{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T17:02:46Z","timestamp":1776358966099,"version":"3.51.2"},"reference-count":66,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["foot.theclinics.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Foot and Ankle Clinics"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.fcl.2016.07.001","type":"journal-article","created":{"date-parts":[[2016,11,19]],"date-time":"2016-11-19T06:18:30Z","timestamp":1479536310000},"page":"793-802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Role of Recombinant Human Bone Morphogenetic Protein-2 on Hindfoot Arthrodesis"],"prefix":"10.1016","volume":"21","author":[{"given":"Jeremy","family":"Hreha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan S.","family":"Krell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Bibbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fcl.2016.07.001_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cpm.2011.09.003","article-title":"Subtalar joint arthrodesis","volume":"29","author":"Lopez","year":"2012","journal-title":"Clin Podiatr Med Surg"},{"issue":"10","key":"10.1016\/j.fcl.2016.07.001_bib2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2106\/00004623-199910000-00004","article-title":"Triple arthrodesis: twenty-five and forty-four-year average follow-up of the same patients","volume":"81","author":"Saltzman","year":"1999","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.fcl.2016.07.001_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2106\/00004623-200001000-00006","article-title":"Clinical outcome after primary triple arthrodesis","volume":"82","author":"RFt","year":"2000","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.fcl.2016.07.001_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1302\/0301-620X.76B1.8300657","article-title":"Simultaneous calcaneocuboid and talonavicular fusion. Long-term follow-up study","volume":"76","author":"Clain","year":"1994","journal-title":"J\u00a0Bone Joint Surg Br"},{"issue":"5","key":"10.1016\/j.fcl.2016.07.001_bib5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2106\/00004623-200005000-00002","article-title":"Isolated subtalar arthrodesis","volume":"82","author":"Easley","year":"2000","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"3","key":"10.1016\/j.fcl.2016.07.001_bib6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3113\/FAI.2007.0295","article-title":"A\u00a0comprehensive review of subtalar arthrodesis","volume":"28","author":"Davies","year":"2007","journal-title":"Foot Ankle Int"},{"issue":"12","key":"10.1016\/j.fcl.2016.07.001_bib7","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3113\/FAI.2008.1195","article-title":"Primary isolated subtalar arthrodesis: outcome after 2 to 5 years followup","volume":"29","author":"Diezi","year":"2008","journal-title":"Foot Ankle Int"},{"issue":"2","key":"10.1016\/j.fcl.2016.07.001_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/1071100714552485","article-title":"Comparison of cannulated screws versus compression staples for subtalar arthrodesis fixation","volume":"36","author":"Herrera-Perez","year":"2015","journal-title":"Foot Ankle Int"},{"issue":"5","key":"10.1016\/j.fcl.2016.07.001_bib9","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/107110070002100506","article-title":"Subtalar arthrodesis for complications of intra-articular calcaneal fractures","volume":"21","author":"Flemister","year":"2000","journal-title":"Foot Ankle Int"},{"issue":"11","key":"10.1016\/j.fcl.2016.07.001_bib10","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1177\/107110070402501103","article-title":"Subtalar joint arthrodesis using a single lag screw","volume":"25","author":"Haskell","year":"2004","journal-title":"Foot Ankle Int"},{"issue":"10","key":"10.1016\/j.fcl.2016.07.001_bib11","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.2106\/00004623-198870100-00005","article-title":"Isolated talocalcaneal arthrodesis. A technique using moldable bone graft","volume":"70","author":"Russotti","year":"1988","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.fcl.2016.07.001_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.fcl.2010.11.002","article-title":"The isolated talonavicular arthrodesis","volume":"16","author":"Crevoisier","year":"2011","journal-title":"Foot Ankle Clin"},{"issue":"4","key":"10.1016\/j.fcl.2016.07.001_bib13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/107110070002100406","article-title":"A\u00a0technique for isolated arthrodesis for inflammatory arthritis of the talonavicular joint","volume":"21","author":"Chiodo","year":"2000","journal-title":"Foot Ankle Int"},{"issue":"6","key":"10.1016\/j.fcl.2016.07.001_bib14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/107110079201300603","article-title":"Talonavicular arthrodesis in the rheumatoid foot","volume":"13","author":"Ljung","year":"1992","journal-title":"Foot Ankle"},{"issue":"8","key":"10.1016\/j.fcl.2016.07.001_bib15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1177\/107110070102200803","article-title":"Isolated talonavicular arthrodesis for talonavicular arthritis","volume":"22","author":"Chen","year":"2001","journal-title":"Foot Ankle Int"},{"issue":"11","key":"10.1016\/j.fcl.2016.07.001_bib16","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.2106\/00004623-199911000-00006","volume":"81","author":"Toolan","year":"1999","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"11","key":"10.1016\/j.fcl.2016.07.001_bib17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1177\/107110079401501102","article-title":"A\u00a0review of ankle arthrodesis: predisposing factors to nonunion","volume":"15","author":"Frey","year":"1994","journal-title":"Foot Ankle Int"},{"issue":"391","key":"10.1016\/j.fcl.2016.07.001_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00003086-200110000-00007","article-title":"Complications of midfoot and hindfoot arthrodesis","author":"Bibbo","year":"2001","journal-title":"Clin Orthop Relat Res"},{"issue":"8","key":"10.1016\/j.fcl.2016.07.001_bib19","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/01.bot.0000211156.13487.6a","article-title":"Factors associated with outcome after subtalar arthrodesis","volume":"20","author":"Chahal","year":"2006","journal-title":"J\u00a0Orthop Trauma"},{"issue":"11","key":"10.1016\/j.fcl.2016.07.001_bib20","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/107110070202301104","article-title":"The effect of cigarette smoking on hindfoot fusions","volume":"23","author":"Ishikawa","year":"2002","journal-title":"Foot Ankle Int"},{"issue":"2","key":"10.1016\/j.fcl.2016.07.001_bib21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/107110079401500202","article-title":"Cigarette smoking and nonunion after ankle arthrodesis","volume":"15","author":"Cobb","year":"1994","journal-title":"Foot Ankle Int"},{"issue":"1","key":"10.1016\/j.fcl.2016.07.001_bib22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3113\/FAI.2012.0020","article-title":"Ankle and hindfoot fusions: comparison of outcomes in patients with and without diabetes","volume":"33","author":"Myers","year":"2012","journal-title":"Foot Ankle Int"},{"issue":"12","key":"10.1016\/j.fcl.2016.07.001_bib23","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1177\/107110070402501205","article-title":"A\u00a0review of rheumatoid arthritis affecting the foot and ankle","volume":"25","author":"Jaakkola","year":"2004","journal-title":"Foot Ankle Int"},{"issue":"4","key":"10.1016\/j.fcl.2016.07.001_bib24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.fcl.2010.08.001","article-title":"The indications and use of bone morphogenetic proteins in foot, ankle, and tibia surgery","volume":"15","author":"El-Amin","year":"2010","journal-title":"Foot Ankle Clin"},{"issue":"6","key":"10.1016\/j.fcl.2016.07.001_bib25","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00586-008-0648-3","article-title":"Donor site morbidity following iliac crest bone harvesting for cervical fusion: a comparison between minimally invasive and open techniques","volume":"17","author":"Pollock","year":"2008","journal-title":"Eur Spine J"},{"issue":"5","key":"10.1016\/j.fcl.2016.07.001_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/BCO.0b013e3182a3ddb6","article-title":"Orthobiologics in Foot and ankle surgery","volume":"24","author":"Pinzur","year":"2013","journal-title":"Curr Orthop Pract"},{"issue":"3698","key":"10.1016\/j.fcl.2016.07.001_bib27","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.150.3698.893","article-title":"Bone: formation by autoinduction","volume":"150","author":"Urist","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.fcl.2016.07.001_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1196\/annals.1346.007","article-title":"Function of BMPs and BMP antagonists in adult bone","volume":"1068","author":"Abe","year":"2006","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"10.1016\/j.fcl.2016.07.001_bib29","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1073\/pnas.87.6.2220","article-title":"Recombinant human bone morphogenetic protein induces bone formation","volume":"87","author":"Wang","year":"1990","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"1","key":"10.1016\/j.fcl.2016.07.001_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1359-6101(97)00036-1","article-title":"Signal transduction by bone morphogenetic proteins","volume":"9","author":"Kawabata","year":"1998","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"10.1016\/j.fcl.2016.07.001_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cellsig.2003.08.011","article-title":"Signal transduction of bone morphogenetic protein receptors","volume":"16","author":"Nohe","year":"2004","journal-title":"Cell Signal"},{"key":"10.1016\/j.fcl.2016.07.001_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1196\/annals.1402.053","article-title":"Multiplicity of BMP signaling in skeletal development","volume":"1116","author":"Wu","year":"2007","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.fcl.2016.07.001_bib33","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1006\/bbrc.2000.2210","article-title":"Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1\/2","volume":"268","author":"Lou","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"issue":"18","key":"10.1016\/j.fcl.2016.07.001_bib34","doi-asserted-by":"crossref","first-page":"15514","DOI":"10.1074\/jbc.M200794200","article-title":"Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells","volume":"277","author":"Lai","year":"2002","journal-title":"J\u00a0Biol Chem"},{"issue":"Suppl 3","key":"10.1016\/j.fcl.2016.07.001_bib35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2106\/00004623-200300003-00010","article-title":"Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein","volume":"85A","author":"Groppe","year":"2003","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.fcl.2016.07.001_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1196\/annals.1346.005","article-title":"BMP and BMP inhibitors in bone","volume":"1068","author":"Rosen","year":"2006","journal-title":"Ann N Y Acad Sci"},{"issue":"23","key":"10.1016\/j.fcl.2016.07.001_bib37","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1101\/gad.1350705","article-title":"Smad transcription factors","volume":"19","author":"Massague","year":"2005","journal-title":"Genes Dev"},{"issue":"8","key":"10.1016\/j.fcl.2016.07.001_bib38","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2106\/00004623-200308000-00017","article-title":"Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)","volume":"85A","author":"Cheng","year":"2003","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"3","key":"10.1016\/j.fcl.2016.07.001_bib39","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/jor.1100130309","article-title":"Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing","volume":"13","author":"Bostrom","year":"1995","journal-title":"J\u00a0Orthop Res"},{"issue":"12","key":"10.1016\/j.fcl.2016.07.001_bib40","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.addr.2003.08.010","article-title":"Collagen sponges for bone regeneration with rhBMP-2","volume":"55","author":"Geiger","year":"2003","journal-title":"Adv Drug Deliv Rev"},{"issue":"361","key":"10.1016\/j.fcl.2016.07.001_bib41","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00003086-199904000-00028","article-title":"Bone marrow and recombinant human bone morphogenetic protein-2 in osseous repair","author":"Lane","year":"1999","journal-title":"Clin Orthop Relat Res"},{"issue":"6","key":"10.1016\/j.fcl.2016.07.001_bib42","first-page":"1323","article-title":"Healing of a critical-sized defect in the rat femur with use of a vascularized periosteal flap, a biodegradable matrix, and bone morphogenetic protein","volume":"87","author":"Vogelin","year":"2005","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.fcl.2016.07.001_bib43","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0736-0266(01)00060-2","article-title":"Osteogenic protein-1 induced bone formation in an infected segmental defect in the rat femur","volume":"20","author":"Chen","year":"2002","journal-title":"J\u00a0Orthop Res"},{"issue":"5","key":"10.1016\/j.fcl.2016.07.001_bib44","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2106\/00004623-199274050-00005","article-title":"The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats","volume":"74","author":"Yasko","year":"1992","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"293","key":"10.1016\/j.fcl.2016.07.001_bib45","first-page":"317","article-title":"Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein","author":"Gerhart","year":"1993","journal-title":"Clin Orthop Relat Res"},{"issue":"9","key":"10.1016\/j.fcl.2016.07.001_bib46","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1359\/jbmr.1998.13.9.1483","article-title":"Effect of recombinant human bone morphogenetic protein-2 on fracture healing in a goat tibial fracture model","volume":"13","author":"Welch","year":"1998","journal-title":"J\u00a0Bone Miner Res"},{"issue":"6","key":"10.1016\/j.fcl.2016.07.001_bib47","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00264-007-0418-6","article-title":"A\u00a0comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE Bone Graft)","volume":"31","author":"McKay","year":"2007","journal-title":"Int Orthop"},{"issue":"19","key":"10.1016\/j.fcl.2016.07.001_bib48","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1097\/BRS.0b013e3181ecf6e4","article-title":"Off-label use of bone morphogenetic proteins in the United States using administrative data","volume":"35","author":"Ong","year":"2010","journal-title":"Spine (Phila Pa 1976)"},{"issue":"7","key":"10.1016\/j.fcl.2016.07.001_bib49","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3113\/FAI.2009.0597","article-title":"Recombinant bone morphogenetic protein-2 (rhBMP-2) in high-risk ankle and hindfoot fusions","volume":"30","author":"Bibbo","year":"2009","journal-title":"Foot Ankle Int"},{"issue":"2","key":"10.1016\/j.fcl.2016.07.001_bib50","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s11999-013-3261-7","article-title":"Recombinant human BMP-2 increases the incidence and rate of healing in complex ankle arthrodesis","volume":"472","author":"Fourman","year":"2014","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"10.1016\/j.fcl.2016.07.001_bib51","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1053\/j.jfas.2012.03.007","article-title":"The effect of recombinant bone morphogenetic protein-2 in revision tibiotalocalcaneal arthrodesis: utilization of the Retrograde Arthrodesis Intramedullary Nail database","volume":"51","author":"DeVries","year":"2012","journal-title":"J\u00a0Foot Ankle Surg"},{"issue":"1","key":"10.1016\/j.fcl.2016.07.001_bib52","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00264-002-0405-x","article-title":"Functional bracing in the treatment of delayed union and nonunion of the tibia","volume":"27","author":"Sarmiento","year":"2003","journal-title":"Int Orthop"},{"issue":"3","key":"10.1016\/j.fcl.2016.07.001_bib53","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000114967","article-title":"Benefit of percutaneous injection of autologous platelet-leukocyte-rich gel in patients with delayed union and nonunion","volume":"40","author":"Bielecki","year":"2008","journal-title":"Eur Surg Res"},{"issue":"8","key":"10.1016\/j.fcl.2016.07.001_bib54","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.injury.2011.01.015","article-title":"Platelet-rich plasma (PRP) enhances bone healing in non-united critical-sized defects: a preliminary study involving rabbit models","volume":"42","author":"Kanthan","year":"2011","journal-title":"Injury"},{"issue":"4","key":"10.1016\/j.fcl.2016.07.001_bib55","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/BOT.0b013e31819f290e","article-title":"rhBMP-2 enhances the bone healing response in a diabetic rat segmental defect model","volume":"23","author":"Azad","year":"2009","journal-title":"J\u00a0Orthop Trauma"},{"issue":"6","key":"10.1016\/j.fcl.2016.07.001_bib56","doi-asserted-by":"crossref","first-page":"e525","DOI":"10.3928\/01477447-20140528-51","article-title":"No advantage to rhBMP-2 in addition to autogenous graft for fracture nonunion","volume":"37","author":"Takemoto","year":"2014","journal-title":"Orthopedics"},{"issue":"12","key":"10.1016\/j.fcl.2016.07.001_bib57","doi-asserted-by":"crossref","first-page":"e877","DOI":"10.3928\/01477447-20111021-09","article-title":"Bone morphogenetic protein-2 compared to autologous iliac crest bone graft in the treatment of long bone nonunion","volume":"34","author":"Tressler","year":"2011","journal-title":"Orthopedics"},{"issue":"Suppl 2","key":"10.1016\/j.fcl.2016.07.001_bib58","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0020-1383(10)70013-9","article-title":"Treatment of recalcitrant, multiply operated tibial nonunions with the RIA graft and rh-BMP2 using intramedullary nails","volume":"41","author":"Desai","year":"2010","journal-title":"Injury"},{"issue":"7","key":"10.1016\/j.fcl.2016.07.001_bib59","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.injury.2015.03.036","article-title":"Can we achieve bone healing using the diamond concept without bone grafting for recalcitrant tibial nonunions?","volume":"46","author":"Ollivier","year":"2015","journal-title":"Injury"},{"issue":"12","key":"10.1016\/j.fcl.2016.07.001_bib60","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.injury.2009.02.007","article-title":"A\u00a0health economic analysis of the use of rhBMP-2 in Gustilo-Anderson grade III open tibial fractures for the UK, Germany, and France","volume":"40","author":"Alt","year":"2009","journal-title":"Injury"},{"issue":"8","key":"10.1016\/j.fcl.2016.07.001_bib61","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1177\/1071100714536166","article-title":"Effectiveness and complications associated with recombinant human bone morphogenetic protein-2 augmentation of foot and ankle fusions and fracture nonunions","volume":"35","author":"Rearick","year":"2014","journal-title":"Foot Ankle Int"},{"issue":"12","key":"10.1016\/j.fcl.2016.07.001_bib62","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1007\/s11999-009-1039-8","article-title":"Complications of recombinant human BMP-2 for treating complex tibial plateau fractures: a preliminary report","volume":"467","author":"Boraiah","year":"2009","journal-title":"Clin Orthop Relat Res"},{"issue":"6","key":"10.1016\/j.fcl.2016.07.001_bib63","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.spinee.2007.06.014","article-title":"Neurologic impairment from ectopic bone in the lumbar canal: a potential complication of off-label PLIF\/TLIF use of bone morphogenetic protein-2 (BMP-2)","volume":"8","author":"Wong","year":"2008","journal-title":"Spine J"},{"issue":"5 Suppl 2","key":"10.1016\/j.fcl.2016.07.001_bib64","first-page":"ONS423","article-title":"A\u00a0comprehensive review of the safety profile of bone morphogenetic protein in spine surgery","volume":"62","author":"Benglis","year":"2008","journal-title":"Neurosurgery"},{"issue":"25","key":"10.1016\/j.fcl.2016.07.001_bib65","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1097\/BRS.0b013e31815b7596","article-title":"Heterotopic bone formation with the use of rhBMP2 in posterior minimal access interbody fusion: a CT analysis","volume":"32","author":"Joseph","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"issue":"16 Suppl 1","key":"10.1016\/j.fcl.2016.07.001_bib66","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1097\/00007632-200208151-00010","article-title":"Safety profile for the clinical use of bone morphogenetic proteins in the spine","volume":"27","author":"Poynton","year":"2002","journal-title":"Spine (Phila Pa 1976)"}],"container-title":["Foot and Ankle Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083751516300444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083751516300444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T05:06:09Z","timestamp":1657775169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083751516300444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1083751516300444"],"URL":"https:\/\/doi.org\/10.1016\/j.fcl.2016.07.001","relation":{},"ISSN":["1083-7515"],"issn-type":[{"value":"1083-7515","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Recombinant Human Bone Morphogenetic Protein-2 on Hindfoot Arthrodesis","name":"articletitle","label":"Article Title"},{"value":"Foot and Ankle Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fcl.2016.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}