{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:42:47Z","timestamp":1774478567741,"version":"3.50.1"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foot and Ankle Clinics"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.fcl.2005.06.009","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T15:10:36Z","timestamp":1168441836000},"page":"621-637","source":"Crossref","is-referenced-by-count":55,"title":["The Role of Platelet-Rich Plasma in Foot and Ankle Surgery"],"prefix":"10.1016","volume":"10","author":[{"given":"Ankur","family":"Gandhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Bibbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Pinzur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheldon S.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fcl.2005.06.009_bib1","first-page":"391","article-title":"Role of growth factors in fracture healing","volume":"365","author":"Joyce","year":"1991","journal-title":"Prog Clin Biol Res"},{"key":"10.1016\/j.fcl.2005.06.009_bib2","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0026-0495(79)90047-7","article-title":"Platelets: cell proliferation and atherosclerosis","volume":"28","author":"Ross","year":"1979","journal-title":"Metabolism"},{"key":"10.1016\/j.fcl.2005.06.009_bib3","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1073\/pnas.85.5.1492","article-title":"Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing","volume":"85","author":"Bonthron","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fcl.2005.06.009_bib4","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1073\/pnas.76.8.3722","article-title":"Platelet derived growth factor: purification and partial characterisation","volume":"76","author":"Heldin","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.fcl.2005.06.009_bib5","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0092-8674(95)90404-2","article-title":"Dimerization of cell surface receptors in signal transduction","volume":"80","author":"Heldin","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.fcl.2005.06.009_bib6","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1172\/JCI112243","article-title":"Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats","volume":"76","author":"Grotendorst","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1016\/j.fcl.2005.06.009_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jor.1100060303","article-title":"The mineral and mechanical properties of bone in chronic experimental diabetes","volume":"6","author":"Einhorn","year":"1988","journal-title":"J Orthop Res"},{"key":"10.1016\/j.fcl.2005.06.009_bib8","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0024-3205(95)02056-O","article-title":"Platelet-derived growth factor levels in wounds of diabetic rats","volume":"57","author":"Doxey","year":"1995","journal-title":"Life Sci"},{"key":"10.1016\/j.fcl.2005.06.009_bib9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/8756-3282(94)90709-9","article-title":"Effect of platelet-derived growth factor on tibial osteotomies in rabbits","volume":"15","author":"Nash","year":"1994","journal-title":"Bone"},{"key":"10.1016\/j.fcl.2005.06.009_bib10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s004180050399","article-title":"Expression of platelet-derived growth factor proteins and their receptor alpha and beta mRNAs during fracture healing in the normal mouse","volume":"112","author":"Fujii","year":"1999","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.fcl.2005.06.009_bib11","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1210\/en.140.11.5036","article-title":"Response of bipotential human marrow stromal cells to insulin-like growth factors: effect on binding protein production, proliferation, and commitment to osteoblasts and adipocytes","volume":"140","author":"Thomas","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.fcl.2005.06.009_bib12","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1210\/en.136.4.1348","article-title":"Insulin-like growth factors inhibit interstitial collagenase synthesis in bone cell cultures","volume":"136","author":"Canalis","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.fcl.2005.06.009_bib13","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF01137966","article-title":"Insulin-like growth factor I enhances the formation of type I collagen in hydrocortisone-treated human osteoblasts","volume":"13","author":"Jonsson","year":"1993","journal-title":"Biosci Rep"},{"key":"10.1016\/j.fcl.2005.06.009_bib14","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1210\/en.139.5.2287","article-title":"Insulin-like growth factor II promoter expression in cultured rodent osteoblasts and adult rat bone","volume":"139","author":"Gangji","year":"1998","journal-title":"Endocrinology"},{"issue":"Suppl 1","key":"10.1016\/j.fcl.2005.06.009_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000184833","article-title":"Insulin-like growth factor system components and the coupling of bone formation to resorption","volume":"45","author":"Mohan","year":"1996","journal-title":"Horm Res"},{"key":"10.1016\/j.fcl.2005.06.009_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3181\/00379727-219-44310","article-title":"Insulin-like growth factors and bone: the osteoporosis connection revisited","volume":"219","author":"Rosen","year":"1998","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.fcl.2005.06.009_bib17","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1210\/en.131.3.1075","article-title":"Insulin-like growth factor-I supports formation and activation of osteoclasts","volume":"131","author":"Mochizuki","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.fcl.2005.06.009_bib18","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1210\/en.136.1.124","article-title":"Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function","volume":"136","author":"Hill","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.fcl.2005.06.009_bib19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/8756-3282(93)90151-Y","article-title":"Insulin like growth factors and the local regulation of bone formation","volume":"14","author":"Canalis","year":"1993","journal-title":"Bone"},{"key":"10.1016\/j.fcl.2005.06.009_bib20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1677\/joe.0.1440251","article-title":"Changes in IGF-I and -II expression and secretion during the proliferation and differentiation of normal rat osteoblasts","volume":"144","author":"Birnbaum","year":"1995","journal-title":"J Endocrinol"},{"key":"10.1016\/j.fcl.2005.06.009_bib21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF01321886","article-title":"Insulinlike growth factor gene expression in human fracture callus","volume":"53","author":"Andrew","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.fcl.2005.06.009_bib22","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/8756-3282(94)00040-9","article-title":"Osteoblasts and osteoclasts in adult human osteophyte tissue express the mRNAs for insulin-like growth factors I and II and the type 1 IGF receptor","volume":"16","author":"Middleton","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.fcl.2005.06.009_bib23","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1210\/en.132.3.1158","article-title":"Differential expression of insulin-like growth factor-I (IGF-I) and IGF-II messenger ribonucleic acid in growing rat bone","volume":"132","author":"Shinar","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.fcl.2005.06.009_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jbmr.5650070212","article-title":"Expression of insulin-like growth factor I messenger ribonucleic acid in regenerating bone after fracture: influence of indomethacin","volume":"7","author":"Edwall","year":"1992","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.fcl.2005.06.009_bib25","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0736-0266(02)00161-4","article-title":"Expression of parathyroid hormone-related peptide and insulin-like growth factor I during rat fracture healing","volume":"21","author":"Okazaki","year":"2003","journal-title":"J Orthop Res"},{"key":"10.1016\/j.fcl.2005.06.009_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1083\/jcb.105.1.457","article-title":"Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro","volume":"105","author":"Robey","year":"1987","journal-title":"J Cell Biol"},{"key":"10.1016\/j.fcl.2005.06.009_bib27","series-title":"Handbook of experimental pharmacology: peptide growth factors and their receptors","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-642-49295-2_1","article-title":"The multifunctional nature of growth factors","author":"Sporn","year":"1990"},{"key":"10.1016\/j.fcl.2005.06.009_bib28","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/00003086-198503000-00035","article-title":"Effect of growth factors on bone cell replication and differentiation","volume":"193","author":"Canalis","year":"1985","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.fcl.2005.06.009_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00298724","article-title":"Proliferative responses to estradiol, IL-1 alpha and TGF beta by cells expressing alkaline phosphatase in human osteoblast-like cell cultures","volume":"52","author":"Rickard","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.fcl.2005.06.009_bib30","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1210\/en.131.6.2863","article-title":"Multiple regulatory effects by transforming growth factor-beta on type I collagen levels in osteoblast-enriched cultures from fetal rat bone","volume":"131","author":"Centrella","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.fcl.2005.06.009_bib31","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1083\/jcb.106.3.915","article-title":"Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations","volume":"106","author":"Wrana","year":"1988","journal-title":"J Cell Biol"},{"key":"10.1016\/j.fcl.2005.06.009_bib32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0030-5898(20)31576-5","article-title":"Transforming growth factor-beta in the regulation of fracture repair","volume":"21","author":"Joyce","year":"1990","journal-title":"Orthop Clin North Am"},{"key":"10.1016\/j.fcl.2005.06.009_bib33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-4827(86)90538-0","article-title":"Differentiation of rat mesenchymal cells by cartilage-inducing factor. Enhanced phenotypic expression by dihydrocytochalasin B","volume":"165","author":"Rosen","year":"1986","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.fcl.2005.06.009_bib34","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1073\/pnas.82.8.2267","article-title":"Purification and characterization of two cartilage-inducing factors from bovine demineralized bone","volume":"82","author":"Seyedin","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.fcl.2005.06.009_bib35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/01.ID.0000052020.81109.C7","article-title":"An in vitro and in vivo evaluation of autologous platelet concentrate in oral reconstruction","volume":"12","author":"Babbush","year":"2003","journal-title":"Implant Dent"},{"key":"10.1016\/j.fcl.2005.06.009_bib36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0278-2391(00)90058-2","article-title":"Quantification of growth factor levels using a simplified method of platelet-rich plasma gel preparation","volume":"58","author":"Landesberg","year":"2000","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.fcl.2005.06.009_bib37","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0022-5223(19)33804-8","article-title":"Redo cardiac surgery: late bleeding complications from topical thrombin-induced factor V deficiency","volume":"105","author":"Cmolik","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.fcl.2005.06.009_bib38","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0278-2391(98)90286-5","article-title":"Risks of using platelet rich plasma gel","volume":"56","author":"Landesberg","year":"1998","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.fcl.2005.06.009_bib39","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.joms.2004.06.047","article-title":"A modified method for preparing platelet-rich plasma: an experimental study","volume":"62","author":"Efeoglu","year":"2004","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.fcl.2005.06.009_bib40","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/00001665-200305000-00006","article-title":"Effect of platelet releasate on bone cell migration and recruitment in vitro","volume":"14","author":"Oprea","year":"2003","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.fcl.2005.06.009_bib41","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.joms.2004.07.016","article-title":"Platelet-rich plasma enhances human osteoblast-like cell proliferation and differentiation","volume":"63","author":"Kanno","year":"2005","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.fcl.2005.06.009_bib42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3928\/0147-7447-20020201-22","article-title":"Platelet concentrate increases bone ingrowth into porous hydroxyapatite","volume":"25","author":"Siebrecht","year":"2002","journal-title":"Orthopedics"},{"key":"10.1016\/j.fcl.2005.06.009_bib43","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.bone.2003.12.010","article-title":"Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration","volume":"34","author":"Weibrich","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.fcl.2005.06.009_bib44","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.orthres.2003.10.006","article-title":"Platelet rich plasma and fresh frozen bone allograft as enhancement of implant fixation. An experimental study in dogs","volume":"22","author":"Jensen","year":"2004","journal-title":"J Orthop Res"},{"key":"10.1016\/j.fcl.2005.06.009_bib45","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00264-004-0622-6","article-title":"No effect of platelet-rich plasma with frozen or processed bone allograft around noncemented implants","volume":"29","author":"Jensen","year":"2005","journal-title":"Int Orthop"},{"key":"10.1016\/j.fcl.2005.06.009_bib46","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1067\/mpr.2001.115874","article-title":"Platelet concentration and its effect on bone formation in calvarial defects: an experimental study in rabbits","volume":"86","author":"Kim","year":"2001","journal-title":"J Prosthet Dent"},{"key":"10.1016\/j.fcl.2005.06.009_bib47","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1053\/joms.2002.34994","article-title":"Investigation of platelet-rich plasma in rabbit cranial defects: a pilot study","volume":"60","author":"Aghaloo","year":"2002","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.fcl.2005.06.009_bib48","first-page":"59","article-title":"Evaluation of platelet-rich plasma in combination with anorganic bovine bone in the rabbit cranium: a pilot study","volume":"19","author":"Aghaloo","year":"2004","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.fcl.2005.06.009_bib49","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1600-0501.2004.01075.x","article-title":"Evaluation of platelet-rich plasma in combination with freeze-dried bone in the rabbit cranium","volume":"16","author":"Aghaloo","year":"2005","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.fcl.2005.06.009_bib50","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1600-0501.2004.00980.x","article-title":"Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. An animal experiment","volume":"15","author":"Wiltfang","year":"2004","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.fcl.2005.06.009_bib51","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1016\/j.biomaterials.2003.12.043","article-title":"De novo bone formation using bovine collagen and platelet-rich plasma","volume":"25","author":"Schlegel","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.fcl.2005.06.009_bib52","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/j.biomaterials.2004.07.041","article-title":"Expression of bone matrix proteins during de novo bone formation using a bovine collagen and platelet-rich plasma (PRP)\u2013an immunohistochemical analysis","volume":"26","author":"Thorwarth","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.fcl.2005.06.009_bib53","unstructured":"Bibbo C. Autologous platelet concentrate in high-risk foot and ankle surgery. Presented at the AOFAS 20th Annual Summer Meeting. Seattle, WA; July 29, 2004"},{"key":"10.1016\/j.fcl.2005.06.009_bib54","first-page":"17","article-title":"Union rates using autologous platelet concentrate alone and with bone graft in high-risk foot and ankle surgery patients","volume":"14","author":"Bibbo","year":"2005","journal-title":"J Surg Orthop Adv"},{"key":"10.1016\/j.fcl.2005.06.009_bib55","unstructured":"Coetzee J., Pometroy G. The use of autologous concentrated growth factors to promote syndesmosis fusion in the Agility total ankle replacement: a preliminary study. Foot Ankle Int, in press"},{"key":"10.1016\/j.fcl.2005.06.009_bib56","unstructured":"Coetzee J., Pometroy G., Watts D., et al. The use of autologous concentrated growth factors in fusion rates in the Agility total ankle replacement: a preliminary study. Presented at the AOFAS 20th Annual Summer Meeting. Seattle, WA; July 29, 2004"},{"key":"10.1016\/j.fcl.2005.06.009_bib57","unstructured":"Gandhi A., Van Gelderen J., Berberian W.S., et al. Platelet releasate enhances healing in patients with a non-union. Presented at the Orthopaedic Research Society 49th Annual Meeting. New Orleans, LA; February 2, 2003"}],"container-title":["Foot and Ankle Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108375150500080X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108375150500080X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T09:53:14Z","timestamp":1683712394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108375150500080X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S108375150500080X"],"URL":"https:\/\/doi.org\/10.1016\/j.fcl.2005.06.009","relation":{},"ISSN":["1083-7515"],"issn-type":[{"value":"1083-7515","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}