{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:01:06Z","timestamp":1771844466239,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.fct.2003.10.016","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T05:58:32Z","timestamp":1071813512000},"page":"509-516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Inhibition of liver carcinogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa"],"prefix":"10.1016","volume":"42","author":[{"given":"E.Gonz\u00e1lez","family":"de Mej\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.V.","family":"Ram\u00edrez-Mares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Arce-Popoca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wallig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Villa-Trevi\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fct.2003.10.016_BIB1","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1002\/ptr.797","article-title":"Inhibition of tumour growth and inflammation by consumption of tea","volume":"16","author":"Das","year":"2002","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.fct.2003.10.016_BIB2","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1111\/j.1753-4887.1996.tb03819.x","article-title":"Bioactive ingredients: antioxidants and polyphenols in tea","volume":"54","author":"Dreosti","year":"1996","journal-title":"Nutrition Reviews"},{"issue":"7","key":"10.1016\/j.fct.2003.10.016_BIB3","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0955-2863(01)00155-3","article-title":"A review of latest research findings on the health promotion properties of tea","volume":"12","author":"Dufresne","year":"2001","journal-title":"Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.fct.2003.10.016_BIB4","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0278-6915(98)00063-5","article-title":"Short- and intermediate-term carcinogenicity testing. A review.Part I: The prototypes mouse skin tumour assay and rat liver focus assay","volume":"36","author":"Enzmann","year":"1998","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.fct.2003.10.016_BIB5","series-title":"Toxic Injury of the Liver (part A)","first-page":"445","article-title":"Response of the liver carcinogens","author":"Farber","year":"1979"},{"issue":"6","key":"10.1016\/j.fct.2003.10.016_BIB6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/10715760100301281","article-title":"Anticarcinogenic antioxidants as inhibitors against intracellular oxidative stress","volume":"35","author":"Feng","year":"2001","journal-title":"Free Radical Research"},{"issue":"1","key":"10.1016\/j.fct.2003.10.016_BIB7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1207\/S15327914NC381_12","article-title":"Effect of tea polyphenols and tea pigments on the inhibition of precancerous liver lesions in rats","volume":"38","author":"Gong","year":"2000","journal-title":"Nutrition and Cancer"},{"issue":"1","key":"10.1016\/j.fct.2003.10.016_BIB8","first-page":"61","article-title":"Leaf extract from Ardisia compressa protects against 1-nitropyrene-induced cytotoxicity and its antioxidant defense disruption in cultured rat hepatocytes","volume":"179","author":"Gonz\u00e1lez de Mej\u00eda","year":"2002","journal-title":"Toxicology"},{"issue":"26","key":"10.1016\/j.fct.2003.10.016_BIB9","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1021\/jf0258757","article-title":"Topoisomerase I and II enzyme inhibitory aqueous extract of Ardisia compressa and Ardisin provide antioxidant protection against benomyl-damaged hepatocytes","volume":"50","author":"Gonz\u00e1lez de Mej\u00eda","year":"2002","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.fct.2003.10.016_BIB10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1021\/jf00017a018","article-title":"Stabilization of the prussian blue color in the determination of polyphenols","volume":"40","author":"Graham","year":"1992","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.fct.2003.10.016_BIB11","doi-asserted-by":"crossref","first-page":"10350","DOI":"10.1073\/pnas.171326098","article-title":"Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols","volume":"98","author":"Gupta","year":"2001","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"10.1016\/j.fct.2003.10.016_BIB12","first-page":"1943","article-title":"Induction of programmed cell death (apoptosis) in human lymphoid leukemia cells by catechin compounds","volume":"16","author":"Hibasami","year":"1996","journal-title":"Anticancer Research"},{"issue":"2\u20133","key":"10.1016\/j.fct.2003.10.016_BIB13","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/em.10066","article-title":"Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats","volume":"39","author":"Hirose","year":"2002","journal-title":"Environmental and Molecular Mutagenesis"},{"key":"10.1016\/j.fct.2003.10.016_BIB14","first-page":"386","article-title":"Rapid bioassay merhods for carcinogens and modifiers of hepatocarcinogenesis","volume":"19","author":"Ito","year":"1989","journal-title":"Critical Reviews in Toxicology"},{"issue":"5","key":"10.1016\/j.fct.2003.10.016_BIB15","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3748\/wjg.v6.i5.699","article-title":"Chemoprevention of tea on colorectal cancer induced by dimethylhydrazine in Wistar rats","volume":"6","author":"Jia","year":"2000","journal-title":"World Journal of Gastroenterology"},{"issue":"6","key":"10.1016\/j.fct.2003.10.016_BIB16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1046\/j.1365-2613.2001.00205.x","article-title":"Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea","volume":"82","author":"Jung","year":"2001","journal-title":"International Journal of Experimental Pathology"},{"key":"10.1016\/j.fct.2003.10.016_BIB17","first-page":"221","article-title":"Tea in chemoprevention of cancer: epidemiologic and experimental studies (review)","volume":"8","author":"Katiyar","year":"1996","journal-title":"International Journal of Oncology"},{"issue":"3","key":"10.1016\/j.fct.2003.10.016_BIB18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/sj.bjc.6600054","article-title":"Congou tea drinking and oesophageal cancer in South China","volume":"86","author":"Ke","year":"2002","journal-title":"British Journal of Cancer"},{"key":"10.1016\/j.fct.2003.10.016_BIB19","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0278-6915(02)00101-1","article-title":"search for dietary antimutagens and anticarcinogens: methodological aspects and extrapolation problems","volume":"40","author":"Knasm\u00fcller","year":"2002","journal-title":"Food and Chemical Toxicology"},{"issue":"4","key":"10.1016\/j.fct.2003.10.016_BIB20","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1211\/0022357011775695","article-title":"Tea consumption modulates hepatic drug metabolizing enzymes in Wistar rats","volume":"53","author":"Maliakal","year":"2001","journal-title":"The Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.fct.2003.10.016_BIB21","first-page":"1","article-title":"Risks associated with consumption of herbal teas","volume":"150","author":"Manteiga","year":"1997","journal-title":"Reviews of Environmental Contamination and Toxicology"},{"key":"10.1016\/j.fct.2003.10.016_BIB22","first-page":"S169","article-title":"Follow-up of GST-P during hepatocarcinogenesis with DEN-2AAF in F344 rats","volume":"26","author":"March\u00e9-Cova","year":"1995","journal-title":"Archives of Medical Research"},{"issue":"1","key":"10.1016\/j.fct.2003.10.016_BIB23","first-page":"1","article-title":"The role of tea in human health: an update","volume":"21","author":"McKay","year":"2002","journal-title":"Journal of the American Clinical Nutrition"},{"key":"10.1016\/j.fct.2003.10.016_BIB24","series-title":"Animal Histology Techniques. Handbook of Laboratory Animal Science vol. II","year":"1974"},{"key":"10.1016\/j.fct.2003.10.016_BIB25","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/jn\/128.7.1172","article-title":"Accumulation of (\u2212) epicatechin metabolites in rat plasma after oral administration and distribution of conjugation enzymes in rat tissues","volume":"128","author":"Piskula","year":"1998","journal-title":"Journal of Nutrition"},{"issue":"2","key":"10.1016\/j.fct.2003.10.016_BIB26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1207\/S15327914NC382_11","article-title":"Chemoprevention of aflatoxin B1-initiated and carbon tetrachloride-promoted hepatocarcinogenesis in the rat by green tea","volume":"38","author":"Qin","year":"2000","journal-title":"Nutrition and Cancer"},{"key":"10.1016\/j.fct.2003.10.016_BIB27","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0887-2333(99)00071-5","article-title":"Protection of extract from leaves of Ardisia compressa against benomyl-induced cytotoxicity and genotoxicity in cultured rat hepatocytes","volume":"13","author":"Ram\u00edrez-Mares","year":"1999","journal-title":"Toxicology in Vitro"},{"issue":"2","key":"10.1016\/j.fct.2003.10.016_BIB28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1207\/S15327914NC402_11","article-title":"Green tea and its catechins inhibit breast cancer xenografts","volume":"40","author":"Sartippour","year":"2001","journal-title":"Nutrition and Cancer"},{"issue":"3","key":"10.1016\/j.fct.2003.10.016_BIB29","first-page":"199","article-title":"The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis","volume":"75","author":"Sato","year":"1984","journal-title":"Japanase Journal of Cancer Research: Gann"},{"key":"10.1016\/j.fct.2003.10.016_BIB30","first-page":"839","article-title":"Promotion of spontaneous cells in rat liver as a possible explanation of tumor production by nonmutagenig compounds","volume":"43","author":"Schulte-Hermann","year":"1983","journal-title":"Cancer Research"},{"key":"10.1016\/j.fct.2003.10.016_BIB31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/ijc.2910400512","article-title":"Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene","volume":"40","author":"Semple-Roberts","year":"1987","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.fct.2003.10.016_BIB32","first-page":"3214","article-title":"Report of a workshop on classification of specific hepatocellular lesions in rats","volume":"35","author":"Squire","year":"1975","journal-title":"Cancer Research"},{"issue":"3","key":"10.1016\/j.fct.2003.10.016_BIB33","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1079\/PHN2001314","article-title":"Tea consumption and the reduced risk of colon cancer\u2014results from a national prospective cohort study","volume":"5","author":"Su","year":"2002","journal-title":"Public Health and Nutrition"},{"issue":"6","key":"10.1016\/j.fct.2003.10.016_BIB34","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00268-001-0290-2","article-title":"Inhibitory effect of epigallocatechin-3-gallate on growth and invasion in human biliary tract carcinoma cells","volume":"26","author":"Takada","year":"2002","journal-title":"World Journal of Surgery"},{"key":"10.1016\/j.fct.2003.10.016_BIB35","first-page":"61","article-title":"An immunohistological study of follicular lymphoma, reticulum cell sarcoma and Hodgki\u0144s disease","volume":"12","author":"Taylor","year":"1976","journal-title":"European Journal of Cancer Clinical Oncology"},{"key":"10.1016\/j.fct.2003.10.016_BIB36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0304-3835(92)90254-S","article-title":"Species and sex differences of aflatoxin B1-induced glutathione S-transferase placental form in single hepatocytes","volume":"66","author":"Tsuji","year":"1992","journal-title":"Cancer Letters"},{"issue":"1","key":"10.1016\/j.fct.2003.10.016_BIB37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3835(01)00571-7","article-title":"Inhibition of green tea catechins against the growth of cancerous human colon and hepatic epithelial cells","volume":"170","author":"Uesato","year":"2001","journal-title":"Cancer Letters"},{"key":"10.1016\/j.fct.2003.10.016_BIB38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/019262338201000204","article-title":"Phenotype properties of preneoplastic rat liver lesions and applications to detection of carcinogens and tumor promoters","volume":"10","author":"Williams","year":"1982","journal-title":"Toxicologic Pathology"},{"key":"10.1016\/j.fct.2003.10.016_BIB39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.pharmtox.42.082101.154309","article-title":"Inhibition of carcinogenesis by tea","volume":"42","author":"Yang","year":"2002","journal-title":"Annual Reviews in Pharmacolical Toxicology"},{"key":"10.1016\/j.fct.2003.10.016_BIB40","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/carcin\/19.4.611","article-title":"Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols","volume":"19","author":"Yang","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2003.10.016_BIB41","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1093\/jnci\/85.13.1038","article-title":"Tea and cancer","volume":"85","author":"Yang","year":"1993","journal-title":"Journal of National Cancer Institute"},{"key":"10.1016\/j.fct.2003.10.016_BIB42","first-page":"129","article-title":"Effects of choline-deficient diet and a hypolipidemic agent on single glutathione S-transferase placental form-positive hepatocytes in rat liver","volume":"81","author":"Yokota","year":"1990","journal-title":"Japon Journal of Cancer Research"},{"key":"10.1016\/j.fct.2003.10.016_BIB43","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/carcin\/18.2.451","article-title":"Activations of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression","volume":"18","author":"Yu","year":"1997","journal-title":"Carcinogenesis"},{"issue":"2","key":"10.1016\/j.fct.2003.10.016_BIB44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1207\/S15327914NC382_16","article-title":"Induction of apoptosis and cell cycle arrest in cancer cells by in vivo metabolites of teas","volume":"38","author":"Zhang","year":"2000","journal-title":"Nutrition and Cancer"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691503003144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691503003144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:34:24Z","timestamp":1759523664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691503003144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0278691503003144"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2003.10.016","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of liver carcinogenesis in Wistar rats by consumption of an aqueous extract from leaves of Ardisia compressa","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2003.10.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}