{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:10:35Z","timestamp":1766733035917,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301822\/2019-0","403230\/2021-7"],"award-info":[{"award-number":["301822\/2019-0","403230\/2021-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.exppara.2023.108568","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T09:12:05Z","timestamp":1686820325000},"page":"108568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Albendazole \u2013 Ivermectin combination decreases inflammation in experimental neurocysticercosis"],"prefix":"10.1016","volume":"251","author":[{"given":"Rafael Caetano","family":"da Silva Santana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago Paiva","family":"Prudente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Henrique","family":"de Sousa Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayana Ferreira","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy","family":"de Souza Lino Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Clare","family":"Vinaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.exppara.2023.108568_bib1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4269\/ajtmh.20-1330","article-title":"Mortality in parenchymal and subarachnoid neurocysticercosis","volume":"105","author":"Abanto","year":"2021","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"1","key":"10.1016\/j.exppara.2023.108568_bib2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/s13071-019-3719-x","article-title":"Nanostructured lipid carriers of ivermectin as a novel drug delivery system in hydatidosis","volume":"12","author":"Ahmadpour","year":"2019","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.exppara.2023.108568_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.914886","article-title":"Pharmacokinetic characterization and comparative bioavailability of an innovative orodispersible fixed-dose combination of ivermectin and albendazole: a single dose, open label, sequence randomized, crossover clinical trial in healthy volunteers","volume":"13","author":"Algorta","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.exppara.2023.108568_bib4","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1017\/S0022149X00006052","article-title":"Efficacy of avermectins against Trichinella spiralis in mice","volume":"53","author":"Campbell","year":"1979","journal-title":"J. Helminthol."},{"issue":"1","key":"10.1016\/j.exppara.2023.108568_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4269\/ajtmh.2010.09-0347","article-title":"Severe cysticercal meningitis: clinical and imaging characteristics","volume":"82","author":"C\u00e1rdenas","year":"2010","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2023.108568_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.seizure.2021.02.019","article-title":"New understanding about the relationship among neurocysticercosis, seizures, and epilepsy","volume":"90","author":"Carpio","year":"2021","journal-title":"Seizure"},{"key":"10.1016\/j.exppara.2023.108568_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2022.106571","article-title":"Oxfendazole induces protein catabolism and gluconeogenesis in experimental neurocysticercosis","volume":"234","author":"Correia","year":"2022","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2023.108568_bib8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s13555-018-0249-y","article-title":"Topical ivermectin in the treatment of papulopustular rosacea: a systematic review of evidence and clinical guideline recommendations","volume":"8","author":"Ebbelaar","year":"2018","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.exppara.2023.108568_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2019.105215","article-title":"Do albendazole-loaded lipid nanocapsules enhance the bioavailability of albendazole in the brain of healthy mice?","volume":"201","author":"Fabbri","year":"2020","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2023.108568_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2019.105238","article-title":"Cysticidal activity of praziquantel-mebendazole combination: in vitro and in vivo studies","volume":"202","author":"Francisca","year":"2020","journal-title":"Acta Trop."},{"issue":"6","key":"10.1016\/j.exppara.2023.108568_bib11","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/QCO.0b013e328010774c","article-title":"Ivermectin: uses and impact 20 years on","volume":"19","author":"Fox","year":"2006","journal-title":"Curr. Opin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.exppara.2023.108568_bib12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00436-012-3117-1","article-title":"Field efficacy of praziquantel oral paste against naturally acquired equine cestodes in Ethiopia","volume":"112","author":"Getachew","year":"2013","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2023.108568_bib13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.actatropica.2016.11.015","article-title":"Neurocysticercosis infection and disease\u2013A review","volume":"166","author":"Gripper","year":"2017","journal-title":"Acta Trop."},{"issue":"6","key":"10.1016\/j.exppara.2023.108568_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00002826-199012000-00008","article-title":"Plasma and CSF levels of albendazole and praziquantel in patients with neurocysticercosis","volume":"13","author":"Jung","year":"1990","journal-title":"Clin. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.exppara.2023.108568_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/trstmh\/trab114","article-title":"Broadening the range of use cases for ivermectin \u2013 a review of the evidence","volume":"116","author":"Kositz","year":"2022","journal-title":"Trans. R. Soc. Trop."},{"issue":"4","key":"10.1016\/j.exppara.2023.108568_bib16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0169-4758(90)90227-U","article-title":"Mode of action of benzimidazoles","volume":"6","author":"Lacey","year":"1990","journal-title":"Parasitol. Today"},{"issue":"6","key":"10.1016\/j.exppara.2023.108568_bib17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1590\/S0037-86822002000600012","article-title":"Caracter\u00edsticas evolutivas do Cysticercus cellulosae no enc\u00e9falo e no cora\u00e7\u00e3o","volume":"35","author":"Lino Junior","year":"2002","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.exppara.2023.108568_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.antiviral.2018.09.010","article-title":"Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo","volume":"159","author":"Lv","year":"2018","journal-title":"Antivir. Res."},{"year":"2022","series-title":"Albendazole. [Updated 2022 May 15]. in: StatPearls","author":"Malik","key":"10.1016\/j.exppara.2023.108568_bib19"},{"issue":"1","key":"10.1016\/j.exppara.2023.108568_bib20","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.pt.2020.10.005","article-title":"Ivermectin: an anthelmintic, an insecticide, and much more","volume":"37","author":"Martin","year":"2021","journal-title":"Trends Parasitol."},{"issue":"4","key":"10.1016\/j.exppara.2023.108568_bib21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/S0004-282X2012005000010","article-title":"Experimental encephalitis caused by Taenia crassiceps cysticerci in mice","volume":"70","author":"Matos-Silva","year":"2012","journal-title":"Arq Neuropsiquiatr"},{"issue":"4","key":"10.1016\/j.exppara.2023.108568_bib22","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4103\/idoj.idoj_298_21","article-title":"Current use of ivermectin in dermatology, tropical medicine, and COVID-19: an update on pharmacology, uses, proven and varied proposed mechanistic action","volume":"12","author":"Mathachan","year":"2021","journal-title":"Indian Dermatol Online J"},{"issue":"6","key":"10.1016\/j.exppara.2023.108568_bib23","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.18203\/2320-6012.ijrms20172497","article-title":"A case of albendazole and niclosamide resistant Taenia saginata infection","volume":"5","author":"Mohanty","year":"2017","journal-title":"Int J Res Med Sci"},{"key":"10.1016\/j.exppara.2023.108568_bib24","first-page":"CD000215","article-title":"Anthelmintics for people with neurocysticercosis","volume":"6","author":"Monk","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"10.1016\/j.exppara.2023.108568_bib25","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1017\/S0031182015001572","article-title":"Cellular immune response in intraventricular experimental neurocysticercosis","volume":"143","author":"Moura","year":"2016","journal-title":"Parasitology"},{"issue":"2","key":"10.1016\/j.exppara.2023.108568_bib26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1590\/0004-282x20190155","article-title":"Demyelination in experimental intraventricular neurocysticercosis","volume":"78","author":"Moura","year":"2020","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.exppara.2023.108568_bib27","doi-asserted-by":"crossref","first-page":"e994","DOI":"10.1038\/cddis.2013.521","article-title":"Plasmodium falciparum signal recognition particle components and anti-parasitic effect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP","volume":"5","author":"Panchal","year":"2014","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.exppara.2023.108568_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008005","article-title":"Host immune responses during Taenia solium Neurocysticercosis infection and treatment","volume":"14","author":"Prodjinotho","year":"2020","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"4","key":"10.1016\/j.exppara.2023.108568_bib29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.anai.2016.07.021","article-title":"Effect of ivermectin on allergy-type manifestations in occult strongyloidiasis","volume":"117","author":"Rampur","year":"2016","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"3","key":"10.1016\/j.exppara.2023.108568_bib30","first-page":"220","article-title":"Field efficacy of ivermectin plus praziquantel oral paste against naturally acquired gastrointestinal nematodes and cestodes of horses in North America and Europe","volume":"4","author":"Rehbein","year":"2003","journal-title":"Vet. Therapeut."},{"key":"10.1016\/j.exppara.2023.108568_bib31","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00204-021-03025-z","article-title":"Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects","volume":"95","author":"Rendic","year":"2021","journal-title":"Arch. Toxicol."},{"issue":"7","key":"10.1016\/j.exppara.2023.108568_bib32","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1017\/S0031182020000505","article-title":"Histopathologic evaluation of experimental murine neurocysticercosis after treatment with albendazole\/nitazoxanide combination","volume":"147","author":"Sampaio","year":"2020","journal-title":"Parasitology"},{"issue":"4","key":"10.1016\/j.exppara.2023.108568_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0092-8674(94)90212-7","article-title":"Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs","volume":"77","author":"Schinkel","year":"1994","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.exppara.2023.108568_bib34","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1172\/JCI118699","article-title":"P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs","volume":"97","author":"Schinkel","year":"1996","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.exppara.2023.108568_bib35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1590\/0004-282x20160194","article-title":"Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis","volume":"75","author":"Silva","year":"2017","journal-title":"Arq Neuropsiquiatr"},{"issue":"5","key":"10.1016\/j.exppara.2023.108568_bib36","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s13346-018-0576-7","article-title":"In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions-a metabolic approach","volume":"8","author":"Silva","year":"2018","journal-title":"Drug Deliv Transl Res"},{"issue":"12","key":"10.1016\/j.exppara.2023.108568_bib37","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.ijpara.2015.05.007","article-title":"Immune response to Taenia solium cysticerci after anti-parasitic therapy","volume":"45","author":"Singh","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2023.108568_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2022.120393","article-title":"The prevalence of and contributors to neurocysticercosis in endemic regions","volume":"441","author":"Ta","year":"2022","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.exppara.2023.108568_bib39","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.3389\/fimmu.2018.02652","article-title":"Human extraparenchymal neurocysticercosis: the control of inflammation favors the host\u2026but also the parasite","volume":"9","author":"Toledo","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exppara.2023.108568_bib40","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4269\/ajtmh.1997.57.354","article-title":"Immunoblot with cerebrospinal fluid from patients with neurocysticercosis using antigen from cysticerci of Taenia solium and Taenia crassiceps","volume":"57","author":"Vaz","year":"1997","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"8","key":"10.1016\/j.exppara.2023.108568_bib41","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1111\/all.13118","article-title":"Topical ivermectin improves allergic skin inflammation","volume":"72","author":"Ventre","year":"2017","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.exppara.2023.108568_bib42","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.exppara.2007.01.013","article-title":"Taenia crassiceps organic acids detected in cysticerci","volume":"116","author":"Vinaud","year":"2007","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2023.108568_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2020.105448","article-title":"Metabolic effects of anthelminthic drugs in the larval stage of the cestode Taenia crassiceps, cysticercosis experimental model - a review","volume":"206","author":"Vinaud","year":"2020","journal-title":"Acta Trop."},{"issue":"4","key":"10.1016\/j.exppara.2023.108568_bib44","doi-asserted-by":"crossref","first-page":"945","DOI":"10.4269\/ajtmh.18-88751","article-title":"Diagnosis and treatment of neurocysticercosis: 2017 clinical practice guidelines by the infectious diseases society of America (IDSA) and the American society of tropical medicine and hygiene (ASTMH)","volume":"98","author":"White","year":"2018","journal-title":"Am. J. Trop. Med. Hyg."},{"isbn-type":"print","year":"2021","series-title":"WHO Guidelines on Management of Taenia Solium Neurocysticercosis","key":"10.1016\/j.exppara.2023.108568_bib45","ISBN":"https:\/\/id.crossref.org\/isbn\/9789240032231"},{"key":"10.1016\/j.exppara.2023.108568_bib46","first-page":"1","article-title":"Ivermectin protects against experimental autoimmune encephalomyelitis in mice by modulating the Th17\/treg balance involved in the IL-2\/STAT5 pathway","author":"Xie","year":"2023","journal-title":"Inflammation"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489423001091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489423001091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T06:33:13Z","timestamp":1758004393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489423001091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":46,"alternative-id":["S0014489423001091"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2023.108568","relation":{},"ISSN":["0014-4894"],"issn-type":[{"type":"print","value":"0014-4894"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Albendazole \u2013 Ivermectin combination decreases inflammation in experimental neurocysticercosis","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2023.108568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108568"}}