{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:03:23Z","timestamp":1789646603430,"version":"4.0.0"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Farmacia Hospitalaria"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.farma.2026.05.004","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:30:14Z","timestamp":1789644614000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-world adherence and effectiveness of lipid-lowering biological therapy in a Spanish cohort: an observational cross-sectional study"],"prefix":"10.1016","author":[{"given":"Thais Lizondo","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnau Torrent","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e0lia Arranz","family":"Pasqual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n Gonz\u00e1lez","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n L\u00f3pez","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Carolina Pazmi\u00f1o","family":"Chango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Balaguer","family":"Romeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolors Soy","family":"Muner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite Mart\u00edn","family":"Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.farma.2026.05.004_bb0005","doi-asserted-by":"crossref","first-page":"403.e1","DOI":"10.1016\/j.recesp.2019.10.031","article-title":"Gu\u00eda ESC\/EAS 2019 sobre el tratamiento de las dislipemias: modificaci\u00f3n de los l\u00edpidos para reducir el riesgo cardiovascular","volume":"73","author":"Mach","year":"2020","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.farma.2026.05.004_bb0010","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41569-019-0325-8","article-title":"Familial hypercholesterolaemia: evolving knowledge for designing adaptive models of care","volume":"17","author":"Watts","year":"2020","journal-title":"Nat Rev Cardiol"},{"issue":"19","key":"10.1016\/j.farma.2026.05.004_bb0015","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.2015.15629","article-title":"Statins for prevention of cardiovascular disease in adults: evidence report and systematic review for the US preventive services task force","volume":"316","author":"Chou","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.farma.2026.05.004_bb0030","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/phar.4635","article-title":"Current and emerging PCSK9-directed therapies to reduce LDL-C and ASCVD risk: a state-of-the-art review","volume":"45","author":"Garwood","year":"2025","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.farma.2026.05.004_bb0035","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4330\/wjc.v9.i2.76","article-title":"PCSK9 inhibitors: a new era of lipid lowering therapy","volume":"9","author":"Chaudhary","year":"2017","journal-title":"World J Cardiol"},{"key":"10.1016\/j.farma.2026.05.004_bb0040","first-page":"690","article-title":"Validation on the simplified medication adherence questionnaire (SMAQ) in renal transplant patients on tacrolimus","volume":"31","author":"Ortega Su\u00e1rez","year":"2011","journal-title":"Nefrologia"},{"key":"10.1016\/j.farma.2026.05.004_bb0045","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/00002030-200203080-00012","article-title":"Validation of a simplified medication adherence questionnaire in a large cohort of HIV-infected patients: the GEEMA study","volume":"16","author":"Knobel","year":"2002","journal-title":"AIDS"},{"key":"10.1016\/j.farma.2026.05.004_bb0050","doi-asserted-by":"crossref","DOI":"10.1186\/s40545-021-00385-w","article-title":"Estimating proportion of days covered (PDC) using real-world online medicine suppliers' datasets","volume":"14","author":"Prieto-Merino","year":"2021","journal-title":"J Pharm Policy Pract"},{"key":"10.1016\/j.farma.2026.05.004_bb0055","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1345\/aph.1K264","article-title":"Adherence analysis using visual analog scale versus claims-based estimation","volume":"41","author":"Nau","year":"2007","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.farma.2026.05.004_bb0060","first-page":"574","article-title":"Proportion and risk indicators of nonadherence to statin therapy: a meta-analysis","volume":"28","author":"Lemstra","year":"2012","journal-title":"Can J Cardiol"},{"issue":"Suppl 1","key":"10.1016\/j.farma.2026.05.004_bb0065","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.3909\/ricm19S1S0005","article-title":"Statin intolerance","volume":"19","author":"Brown","year":"2018","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.farma.2026.05.004_bb0070","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5551\/jat.RV17030","article-title":"Diagnosis and management of statin intolerance","volume":"26","author":"Alonso","year":"2019","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.farma.2026.05.004_bb0075","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1089\/jwh.2012.3972","article-title":"Influence of patient sex and gender on medication use, adherence, and prescribing alignment with guidelines","volume":"23","author":"Manteuffel","year":"2014","journal-title":"J Women's Health"},{"key":"10.1016\/j.farma.2026.05.004_bb0080","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1331\/1544345053623573","article-title":"Concordance among three self-reported measures of medication adherence and pharmacy refill records","volume":"45","author":"Cook","year":"2005","journal-title":"J Am Pharm Assoc"},{"key":"10.1016\/j.farma.2026.05.004_bb0085","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1093\/eurheartj\/eht295","article-title":"Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences","volume":"34","author":"Chowdhury","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.farma.2026.05.004_bb0090","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.clinthera.2021.02.002","article-title":"Effectiveness, safety, and adherence to treatment of proprotein convertase subtilisin\/kexin type 9 inhibitors in real practice","volume":"43","author":"Gayoso-Rey","year":"2021","journal-title":"Clin Ther"}],"container-title":["Farmacia Hospitalaria"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1130634326001169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1130634326001169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:30:17Z","timestamp":1789644617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1130634326001169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":16,"alternative-id":["S1130634326001169"],"URL":"https:\/\/doi.org\/10.1016\/j.farma.2026.05.004","relation":{},"ISSN":["1130-6343"],"issn-type":[{"value":"1130-6343","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Real-world adherence and effectiveness of lipid-lowering biological therapy in a Spanish cohort: an observational cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Farmacia Hospitalaria","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.farma.2026.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Sociedad Espa\u00f1ola de Farmacia Hospitalaria (S.E.F.H). Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}]}}