{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:46:14Z","timestamp":1792039574065,"version":"4.4.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["403278\/2023-6"],"award-info":[{"award-number":["403278\/2023-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007375","name":"Pr\u00f3-Reitoria de Pesquisa, Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02628-24"],"award-info":[{"award-number":["APQ-02628-24"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Experimental Parasitology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.exppara.2026.109220","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:40:16Z","timestamp":1791330016000},"page":"109220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Biomarkers of experimental Toxocara canis infection are context-dependent: A systematic review of murine models"],"prefix":"10.1016","volume":"290","author":[{"given":"Andressa Mariana","family":"Saldanha-Elias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Laura","family":"Grossi de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Lucas Nascimento","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Toshio","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa Mour\u00e3o Dias","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Lacerda","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.exppara.2026.109220_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2025.109082","article-title":"Histopathological changes, dynamics of macrophage polarization and deposition of type I and III collagen along the course of experimental hepatic toxocariasis","volume":"280","author":"Abou-El-Naga","year":"2026","journal-title":"Exp. Parasitol."},{"issue":"4","key":"10.1016\/j.exppara.2026.109220_bib2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1007\/s11686-024-00869-0","article-title":"Neurobehavioral disorders and pathological changes in the brain of mice are caused by chronic Toxocara canis larval invasion with low to moderate inoculum","volume":"69","author":"Bernardov\u00e1","year":"2024","journal-title":"Acta Parasitol."},{"issue":"e14","key":"10.1016\/j.exppara.2026.109220_bib3","article-title":"Toxocara canis infections in mice: from subtle to severe consequences in 100 weeks","volume":"99","author":"Bernardov\u00e1","year":"2025","journal-title":"J. Helminthol."},{"issue":"4","key":"10.1016\/j.exppara.2026.109220_bib4","doi-asserted-by":"crossref","DOI":"10.1590\/s1984-29612022056","article-title":"Acute and chronic immunomodulatory response mechanisms against Toxocara canis larvae infection in mice","volume":"31","author":"Borchard","year":"2022","journal-title":"Rev. Bras. Parasitol. Vet."},{"key":"10.1016\/j.exppara.2026.109220_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-3024.1994.tb00297.x","article-title":"Toxocara canis-induced murine pulmonary inflammation: analysis of cells and proteins in lung tissue and bronchoalveolar lavage fluid","volume":"16","author":"Buijs","year":"1994","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.exppara.2026.109220_bib6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0304-4017(92)90068-K","article-title":"Renal involvement in mice experimentally infected with Toxocara canis embryonated eggs","volume":"42","author":"Casarosa","year":"1992","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2026.109220_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40249-018-0437-0","article-title":"Toxocariasis: a silent threat with a progressive public health impact","volume":"7","author":"Chen","year":"2018","journal-title":"Infect. Dis. Poverty"},{"key":"10.1016\/j.exppara.2026.109220_bib8","first-page":"187","volume":"37","author":"Chieffi","year":"1995"},{"key":"10.1016\/j.exppara.2026.109220_bib9","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1186\/s13071-017-2578-6","article-title":"Enhanced neurodegeneration-associated factors in mice infected with Toxocara canis","volume":"10","author":"Chou","year":"2017","journal-title":"Parasites Vectors"},{"issue":"1","key":"10.1016\/j.exppara.2026.109220_bib10","article-title":"Dynamics of ex vivo cytokine transcription during experimental Toxocara canis infection in Balb\/c mice","volume":"33","author":"Conrad","year":"2024","journal-title":"Braz. J. Vet. Parasitol."},{"issue":"12","key":"10.1016\/j.exppara.2026.109220_bib11","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/s004360050678","article-title":"Immunomodulative effect of muramyldipeptide in mice with larval toxocarosis","volume":"85","author":"Dvoro\u017e\u0148\u00e1kov\u00e1","year":"1999","journal-title":"Parasitol. Res."},{"issue":"1","key":"10.1016\/j.exppara.2026.109220_bib12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3347\/kjp.2015.53.1.51","article-title":"Immunopathological changes in the brain of immunosuppressed mice experimentally infected with Toxocara canis","volume":"53","author":"Eid","year":"2015","journal-title":"Kor. J. Parasitol."},{"key":"10.1016\/j.exppara.2026.109220_bib13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/pim.12311","article-title":"Evaluation of a di-O-methylated glycan as a potential antigenic target for serodiagnosis of human toxocariasis","volume":"38","author":"Elefant","year":"2016","journal-title":"Parasite Immunol."},{"issue":"8","key":"10.1016\/j.exppara.2026.109220_bib14","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/BF00932955","article-title":"The behavior and pathogenicity of Toxacara canis larvae in mice of different strains","volume":"80","author":"Epe","year":"1994","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2026.109220_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-4017(03)00046-3","article-title":"Infectivity and pathogenicity of 14-month-cultured embryonated eggs of Toxocara canis in mice","volume":"113","author":"Fan","year":"2003","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2026.109220_bib16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00436-004-1233-2","article-title":"Enhanced expression of transforming growth factor-\u03b21 in inflammatory cells and secretory granules in Paneth cells in the small intestine of mice infected with Toxocara canis","volume":"94","author":"Fan","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2026.109220_bib17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.0141-9838.2004.00708.x","article-title":"Enhanced inducible nitric oxide synthase expression and nitrotyrosine accumulation in experimental granulomatous hepatitis caused by Toxocara canis in mice","volume":"26","author":"Fan","year":"2004","journal-title":"Parasite Immunol."},{"issue":"4","key":"10.1016\/j.exppara.2026.109220_bib18","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0934-8840(11)80720-6","article-title":"Relationship between parasitical inoculum and immunological parameters in experimental toxocariasis","volume":"282","author":"Farjat","year":"1995","journal-title":"Zentralbl. Bakteriol."},{"key":"10.1016\/j.exppara.2026.109220_bib19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3390\/pathogens8040280","article-title":"A dual role for macrophages during Toxocara canis infection","volume":"8","author":"Faz-L\u00f3pez","year":"2019","journal-title":"Pathogens"},{"issue":"5","key":"10.1016\/j.exppara.2026.109220_bib80","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1590\/0074-02760160341","article-title":"Experimental toxocariasis in BALB\/c mice: relationship between parasite inoculum and the IgG immune response","volume":"112","author":"Fonseca","year":"2017","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"2","key":"10.1016\/j.exppara.2026.109220_bib20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/bjo.68.2.89","article-title":"Experimental ocular toxocariasis: a mouse model","volume":"68","author":"Gh\u0430foor","year":"1984","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.exppara.2026.109220_bib21","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-3024.2007.01002.x","article-title":"Cytokine expression in the brains of Toxocara canis-infected mice","volume":"30","author":"Hamilton","year":"2008","journal-title":"Parasite Immunol."},{"issue":"6","key":"10.1016\/j.exppara.2026.109220_bib22","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.4269\/ajtmh.20-0484","article-title":"Evidence for asthma in the lungs of mice inoculated with different doses of Toxocara canis","volume":"103","author":"Hanh","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.exppara.2026.109220_bib23","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1007\/s00436-015-4407-1","article-title":"Neurotoxocarosis alters myelin protein gene transcription and expression","volume":"114","author":"Heuer","year":"2015","journal-title":"Parasitol. Res."},{"issue":"3","key":"10.1016\/j.exppara.2026.109220_bib24","first-page":"239","article-title":"Effects of Toxocara canis infection on hemopoietic stem cells and hemopoietic factors in mice","volume":"91","author":"Higa","year":"1990","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1016\/j.exppara.2026.109220_bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.exppara.2026.109220_bib26","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/1756-3305-7-194","article-title":"Neurotoxocarosis: marked preference of Toxocara canis for the cerebrum and T. cati for the cerebellum in the paratenic model host mouse","volume":"7","author":"Janecek","year":"2014","journal-title":"Parasites Vectors"},{"issue":"7","key":"10.1016\/j.exppara.2026.109220_bib27","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ijpara.2015.02.009","article-title":"Microarray gene expression analysis reveals major differences between Toxocara canis and Toxocara cati neurotoxocarosis and involvement of T. canis in lipid biosynthetic processes","volume":"45","author":"Janecek","year":"2015","journal-title":"Int. J. Parasitol."},{"issue":"5","key":"10.1016\/j.exppara.2026.109220_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005594","article-title":"Abnormal neurobehaviour and impaired memory function as a consequence of Toxocara canis- as well as Toxocara cati-induced neurotoxocarosis","volume":"11","author":"Janecek","year":"2017","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2026.109220_bib29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/expr.1994.1006","article-title":"Toxocara canis: failure to find IgE receptors (Fc\u03b5R) on eosinophils from infected mice suggests that murine eosinophils do not kill helminth larvae by an IgE-dependent mechanism","volume":"78","author":"Jones","year":"1994","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2026.109220_bib30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11686-024-00940-w","article-title":"Analysis of seroreactivity and seropositivity in BALB\/c mice experimentally infected with Toxocara canis using two recombinant (rTc-CTL-1 and rTES-120) antigens","volume":"70","author":"Kavitha","year":"2025","journal-title":"Acta Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2026.109220_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0090-1229(86)90051-6","article-title":"Nonspecific allergic granulomatosis in the lungs of mice infected with large but not small inocula of the canine ascarid, Toxocara canis","volume":"41","author":"Kayes","year":"1986","journal-title":"Clin. Immunol. Immunopathol."},{"issue":"1","key":"10.1016\/j.exppara.2026.109220_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-4894(80)90055-7","article-title":"Toxocara canis: t lymphocyte function in murine visceral larva migrans and eosinophilia onset","volume":"49","author":"Kayes","year":"1980","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2026.109220_bib32","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/iai.48.3.697-703.1985","article-title":"Immune responses of CBA\/J mice to graded infections with Toxocara canis","volume":"48","author":"Kayes","year":"1985","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.exppara.2026.109220_bib34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3347\/PHD.23125","article-title":"Organ-specific Toxocara canis larvae migration and host immune response in experimentally infected mice. Parasites","volume":"62","author":"Kim","year":"2024","journal-title":"Hosts Dis."},{"issue":"3","key":"10.1016\/j.exppara.2026.109220_bib35","first-page":"461","article-title":"Mechanisms of eosinophilia in BALB\/c-nu\/+ and congenitally athymic BALB\/c-nu\/nu mice infected with Toxocara canis","volume":"84","author":"Kusama","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/j.exppara.2026.109220_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-22711-x","article-title":"COX-2\/PGE2 signaling drives Toxocara canis-induced lung pathology by enhancing plasminogen activator activity and collagen VI degradation","volume":"15","author":"Lai","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.exppara.2026.109220_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009639","article-title":"Detrimental role of IL-33\/ST2 pathway sustaining a chronic eosinophil-dependent Th2 inflammatory response, tissue damage and parasite burden during Toxocara canis infection in mice","volume":"15","author":"Leal-Silva","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.exppara.2026.109220_bib39","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1017\/S0031182022000075","article-title":"Tissue eosinophilia correlates with mice susceptibility, granuloma formation and damage during Toxocara canis infection","volume":"149","author":"Leal-Silva","year":"2022","journal-title":"Parasitology"},{"key":"10.1016\/j.exppara.2026.109220_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.864632","article-title":"IL-17RA receptor signaling contributes to lung inflammation and parasite burden during Toxocara canis infection in mice","volume":"13","author":"Leal-Silva","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.exppara.2026.109220_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1597778","article-title":"Characteristics of Toxocara canis induced lung inflammation in C57BL\/6 mice","volume":"16","author":"Lekki-J\u00f3\u017awiak","year":"2025","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.exppara.2026.109220_bib41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1590\/S0036-46652012000300006","article-title":"IgG antibody responses in mice coinfected with Toxocara canis and other helminths or protozoan parasites","volume":"54","author":"Lescano","year":"2012","journal-title":"Rev. do Inst. Med. Trop. S\u00e3o Paulo"},{"issue":"6","key":"10.1016\/j.exppara.2026.109220_bib42","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.jmii.2020.07.022","article-title":"Matrix metalloproteinases activation in Toxocara canis-induced pulmonary pathogenesis","volume":"54","author":"Lu","year":"2021","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.exppara.2026.109220_bib43","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.rvsc.2015.09.002","article-title":"Short communication: experimental toxocarosis in Chinese Kun Ming mice: dose-dependent larval distribution and modulation of immune responses","volume":"103","author":"Ma","year":"2015","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.exppara.2026.109220_bib44","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/01.STR.0000125719.25853.20","article-title":"Pooling of animal experimental data reveals influence of study design and publication bias","volume":"35","author":"Macleod","year":"2004","journal-title":"Stroke"},{"issue":"12\u201313","key":"10.1016\/j.exppara.2026.109220_bib45","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.ijpara.2013.07.004","article-title":"The epidemiology and public health importance of toxocariasis: a zoonosis of global importance","volume":"43","author":"Macpherson","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.exppara.2026.109220_bib46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.actatropica.2018.07.017","article-title":"Detection of Toxocara canis DNA in tissues of experimentally infected mice","volume":"187","author":"Moura","year":"2018","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2026.109220_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2020.102134","article-title":"Quantification of Toxocara canis DNA by qPCR in mice inoculated with different infective doses","volume":"78","author":"Moura","year":"2020","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.exppara.2026.109220_bib48","first-page":"131","article-title":"Serodiagnostic methods for diagnosing larval toxocariasis","volume":"109","author":"Noordin","year":"2020"},{"issue":"13","key":"10.1016\/j.exppara.2026.109220_bib50","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1017\/S0031182022001238","article-title":"Toxocara canis infection worsens the course of experimental autoimmune encephalomyelitis in mice","volume":"149","author":"Nov\u00e1k","year":"2022","journal-title":"Parasitology"},{"issue":"4","key":"10.1016\/j.exppara.2026.109220_bib49","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1515\/ap-2017-0099","article-title":"Humoral response of mice infected with Toxocara canis following different infection schemes","volume":"62","author":"Nov\u00e1k","year":"2017","journal-title":"Acta Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2026.109220_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2010.03.006","article-title":"Biochemical and immunopathological changes in experimental neurotoxocariasis","volume":"172","author":"Othman","year":"2010","journal-title":"Mol. Biochem. Parasitol."},{"issue":"1","key":"10.1016\/j.exppara.2026.109220_bib52","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exppara.2013.02.001","article-title":"Toxocara-induced hepatic inflammation: immunohistochemical characterization of lymphocyte subpopulations and Bcl-2 expression","volume":"134","author":"Othman","year":"2013","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.exppara.2026.109220_bib53","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014A web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev."},{"issue":"2","key":"10.1016\/j.exppara.2026.109220_bib54","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s004360050370","article-title":"Production of eosinophil chemotactic factor by CD8+ T-cells in Toxocara canis-infected mice","volume":"84","author":"Owhashi","year":"1998","journal-title":"Parasitol. Res."},{"issue":"71","key":"10.1016\/j.exppara.2026.109220_bib55","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.exppara.2026.109220_bib56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.vetpar.2005.06.022","article-title":"Influence of murine Toxocara canis infection on plasma and bronchoalveolar lavage fluid eosinophil numbers and its correlation with cytokine levels","volume":"134","author":"Pecinali","year":"2005","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.exppara.2026.109220_bib57","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1365-2222.2005.02250.x","article-title":"Persistent airway hyper-responsiveness and inflammation in Toxocara canis-infected BALB\/c mice","volume":"35","author":"Pinelli","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.exppara.2026.109220_bib58","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exppara.2006.06.002","article-title":"Toxocara canis: effect of inoculum size on pulmonary pathology and cytokine expression in BALB\/c mice","volume":"115","author":"Pinelli","year":"2007","journal-title":"Exp. Parasitol."},{"issue":"4","key":"10.1016\/j.exppara.2026.109220_bib59","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1365-2222.2007.02908.x","article-title":"Infection with the roundworm Toxocara canis leads to exacerbation of experimental allergic airway inflammation","volume":"38","author":"Pinelli","year":"2008","journal-title":"Clin. Exp. Allergy"},{"issue":"7","key":"10.1016\/j.exppara.2026.109220_bib61","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1365-3024.2003.00642.x","article-title":"Influence of maternal infection on offspring immune response in murine larval toxocariasis","volume":"25","author":"Reiterov\u00e1","year":"2003","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.exppara.2026.109220_bib60","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s13071-015-0962-7","article-title":"New insights into the immunopathology of early Toxocara canis infection in mice","volume":"8","author":"Resende","year":"2015","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.exppara.2026.109220_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2019.104002","article-title":"Human toxocariasis \u2013 a look at a neglected disease through an epidemiological \u2018prism\u2019","volume":"74","author":"Rostami","year":"2019","journal-title":"Infect. Genet. Evol."},{"issue":"1","key":"10.1016\/j.exppara.2026.109220_bib64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1179\/136485910X12607012373957","article-title":"Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms","volume":"104","author":"Rubinsky-Elefant","year":"2010","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.exppara.2026.109220_bib65","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12672","article-title":"Immune response to chronic Toxocara canis infection in a mice model","volume":"41","author":"Ruiz-Manzano","year":"2019","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.exppara.2026.109220_bib66","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00436-018-06196-4","article-title":"MMP-2\/MMP-9 ocular toxocariasis","volume":"118","author":"Shyu","year":"2019","journal-title":"Parasitol. Res."},{"issue":"4","key":"10.1016\/j.exppara.2026.109220_bib67","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pt.2009.01.006","article-title":"How common is human toxocariasis? Towards standardizing our knowledge","volume":"25","author":"Smith","year":"2009","journal-title":"Trends Parasitol."},{"issue":"9","key":"10.1016\/j.exppara.2026.109220_bib68","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1007\/s00436-019-06395-7","article-title":"Histopathological characterization of Toxocara canis- and T. Cati-induced neurotoxocarosis in the mouse model","volume":"118","author":"Springer","year":"2019","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.exppara.2026.109220_bib69","first-page":"189","article-title":"Toxocara-induced neural larva migrans (neurotoxocarosis) in rodent model hosts","volume":"109","author":"Strube","year":"2020"},{"issue":"4","key":"10.1016\/j.exppara.2026.109220_bib70","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0361-9230(83)90153-3","article-title":"Neuropathological studies of experimental toxocariasis in lead exposed mice","volume":"10","author":"Summers","year":"1983","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.exppara.2026.109220_bib71","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2567.1997.00208.x","article-title":"Eosinophilia, parasite burden and lung damage in Toxocara canis infection in C57BL\/6 mice genetically deficient in IL-5","volume":"90","author":"Takamoto","year":"1997","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.exppara.2026.109220_bib72","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1046\/j.1365-2567.1998.00616.x","article-title":"The role of ICAM-1\/LFA-1 and VCAM-1\/VLA-4 interactions on T helper 2 cytokine production by lung T cells of Toxocara canis-infected mice","volume":"95","author":"Takamoto","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/j.exppara.2026.109220_bib73","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1051\/parasite\/2025019","article-title":"No evidence of Alzheimer's disease pathology in mice infected with Toxocara canis","volume":"32","author":"Vos\u00e1la","year":"2025","journal-title":"Parasite"},{"issue":"9","key":"10.1016\/j.exppara.2026.109220_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007706","article-title":"Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis","volume":"13","author":"Waindok","year":"2019","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"1","key":"10.1016\/j.exppara.2026.109220_bib76","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/microorganisms10010177","article-title":"Toxocara canis- and Toxocara cati-induced neurotoxocarosis is associated with comprehensive brain transcriptomic alterations","volume":"10","author":"Waindok","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.exppara.2026.109220_bib74","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12974-019-1537-x","article-title":"Neuroinvasion of Toxocara canis and T. cati larvae mediates dynamic changes in brain cytokine and chemokine profile","volume":"16","author":"Waindok","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.exppara.2026.109220_bib77","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.actatropica.2007.11.005","article-title":"Enhanced expression of transforming growth factor-\u03b21 in inflammatory cells, \u03b1-smooth muscle actin in stellate cells, and collagen accumulation in experimental granulomatous hepatitis caused by Toxocara canis in mice","volume":"105","author":"Wu","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/j.exppara.2026.109220_bib78","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s13071-024-06327-0","article-title":"Alterations of plasma circulating microRNAs in BALB\/c mice with Toxocara canis visceral and cerebral larva migrans","volume":"17","author":"Yang","year":"2024","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.exppara.2026.109220_bib79","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.1038\/s41467-026-72114-3","article-title":"Spatial transcriptomic atlas of murine neurotoxocariasis reveals region-specific host responses and dysfunction in the brain","volume":"17","author":"Zou","year":"2026","journal-title":"Nat. Commun."}],"container-title":["Experimental Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448942600127X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001448942600127X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:04:37Z","timestamp":1792037077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001448942600127X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":79,"alternative-id":["S001448942600127X"],"URL":"https:\/\/doi.org\/10.1016\/j.exppara.2026.109220","relation":{},"ISSN":["0014-4894"],"issn-type":[{"value":"0014-4894","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarkers of experimental Toxocara canis infection are context-dependent: A systematic review of murine models","name":"articletitle","label":"Article Title"},{"value":"Experimental Parasitology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.exppara.2026.109220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109220"}}