{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:08:26Z","timestamp":1777576106058,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["441634\/2024-9"],"award-info":[{"award-number":["441634\/2024-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["152770\/2024-0"],"award-info":[{"award-number":["152770\/2024-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["305287 \/2023-0"],"award-info":[{"award-number":["305287 \/2023-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["404212\/2023-9"],"award-info":[{"award-number":["404212\/2023-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["441649\/2024-6"],"award-info":[{"award-number":["441649\/2024-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26\/201.001\/2022"],"award-info":[{"award-number":["E-26\/201.001\/2022"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26 \/010.000983\/2019"],"award-info":[{"award-number":["E-26 \/010.000983\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26\/203.931\/2024"],"award-info":[{"award-number":["E-26\/203.931\/2024"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26\/202.409\/2021"],"award-info":[{"award-number":["E-26\/202.409\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State","doi-asserted-by":"publisher","award":["E-26\/210.613\/2023"],"award-info":[{"award-number":["E-26\/210.613\/2023"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.exppara.2026.109133","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:56:23Z","timestamp":1775030183000},"page":"109133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Combination treatment of topical nystatin and systemic meglumine antimoniate in the BALB\/c - Leishmania (Leishmania) amazonensis model"],"prefix":"10.1016","volume":"284","author":[{"given":"Marcella","family":"Silva-Figueiredo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luzia Monteiro","family":"Castro C\u00f4rtes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geovane","family":"Dias-Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franklin","family":"Souza-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Soares Dias","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Silva Lara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirian Claudia","family":"Souza Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Filipe","family":"Gon\u00e7alves-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-426X","authenticated-orcid":false,"given":"Carlos Roberto","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.exppara.2026.109133_bib49","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1128\/AAC.00809-10","article-title":"Reductions in skin and systemic parasite burdens as a combined effect of topical paromomycin and oral miltefosine treatment of mice experimentally infected with Leishmania (Leishmania) amazonensis","volume":"54","author":"Aguiar","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"issue":"10","key":"10.1016\/j.exppara.2026.109133_bib1","first-page":"246","article-title":"Leishmanicidal activity of nystatin (mycostatin): a potent polyene compound","volume":"47","author":"Ali","year":"1997","journal-title":"J. Pakistan Med. Assoc."},{"key":"10.1016\/j.exppara.2026.109133_bib2","doi-asserted-by":"crossref","DOI":"10.1093\/jac\/dkaf362","article-title":"Efficacy of topical hydrophilic gel of paromomycin combined with systemic or locally administered leishmanicidal drugs for treatment of experimental leishmaniasis caused by Leishmania (Viannia) braziliensis","author":"Alves","year":"2025","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.exppara.2026.109133_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009099","article-title":"Therapeutic advances in the topical treatment of cutaneous leishmaniasis: a review","author":"Azim","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2026.109133_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijid.2020.06.003","article-title":"Refractory mucocutaneous leishmaniasis resolved with combination treatment based on intravenous pentamidine, oral azole, aerosolized liposomal amphotericin B, and intralesional meglumine antimoniate","author":"Basile","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.exppara.2026.109133_bib5","doi-asserted-by":"crossref","DOI":"10.4103\/0019-5154.156416","article-title":"Evaluation of organelle changes in promastigotes of unresponsive Leishmania tropica to meglumine antimoniate in comparison with sensitive and standard isolates by electron microscopy","author":"Bahreini","year":"2015","journal-title":"Indian J. Dermatol."},{"key":"10.1016\/j.exppara.2026.109133_bib6","article-title":"Topical paromomycin with or without gentamicin for cutaneous leishmaniasis","author":"Ben","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.exppara.2026.109133_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens13050416","article-title":"Improved treatment outcome following the use of a wound dressings in cutaneous leishmaniasis lesions","author":"Borba","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.exppara.2026.109133_bib9","doi-asserted-by":"crossref","DOI":"10.1089\/jir.2015.0043","article-title":"IFN-\u03b3-Dependent recruitment of CD4(+) T cells and macrophages contributes to pathogenesis during Leishmania amazonensis infection","author":"Carneiro","year":"2015","journal-title":"J. Interferon Cytokine Res."},{"issue":"4","key":"10.1016\/j.exppara.2026.109133_bib10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/tmi.13210","article-title":"American tegumentary leishmaniasis in Brazil: a critical review of the current therapeutic approach with systemic meglumine antimoniate and short-term possibilities for an alternative treatment","volume":"24","author":"Carvalho","year":"2019","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.exppara.2026.109133_bib11","first-page":"399","article-title":"Current scenario of drug development for leishmaniasis","volume":"123","author":"Croft","year":"2006","journal-title":"Indian J. Med. Res."},{"issue":"6","key":"10.1016\/j.exppara.2026.109133_bib12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s40257-022-00726-8","article-title":"Cutaneous leishmaniasis: a 2022 updated narrative review into diagnosis and management developments","volume":"23","author":"de Vries","year":"2022","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.exppara.2026.109133_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2024.108886","article-title":"Exploring the binomial BALB\/c-Leishmania (Viannia) braziliensis model to assess the in vivo performance of thor strain subpopulations","volume":"269","author":"Dias-Lopes","year":"2025","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2026.109133_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biochi.2025.03.007","article-title":"Molecular and biochemical approaches of the trypanothione system in Leishmania spp.: a key player in parasite resistance to antimonial therapy","volume":"234","author":"Dias-Lopes","year":"2025","journal-title":"Biochimie"},{"issue":"6","key":"10.1016\/j.exppara.2026.109133_bib15","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1590\/0037-8682-0104-2013","article-title":"Treatment of American tegumentary leishmaniasis in special populations: a summary of evidence","volume":"46","author":"Fontenele","year":"2013","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.exppara.2026.109133_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.12703\/r\/9-28","article-title":"An overview of the treatment of cutaneous leishmaniasis","volume":"9","author":"Garza-Tovar","year":"2020","journal-title":"Fac Rev"},{"key":"10.1016\/j.exppara.2026.109133_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/DDDT.S146521","article-title":"Leishmaniasis in humans: drug or vaccine therapy?","volume":"12","author":"Ghorbani","year":"2017","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.exppara.2026.109133_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2023.108547","article-title":"Assessing nystatin cream treatment efficacy against Leishmania (L.) amazonensis infection in BALB\/c model","volume":"250","author":"Gon\u00e7alves-Oliveira","year":"2023","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2026.109133_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijpddr.2019.08.002","article-title":"The combination therapy of meglumine antimoniate and oxiranes (epoxy-\u03b1-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis","volume":"10","author":"Gon\u00e7alves-Oliveira","year":"2019","journal-title":"Int J Parasitol Drugs Drug Resist"},{"issue":"2","key":"10.1016\/j.exppara.2026.109133_bib20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.actatropica.2004.10.007","article-title":"Activity of a paromomycin hydrophilic formulation for topical treatment of infections by Leishmania (Leishmania) amazonensis and Leishmania (vVannia) braziliensis","volume":"93","author":"Gon\u00e7alves","year":"2005","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2026.109133_bib21","doi-asserted-by":"crossref","unstructured":"Guerra, J.A., Prestes, S.R., Silveira, H., Coelho, L.I., Gama, P., Moura, A. Amato, V. Barbosa, Md. Ferreira, L.C., 2011. Mucosal Leishmaniasis caused by Leishmania (Viannia) braziliensis and Leishmania (Viannia) guyanensis in the Brazilian amazon. PLoS Neglected Trop. Dis. 5 (3), e980. doi:10.1371\/journal.pntd.0000980.","DOI":"10.1371\/journal.pntd.0000980"},{"issue":"2","key":"10.1016\/j.exppara.2026.109133_bib22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2307\/3285646","article-title":"Successful topical treatment of murine cutaneous leishmaniasis with a combination of paromomycin (Aminosidine) and gentamicin","volume":"85","author":"Grogl","year":"1999","journal-title":"J. Parasitol."},{"issue":"4","key":"10.1016\/j.exppara.2026.109133_bib23","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1128\/IAI.70.4.2151-2158.2002","article-title":"Early enhanced Th1 response after Leishmania amazonensis infection of C57BL\/6 interleukin-10-deficient mice does not lead to resolution of infection","volume":"70","author":"Jones","year":"2002","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.exppara.2026.109133_bib24","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.4049\/jimmunol.166.2.1141","article-title":"The role of IL-10 in promoting disease progression in leishmaniasis","volume":"166","author":"Kane","year":"2001","journal-title":"J. Immunol."},{"issue":"Pt 1","key":"10.1016\/j.exppara.2026.109133_bib25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1042\/bj20030544","article-title":"Identification of new leishmanicidal peptide lead structures by automated real-time monitoring of changes in intracellular ATP","volume":"375","author":"Luque-Ortega","year":"2003","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.exppara.2026.109133_bib26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1590\/abd1806-4841.20198388","article-title":"American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure","volume":"94","author":"Marques","year":"2019","journal-title":"An. Bras. Dermatol."},{"issue":"2","key":"10.1016\/j.exppara.2026.109133_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.actatropica.2011.02.007","article-title":"Systematic review of the adverse effects of cutaneous leishmaniasis treatment in the New world","volume":"118","author":"Oliveira","year":"2011","journal-title":"Acta Trop."},{"issue":"13","key":"10.1016\/j.exppara.2026.109133_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2369-13-44","article-title":"Renal function evaluation in patients with American cutaneous leishmaniasis after specific treatment with pentavalent antimonial","volume":"20","author":"Oliveira","year":"2012","journal-title":"BMC Nephrol."},{"issue":"4","key":"10.1016\/j.exppara.2026.109133_bib29","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3390\/molecules23040864","article-title":"Antileishmanial activity of 2-Methoxy-4H-spiro-[naphthalene-1,2'-oxiran]-4-one (Epoxymethoxy-lawsone): a promising new drug candidate for leishmaniasis treatment","volume":"23","author":"Oliveira","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.exppara.2026.109133_bib30","series-title":"Leishmaniasis En Las Americas: Recomendaciones Para El Tratamiento. Washington, DC","year":"2013"},{"key":"10.1016\/j.exppara.2026.109133_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpddr.2024.100525","article-title":"Efficacy of the treatment using a microemulsion loaded with epoxy-\u03b1-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis","volume":"24","author":"Peixoto","year":"2024","journal-title":"Int J Parasitol Drugs Drug Resist"},{"issue":"4","key":"10.1016\/j.exppara.2026.109133_bib32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.vetpar.2008.09.015","article-title":"Immunological characteristics of experimental murine infection with Leishmania (Leishmania) amazonensis","volume":"158","author":"Pereira","year":"2008","journal-title":"Vet. Parasitol."},{"issue":"21","key":"10.1016\/j.exppara.2026.109133_bib33","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1007\/s00253-020-10856-w","article-title":"Recent advances and new strategies on leishmaniasis treatment","volume":"104","author":"Roatt","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.exppara.2026.109133_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1590\/S0036-46651999000100007","article-title":"Nephrotoxicity attributed to meglumine antimoniate (Glucantime) in the treatment of generalized cutaneous leishmaniasis","volume":"41","author":"Rodrigues","year":"1999","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"issue":"5","key":"10.1016\/j.exppara.2026.109133_bib35","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.exppara.2026.109133_bib36","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/jac\/dks117","article-title":"Pharmacokinetics, tissue distribution, and immunomodulatory effect of intralipid formulation of nystatin in mice","volume":"67","author":"Semis","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"issue":"4","key":"10.1016\/j.exppara.2026.109133_bib37","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.bjid.2013.11.013","article-title":"Kidney involvement in leishmaniasis: a review","volume":"18","author":"Silva Junior","year":"2014","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.exppara.2026.109133_bib38","doi-asserted-by":"crossref","first-page":"114969","DOI":"10.1016\/j.addr.2023.114969","article-title":"Reviving the interest in the versatile drug nystatin: a multitude of strategies to increase its potential as an effective and safe antifungal agent","volume":"199","author":"Sousa","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.exppara.2026.109133_bib39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1517\/14656566.2015.973850","article-title":"An update on pharmacotherapy for leishmaniasis","volume":"16","author":"Sundar","year":"2015","journal-title":"Expet Opin. Pharmacother."},{"issue":"4","key":"10.1016\/j.exppara.2026.109133_bib40","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.micinf.2005.09.018","article-title":"Inflammatory lesion and parasite load are inversely associated in Leishmania amazonensis infected mice genetically selected according to oral tolerance susceptibility","volume":"8","author":"Tavares","year":"2006","journal-title":"Microb. Infect."},{"key":"10.1016\/j.exppara.2026.109133_bib41","doi-asserted-by":"crossref","DOI":"10.1007\/s00232-025-00354-3","article-title":"Passage of the channel-forming agent nystatin through ergosterol-containing lipid membranes","author":"Tinev","year":"2025","journal-title":"J. Membr. Biol."},{"issue":"4","key":"10.1016\/j.exppara.2026.109133_bib42","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1017\/S0031182016002523","article-title":"Chemotherapy of leishmaniasis: present challenges","volume":"145","author":"Uliana","year":"2018","journal-title":"Parasitology"},{"issue":"4","key":"10.1016\/j.exppara.2026.109133_bib43","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.179.4.1367","article-title":"CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major","volume":"179","author":"Wang","year":"1994","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.exppara.2026.109133_bib44","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1128\/JCM.r00764-11","article-title":"Serial quantitative PCR assay for detection, species discrimination, and quantification of Leishmania spp. in human samples","volume":"49","author":"Weirather","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.exppara.2026.109133_bib45","series-title":"Control of the Leishmaniases: Report of a Meeting of the WHO Expert Committee on the Control of Leishmaniases","year":"2010"},{"issue":"38","key":"10.1016\/j.exppara.2026.109133_bib46","doi-asserted-by":"crossref","first-page":"39925","DOI":"10.1074\/jbc.M405635200","article-title":"Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani","volume":"279","author":"Wyllie","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"27","key":"10.1016\/j.exppara.2026.109133_bib47","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.2174\/1568026619666181220114627","article-title":"Activity of fenticonazole, tioconazole and Nystatin on new world Leishmania species","volume":"18","author":"Yamamoto","year":"2018","journal-title":"Curr. Top. Med. Chem."},{"issue":"6","key":"10.1016\/j.exppara.2026.109133_bib48","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00775-003-0468-1","article-title":"Reduction of pentavalent antimony by trypanothione and formation of a binary and ternary complex of antimony (III) and trypanothione","volume":"8","author":"Yan","year":"2003","journal-title":"J Biol Inorg Chem"}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489426000408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014489426000408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:27:24Z","timestamp":1777404444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014489426000408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":48,"alternative-id":["S0014489426000408"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2026.109133","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination treatment of topical nystatin and systemic meglumine antimoniate in the BALB\/c - Leishmania (Leishmania) amazonensis model","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2026.109133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109133"}}