{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:03:49Z","timestamp":1789668229946,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003410","name":"Department of Education of Fujian Province","doi-asserted-by":"publisher","award":["JAT190125"],"award-info":[{"award-number":["JAT190125"]}],"id":[{"id":"10.13039\/501100003410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2020J05024"],"award-info":[{"award-number":["2020J05024"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102734"],"award-info":[{"award-number":["32102734"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.exppara.2022.108429","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T11:04:16Z","timestamp":1668683056000},"page":"108429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Toxoplasma gondii induces MLTC-1 apoptosis via ERS pathway"],"prefix":"10.1016","volume":"244","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingrui","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwen","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.exppara.2022.108429_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens11040437","article-title":"Molecular characterization of toxoplasma gondii in cats and its zoonotic potential for public health significance","volume":"11","author":"Abdul Hafeez","year":"2022","journal-title":"Pathogens"},{"issue":"8","key":"10.1016\/j.exppara.2022.108429_bib2","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.ijpara.2009.02.006","article-title":"A century of Toxoplasma research","volume":"39","author":"Ajioka","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2022.108429_bib3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.rvsc.2020.10.019","article-title":"Foodborne transmission of Toxoplasma gondii infection in the last decade. An overview","volume":"135","author":"Almeria","year":"2021","journal-title":"Res. Vet. Sci."},{"issue":"23","key":"10.1016\/j.exppara.2022.108429_bib4","doi-asserted-by":"crossref","first-page":"E5344","DOI":"10.1073\/pnas.1801118115","article-title":"Encephalitis is mediated by ROP18 of Toxoplasma gondii, a severe pathogen in AIDS patients","volume":"115","author":"An","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"4","key":"10.1016\/j.exppara.2022.108429_bib5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/path.4738","article-title":"GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis","volume":"239","author":"Ayaub","year":"2016","journal-title":"J. Pathol."},{"issue":"1","key":"10.1016\/j.exppara.2022.108429_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-020-00212-1","article-title":"Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia","volume":"25","author":"Bartoszewska","year":"2020","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.exppara.2022.108429_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69078-9","article-title":"Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis","volume":"10","author":"Bigna","year":"2020","journal-title":"Sci. Rep."},{"issue":"80","key":"10.1016\/j.exppara.2022.108429_bib8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-biochem-062209-093836","article-title":"Protein folding and modification in the mammalian endoplasmic reticulum","volume":"80","author":"Braakman","year":"2011","journal-title":"Annu. Rev. Biochem."},{"issue":"2","key":"10.1016\/j.exppara.2022.108429_bib9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1462-5822.2005.00622.x","article-title":"Toxoplasma gondii inhibits ultraviolet light-induced apoptosis through multiple interactions with the mitochondrion-dependent programmed cell death pathway","volume":"8","author":"Carmen","year":"2006","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.exppara.2022.108429_bib10","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/978-1-4614-3209-8_83","article-title":"The effects of IRE1, ATF6, and PERK signaling on adRP-linked rhodopsins","volume":"801","author":"Chiang","year":"2014","journal-title":"Retin. Degener. Dis. Mech. Exp. Ther."},{"issue":"5","key":"10.1016\/j.exppara.2022.108429_bib11","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/15384101.2017.1281484","article-title":"Toxoplasma gondii induces autophagy and apoptosis in human umbilical cord mesenchymal stem cells via downregulation of Mcl-1","volume":"16","author":"Chu","year":"2017","journal-title":"Cell Cycle"},{"issue":"4","key":"10.1016\/j.exppara.2022.108429_bib12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1631\/jzus.B2100877","article-title":"Toxoplasma gondii infection induces cell apoptosis via multiple pathways revealed by transcriptome analysis","volume":"23","author":"Du","year":"2022","journal-title":"J. Zhejiang Univ. - Sci. B"},{"issue":"8","key":"10.1016\/j.exppara.2022.108429_bib13","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.ijpara.2009.01.005","article-title":"History of the discovery of the life cycle of Toxoplasma gondii","volume":"39","author":"Dubey","year":"2009","journal-title":"Int. J. Parasitol."},{"issue":"3","key":"10.1016\/j.exppara.2022.108429_bib14","doi-asserted-by":"crossref","first-page":"FSO198","DOI":"10.4155\/fsoa-2017-0020","article-title":"Endoplasmic reticulum stress and unfolded protein response in infection by intracellular parasites","volume":"3","author":"Galluzzi","year":"2017","journal-title":"Future Sci OA"},{"issue":"19","key":"10.1016\/j.exppara.2022.108429_bib15","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1242\/jcs.114.19.3495","article-title":"Inhibition of host cell apoptosis by Toxoplasma gondii is accompanied by reduced activation of the caspase cascade and alterations of poly(ADP-ribose) polymerase expression","volume":"114","author":"Goebel","year":"2001","journal-title":"J. Cell Sci."},{"issue":"3","key":"10.1016\/j.exppara.2022.108429_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/pim.12163","article-title":"Toxoplasma gondii dissemination: a parasite's journey through the infected host","volume":"37","author":"Harker","year":"2015","journal-title":"Parasite Immunol."},{"issue":"2","key":"10.1016\/j.exppara.2022.108429_bib17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0079-6107(95)00005-8","article-title":"Protein translocation at the membrane of the endoplasmic-reticulum","volume":"63","author":"High","year":"1995","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"10","key":"10.1016\/j.exppara.2022.108429_bib18","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1469-0691.2002.00485.x","article-title":"Toxoplasma gondii: transmission, diagnosis and prevention","volume":"8","author":"Hill","year":"2002","journal-title":"Clin. Microbiol. Infect."},{"issue":"7","key":"10.1016\/j.exppara.2022.108429_bib19","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1128\/IAI.01546-07","article-title":"Fas\/CD95-mediated apoptosis of type II cells is blocked by Toxoplasma gondii primarily via interference with the mitochondrial amplification loop","volume":"76","author":"Hippe","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.exppara.2022.108429_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.827570","article-title":"Global MicroRNAs expression profile Analysis reveals possible regulatory mechanisms of brain injury induced by toxoplasma gondii infection","volume":"16","author":"Hou","year":"2022","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.exppara.2022.108429_bib21","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00436-010-1999-3","article-title":"Toxoplasma gondii infection inhibits the mitochondrial apoptosis through induction of Bcl-2 and HSP70","volume":"107","author":"Hwang","year":"2010","journal-title":"Parasitol. Res."},{"issue":"4","key":"10.1016\/j.exppara.2022.108429_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12040938","article-title":"BCL-2 proteins in pathogenesis and therapy of B-cell non-hodgkin lymphomas","volume":"12","author":"Klanova","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.exppara.2022.108429_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6152489","article-title":"Toxoplasma gondii modulates the host cell responses: an overview of apoptosis pathways","volume":"2019","author":"Mammari","year":"2019","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.exppara.2022.108429_bib24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1210\/me.2012-1317","article-title":"Minireview: endoplasmic reticulum stress: control in protein, lipid, and signal homeostasis","volume":"27","author":"Mandl","year":"2013","journal-title":"Mol. Endocrinol."},{"issue":"1\u20132","key":"10.1016\/j.exppara.2022.108429_bib25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11010-010-0709-x","article-title":"Role of Bcl-2 family proteins and caspases in the regulation of apoptosis","volume":"351","author":"Ola","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.exppara.2022.108429_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.01825","article-title":"Sixty years (1957-2017) of research on toxoplasmosis in China-an overview","volume":"8","author":"Pan","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.exppara.2022.108429_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2021.106070","article-title":"Biogenic silver nanoparticles (AgNp-Bio) reduce Toxoplasma gondii infection and proliferation in HeLa cells, and induce autophagy and death of tachyzoites by apoptosis-like mechanism","volume":"222","author":"Sanfelice","year":"2021","journal-title":"Acta Trop."},{"issue":"1","key":"10.1016\/j.exppara.2022.108429_bib28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.apjtm.2015.12.013","article-title":"Influence of Toxoplasma gondii on in vitro proliferation and apoptosis of hepatoma carcinoma H7402 cell","volume":"9","author":"Wang","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"9","key":"10.1016\/j.exppara.2022.108429_bib29","doi-asserted-by":"crossref","first-page":"15257","DOI":"10.1002\/jcp.28171","article-title":"Inhibition of Luman\/CREB3 expression leads to the upregulation of testosterone synthesis in mouse Leydig cells","volume":"234","author":"Wang","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.exppara.2022.108429_bib30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3347\/kjp.2021.59.6.573","article-title":"Toxoplasma gondii induces apoptosis via endoplasmic reticulum stress-derived mitochondrial pathway in human small intestinal epithelial cell-line","volume":"59","author":"Wang","year":"2021","journal-title":"Kor. J. Parasitol."},{"key":"10.1016\/j.exppara.2022.108429_bib31","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.theriogenology.2020.11.010","article-title":"Luman\/CREB3 knock-down inhibit hCG induced MLTC-1 apoptosis","volume":"161","author":"Wang","year":"2021","journal-title":"Theriogenology"},{"key":"10.1016\/j.exppara.2022.108429_bib32","series-title":"Toxoplasma Gondii Dense Granule Protein 15 Induces Apoptosis in Choriocarcinoma JEG-3 Cells through Endoplasmic Reticulum Stress","first-page":"11","author":"Wei","year":"2018"},{"issue":"6","key":"10.1016\/j.exppara.2022.108429_bib33","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1007\/s00436-016-4993-6","article-title":"Toxoplasma gondii ROP18: potential to manipulate host cell mitochondrial apoptosis","volume":"115","author":"Wu","year":"2016","journal-title":"Parasitol. Res."},{"issue":"7","key":"10.1016\/j.exppara.2022.108429_bib34","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1084\/jem.20101660","article-title":"ATF6 beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18","volume":"208","author":"Yamamoto","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.exppara.2022.108429_bib35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biopha.2018.02.076","article-title":"Hinokiflavone induces apoptosis in melanoma cells through the ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion","volume":"103","author":"Yang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.exppara.2022.108429_bib36","article-title":"The putative TCP-1 chaperonin is an important player involved in sialic acid-dependent host cell invasion by toxoplasma gondii","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Microbiol."},{"issue":"9","key":"10.1016\/j.exppara.2022.108429_bib37","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1017\/S0031182020000177","article-title":"Production and characterization of monoclonal antibodies against Toxoplasma gondii ROP18 with strain-specific reactivity","volume":"147","author":"Zhang","year":"2020","journal-title":"Parasitology"},{"issue":"7","key":"10.1016\/j.exppara.2022.108429_bib38","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1172\/JCI136226","article-title":"The molecular biology and immune control of chronic Toxoplasma gondii infection","volume":"130","author":"Zhao","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.exppara.2022.108429_bib39","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-019-3529-1","article-title":"Toxoplasma Gondii ROP18 Inhibits Human Glioblastoma Cell Apoptosis through a Mitochondrial Pathway by Targeting Host Cell P2X1","volume":"12","author":"Zhou","year":"2019","journal-title":"Parasites Vectors"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489422002235?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489422002235?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T06:03:59Z","timestamp":1762149839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489422002235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":39,"alternative-id":["S0014489422002235"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108429","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxoplasma gondii induces MLTC-1 apoptosis via ERS pathway","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2022.108429","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108429"}}