{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:32:17Z","timestamp":1778761937131,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873988"],"award-info":[{"award-number":["81873988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Foot and Ankle Surgery"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.fas.2022.03.012","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T21:25:00Z","timestamp":1649193900000},"page":"1120-1128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Negative pressure wound therapy versus gauze dressings in managing open fracture wound of lower limbs: A meta-analysis of randomized controlled trials"],"prefix":"10.1016","volume":"28","author":[{"given":"Hu","family":"Qian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.fas.2022.03.012_bib1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/BOT.0b013e3181a2e2b6","article-title":"Negative pressure wound therapy after severe open fractures: a prospective randomized study","volume":"23","author":"Stannard","year":"2009","journal-title":"J Orthop Trauma"},{"issue":"10","key":"10.1016\/j.fas.2022.03.012_bib2","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.spinee.2013.06.040","article-title":"Negative pressure wound therapy (NPWT) for spinal wounds: a systematic review","volume":"13","author":"Ousey","year":"2013","journal-title":"Spine J: J North Am Spine Soc"},{"issue":"1","key":"10.1016\/j.fas.2022.03.012_bib3","first-page":"65","article-title":"Comparison of negative pressure wound therapy (NPWT) &conventional wound dressings in the open fracture wounds","volume":"32","author":"Arti","year":"2016","journal-title":"Pak J Med Sci"},{"issue":"1","key":"10.1016\/j.fas.2022.03.012_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/BOT.0b013e31802cbc54","article-title":"The use of negative-pressure wound therapy (NPWT) in the temporary treatment of soft-tissue injuries associated with high-energy open tibial shaft fractures","volume":"21","author":"Dedmond","year":"2007","journal-title":"J Orthop Trauma"},{"issue":"22","key":"10.1016\/j.fas.2022.03.012_bib5","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1001\/jama.2018.6452","article-title":"Effect of negative pressure wound therapy vs standard wound management on 12-month disability among adults with severe open fracture of the lower limb: the WOLLF randomized clinical trial","volume":"319","author":"Costa","year":"2018","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.fas.2022.03.012_bib6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/BOT.0b013e31824133e3","article-title":"Negative pressure wound therapy reduces deep infection rate in open tibial fractures","volume":"26","author":"Blum","year":"2012","journal-title":"J Orthop Trauma"},{"issue":"10","key":"10.1016\/j.fas.2022.03.012_bib7","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.injury.2019.04.018","article-title":"Negative pressure wound therapy vs. conventional management in open tibia fractures: systematic review and meta-analysis","volume":"50","author":"Kim","year":"2019","journal-title":"Injury"},{"issue":"5","key":"10.1016\/j.fas.2022.03.012_bib8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/BOT.0000000000001750","article-title":"The effectiveness of negative pressure wound therapy versus conventional dressing in the treatment of open fractures: a systematic review and meta-analysis","volume":"34","author":"Grant-Freemantle","year":"2020","journal-title":"J Orthop Trauma"},{"key":"10.1016\/j.fas.2022.03.012_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ijsu.2018.02.064","article-title":"Negative pressure wound therapy versus conventional wound dressings in treatment of open fractures: a systematic review and meta-analysis","volume":"53","author":"Liu","year":"2018","journal-title":"Int J Surg"},{"issue":"6","key":"10.1016\/j.fas.2022.03.012_bib10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1001\/jama.2020.0059","article-title":"Effect of incisional negative pressure wound therapy vs standard wound dressing on deep surgical site infection after surgery for lower limb fractures associated with major trauma: the WHIST randomized clinical trial","volume":"323","author":"Costa","year":"2020","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.fas.2022.03.012_bib11","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1302\/0301-620X.102B7.BJJ-2019-1462.R1","article-title":"Negative pressure wound therapy versus conventional dressing for open fractures in lower extremity trauma","volume":"102","author":"Tahir","year":"2020","journal-title":"Bone Jt J"},{"issue":"7","key":"10.1016\/j.fas.2022.03.012_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLOS Med"},{"key":"10.1016\/j.fas.2022.03.012_bib13","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.fas.2022.03.012_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med Res Method"},{"key":"10.1016\/j.fas.2022.03.012_bib15","first-page":"382","article-title":"Vacuum assited wound closure and normal saline dressing in treatment of Gustilo type II, type IIIa and IIIb open fracture of tibia","volume":"38","author":"Ghulam Rasool","year":"2013","journal-title":"Rawal Med J"},{"key":"10.1016\/j.fas.2022.03.012_bib16","first-page":"8","article-title":"A comparative study between primary vacuum assisted closure and conventional sterile dressing in treatment of soft tissue injuries associated with severe open fractures of both bones leg","volume":"26","author":"Jayakumar","year":"2013","journal-title":"Kerala J Orthop"},{"key":"10.1016\/j.fas.2022.03.012_bib17","first-page":"168","article-title":"Comparison of vacuum assisted closure therapy with standard wound therapy for open musculoskeletal injuries","volume":"9","author":"Ketan Gupta","year":"2013","journal-title":"Int J Recent Trends Sci Technol"},{"key":"10.1016\/j.fas.2022.03.012_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/245940","article-title":"Vacuum assisted closure therapy versus standard wound therapy for open musculoskeletal injuries","volume":"2013","author":"Sinha","year":"2013","journal-title":"Adv Orthop"},{"issue":"4","key":"10.1016\/j.fas.2022.03.012_bib19","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jcot.2016.05.007","article-title":"Impact of negative pressure wound therapy on open diaphyseal tibial fractures: a prospective randomized trial","volume":"7","author":"Virani","year":"2016","journal-title":"J Clin Orthop Trauma"},{"issue":"5","key":"10.1016\/j.fas.2022.03.012_bib20","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1097\/PRS.0b013e31816a8d9d","article-title":"Subatmospheric pressure dressing as a bridge to free tissue transfer in the treatment of open tibia fractures","volume":"121","author":"Rinker","year":"2008","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"10.1016\/j.fas.2022.03.012_bib21","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s12013-014-9953-0","article-title":"Negative-pressure wound therapy enhances local inflammatory responses in acute infected soft-tissue wound","volume":"70","author":"Liu","year":"2014","journal-title":"Cell Biochem Biophys"},{"issue":"1","key":"10.1016\/j.fas.2022.03.012_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1089\/wound.2014.0531","article-title":"Current concepts and ongoing research in the prevention and treatment of open fracture infections","volume":"4","author":"Hannigan","year":"2015","journal-title":"Adv Wound Care"}],"container-title":["Foot and Ankle Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S126877312200073X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S126877312200073X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:09:49Z","timestamp":1761131389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S126877312200073X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S126877312200073X"],"URL":"https:\/\/doi.org\/10.1016\/j.fas.2022.03.012","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-942319\/v1","asserted-by":"object"}]},"ISSN":["1268-7731"],"issn-type":[{"value":"1268-7731","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Negative pressure wound therapy versus gauze dressings in managing open fracture wound of lower limbs: A meta-analysis of randomized controlled trials","name":"articletitle","label":"Article Title"},{"value":"Foot and Ankle Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fas.2022.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}