{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:34:13Z","timestamp":1790444053820,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.exppara.2025.109028","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:20:30Z","timestamp":1758126030000},"page":"109028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Current challenges and future prospects in patients with recurrent cystic echinococcosis; an updated mini review"],"prefix":"10.1016","volume":"277","author":[{"given":"Nayer Mehdizad","family":"Bakhtiar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Mahami-Oskouei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Ahmadpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hasan","family":"Kohansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3009-9537","authenticated-orcid":false,"given":"Adel","family":"Spotin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2025.109028_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-019-3719-x","article-title":"Nanostructured lipid carriers of ivermectin as a novel drug delivery system in hydatidosis","volume":"12","author":"Ahmadpour","year":"2019","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.exppara.2025.109028_bib2","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.exppara.2025.109028_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007516","article-title":"Standardized endocystectomy technique for surgical treatment of uncomplicated hepatic cystic echinococcosis","volume":"13","author":"Al-Saeedi","year":"2019","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2025.109028_bib4","series-title":"New Insight into the Immunity During Echinococcus granulosus Infection, Echinococcosis-New Perspectives","author":"Ali","year":"2022"},{"key":"10.1016\/j.exppara.2025.109028_bib5","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2174\/1566524021666211108114009","article-title":"MicroRNAs in helminth parasites: a systematic review","volume":"22","author":"Alizadeh","year":"2022","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.exppara.2025.109028_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2019.105255","article-title":"Parasite-derived microRNAs in plasma as novel promising biomarkers for the early detection of hydatid cyst infection and post-surgery follow-up","volume":"202","author":"Alizadeh","year":"2020","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2025.109028_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2023.1191271","article-title":"Revealing novel cytb and nad 5 genes-based population diversity and benzimidazole resistance in Echinococcus granulosus of bovine origin","volume":"10","author":"Alvi","year":"2023","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.exppara.2025.109028_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2165\/00128072-200103020-00005","article-title":"Treatment of hydatid disease","volume":"3","author":"Anadol","year":"2001","journal-title":"Paediatric drugs"},{"key":"10.1016\/j.exppara.2025.109028_bib9","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.3390\/medicina60101696","article-title":"Analysis of complications of a neglected disease: 13 years of experience with liver hydatid cysts in a high-volume hospital","volume":"60","author":"Azizo\u011flu","year":"2024","journal-title":"Medicina"},{"key":"10.1016\/j.exppara.2025.109028_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2022.108428","article-title":"In vitro efficacy of albendazole-loaded \u03b2-cyclodextrin against protoscoleces of Echinococcus granulosus sensu stricto","volume":"243","author":"Bakhtiar","year":"2022","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2025.109028_bib11","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1007\/s00436-019-06416-5","article-title":"Therapeutic efficacy of nanocompounds in the treatment of cystic and alveolar echinococcoses: challenges and future prospects","volume":"118","author":"Bakhtiar","year":"2019","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2025.109028_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-020-04103-4","article-title":"Recent advances on innate immune pathways related to host\u2013parasite cross-talk in cystic and alveolar echinococcosis","volume":"13","author":"Bakhtiar","year":"2020","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.exppara.2025.109028_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12893-019-0553-1","article-title":"Current approaches in the surgical treatment of liver hydatid disease: single center experience","volume":"19","author":"Bayrak","year":"2019","journal-title":"BMC Surg."},{"key":"10.1016\/j.exppara.2025.109028_bib14","first-page":"1399","article-title":"TLRs and innate immunity","volume":"113","author":"Beutler","year":"2009","journal-title":"Blood, The Journal of the American Society of Hematology"},{"key":"10.1016\/j.exppara.2025.109028_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","article-title":"Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans","volume":"114","author":"Brunetti","year":"2010","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2025.109028_bib16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00423-003-0397-z","article-title":"Echinococcus granulosus infection: the challenge of surgical treatment","volume":"388","author":"Buttenschoen","year":"2003","journal-title":"Langenbecks Arch. Surg."},{"key":"10.1016\/j.exppara.2025.109028_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pt.2015.09.003","article-title":"MicroRNAs in parasitic helminthiases: current status and future perspectives","volume":"32","author":"Cai","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.exppara.2025.109028_bib18","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.pt.2019.05.006","article-title":"Echinococcus granulosus sensu lato","volume":"35","author":"Casulli","year":"2019","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.exppara.2025.109028_bib19","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1046\/j.1365-3156.1998.00257.x","article-title":"Albendazole plus praziquantel versus albendazole alone as a pre\u2010operative treatment in intra\u2010abdominal hydatidosis caused by Echinococcus granulosus","volume":"3","author":"Cobo","year":"1998","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.exppara.2025.109028_bib20","first-page":"117","article-title":"Spectrotypic analysis of humoral response in human hydatidosis","volume":"76","author":"D'Amelio","year":"1989","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.exppara.2025.109028_bib21","doi-asserted-by":"crossref","DOI":"10.21037\/ales.2019.08.01","article-title":"Radical surgery decreases overall morbidity and recurrence compared with conservative surgery for liver cystic echinococcosis: systematic review with meta-analysis","volume":"4","author":"Dziri","year":"2019","journal-title":"Annals of Laparoscopic and Endoscopic Surgery"},{"key":"10.1016\/j.exppara.2025.109028_bib22","first-page":"231","article-title":"Guidelines for treatment of cystic and alveolar echinococcosis in humans","volume":"74","author":"Eckert","year":"1996","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.exppara.2025.109028_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0001-706X(02)00217-6","article-title":"Benzimidazole treatment of cystic echinococcosis","volume":"85","author":"El-On","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2025.109028_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12817","article-title":"MicroRNA profile in immune response of alveolar and cystic echinococcosis patients","volume":"43","author":"Eroglu","year":"2021","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.exppara.2025.109028_bib25","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11686-022-00654-x","article-title":"Can echinococcus granulosus-derived microRNAs be biomarkers for diagnosis and follow-up of cystic echinococcosis patients?","volume":"68","author":"Fasihi Karami","year":"2023","journal-title":"Acta Parasitol."},{"key":"10.1016\/j.exppara.2025.109028_bib26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s002689910115","article-title":"Radical surgical therapy of abdominal cystic hydatid disease: factors of recurrence","volume":"24","author":"Gollackner","year":"2000","journal-title":"World J. Surg."},{"key":"10.1016\/j.exppara.2025.109028_bib27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5152\/EurJTher.2019.18076","article-title":"Basic problems in serological diagnosis of cystic echinococcosis","volume":"25","author":"G\u00fcreser","year":"2019","journal-title":"European Journal of Therapeutics"},{"key":"10.1016\/j.exppara.2025.109028_bib28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/14737159.2023.2246367","article-title":"Cystic echinococcosis microRNAs as potential noninvasive biomarkers: current insights and upcoming perspective","volume":"23","author":"Habibi","year":"2023","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.exppara.2025.109028_bib29","doi-asserted-by":"crossref","DOI":"10.1051\/parasite\/2014073","article-title":"Treatment of echinococcosis: albendazole and mebendazole\u2013what else?","volume":"21","author":"Hemphill","year":"2014","journal-title":"Parasite"},{"key":"10.1016\/j.exppara.2025.109028_bib30","first-page":"267","article-title":"Disasters that develop in the liver due to hydatid cyst: a case report","volume":"92","author":"Karahan","year":"2024","journal-title":"Cirug\u00eda y cirujanos"},{"key":"10.1016\/j.exppara.2025.109028_bib31","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s11686-022-00641-2","article-title":"Serum level of egr-miR-2a-3p as a potential diagnostic biomarker for cystic echinococcosis","volume":"68","author":"Karami","year":"2023","journal-title":"Acta Parasitol."},{"key":"10.1016\/j.exppara.2025.109028_bib32","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jceh.2021.05.005","article-title":"Percutaneous drainage in hepatic hydatidosis-the PAIR technique: concept, technique, and results","volume":"11","author":"Khuroo","year":"2021","journal-title":"Journal of Clinical and Experimental Hepatology"},{"key":"10.1016\/j.exppara.2025.109028_bib33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.actatropica.2017.09.013","article-title":"Natural products applied against hydatid cyst protoscolices: a review of past to present","volume":"176","author":"Kohansal","year":"2017","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2025.109028_bib34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0169-4758(90)90227-U","article-title":"Mode of action of benzimidazoles","volume":"6","author":"Lacey","year":"1990","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.exppara.2025.109028_bib35","first-page":"206","article-title":"Comparison of scolicidal effects of amphotricin B, silver nanoparticles, _and Foeniculum vulgare mill on hydatid cysts protoscoleces","volume":"10","author":"Lashkarizadeh","year":"2015","journal-title":"Iran. J. Parasitol."},{"key":"10.1016\/j.exppara.2025.109028_bib36","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4269\/ajtmh.15-0219","article-title":"Factors influencing the serological response in hepatic Echinococcus granulosus infection","volume":"94","author":"Lissandrin","year":"2016","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2025.109028_bib37","doi-asserted-by":"crossref","DOI":"10.1051\/parasite\/2018063","article-title":"Recombinant \u03b1-and \u03b2-tubulin from echinococcus granulosus: expression, purification and polymerization","volume":"25","author":"Liu","year":"2018","journal-title":"Parasite"},{"key":"10.1016\/j.exppara.2025.109028_bib38","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1007\/s00436-016-5054-x","article-title":"Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data","volume":"115","author":"L\u00f6tsch","year":"2016","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2025.109028_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.104962","article-title":"Expression analysis of circulating miR-146a and miR-155 as novel biomarkers related to effective immune responses in human cystic echinococcosis","volume":"157","author":"Mahami-Oskouei","year":"2021","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.exppara.2025.109028_bib40","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/428205","article-title":"Serological diagnosis and follow\u2010up of human cystic echinococcosis: a new hope for the future?","volume":"2015","author":"Manzano-Rom\u00e1n","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.exppara.2025.109028_bib41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12026-018-9041-4","article-title":"Role of microRNAs in host defense against Echinococcus granulosus infection: a preliminary assessment","volume":"67","author":"Mariconti","year":"2019","journal-title":"Immunol. Res."},{"key":"10.1016\/j.exppara.2025.109028_bib42","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e3866","article-title":"Diagnosis, treatment, and management of echinococcosis","volume":"344","author":"McManus","year":"2012","journal-title":"Bmj"},{"key":"10.1016\/j.exppara.2025.109028_bib43","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3390\/diagnostics14131399","article-title":"Therapeutic options in hydatid hepatic cyst surgery: a retrospective analysis of three surgical approaches","volume":"14","author":"Mihetiu","year":"2024","journal-title":"Diagnostics"},{"key":"10.1016\/j.exppara.2025.109028_bib44","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4254\/wjh.v8.i28.1169","article-title":"Current status of diagnosis and treatment of hepatic echinococcosis","volume":"8","author":"Mihmanli","year":"2016","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.exppara.2025.109028_bib45","series-title":"Overview on Echinococcosis","article-title":"The surgical management of hydatid cyst of the liver: what is new?","author":"Mihmanli","year":"2020"},{"key":"10.1016\/j.exppara.2025.109028_bib46","doi-asserted-by":"crossref","DOI":"10.1051\/parasite\/2019070","article-title":"Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities","volume":"26","author":"Moghaddam","year":"2019","journal-title":"Parasite"},{"key":"10.1016\/j.exppara.2025.109028_bib47","first-page":"1690","article-title":"Combined albendazole and praziquantel versus albendazole alone in the treatment of hydatid disease","volume":"45","author":"Mohamed","year":"1998","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.exppara.2025.109028_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.cimid.2019.101336","article-title":"A clinical association between toll-like receptor 2 Arg753Gln polymorphism with recurrent cystic echinococcosis in postsurgery patients: a case control study","volume":"66","author":"Moradkhani","year":"2019","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.exppara.2025.109028_bib49","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1183\/09031936.03.00108403","article-title":"Pulmonary echinococcosis","volume":"21","author":"Morar","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.exppara.2025.109028_bib50","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijid.2008.03.037","article-title":"Echinococcosis: a review","volume":"13","author":"Moro","year":"2009","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.exppara.2025.109028_bib51","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1007\/s00436-016-5250-8","article-title":"Scolicidal and apoptotic activities of albendazole sulfoxide and albendazole sulfoxide-loaded PLGA-PEG as a novel nanopolymeric particle against Echinococcus granulosus protoscoleces","volume":"115","author":"Naseri","year":"2016","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2025.109028_bib52","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00436-018-5850-6","article-title":"The potential role of toll-like receptor 4 Asp299Gly polymorphism and its association with recurrent cystic echinococcosis in postoperative patients","volume":"117","author":"Noori","year":"2018","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2025.109028_bib53","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1017\/S0022149X2000098X","article-title":"MicroRNA expression profile in patients with cystic echinococcosis and identification of possible cellular pathways","volume":"95","author":"Orsten","year":"2021","journal-title":"J. Helminthol."},{"key":"10.1016\/j.exppara.2025.109028_bib54","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00436-021-07382-7","article-title":"Can parasite-derived microRNAs differentiate active and inactive cystic echinococcosis patients?","volume":"121","author":"\u00d6rsten","year":"2022","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2025.109028_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12865-018-0267-7","article-title":"The excretory-secretory products of Echinococcus granulosus protoscoleces stimulated IL-10 production in B cells via TLR-2 signaling","volume":"19","author":"Pan","year":"2018","journal-title":"BMC Immunol."},{"key":"10.1016\/j.exppara.2025.109028_bib56","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s11684-017-0559-y","article-title":"Radical versus conservative surgical treatment of liver hydatid cysts: a meta-analysis","volume":"12","author":"Pang","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/j.exppara.2025.109028_bib57","series-title":"Clinical management, epidemiology, and recurrence of human cystic echinococcosis in a secondary care level hospital in an endemic area of the andes in sicuani, Cusco, Peru. medRxiv (2024): 2024-09","author":"Pineda-Reyes","year":"2024"},{"key":"10.1016\/j.exppara.2025.109028_bib58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1503\/cjs.013010","article-title":"Postoperative recurrence of cystic hydatidosis","volume":"55","author":"Prousalidis","year":"2012","journal-title":"Can. J. Surg."},{"key":"10.1016\/j.exppara.2025.109028_bib59","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210395","article-title":"MicroRNAs: master regulators in host\u2013parasitic protist interactions","volume":"12","author":"Rojas-Pirela","year":"2022","journal-title":"Open biology"},{"key":"10.1016\/j.exppara.2025.109028_bib60","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.mehy.2013.07.003","article-title":"Using specific synthetic peptide (p176) derived AgB 8\/1-kDa accompanied by modified patient's sera: a novel hypothesis to follow-up of Cystic echinococcosis after surgery","volume":"81","author":"Rouhani","year":"2013","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.exppara.2025.109028_bib61","first-page":"1764","article-title":"Comparison of native hydatid cyst fluid (HCF), lyophilized HCF, antigen B (AgB) and lyophilized AgB (LAgB) originated from Echinococcus granulosus sensu stricto for sero-diagnosis of active, transitional and inactive human liver cystic echinococcosis","volume":"52","author":"Sadjjadi","year":"2023","journal-title":"Iran. J. Public Health"},{"key":"10.1016\/j.exppara.2025.109028_bib62","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3347\/kjp.2009.47.2.153","article-title":"Serum antigen and antibody detection in echinococcosis: application in serodiagnosis of human hydatidosis","volume":"47","author":"Sadjjadi","year":"2009","journal-title":"Kor. J. Parasitol."},{"key":"10.1016\/j.exppara.2025.109028_bib63","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s002689900643","article-title":"Surgical treatment for lung hydatid disease","volume":"23","author":"Safioleas","year":"1999","journal-title":"World J. Surg."},{"key":"10.1016\/j.exppara.2025.109028_bib64","first-page":"131","article-title":"Surgical treatment of hydatid cysts of the lung: analysis of 405 patients","volume":"41","author":"Salih","year":"1998","journal-title":"Can. J. Surg."},{"key":"10.1016\/j.exppara.2025.109028_bib65","first-page":"527","article-title":"Combined chemotherapy (mebendazole plus praziquantel) in patients with hydatidosis","volume":"9","author":"Salto","year":"1991","journal-title":"Enferm. Infecc. Microbiol. Cl\u00edn."},{"key":"10.1016\/j.exppara.2025.109028_bib66","doi-asserted-by":"crossref","first-page":"185","DOI":"10.5662\/wjm.v5.i4.185","article-title":"Immunodiagnosis of human hydatid disease: where do we stand?","volume":"5","author":"Sarkari","year":"2015","journal-title":"World J. Methodol."},{"key":"10.1016\/j.exppara.2025.109028_bib67","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1365-3024.2011.01335.x","article-title":"TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL\u201010","volume":"33","author":"Shan","year":"2011","journal-title":"Parasite immunology"},{"key":"10.1016\/j.exppara.2025.109028_bib68","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s002680020011","article-title":"Recurrence of hydatid disease","volume":"25","author":"Sielaff","year":"2001","journal-title":"World J. Surg."},{"key":"10.1016\/j.exppara.2025.109028_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006422","article-title":"Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: compounds and therapeutic targets","volume":"12","author":"Siles-Lucas","year":"2018","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2025.109028_bib70","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/bs.apar.2016.09.003","article-title":"Laboratory diagnosis of echinococcus spp. in human patients and infected animals","volume":"96","author":"Siles-Lucas","year":"2017","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.exppara.2025.109028_bib71","article-title":"Laparoscopic management of abdominal echinococcosis: a technical report on surgical techniques and outcomes","volume":"16","author":"Slavu","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.exppara.2025.109028_bib72","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijid.2004.08.001","article-title":"Treatment options for hepatic cystic echinococcosis","volume":"9","author":"Smego Jr","year":"2005","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.exppara.2025.109028_bib73","doi-asserted-by":"crossref","first-page":"764","DOI":"10.9738\/INTSURG-D-14-00069.1","article-title":"Open surgery for hepatic hydatid disease","volume":"99","author":"Sozuer","year":"2014","journal-title":"Int. Surg."},{"key":"10.1016\/j.exppara.2025.109028_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008519","article-title":"Epidemiological distribution of Echinococcus granulosus s. l. infection in human and domestic animal hosts in european mediterranean and Balkan countries: a systematic review","volume":"14","author":"Tamarozzi","year":"2020","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2025.109028_bib75","first-page":"186","article-title":"Recurrence of hepatic hydatidosis: how and why? Middle black sea","volume":"7","author":"Tar\u0131m","year":"2021","journal-title":"J. Health Sci."},{"key":"10.1016\/j.exppara.2025.109028_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0012289","article-title":"Standardized approach to the conservative surgery of hepatic cystic echinococcosis: a prospective study","volume":"18","author":"Trigui","year":"2024","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2025.109028_bib77","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/632760","article-title":"Expression of toll\u2010like receptors 2 and 4 and related cytokines in patients with hepatic cystic and alveolar echinococcosis","volume":"2015","author":"Tuxun","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.exppara.2025.109028_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-018-3201-y","article-title":"Medical treatment of cystic echinococcosis: systematic review and meta-analysis","volume":"18","author":"Velasco-Tirado","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.exppara.2025.109028_bib79","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S2222-1808(13)60085-7","article-title":"Genotypic characterization of Echinococcus granulosus in Iranian goats","volume":"3","author":"Youssefi","year":"2013","journal-title":"Asian Pacific Journal of Tropical Disease"},{"key":"10.1016\/j.exppara.2025.109028_bib80","first-page":"858","article-title":"The expression of TLR4 in fiver cell treated with cyst fluid of echinocaccus granulosus","author":"Zhang","year":"2009","journal-title":"Chin. J. Microbiol. Immunol."},{"key":"10.1016\/j.exppara.2025.109028_bib81","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.2757","article-title":"The genome of the hydatid tapeworm Echinococcus granulosus","volume":"45","author":"Zheng","year":"2013","journal-title":"Nat. Genet."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448942500133X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448942500133X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T22:13:14Z","timestamp":1760047994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448942500133X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":81,"alternative-id":["S001448942500133X"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2025.109028","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current challenges and future prospects in patients with recurrent cystic echinococcosis; an updated mini review","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2025.109028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109028"}}