{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T23:57:32Z","timestamp":1761177452397,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Foot and Ankle Surgery"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.fas.2022.02.015","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T22:48:52Z","timestamp":1645742932000},"page":"1050-1054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic contribution to the etiology of Achilles tendon rupture. A Danish nationwide register study of twins"],"prefix":"10.1016","volume":"28","author":[{"given":"Allan","family":"Cramer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristoffer Weisskirchner","family":"Barfod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"H\u00f6lmich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorthe Almind","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaare","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fas.2022.02.015_bib1","first-page":"B4837","article-title":"Achilles tendon rupture; assessment of nonoperative treatment","volume":"61","author":"Barfod","year":"2014","journal-title":"Dan Med J"},{"key":"10.1016\/j.fas.2022.02.015_bib2","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1177\/0363546514540599","article-title":"Acute achilles tendon ruptures: incidence of injury and surgery in Sweden between 2001 and 2012","volume":"42","author":"Huttunen","year":"2014","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.fas.2022.02.015_bib3","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1007\/s00167-015-3544-5","article-title":"Increasing incidence of acute Achilles tendon rupture and a noticeable decline in surgical treatment from 1994 to 2013. A nationwide registry study of 33,160 patients","volume":"24","author":"Ganestam","year":"2016","journal-title":"Knee Surg Sports Trauma Arthrosc"},{"key":"10.1016\/j.fas.2022.02.015_bib4","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s00167-011-1511-3","article-title":"Major functional deficits persist 2 years after acute Achilles tendon rupture","volume":"19","author":"Olsson","year":"2011","journal-title":"Knee Surg Sports Trauma Arthrosc"},{"key":"10.1016\/j.fas.2022.02.015_bib5","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1007\/s00167-018-4953-z","article-title":"Cost-effectiveness analysis of surgical versus non-surgical management of acute Achilles tendon ruptures","volume":"26","author":"Westin","year":"2018","journal-title":"Knee Surg Sports Trauma Arthrosc"},{"key":"10.1016\/j.fas.2022.02.015_bib6","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1007\/s00167-014-3180-5","article-title":"Functional rehabilitation of patients with acute Achilles tendon rupture: a meta-analysis of current evidence","volume":"24","author":"Mark-Christensen","year":"2016","journal-title":"Knee Surg Sports Trauma Arthrosc"},{"key":"10.1016\/j.fas.2022.02.015_bib7","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2106\/00004623-199173100-00009","article-title":"Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patients","volume":"73","author":"Kannus","year":"1991","journal-title":"J Bone Jt Surg Am"},{"key":"10.1016\/j.fas.2022.02.015_bib8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1080\/00016470310013707","article-title":"Spontaneous rupture of the Achilles tendon is preceded by widespread and bilateral tendon damage and ipsilateral inflammation: a clinical and histopathologic study of 60 patients","volume":"74","author":"Cetti","year":"2003","journal-title":"Acta Orthop Scand"},{"key":"10.1016\/j.fas.2022.02.015_bib9","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1136\/bjsports-2017-098161","article-title":"Chronic inflammation is a feature of Achilles tendinopathy and rupture","volume":"52","author":"Dakin","year":"2017","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.fas.2022.02.015_bib10","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/00005768-200112000-00002","article-title":"Ruptured Achilles tendons are significantly more degenerated than tendinopathic tendons","volume":"33","author":"Tallon","year":"2001","journal-title":"Med Sci Sport Exerc"},{"key":"10.1016\/j.fas.2022.02.015_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/1071100712460223","article-title":"Achilles tendon rupture in women","volume":"34","author":"Vosseller","year":"2013","journal-title":"Foot Ankle Int"},{"key":"10.1016\/j.fas.2022.02.015_bib12","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jdiacomp.2016.02.017","article-title":"Achilles or biceps tendon rupture in women and men with type 2 diabetes: a population-based case-control study","volume":"30","author":"Spoendlin","year":"2016","journal-title":"J Diabetes Complicat"},{"key":"10.1016\/j.fas.2022.02.015_bib13","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1001\/archinte.163.15.1801","article-title":"Increased risk of Achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids","volume":"163","author":"Van der Linden","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.fas.2022.02.015_bib14","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3109\/07853890.2015.1074272","article-title":"Oral and inhaled glucocorticoid use and risk of Achilles or biceps tendon rupture: a population-based case-control study","volume":"47","author":"Spoendlin","year":"2015","journal-title":"Ann Med"},{"key":"10.1016\/j.fas.2022.02.015_bib15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1177\/1071100718762089","article-title":"Incidence, risk factors, and treatment of achilles tendon rupture in patients with end-stage renal disease","volume":"39","author":"Humbyrd","year":"2018","journal-title":"Foot Ankle Int"},{"key":"10.1016\/j.fas.2022.02.015_bib16","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00402-012-1476-9","article-title":"Analysis of hereditary and medical risk factors in Achilles tendinopathy and Achilles tendon ruptures: a matched pair analysis","volume":"132","author":"Kraemer","year":"2012","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.fas.2022.02.015_bib17","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1177\/0363546504271986","article-title":"The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with achilles tendon injuries","volume":"33","author":"Mokone","year":"2005","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.fas.2022.02.015_bib18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.mgene.2016.03.007","article-title":"MMP3 and TIMP2 gene variants as predisposing factors for Achilles tendon pathologies: attempted replication study in a British case-control cohort","volume":"9","author":"El Khoury","year":"2016","journal-title":"Meta Gene"},{"key":"10.1016\/j.fas.2022.02.015_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0020-1383(92)90050-3","article-title":"ABO blood groups and musculoskeletal injuries","volume":"23","author":"Kujala","year":"1992","journal-title":"Injury"},{"key":"10.1016\/j.fas.2022.02.015_bib20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1302\/0301-620X.71B2.2494187","article-title":"Distribution of blood groups in patients with tendon rupture. An analysis of 832 cases","volume":"71","author":"Jozsa","year":"1989","journal-title":"J Bone Jt Surg Ser B"},{"key":"10.1016\/j.fas.2022.02.015_bib21","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1017\/thg.2019.72","article-title":"The Danish twin registry: an updated overview","volume":"22","author":"Pedersen","year":"2019","journal-title":"Twin Res Hum Genet"},{"key":"10.1016\/j.fas.2022.02.015_bib22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1375\/136905203322296610","article-title":"Age- and sex-differences in the validity of questionnaire-based zygosity in twins","volume":"6","author":"Christiansen","year":"2003","journal-title":"Twin Res"},{"key":"10.1016\/j.fas.2022.02.015_bib23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish civil registration system","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand J Public Health"},{"key":"10.1016\/j.fas.2022.02.015_bib24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/1403494811401482","article-title":"The Danish national patient register","volume":"39","author":"Lynge","year":"2011","journal-title":"Scand J Public Health"},{"key":"10.1016\/j.fas.2022.02.015_bib25","first-page":"A5548","article-title":"Completeness and data validity in the Danish Achilles tendon Database","volume":"66","author":"Cramer","year":"2019","journal-title":"Dan Med J"},{"key":"10.1016\/j.fas.2022.02.015_bib26","article-title":"Validity of sports-related diagnosis codes in the Danish National Patient Register the Danish National Patient Register","volume":"68","author":"Gadeberg","year":"2021","journal-title":"Dan Med J"},{"key":"10.1016\/j.fas.2022.02.015_bib27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/schbul\/18.2.171","article-title":"When assessing twin concordance, use the probandwise not the pairwise rate","volume":"18","author":"McGue","year":"1992","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.fas.2022.02.015_bib28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1469-1809.1965.tb00500.x","article-title":"The inheritance of liability to certain diseases, estimated from the incidence among relatives","volume":"29","author":"Falconer","year":"1965","journal-title":"Ann Hum Genet"},{"year":"2004","series-title":"Methodology for genetic studies of twins and families","author":"Neale","key":"10.1016\/j.fas.2022.02.015_bib29"},{"key":"10.1016\/j.fas.2022.02.015_bib30","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s10985-013-9244-x","article-title":"Estimating heritability for cause specific mortality based on twin studies","volume":"20","author":"Scheike","year":"2014","journal-title":"Lifetime Data Anal"},{"key":"10.1016\/j.fas.2022.02.015_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/bjsports-2020-102392","article-title":"High genetic contribution to anterior cruciate ligament rupture: heritability \u223c69%","volume":"55","author":"Magnusson","year":"2021","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.fas.2022.02.015_bib32","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.joca.2021.03.005","article-title":"The heritability of doctor-diagnosed traumatic and degenerative meniscus tears","volume":"29","author":"Magnusson","year":"2021","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.fas.2022.02.015_bib33","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/hs0302.103619","article-title":"Genetic liability in stroke: a long-term follow-up study of Danish twins","volume":"33","author":"Bak","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.fas.2022.02.015_bib34","first-page":"369","article-title":"ABO blood group and Achilles tendon rupture","volume":"85","author":"Leppilahti","year":"1996","journal-title":"Ann Chir Gynaecol"},{"key":"10.1016\/j.fas.2022.02.015_bib35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00042752-200010000-00008","article-title":"ABO blood groups and Achilles tendon rupture in the Grampian region of Scotland","volume":"10","author":"Maffulli","year":"2000","journal-title":"Clin J Sport Med"},{"key":"10.1016\/j.fas.2022.02.015_bib36","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000107084","article-title":"Validity of dementia diagnoses in the Danish hospital registers","volume":"24","author":"Phung","year":"2007","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.fas.2022.02.015_bib37","first-page":"235","article-title":"Positive predictive value and impact of misdiagnosis of a heart failure diagnosis in administrative registers among patients admitted to a University Hospital cardiac care unit","volume":"2","author":"Mard","year":"2010","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.fas.2022.02.015_bib38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/1403494810387966","article-title":"The Danish twin registry","volume":"39","author":"Skytthe","year":"2011","journal-title":"Scand J Public Health"}],"container-title":["Foot and Ankle Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1268773122000467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1268773122000467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:09:23Z","timestamp":1761131363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1268773122000467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1268773122000467"],"URL":"https:\/\/doi.org\/10.1016\/j.fas.2022.02.015","relation":{},"ISSN":["1268-7731"],"issn-type":[{"type":"print","value":"1268-7731"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic contribution to the etiology of Achilles tendon rupture. A Danish nationwide register study of twins","name":"articletitle","label":"Article Title"},{"value":"Foot and Ankle Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fas.2022.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of European Foot and Ankle Society.","name":"copyright","label":"Copyright"}]}}