccharide-induced mouse macrophages via downregulation of the MAPK\/NF-\u03baB Signaling Pathway","author":"Lee","year":"2016","journal-title":"J. Chem."},{"key":"10.1016\/j.exppara.2022.108365_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11302-009-9133-7","article-title":"Cell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking","volume":"5","author":"Lenertz","year":"2009","journal-title":"Purinergic Signal."},{"key":"10.1016\/j.exppara.2022.108365_bib30","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1016\/j.bmc.2010.05.034","article-title":"Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents","volume":"18","author":"Lv","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.exppara.2022.108365_bib31","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1093\/carcin\/bgs241","article-title":"Inducible nitric oxide synthase (iNOS) and nitric oxide (NO) are important mediators of reflux-induced cell signalling in esophageal cells","volume":"33","author":"McAdam","year":"2012","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.exppara.2022.108365_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002212","article-title":"The role of the P2X7 receptor in infectious diseases","volume":"7","author":"Miller","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.exppara.2022.108365_bib33","first-page":"121","article-title":"Leishmania promastigotes: building a safe niche within macrophages. Front","volume":"2","author":"Moradin","year":"2012","journal-title":"Cell Infect. Microbiol."},{"key":"10.1016\/j.exppara.2022.108365_bib34","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.exppara.2022.108365_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0915s57","article-title":"High throughput functional assays for P2X receptors","author":"Namovic","year":"2012","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.exppara.2022.108365_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1189\/jlb.0110028","article-title":"The role of calcium signaling in phagocytosis","volume":"88","author":"Nunes","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.exppara.2022.108365_bib37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/CMR.18.2.293-305.2005","article-title":"Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view","volume":"18","author":"Olivier","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.exppara.2022.108365_bib38","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.freeradbiomed.2007.02.010","article-title":"Nucleotide receptor signalling in murine macrophages is linked to reactive oxygen species generation","volume":"42","author":"Pfeiffer","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exppara.2022.108365_bib39","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s11101-010-9183-z","article-title":"Saponins as cytotoxic agents: a review","volume":"9","author":"Podolak","year":"2010","journal-title":"Phytochemistry Rev."},{"key":"10.1016\/j.exppara.2022.108365_bib40","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1002\/1521-4141(2000)30:8<2235::AID-IMMU2235>3.0.CO;2-9","article-title":"Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1\/2 during infection of naive macrophages","volume":"30","author":"Prive","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.exppara.2022.108365_bib41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fphar.2018.00052","article-title":"The P2X7 receptor in inflammatory diseases: angel or demon?","volume":"9","author":"Savio","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.exppara.2022.108365_bib42","article-title":"An improved method for P2X7R antagonist screening","volume":"10","author":"Soares-Bezerra","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.exppara.2022.108365_bib43","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3389\/fimmu.2017.01838","article-title":"Function of macrophage and parasite phosphatases in Leishmaniasis","volume":"8","author":"Soulat","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exppara.2022.108365_bib44","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/00024382-200208000-00001","article-title":"NF-kappaB activation and inhibition: a review","volume":"18","author":"Sun","year":"2002","journal-title":"Shock"},{"key":"10.1016\/j.exppara.2022.108365_bib45","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.3390\/ijms19123824","article-title":"The role of NADPH oxidases and oxidative stress in neurodegenerative disorders","volume":"19","author":"Tarafdar","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.exppara.2022.108365_bib46","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.1016\/j.ijid.2011.03.021","article-title":"Recent advances in leishmaniasis treatment","volume":"15","author":"Tiuman","year":"2011","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.exppara.2022.108365_bib47","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1021\/acs.bioconjchem.0c00667","article-title":"Redox-responsive nanocapsules for the spatiotemporal release of miltefosine in lysosome: protection against leishmania","volume":"32","author":"Tiwari","year":"2021","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.exppara.2022.108365_bib48","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.exppara.2022.108365_bib49","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.freeradbiomed.2011.05.011","article-title":"Leishmania-macrophage interactions: insights into the redox biology","volume":"51","author":"Van Assche","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.exppara.2022.108365_bib50","doi-asserted-by":"crossref","first-page":"7993","DOI":"10.1073\/pnas.95.14.7993","article-title":"Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase","author":"Yu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA95"},{"key":"10.1016\/j.exppara.2022.108365_bib51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.cr.7290257","article-title":"Activation and signaling of the p38 MAP kinase pathway","volume":"15","author":"Zarubin","year":"2005","journal-title":"Cell Res."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448942200159X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448942200159X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T06:30:09Z","timestamp":1758004209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448942200159X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":50,"alternative-id":["S001448942200159X"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108365","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2019.12.14.876391","asserted-by":"object"}]},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Host P2X7R-p38MAPK axis mediated intra-macrophage leishmanicidal activity of Spergulin-A","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108365","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108365"}}