{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:01:57Z","timestamp":1790420517257,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Foot and Ankle Clinics"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.fcl.2020.11.001","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:30:47Z","timestamp":1607301047000},"page":"225-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Emerging Biological Treatment Methods for Ankle Joint and Soft Tissue Conditions"],"prefix":"10.1016","volume":"26","author":[{"given":"J. Nienke","family":"Altink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino M.M.J.","family":"Kerkhoffs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.fcl.2020.11.001_bib1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2106\/JBJS.16.00793","article-title":"Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO): Platelet-Rich Plasma and Mesenchymal Stem Cells","volume":"99","author":"Murray","year":"2017","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"2","key":"10.1016\/j.fcl.2020.11.001_bib2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/0363546510387517","article-title":"Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems","volume":"39","author":"Castillo","year":"2011","journal-title":"Am J Sports Med"},{"issue":"4","key":"10.1016\/j.fcl.2020.11.001_bib3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2106\/JBJS.K.00430","article-title":"Platelet-rich plasma differs according to preparation method and human variability","volume":"94","author":"Mazzocca","year":"2012","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"20","key":"10.1016\/j.fcl.2020.11.001_bib4","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.2106\/JBJS.16.01374","article-title":"A\u00a0Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature","volume":"99","author":"Chahla","year":"2017","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"10","key":"10.1016\/j.fcl.2020.11.001_bib5","doi-asserted-by":"crossref","first-page":"e030961","DOI":"10.1136\/bmjopen-2019-030961","article-title":"Platelet-Rich plasma Injection Management for Ankle osteoarthritis study (PRIMA): protocol of a Dutch multicentre, stratified, block-randomised, double-blind, placebo-controlled trial","volume":"9","author":"Paget","year":"2019","journal-title":"BMJ Open"},{"issue":"6","key":"10.1016\/j.fcl.2020.11.001_bib6","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/1071100717700377","article-title":"Safety and Efficacy of Intra-articular Injection of Platelet-Rich Plasma in Patients With Ankle Osteoarthritis","volume":"38","author":"Fukawa","year":"2017","journal-title":"Foot Ankle Int"},{"issue":"10","key":"10.1016\/j.fcl.2020.11.001_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1302\/2046-3758.210.2000200","article-title":"Achilles tendinopathy management: A pilot randomised controlled trial comparing platelet-richplasma injection with an eccentric loading programme","volume":"2","author":"Kearney","year":"2013","journal-title":"Bone Joint Res"},{"issue":"8","key":"10.1016\/j.fcl.2020.11.001_bib8","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1177\/0363546516647958","article-title":"Ultrasound-Guided Injection Therapy of Achilles Tendinopathy With Platelet-Rich Plasma or Saline: A Randomized, Blinded, Placebo-Controlled Trial","volume":"44","author":"Krogh","year":"2016","journal-title":"Am J Sports Med"},{"issue":"1","key":"10.1016\/j.fcl.2020.11.001_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13018-017-0521-3","article-title":"The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials","volume":"12","author":"Shen","year":"2017","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.fcl.2020.11.001_bib10","unstructured":"RevMan, V.5.3, Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014."},{"issue":"1","key":"10.1016\/j.fcl.2020.11.001_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/0363546510383515","article-title":"Autologous platelets have no effect on the healing of human achilles tendon ruptures: a randomized single-blind study","volume":"39","author":"Schepull","year":"2011","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.fcl.2020.11.001_bib12","doi-asserted-by":"crossref","first-page":"l6132","DOI":"10.1136\/bmj.l6132","article-title":"Platelet rich plasma injection for acute Achilles tendon rupture: PATH-2 randomised, placebo controlled, superiority trial","volume":"367","author":"Keene","year":"2019","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.fcl.2020.11.001_bib13","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1056\/NEJMsr1715626","article-title":"Balancing Safety and Innovation for Cell-Based Regenerative Medicine","volume":"378","author":"Marks","year":"2018","journal-title":"N\u00a0Engl J Med"},{"issue":"19","key":"10.1016\/j.fcl.2020.11.001_bib14","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.2106\/JBJS.19.00266","article-title":"Direct-to-Consumer Advertising of Stem Cell Clinics: Ethical Considerations and Recommendations for the Health-Care Community","volume":"101","author":"Pean","year":"2019","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"1","key":"10.1016\/j.fcl.2020.11.001_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2106\/JBJS.19.00714","article-title":"Online Direct-to-Consumer Advertising of Stem Cell Therapy for Musculoskeletal Injury and Disease: Misinformation and Violation of Ethical and Legal Advertising Parameters","volume":"102","author":"Kingery","year":"2020","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"3","key":"10.1016\/j.fcl.2020.11.001_bib16","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/0363546511431238","article-title":"Platelet-rich plasma or hyaluronate in the management of osteochondral lesions of the talus","volume":"40","author":"Mei-Dan","year":"2012","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.fcl.2020.11.001_bib17","article-title":"Kobe Bryant to have treatment on knee in Germany","author":"Boren","year":"2013","journal-title":"Washington Post"},{"key":"10.1016\/j.fcl.2020.11.001_bib18","author":"Cox"},{"issue":"2","key":"10.1016\/j.fcl.2020.11.001_bib19","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.5435\/JAAOS-D-18-00305","article-title":"Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS\/NIH U-13 Conference","volume":"27","author":"Chu","year":"2019","journal-title":"J\u00a0Am Acad Orthop Surg"},{"issue":"8","key":"10.1016\/j.fcl.2020.11.001_bib20","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1007\/s00167-013-2784-5","article-title":"Clinical outcomes of platelet rich plasma (PRP) as an adjunct to microfracture surgery in osteochondral lesions of the talus","volume":"23","author":"Guney","year":"2015","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"8","key":"10.1016\/j.fcl.2020.11.001_bib21","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1177\/1071100715578435","article-title":"Clinical Effects of Platelet-Rich Plasma and Hyaluronic Acid as an Additional Therapy for Talar Osteochondral Lesions Treated with Microfracture Surgery: A Prospective Randomized Clinical Trial","volume":"36","author":"G\u00f6rmeli","year":"2015","journal-title":"Foot Ankle Int"},{"issue":"9","key":"10.1016\/j.fcl.2020.11.001_bib22","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1177\/0363546517702862","article-title":"Effect of High-Volume Injection, Platelet-Rich Plasma, and Sham Treatment in Chronic Midportion Achilles Tendinopathy: A Randomized Double-Blinded Prospective Study","volume":"45","author":"Boesen","year":"2017","journal-title":"Am J Sports Med"},{"issue":"5","key":"10.1016\/j.fcl.2020.11.001_bib23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/bjsm.2010.076398","article-title":"No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy","volume":"45","author":"de Vos","year":"2011","journal-title":"Br J Sports Med"},{"issue":"5411","key":"10.1016\/j.fcl.2020.11.001_bib24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.fcl.2020.11.001_bib25","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","article-title":"Human mesenchymal stem cells modulate allogeneic immune cell responses","volume":"105","author":"Aggarwal","year":"2005","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.fcl.2020.11.001_bib26","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1016\/j.arth.2017.02.075","article-title":"Analysis of Cell Therapies Used in Clinical Trials for the Treatment of Osteonecrosis of the Femoral Head: A Systematic Review of the Literature","volume":"32","author":"Piuzzi","year":"2017","journal-title":"J\u00a0Arthroplasty"},{"issue":"1","key":"10.1016\/j.fcl.2020.11.001_bib27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12967-019-1866-7","article-title":"Quantitation of progenitor cell populations and growth factors after bone marrow aspirate concentration","volume":"17","author":"Schafer","year":"2019","journal-title":"J\u00a0Transl Med"},{"issue":"14","key":"10.1016\/j.fcl.2020.11.001_bib28","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.2106\/JBJS.L.01529","article-title":"Quantitative assessment of the yield of osteoblastic connective tissue progenitors in bone marrow aspirate from the iliac crest, tibia, and calcaneus","volume":"95","author":"Hyer","year":"2013","journal-title":"J\u00a0Bone Joint Surg Am"},{"issue":"12","key":"10.1016\/j.fcl.2020.11.001_bib29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.2106\/JBJS.L.00429","article-title":"The posterior iliac crest outperforms the anterior iliac crest when obtaining mesenchymal stem cells from bone marrow","volume":"95","author":"Pierini","year":"2013","journal-title":"J\u00a0Bone Joint Surg Am"},{"key":"10.1016\/j.fcl.2020.11.001_bib30","article-title":"Human bone marrow mesenchymal stem cell injection in subchondral lesions of knee osteoarthritis: a prospective randomized study versus contralateral arthroplasty at a mean fifteen year follow-up","author":"Hernigou","year":"2020","journal-title":"Int Orthop"},{"issue":"1","key":"10.1016\/j.fcl.2020.11.001_bib31","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/0363546516662455","article-title":"A\u00a0Prospective, Single-Blind, Placebo-Controlled Trial of Bone Marrow Aspirate Concentrate for Knee Osteoarthritis","volume":"45","author":"Shapiro","year":"2017","journal-title":"Am J Sports Med"},{"issue":"5","key":"10.1016\/j.fcl.2020.11.001_bib32","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00264-018-4099-0","article-title":"Intra-articular injection of autologous adipose-derived stromal vascular fractions for knee osteoarthritis: a double-blind randomized self-controlled trial","volume":"43","author":"Hong","year":"2019","journal-title":"Int Orthop"},{"issue":"4","key":"10.1016\/j.fcl.2020.11.001_bib33","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.fas.2018.02.011","article-title":"A\u00a0prospective evaluation of bone marrow aspirate concentrate and microfracture in the treatment of osteochondral lesions of the talus","volume":"25","author":"Murphy","year":"2019","journal-title":"Foot Ankle Surg"},{"issue":"2","key":"10.1016\/j.fcl.2020.11.001_bib34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.arthro.2015.07.012","article-title":"Arthroscopic Bone Marrow Stimulation and Concentrated Bone Marrow Aspirate for Osteochondral Lesions of the Talus: A Case-Control Study of Functional and Magnetic Resonance Observation of Cartilage Repair Tissue Outcomes","volume":"32","author":"Hannon","year":"2016","journal-title":"Arthroscopy"},{"issue":"1","key":"10.1016\/j.fcl.2020.11.001_bib35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.arthro.2018.06.047","article-title":"Concentrated Bone Marrow Aspirate May Decrease Postoperative Cyst Occurrence Rate in Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus","volume":"35","author":"Shimozono","year":"2019","journal-title":"Arthroscopy"},{"issue":"4","key":"10.1016\/j.fcl.2020.11.001_bib36","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/1071100717746627","article-title":"Comparison of Juvenile Allogenous Articular Cartilage and Bone Marrow Aspirate Concentrate Versus Microfracture With and Without Bone Marrow Aspirate Concentrate in Arthroscopic Treatment of Talar Osteochondral Lesions","volume":"39","author":"Karnovsky","year":"2018","journal-title":"Foot Ankle Int"},{"issue":"4","key":"10.1016\/j.fcl.2020.11.001_bib37","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.fas.2016.05.320","article-title":"Matrix-associated stem cell transplantation (MAST) in chondral defects of the ankle is safe and effective - 2-year-followup in 130 patients","volume":"23","author":"Richter","year":"2017","journal-title":"Foot Ankle Surg"},{"issue":"5","key":"10.1016\/j.fcl.2020.11.001_bib38","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00264-015-2725-7","article-title":"Outcomes of acute Achilles tendon rupture repair with bone marrow aspirate concentrate augmentation","volume":"39","author":"Stein","year":"2015","journal-title":"Int Orthop"},{"issue":"7","key":"10.1016\/j.fcl.2020.11.001_bib39","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1007\/s00167-017-4479-9","article-title":"Intratendinous adipose-derived stromal vascular fraction (SVF) injection provides a safe, efficacious treatment for Achilles tendinopathy: results of a randomized controlled clinical trial at a 6-month follow-up","volume":"26","author":"Usuelli","year":"2018","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.fcl.2020.11.001_bib40","author":"FDA"},{"issue":"14","key":"10.1016\/j.fcl.2020.11.001_bib41","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1177\/0363546517735844","article-title":"Intra-articular Mesenchymal Stem Cell Therapy for the Human Joint: A Systematic Review","volume":"46","author":"McIntyre","year":"2018","journal-title":"Am J Sports Med"},{"issue":"5","key":"10.1016\/j.fcl.2020.11.001_bib42","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.arthro.2016.01.020","article-title":"Injection of Mesenchymal Stem Cells as a Supplementary Strategy of Marrow Stimulation Improves Cartilage Regeneration After Lateral Sliding Calcaneal Osteotomy for Varus Ankle Osteoarthritis: Clinical and Second-Look Arthroscopic Results","volume":"32","author":"Kim","year":"2016","journal-title":"Arthroscopy"},{"issue":"5","key":"10.1016\/j.fcl.2020.11.001_bib43","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1177\/0363546513479018","article-title":"Clinical outcomes of mesenchymal stem cell injection with arthroscopic treatment in older patients with osteochondral lesions of the talus","volume":"41","author":"Kim","year":"2013","journal-title":"Am J Sports Med"}],"container-title":["Foot and Ankle Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083751520301406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1083751520301406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:52:33Z","timestamp":1761054753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1083751520301406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1083751520301406"],"URL":"https:\/\/doi.org\/10.1016\/j.fcl.2020.11.001","relation":{},"ISSN":["1083-7515"],"issn-type":[{"value":"1083-7515","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging Biological Treatment Methods for Ankle Joint and Soft Tissue Conditions","name":"articletitle","label":"Article Title"},{"value":"Foot and Ankle Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fcl.2020.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}