{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:04:03Z","timestamp":1790856243459,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.fct.2006.01.002","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T10:57:23Z","timestamp":1140433043000},"page":"1082-1091","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro"],"prefix":"10.1016","volume":"44","author":[{"given":"A.N.","family":"Sayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Bourdelais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.G.","family":"Baden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2006.01.002_bib1","unstructured":"Abraham, W.M., Bourdelais, A.J., Sabater, J.R., Ahmed , A., Lee, T.A., Serebriakov, I., Baden, D.G., 2004. Airway responses to aerosolized brevetoxins in an animal model of asthma. Am. J. Respir. Crit. Care Med., 10, 1164\/rccm."},{"key":"10.1016\/j.fct.2006.01.002_bib2","doi-asserted-by":"crossref","unstructured":"Anderson, D.M., Kaoru, Y., White, A.W., 2000. Estimated annual economic impacts from harmful algal blooms (HABs) in the United States. Woods Hole Oceanographic Institution Technical Report.","DOI":"10.1575\/1912\/96"},{"key":"10.1016\/j.fct.2006.01.002_bib3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0091-6749(82)90116-6","article-title":"Effects of toxin of red tide, Ptychodiscus brevis, on canine tracheal smooth muscle: a possible new asthma-triggering mechanism","volume":"69","author":"Asai","year":"1982","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fct.2006.01.002_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1568-9883(03)00005-2","article-title":"Recreational exposure to aerosolized brevetoxins during Florida red tide events","volume":"2","author":"Backer","year":"2003","journal-title":"Harm. Algae"},{"key":"10.1016\/j.fct.2006.01.002_bib5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1383-5718(97)00004-1","article-title":"Selenium salts and chromosome damage","volume":"390","author":"Biswas","year":"1997","journal-title":"Mut. Res."},{"key":"10.1016\/j.fct.2006.01.002_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/np049797o","article-title":"A new polyether ladder compound produced by the dinoflagellate Karenia brevis","volume":"68","author":"Bourdelais","year":"2005","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.fct.2006.01.002_bib7","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1023\/B:CEMN.0000023629.81595.09","article-title":"Brevenal is a natural inhibitor of Brevetoxin action in sodium channel receptor binding assays","volume":"24","author":"Bourdelais","year":"2004","journal-title":"Cell Mol. Neurobiol."},{"key":"10.1016\/j.fct.2006.01.002_bib8","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S0278-6915(02)00085-6","article-title":"An in vitro screening paradigm for extracts of whole foods for detection of potential toxicants","volume":"40","author":"Charles","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2006.01.002_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0165-1110(94)90010-8","article-title":"International commission for protection against environmental mutagens and carcinogens: oxidative DNA damage-the effects of certain genotoxic and operationally non-genotoxic carcinogens","volume":"317","author":"Clayson","year":"1994","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2006.01.002_bib10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1289\/ehp.01109717","article-title":"Biomonitoring brevetoxin exposure in mammals using blood collection cards","volume":"109","author":"Fairey","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2006.01.002_bib11","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/S0041-0101(01)00092-7","article-title":"Acute and delayed thermoregulatory response of mice exposed to brevetoxin","volume":"39","author":"Gordon","year":"2001","journal-title":"Toxicon"},{"key":"10.1016\/j.fct.2006.01.002_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0014-5793(03)00418-6","article-title":"Channel induction by palytoxin in yeast cells expressing Na+, K+-ATPase or its chimera with sarco\/endoplasmic reticulum Ca2+-ATPase","volume":"543","author":"Ito","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.fct.2006.01.002_bib13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0022-3565(24)37263-5","article-title":"Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons","volume":"284","author":"Jeglitsch","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.fct.2006.01.002_bib14","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.toxicon.2004.07.023","article-title":"Pharmacological effects of the marine toxins, brevetoxin and saxitoxin, on murine frontal cortex neuronal networks","volume":"44","author":"Kulagina","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.fct.2006.01.002_bib15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0006-8993(02)03737-X","article-title":"Brevetoxin derivatives act as partial agonists at neurotoxin site 5 on the voltage gated Na+ channel","volume":"959","author":"LePage","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.fct.2006.01.002_bib16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0014-5793(87)80252-1","article-title":"Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage-dependent Na+ channel","volume":"219","author":"Lombet","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1016\/j.fct.2006.01.002_bib17","first-page":"223","article-title":"Clastogenicity of low pH to various cultured mammalian cells","volume":"272","author":"Morita","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/j.fct.2006.01.002_bib18","first-page":"27","article-title":"Red tide, its public health implications","volume":"60","author":"Music","year":"1973","journal-title":"JFMA"},{"key":"10.1016\/j.fct.2006.01.002_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/019262338701500106","article-title":"Free radical injury and liver tumor promotion","volume":"15","author":"Perera","year":"1991","journal-title":"Toxicol. Path."},{"key":"10.1016\/j.fct.2006.01.002_bib20","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0041-0101(99)00191-9","article-title":"Neurotoxic shellfish poisoning and brevetoxin metabolites: a case study from Florida","volume":"38","author":"Poli","year":"2000","journal-title":"Toxicon"},{"key":"10.1016\/j.fct.2006.01.002_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0305-0491(99)00107-8","article-title":"Polyketides form dinoflagellates: origins, pharmacology and biosynthesis","volume":"124","author":"Rein","year":"1999","journal-title":"Comp. Biochem. Physio. B"},{"key":"10.1016\/j.fct.2006.01.002_bib22","series-title":"Human Cytogenetics: A Practical Approach","author":"Rooney","year":"1986"},{"key":"10.1016\/j.fct.2006.01.002_bib23","unstructured":"Savage, J.R., 1999. An introduction to chromosomal aberrations. Atlas of Genetics and Cytogenetics in Oncology and Haematology."},{"key":"10.1016\/j.fct.2006.01.002_bib24","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00204-005-0676-2","article-title":"The effect of brevenal on brevetoxin-induced DNA damage in human lymphocytes","volume":"79","author":"Sayer","year":"2005","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.fct.2006.01.002_bib25","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1021\/ja01576a044","volume":"79","author":"Schantz","year":"1957","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.fct.2006.01.002_bib26","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1164\/ajrccm.161.2.9812021","article-title":"Lymphocytes migrate from the blood into the bronchoalveolar lavage and lung parenchyma in the asthma model of the brown Norway rat","volume":"161","author":"Schuster","year":"2000","journal-title":"Am. I. Respir. Crit. Care Med."},{"key":"10.1016\/j.fct.2006.01.002_bib27","series-title":"Biometry","author":"Sokal","year":"2003"},{"key":"10.1016\/j.fct.2006.01.002_bib28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0166-445X(98)00125-8","article-title":"High affinity binding of red tide neurotoxins to marine mammal brain","volume":"46","author":"Trainer","year":"1999","journal-title":"Aqua. Toxicol."},{"key":"10.1016\/j.fct.2006.01.002_bib29","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/abio.1997.2127","article-title":"A fluorescent microplate assay for diarrheic shellfish toxins","volume":"248","author":"Vieytes","year":"1997","journal-title":"Anal. Biochem."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691506000081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691506000081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:38:34Z","timestamp":1759523914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691506000081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S0278691506000081"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2006.01.002","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2006.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}