{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:00:55Z","timestamp":1780113655332,"version":"3.54.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012335","name":"Medical and Life Sciences Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009827","name":"Alexandria University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.exppara.2024.108843","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:48:08Z","timestamp":1728089288000},"page":"108843","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Therapeutic efficacy of praziquantel loaded-chitosan nanoparticles on juvenile Schistosoma mansoni worms in murine model"],"prefix":"10.1016","volume":"266","author":[{"given":"Mai","family":"Mahmoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4965-9469","authenticated-orcid":false,"given":"Amal Farahat","family":"Allam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina Essawy","family":"Essawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanaa Ibrahim","family":"Shalaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheir Salem","family":"El-Sherif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.exppara.2024.108843_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009423","article-title":"Ginger (Zingiber Officinale)-derived nanoparticles in Schistosoma mansoni infected mice: hepatoprotective and enhancer of etiological treatment","volume":"15","author":"Abd El Wahab","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2024.108843_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00436-010-1855-5","article-title":"Murine schistosomiasis as a model for human schistosomiasis mansoni: similarities and discrepancies","volume":"107","author":"Abdul-Ghani","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2024.108843_bib3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainresbull.2017.04.004","article-title":"L-carnitine prevents memory impairment induced by chronic REM-sleep deprivation","volume":"131","author":"Alzoubi","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.exppara.2024.108843_bib4","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.exppara.2024.108843_bib5","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.2174\/1871527313666140806120717","article-title":"The potential role of Morus alba leaves extract on the brain of mice infected with Schistosoma mansoni","volume":"13","author":"Bauomy","year":"2014","journal-title":"CNS Neurol. Disord.: Drug Targets"},{"issue":"15","key":"10.1016\/j.exppara.2024.108843_bib6","doi-asserted-by":"crossref","first-page":"18699","DOI":"10.1007\/s11356-020-08356-5","article-title":"Zinc oxide nanoparticles and L-carnitine effects on neuro-schistosomiasis mansoni induced in mice","volume":"27","author":"Bauomy","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"1","key":"10.1016\/j.exppara.2024.108843_bib7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4269\/ajtmh.1971.20.62","article-title":"Rate of destruction of Schistosoma mansoni eggs in the tissues of mice","volume":"20","author":"Cheever","year":"1971","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2024.108843_bib8","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1590\/S0074-02762002000700002","article-title":"Experimental models of Schistosoma mansoni infection","volume":"97","author":"Cheever","year":"2002","journal-title":"Mem. Inst. Oswaldo Cruz"},{"issue":"1","key":"10.1016\/j.exppara.2024.108843_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molbiopara.2014.06.002","article-title":"Schistosomiasis control: praziquantel forever?","volume":"195","author":"Cioli","year":"2014","journal-title":"Mol. Biochem. Parasitol."},{"issue":"12","key":"10.1016\/j.exppara.2024.108843_bib10","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.3390\/molecules26123694","article-title":"Preparation and antimicrobial activity of chitosan and its derivatives: a concise review","volume":"26","author":"Confederat","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.exppara.2024.108843_bib11","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.3389\/fimmu.2018.03042","article-title":"Schistosome egg migration: mechanisms, pathogenesis and host immune responses","volume":"9","author":"Costain","year":"2018","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.exppara.2024.108843_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01372-20","article-title":"Therapeutic effect of diminazene aceturate on parasitic blood fluke Schistosoma mansoni infection","volume":"64","author":"de Brito","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.exppara.2024.108843_bib13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijpara.2012.12.006","article-title":"Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice","volume":"43","author":"de Oliveira","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2024.108843_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.exppara.2014.02.010","article-title":"Anthelmintic activity in vitro and in vivo of Baccharis trimera (Less) DC against immature and adult worms of Schistosoma mansoni","volume":"139","author":"de Oliveira","year":"2014","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2024.108843_bib15","first-page":"7467","article-title":"Antioxidant and hepatoprotective role of gold nanoparticles against murine hepatic schistosomiasis","volume":"10","author":"Dkhil","year":"2015","journal-title":"Int. J. Nanomed."},{"issue":"10","key":"10.1016\/j.exppara.2024.108843_bib16","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1007\/s00436-015-4600-2","article-title":"Impact of gold nanoparticles on brain of mice infected with Schistosoma mansoni","volume":"114","author":"Dkhil","year":"2015","journal-title":"Parasitol. Res."},{"issue":"4","key":"10.1016\/j.exppara.2024.108843_bib17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4269\/ajtmh.1967.16.483","article-title":"An improved perfusion technique for recovering adult schistosomes from laboratory animals","volume":"16","author":"Duvall","year":"1967","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"18","key":"10.1016\/j.exppara.2024.108843_bib18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.5897\/JMPR2019.6842","article-title":"Therapeutic role of chitosan nanoparticles in murine schistosomiasis mansoni. Hendawi, F. F","volume":"13","author":"Elawamy","year":"2019","journal-title":"J. Med. Plants Res."},{"issue":"1","key":"10.1016\/j.exppara.2024.108843_bib19","first-page":"32","article-title":"Therapeutic effect of chitosan nanoparticles and metronidazole in treatment of experimentally giardiasis infected hamsters","volume":"16","author":"El-Gendy","year":"2021","journal-title":"Iran. J. Parasitol."},{"key":"10.1016\/j.exppara.2024.108843_bib20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.actatropica.2016.03.038","article-title":"Miltefosine lipid nanocapsules: intersection of drug repurposing and nanotechnology for single dose oral treatment of pre-patent schistosomiasis mansoni","volume":"159","author":"El-Moslemany","year":"2016","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2024.108843_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2022.108260","article-title":"Schistosomicidal and hepatoprotective activity of gamma-aminobutyric acid (GABA) alone or combined with praziquantel against Schistosoma mansoni infection in murine model","volume":"238","author":"Fahmy","year":"2022","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2024.108843_bib22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-1050-2_3","article-title":"Tissue processing and hematoxylin and eosin staining","volume":"1180","author":"Feldman","year":"2014","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.exppara.2024.108843_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.15171\/apb.2019.023","article-title":"Current advances in chitosan nanoparticles based drug delivery and targeting","volume":"9","author":"Garg","year":"2019","journal-title":"Adv. Pharmaceut. Bull."},{"issue":"2","key":"10.1016\/j.exppara.2024.108843_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011992","article-title":"Effects of structurally distinct human HDAC6 and HDAC6\/HDAC8 inhibitors against Schistosoma mansoni larval and adult worm stages","volume":"18","author":"Gimmelli","year":"2024","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2024.108843_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2019.107717","article-title":"Successful treatment of acute experimental toxoplasmosis by spiramycin-loaded chitosan nanoparticles","volume":"204","author":"Hagras","year":"2019","journal-title":"Exp. Parasitol."},{"issue":"2","key":"10.1016\/j.exppara.2024.108843_bib26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3390\/molecules26020272","article-title":"Chitosan nanoparticles-insight into properties, functionalization and applications in drug delivery and theranostics","volume":"26","author":"Jhaveri","year":"2021","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.exppara.2024.108843_bib27","first-page":"155","article-title":"Oxidative stress: a review","volume":"3","author":"Keshari","year":"2015","journal-title":"Int. J. Sci. Techno. ledge"},{"key":"10.1016\/j.exppara.2024.108843_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00560463","article-title":"Clinical pharmacology in normal volunteers of praziquantel, a new drug against schistosomes and cestodes: an example of a complex study covering both tolerance and pharmacokinetics","volume":"14","author":"Leopold","year":"1978","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.exppara.2024.108843_bib29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2174\/1389557513666131119204558","article-title":"Recent advances in antischistosomal drugs agents","volume":"17","author":"Liu","year":"2017","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.exppara.2024.108843_bib30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fcimb.2020.00057","article-title":"Elucidation of cellular responses in non-human primates with chronic schistosomiasis followed by praziquantel treatment","volume":"10","author":"Melkus","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"9","key":"10.1016\/j.exppara.2024.108843_bib31","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1128\/AAC.02741-14","article-title":"Activity of praziquantel enantiomers and main metabolites against Schistosoma mansoni","volume":"58","author":"Meister","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.exppara.2024.108843_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010382","article-title":"Pathological and immunological evaluation of different regimens of praziquantel treatment in a mouse model of Schistosoma mansoni infection","volume":"16","author":"Membe Femoe","year":"2022","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"5","key":"10.1016\/j.exppara.2024.108843_bib33","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3390\/ph14050400","article-title":"Effect of dihydroartemisinin-piperaquine on the pharmacokinetics of praziquantel for treatment of Schistosoma mansoni infection","volume":"14","author":"Minzi","year":"2021","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.exppara.2024.108843_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-72901-y","article-title":"In vivo assessment of the antischistosomal activity of curcumin loaded nanoparticles versus praziquantel in the treatment of Schistosoma mansoni","volume":"10","author":"Mokbel","year":"2020","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.exppara.2024.108843_bib35","doi-asserted-by":"crossref","first-page":"e1894","DOI":"10.1371\/journal.pntd.0001894","article-title":"A new strategy based on SmRho protein loaded chitosan nanoparticles as a candidate oral vaccine against schistosomiasis","volume":"6","author":"Oliveira","year":"2012","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"1","key":"10.1016\/j.exppara.2024.108843_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2307\/3274166","article-title":"An efficient method for exposure of mice to cercariae of Schistosoma mansoni","volume":"38","author":"Olivier","year":"1952","journal-title":"J. Parasitol."},{"issue":"2","key":"10.1016\/j.exppara.2024.108843_bib37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4269\/ajtmh.1962.11.201","article-title":"New approach to the screening of drugs in experimental schistosomiasis mansoni in mice","volume":"11","author":"Pellegrino","year":"1962","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2024.108843_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2022.108293","article-title":"Itraconazole, a cytochrome P450 inhibitor, enhanced the efficacy of praziquantel against Schistosoma mansoni infection and alleviated liver injury in mice","volume":"239","author":"Sabra","year":"2022","journal-title":"Exp. Parasitol."},{"issue":"3","key":"10.1016\/j.exppara.2024.108843_bib39","doi-asserted-by":"crossref","first-page":"629","DOI":"10.21608\/jesp.2018.76578","article-title":"Efficacy of praziquantel loaded chitosan nanoparticles against both adult and schistosomula stages of Schistosoma mansoni","volume":"48","author":"Sadek","year":"2018","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"10.1016\/j.exppara.2024.108843_bib40","first-page":"1","article-title":"Development and characterization of chitosan nanoparticles containing erthromycin estolate","volume":"5","author":"Shende","year":"2014","journal-title":"Int. J. Pharmaceut. Appl."},{"key":"10.1016\/j.exppara.2024.108843_bib41","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.exppara.2017.02.008","article-title":"Resveratrol ameliorates oxidative stress and organ dysfunction in Schistosoma mansoni infected mice","volume":"174","author":"Soliman","year":"2017","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2024.108843_bib42","doi-asserted-by":"crossref","DOI":"10.1093\/qjmed\/hcaa060.001","article-title":"Praziquantel - chitosan nanoformulation against murine Schistosoma mansoni infection","volume":"113","author":"Tawfeek","year":"2020","journal-title":"QJM: IGM"},{"key":"10.1016\/j.exppara.2024.108843_bib43","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.actatropica.2017.06.025","article-title":"Nanotechnology as a potential therapeutic alternative for schistosomiasis","volume":"174","author":"Tomiotto-Pellissier","year":"2017","journal-title":"Acta Trop."},{"issue":"2","key":"10.1016\/j.exppara.2024.108843_bib45","first-page":"409","article-title":"Concentration time course of praziquantel in Filipinos with mild Schistosoma japonicum infection","volume":"25","author":"Valencia","year":"1994","journal-title":"Southeast Asian J. Trop. Med. Publ. Health"},{"key":"10.1016\/j.exppara.2024.108843_bib44","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s40995-017-0150-z","article-title":"Albendazole and praziquantel chitosan nanoparticles: preparation, characterization, and in vitro release study","volume":"42","author":"Torabi","year":"2018","journal-title":"Iranian J. Sci. Technol. Trans. A: Science"},{"issue":"34","key":"10.1016\/j.exppara.2024.108843_bib46","doi-asserted-by":"crossref","first-page":"12676","DOI":"10.1073\/pnas.0404878101","article-title":"Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification","volume":"101","author":"Wang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.exppara.2024.108843_bib47","series-title":"WHO Guideline on Control and Elimination of Human Schistosomiasis","year":"2022"},{"issue":"4","key":"10.1016\/j.exppara.2024.108843_bib48","first-page":"41","article-title":"34th meeting of the international task force for disease eradication, 19\u201320 september 2022","volume":"98","year":"2023","journal-title":"Wkly. Epidemiol. Rec."},{"issue":"1","key":"10.1016\/j.exppara.2024.108843_bib49","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202001745RR","article-title":"CRISPR\/Cas9\u2010mediated genome editing of Schistosoma mansoni acetylcholinesterase","volume":"35","author":"You","year":"2021","journal-title":"Faseb. J."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489424001462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489424001462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T01:25:39Z","timestamp":1729819539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489424001462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":49,"alternative-id":["S0014489424001462"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2024.108843","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic efficacy of praziquantel loaded-chitosan nanoparticles on juvenile Schistosoma mansoni worms in murine model","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2024.108843","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108843"}}