{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:09:00Z","timestamp":1771006140167,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.fct.2003.11.011","type":"journal-article","created":{"date-parts":[[2004,1,22]],"date-time":"2004-01-22T05:19:43Z","timestamp":1074748783000},"page":"609-617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Hepatoprotective and antioxidant effects of Bupleurum kaoi Liu (Chao et Chuang) extract and its fractions fractionated using supercritical CO2 on CCl4-induced liver damage"],"prefix":"10.1016","volume":"42","author":[{"given":"Be-Jen","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu-Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Yin","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zer-Ran","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2003.11.011_BIB1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1055\/s-2008-1074987","article-title":"Pharmacological actions of saikosaponins isolated from Bupleurum falcatum. L. effects of saikosaponins on liver function","volume":"40","author":"Abe","year":"1980","journal-title":"Planta Medica"},{"key":"10.1016\/j.fct.2003.11.011_BIB2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.fct.2003.11.011_BIB3","first-page":"722","article-title":"High yield production of isolated rat liver parenchymal cells","volume":"59","author":"Berry","year":"1973","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.fct.2003.11.011_BIB4","first-page":"524","article-title":"Strain differences in mice in carbon tetrachloride-induced liver injury","volume":"64","author":"Bhathal","year":"1983","journal-title":"British Journal of Experimental Pathology"},{"key":"10.1016\/j.fct.2003.11.011_BIB5","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/BF02615992","article-title":"Primary monolayer cultures of rat liver parenchymal cells suitable for study of regulation of enzyme synthesis","volume":"9","author":"Bonney","year":"1974","journal-title":"In Vitro"},{"key":"10.1016\/j.fct.2003.11.011_BIB6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1142\/S0192415X89000048","article-title":"The pharmacological and pathological studies on several hepatic protective crude drugs from Taiwan (II)","volume":"17","author":"Chiu","year":"1989","journal-title":"American Journal of Chinese Medicine"},{"key":"10.1016\/j.fct.2003.11.011_BIB7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/phrs.1999.0648","article-title":"Mechanisms for the hepatoprotective action of kolaviron","volume":"42","author":"Farombi","year":"2000","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.fct.2003.11.011_BIB8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0891-5849(88)90023-8","article-title":"Lipid peroxidation measured as thiobarbituric acid-reactive substance in tissue slices","volume":"4","author":"Fraga","year":"1988","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.fct.2003.11.011_BIB9","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0140-6736(00)02075-4","article-title":"The antioxidant paradox","volume":"355","author":"Halliwell","year":"2000","journal-title":"The Lancet"},{"key":"10.1016\/j.fct.2003.11.011_BIB10","first-page":"59","article-title":"Role of free radicals and catalytic metal irons in human disease","volume":"186","author":"Halliwell","year":"1990","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.fct.2003.11.011_BIB11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1254\/fpj.97.1_13","article-title":"Studies on antinephritic effects of plant components in rats (1). Effects of saikosaponins original-type anti-GBM nephritis in rats and its mechanisms","volume":"97","author":"Hattori","year":"1991","journal-title":"Nippon Yakurigaku Zasshi"},{"key":"10.1016\/j.fct.2003.11.011_BIB12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2007-969730","article-title":"Analgesic and antihepatotoxic actions of dianosides, triterpenoid saponins of dianthus superbus var logicalycinus herbs","volume":"50","author":"Hikino","year":"1984","journal-title":"Planta Medica"},{"key":"10.1016\/j.fct.2003.11.011_BIB13","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1021\/jf021159t","article-title":"Antioxidative and hepatoprotective effects of Antrodia camphorate extract","volume":"51","author":"Hsiao","year":"2003","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.fct.2003.11.011_BIB14","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0955-2863(01)00160-7","article-title":"Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes","volume":"12","author":"John","year":"2001","journal-title":"Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.fct.2003.11.011_BIB15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02623304","article-title":"Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations","volume":"22","author":"Kreamer","year":"1986","journal-title":"In Vitro Cellular and Developmental Biology"},{"key":"10.1016\/j.fct.2003.11.011_BIB16","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0006-291X(87)90491-8","article-title":"Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen","volume":"149","author":"Kyle","year":"1987","journal-title":"Biochemical and Biophysical Research Communication"},{"key":"10.1016\/j.fct.2003.11.011_BIB17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1142\/S0192415X90000149","article-title":"The pharmacological and pathological studies on Taiwan folk medicine (III)","volume":"3\u20134","author":"Lin","year":"1990","journal-title":"American Journal of Chinese Medicine"},{"key":"10.1016\/j.fct.2003.11.011_BIB18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/(SICI)1099-1573(199609)10:6<483::AID-PTR884>3.0.CO;2-2","article-title":"Hepatoprotective activity of Taiwan folk medicine","volume":"10","author":"Lin","year":"1996","journal-title":"Phytotherapy Research"},{"key":"10.1016\/j.fct.2003.11.011_BIB19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0378-8741(95)90032-2","article-title":"Pharmacology of oleanolic acid and ursolic acid","volume":"49","author":"Liu","year":"1995","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.fct.2003.11.011_BIB20","first-page":"16","article-title":"The effect of oleanolic acid on chemical-induced liver injury in mice","volume":"15","author":"Liu","year":"1995","journal-title":"Acta Pharmcologica"},{"key":"10.1016\/j.fct.2003.11.011_BIB21","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1142\/S0192415X95000249","article-title":"Studies on the agronomic characteristics, yield, and saikosaponin content of two Bupleurum species in Taiwan","volume":"2","author":"Liu","year":"1995","journal-title":"American Journal of Chinese Medicine"},{"key":"10.1016\/j.fct.2003.11.011_BIB22","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/S0960-894X(97)00418-6","article-title":"New hepatoprotective saponins, bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri Radix","volume":"7","author":"Matsuda","year":"1997","journal-title":"Bioorganic and Medicinal Chemistry Letters"},{"key":"10.1016\/j.fct.2003.11.011_BIB23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/chromsci\/38.6.229","article-title":"High-performance liquid chromatographic analysis of saponin compounds in Bupleurum falcatum","volume":"38","author":"Park","year":"2000","journal-title":"Journal of Chromatographic Science"},{"key":"10.1016\/j.fct.2003.11.011_BIB24","first-page":"246","article-title":"Phytotherapeutic aspects of diseases of the cardiovascular system. 5. Saponins and possibilities of their use in prevention and therapy","volume":"44","author":"Purmova","year":"1995","journal-title":"Ceska Slovenska Farmacie"},{"key":"10.1016\/j.fct.2003.11.011_BIB25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanism of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacological Therapy"},{"key":"10.1016\/j.fct.2003.11.011_BIB26","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1046\/j.1365-2567.1999.00774.x","article-title":"B-cell proliferation activity of pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. and its structural requirement","volume":"97","author":"Sakurai","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/j.fct.2003.11.011_BIB27","first-page":"41","article-title":"Halogenated hydrocarbon and hydroperoxide-induced peroxidation in rat tissue slices","volume":"2","author":"Sano","year":"1986","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.fct.2003.11.011_BIB28","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1016\/S0009-2509(98)00212-7","article-title":"New fractionation process for citrus oil by pressure swing adsorption in supercritical carbon dioxide","volume":"53","author":"Sato","year":"1998","journal-title":"Chemical Engineering Science"},{"key":"10.1016\/j.fct.2003.11.011_BIB29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1042\/bj1230823","article-title":"The stimulatory effects of carbon tetrachloride on peroxidative reactions in rat liver fractions in vitro. Inhibitory effects of free-radical scavengers and other agents","volume":"123","author":"Slater","year":"1971","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.fct.2003.11.011_BIB30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0165-1110(87)90014-5","article-title":"Reduced oxygen species, mutation, induction and cancer initiation","volume":"186","author":"Vuillaume","year":"1987","journal-title":"Mutation Research"},{"key":"10.1016\/j.fct.2003.11.011_BIB31","unstructured":"Wang, B. J., Liu, C. T., Tseng, C. T., Yu, Z. R., 2003. Fractionation using supercritical CO2 changes the antioxidant activity of Bupleurum kaoi Liu (Chao et Chuang). Food Science and Technology-Lebensmittel-Wissenschaft and Technologie (Submitted for publication)."},{"key":"10.1016\/j.fct.2003.11.011_BIB32","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0278-6915(00)00011-9","article-title":"Protective effect of Hibiscus anthocyanins against tert-butylhydroperoxide-induced hepatic toxicity in rats","volume":"38","author":"Wang","year":"2000","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.fct.2003.11.011_BIB33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0920-4105(98)00056-4","article-title":"The supercritical fluid extractive fractionation and the characterization of heavy oils and petroleum residua","volume":"22","author":"Yang","year":"1999","journal-title":"Journal of Petroleum Science and Engineering"},{"key":"10.1016\/j.fct.2003.11.011_BIB34","first-page":"409","article-title":"Anti-inflammatory and hepatoprotective activity of saikosaponin-f and the root extract of Bupleurumj kaoi","volume":"65","author":"Yen","year":"1994","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fct.2003.11.011_BIB35","first-page":"24","article-title":"Study on the mechanism of oleanolic acid against experimental liver injury in rats","volume":"8","author":"Zhang","year":"1992","journal-title":"Traditional Medicine and Clinical Pharmacology"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691503003326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691503003326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:33:15Z","timestamp":1759523595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691503003326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0278691503003326"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2003.11.011","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotective and antioxidant effects of Bupleurum kaoi Liu (Chao et Chuang) extract and its fractions fractionated using supercritical CO2 on CCl4-induced liver damage","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2003.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}