{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:22:32Z","timestamp":1791350552349,"version":"4.3.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.fct.2005.10.006","type":"journal-article","created":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T07:24:58Z","timestamp":1133508298000},"page":"739-746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"title":["Investigation of the dermal sensitization potential of various essential oils in the local lymph node assay"],"prefix":"10.1016","volume":"44","author":[{"given":"J.","family":"Lalko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Api","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 2","key":"10.1016\/j.fct.2005.10.006_bib1","first-page":"40","article-title":"Quenching of citral, cinnamaldehyde and phenylacetaldehyde sensitization in human repeated insult patch tests","volume":"42","author":"Api","year":"2000","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2005.10.006_bib2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1159\/000063153","article-title":"Sensitization methodology and primary prevention of the research institute for fragrance materials","volume":"205","author":"Api","year":"2002","journal-title":"Dermatology"},{"issue":"Suppl. 4","key":"10.1016\/j.fct.2005.10.006_bib3","first-page":"37","article-title":"Quenching of citral sensitization demonstrated in a human repeated insult patch test","volume":"46","author":"Api","year":"2000","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2005.10.006_bib4","series-title":"Perfume and Flavor Materials of Natural Origin","author":"Arctander","year":"1960"},{"issue":"5","key":"10.1016\/j.fct.2005.10.006_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1034\/j.1600-0536.2000.043005253.x","article-title":"Quenching: Fact or fiction?","volume":"43","author":"Basketter","year":"2000","journal-title":"Contact Dermatitis"},{"issue":"1","key":"10.1016\/j.fct.2005.10.006_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.0105-1873.2004.00278.x","article-title":"Reproducible prediction of contact allergenic potency using the local lymph node assay","volume":"50","author":"Basketter","year":"2004","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2005.10.006_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1099-1263(199907\/08)19:4<261::AID-JAT572>3.0.CO;2-5","article-title":"A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses","volume":"19","author":"Basketter","year":"1999","journal-title":"Journal of Applied Toxicology"},{"key":"10.1016\/j.fct.2005.10.006_bib8","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1034\/j.1600-0536.2000.042006344.x","article-title":"Use of the local lymph node assay for estimation of relative contact allergenic potential","volume":"42","author":"Basketter","year":"2000","journal-title":"Contact Dermatitis"},{"issue":"3","key":"10.1016\/j.fct.2005.10.006_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1034\/j.1600-0536.2002.470307.x","article-title":"Investigation of the skin sensitizing activity of linalool","volume":"47","author":"Basketter","year":"2002","journal-title":"Contact Dermatitis"},{"issue":"S-1","key":"10.1016\/j.fct.2005.10.006_bib10","first-page":"246","article-title":"Correlation of LLNA and human skin sensitization thresholds","volume":"84","author":"Basketter","year":"2005","journal-title":"The Toxicologist"},{"issue":"1","key":"10.1016\/j.fct.2005.10.006_bib11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.0105-1873.2005.00490.x","article-title":"Evaluation of the skin sensitizing potency of chemicals by using the existing methods and considerations of relevance for elicitation","volume":"52","author":"Basketter","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2005.10.006_bib12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/rtph.2002.1581","article-title":"Consumer exposure to fragrance ingredients: providing estimates for safety evaluation","volume":"36","author":"Cadby","year":"2002","journal-title":"Regulatory Toxicology and Pharmacology"},{"issue":"6","key":"10.1016\/j.fct.2005.10.006_bib13","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.fct.2004.09.014","article-title":"Fragrance material review on cinnamaldehyde","volume":"43","author":"Cocchiara","year":"2004","journal-title":"Food and Chemical Toxicology"},{"issue":"6","key":"10.1016\/j.fct.2005.10.006_bib14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1034\/j.1600-0536.2001.044006357.x","article-title":"The suitability of hexyl cinnamic aldehyde as a calibrant for the murine local lymph node assay","volume":"44","author":"Dearman","year":"2001","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2005.10.006_bib15","first-page":"365","article-title":"Statement on the validity of the local lymph node assay for skin sensitization testing","volume":"28","author":"ECVAM (European Centre for the Validation of Alternative Methods)","year":"2000","journal-title":"ATLA"},{"key":"10.1016\/j.fct.2005.10.006_bib16","series-title":"Analytical Procedure 30: Peroxide Value","author":"FMA (Fragrance Materials Association)","year":"2002"},{"key":"10.1016\/j.fct.2005.10.006_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1046-199X(00)90027-7","article-title":"Local lymph node assay: validation for regulatory purposes","volume":"11","author":"Gerberick","year":"2000","journal-title":"American Journal of Contact Dermatitis"},{"issue":"6","key":"10.1016\/j.fct.2005.10.006_bib18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1034\/j.1600-0536.2001.450603.x","article-title":"Understanding fragrance allergy using an exposure-based risk assessment approach","volume":"45","author":"Gerberick","year":"2001","journal-title":"Contact Dermatitis"},{"issue":"3","key":"10.1016\/j.fct.2005.10.006_bib19","first-page":"156","article-title":"Contact allergenic potency: correlation of human and local lymph node assay data","volume":"12","author":"Gerberick","year":"2001","journal-title":"American Journal of Contact Dermatitis"},{"key":"10.1016\/j.fct.2005.10.006_bib20","series-title":"Guidance on the Operation of the Animals (Scientific Procedures) Act, 1986","author":"Home Office","year":"2000"},{"key":"10.1016\/j.fct.2005.10.006_bib21","series-title":"Code of Practice, Standard on Cinnamaldehyde","author":"IFRA (International Fragrance Association)","year":"2003"},{"issue":"5","key":"10.1016\/j.fct.2005.10.006_bib22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1600-0536.1992.tb00129.x","article-title":"Air oxidation of d-limonene (the citrus solvent) creates potent allergens","volume":"26","author":"Karlberg","year":"1992","journal-title":"Contact Dermatitis"},{"issue":"6","key":"10.1016\/j.fct.2005.10.006_bib23","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/000155501317208318","article-title":"Structural analogues inhibit the sensitizing capacity of carvone","volume":"81","author":"Karlberg","year":"2001","journal-title":"Acta Dermato-Venereologica"},{"key":"10.1016\/j.fct.2005.10.006_bib24","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0278-6915(92)90153-C","article-title":"The murine local lymph node assay: a commentary on collaborative studies and new directions","volume":"30","author":"Kimber","year":"1992","journal-title":"Food and Chemical Toxicology"},{"issue":"1","key":"10.1016\/j.fct.2005.10.006_bib25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0300-483X(94)90193-7","article-title":"The local lymph node assay: developments and applications","volume":"93","author":"Kimber","year":"1994","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2005.10.006_bib26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/jid.1966.159","article-title":"The identification of contact allergens by human assay. II. Factors influencing the induction and measurement of allergic contact dermatitis","volume":"47","author":"Kligman","year":"1966","journal-title":"Journal of Investigative Dermatology"},{"key":"10.1016\/j.fct.2005.10.006_bib27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1600-0536.1975.tb05389.x","article-title":"Updating the maximization test for identifying contact allergens","volume":"1","author":"Kligman","year":"1975","journal-title":"Contact Dermatitis"},{"issue":"S-1","key":"10.1016\/j.fct.2005.10.006_bib28","first-page":"246","article-title":"Potency estimations for several fragrance materials in the local lymph node assay and their correlation to human studies","volume":"84","author":"Lalko","year":"2005","journal-title":"The Toxicologist"},{"issue":"3","key":"10.1016\/j.fct.2005.10.006_bib29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/10915810490471343","article-title":"Ethanol and diethyl phthalate: vehicle effects in the local lymph node assay","volume":"23","author":"Lalko","year":"2004","journal-title":"International Journal of Toxicology"},{"key":"10.1016\/j.fct.2005.10.006_bib30","series-title":"Progress in Essential oils 1976\u20131978","author":"Lawrence","year":"1979"},{"key":"10.1016\/j.fct.2005.10.006_bib31","series-title":"Progress in Essential oils 1978","author":"Lawrence","year":"1979"},{"key":"10.1016\/j.fct.2005.10.006_bib32","series-title":"Progress in Essential oils 1979\u20131980","author":"Lawrence","year":"1981"},{"key":"10.1016\/j.fct.2005.10.006_bib33","series-title":"Progress in Essential oils 1981\u20131987","author":"Lawrence","year":"1989"},{"key":"10.1016\/j.fct.2005.10.006_bib34","series-title":"Progress in Essential oils 1988\u20131991","author":"Lawrence","year":"1993"},{"key":"10.1016\/j.fct.2005.10.006_bib35","series-title":"Progress in Essential oils 1992\u20131994","author":"Lawrence","year":"1995"},{"key":"10.1016\/j.fct.2005.10.006_bib36","series-title":"Progress in Essential oils 1995\u20132000","author":"Lawrence","year":"2003"},{"issue":"September","key":"10.1016\/j.fct.2005.10.006_bib37","first-page":"80","article-title":"Progress in essential oils: basil oil","volume":"30","author":"Lawrence","year":"2004","journal-title":"Perfumer and Flavorist"},{"key":"10.1016\/j.fct.2005.10.006_bib38","first-page":"213","article-title":"The impact of vehicle on assessment of relative skin sensitization potency of 1,4-dihydroquinone in the local lymph node assay","volume":"10","author":"Lea","year":"1999","journal-title":"American Journal of Contact Dermatitis"},{"issue":"1\u20132","key":"10.1016\/j.fct.2005.10.006_bib39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0300-483X(95)03279-O","article-title":"Further evaluation of the local lymph node assay in the final phase of an international collaborative trial","volume":"108","author":"Loveless","year":"1996","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2005.10.006_bib40","first-page":"353","article-title":"Contact allergy: predictive testing in humans","volume":"vol. 4","author":"Marzulli","year":"1977"},{"key":"10.1016\/j.fct.2005.10.006_bib41","unstructured":"McNamee, P.M., Gilpin, D.A., Robinson , M.K., Gerberick, G.F., in press. A review of critical factors in the conduct and interpretation of the human repeat insult patch test. Contact Dermatitis."},{"key":"10.1016\/j.fct.2005.10.006_bib42","unstructured":"NIH (National Institutes of Health) 1999. The murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals\/compounds. Publication No: 99-4494. Bethesda, Maryland, NIH."},{"key":"10.1016\/j.fct.2005.10.006_bib43","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1034\/j.1600-0536.2001.044006347.x","article-title":"Mechanism of the antigen formation of carvone and related alpha,beta-unsaturated ketones","volume":"44","author":"Nilsson","year":"2001","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2005.10.006_bib44","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/00015550310006770","article-title":"Inhibition of the sensitising effects of carvone by the addition of non-allergenic compounds","volume":"84","author":"Nilsson","year":"2004","journal-title":"Acta Dermato-Venereologica"},{"key":"10.1016\/j.fct.2005.10.006_bib45","series-title":"Skin Sensitization: Local Lymph Node Assay. Guideline reference 429","author":"OECD (Organization for Economic Co-Operation and Development)","year":"2002"},{"issue":"3","key":"10.1016\/j.fct.2005.10.006_bib46","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0015-6264(76)80424-5","article-title":"Inhibition of sensitization reactions induced by certain aldehydes","volume":"14","author":"Opdyke","year":"1976","journal-title":"Food and Cosmetics Toxicology"},{"key":"10.1016\/j.fct.2005.10.006_bib47","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.) 1971. Appraisal of sensitizing powers by maximization testing in humans. Report number 1805, September 27, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2005.10.006_bib48","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.) 1972a. The contact-sensitization potential of fragrance materials by maximization testing in humans. Report number 1804, February 18, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2005.10.006_bib49","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.) 1972b. The contact-sensitization potential of fragrance materials by maximization testing in humans. Report number 1804, March 14, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2005.10.006_bib50","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.) 1973. Report on human maximization studies, Report number 1803, July 17, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2005.10.006_bib51","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.) 1974a. Report on human maximization studies. Report number 1801, August 19, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2005.10.006_bib52","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.) 1974b. Report on human maximization studies. Report number 1779, October 18, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2005.10.006_bib53","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.) 1976. Report on human maximization studies. Report number 1796, October 8, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2005.10.006_bib54","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.) 2004a. Citronellal: local lymph node assay. Unpublished report from IFF. Report number 47817, RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2005.10.006_bib55","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.) 2004b. Local lymph node assay on d-Limonene. Report number 45754, RIFM, Woodcliff Lake, NJ, USA."},{"issue":"3","key":"10.1016\/j.fct.2005.10.006_bib56","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yrtph.2004.02.002","article-title":"Quantitative relationship between the local lymph node assay and human skin sensitization assays","volume":"39","author":"Schneider","year":"2004","journal-title":"Regulatory Toxicology and Pharmacology"},{"issue":"12","key":"10.1016\/j.fct.2005.10.006_bib57","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1021\/tx049831z","article-title":"Contact allergens formed on air exposure of linalool. Identification and quantification of primary and secondary oxidation products and the effect on skin sensitization","volume":"17","author":"Skold","year":"2004","journal-title":"Chemical Research in Toxicology"},{"key":"10.1016\/j.fct.2005.10.006_bib58","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1099-1263(199907\/08)19:4<255::AID-JAT573>3.0.CO;2-S","article-title":"Local lymph node assay responses to paraphenylenediamine intra- and inter-laboratory evaluations","volume":"19","author":"Warbrick","year":"1999","journal-title":"Journal of Applied Toxicology"},{"key":"10.1016\/j.fct.2005.10.006_bib59","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1600-0536.1999.tb06181.x","article-title":"Influence of application vehicle on skin sensitization to methylchloroisothiazolinone\/methylisothiazolinone: an analysis using the local lymph node assay","volume":"41","author":"Warbrick","year":"1999","journal-title":"Contact Dermatitis"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691505003236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691505003236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:37:39Z","timestamp":1759523859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691505003236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0278691505003236"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2005.10.006","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of the dermal sensitization potential of various essential oils in the local lymph node assay","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2005.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}