{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:58:21Z","timestamp":1770479901863,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.fct.2006.09.009","type":"journal-article","created":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T08:24:00Z","timestamp":1159777440000},"page":"456-464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Drinking of Salvia officinalis tea increases CCl4-induced hepatotoxicity in mice"],"prefix":"10.1016","volume":"45","author":[{"given":"Cristovao F.","family":"Lima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Fernandes-Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Pereira-Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2006.09.009_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/abio.1994.1230","article-title":"A kinetic assay for p-nitrophenol hydroxylase in rat liver microsomes","volume":"219","author":"Allis","year":"1994","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2006.09.009_bib2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.lfs.2004.09.048","article-title":"Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats","volume":"77","author":"Amin","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2006.09.009_bib3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/PL00000897","article-title":"Cytochromes P450 and metabolism of xenobiotics","volume":"58","author":"Anzenbacher","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.fct.2006.09.009_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0163-7258(03)00031-7","article-title":"Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes","volume":"98","author":"Backes","year":"2003","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fct.2006.09.009_bib5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0304-3835(94)03633-T","article-title":"Modulatory influence of camphor on the activities of hepatic carcinogen metabolizing enzymes and the levels of hepatic and extrahepatic reduced glutathione in mice","volume":"88","author":"Banerjee","year":"1995","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2006.09.009_bib6","first-page":"4819","article-title":"Cellular localization of uridine diphosphoglucuronosyltransferase 2B enzymes in the human prostate by in situ hybridization and immunohistochemistry","volume":"85","author":"Barbier","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.fct.2006.09.009_bib7","series-title":"SAGE \u2013 The Genus Salvia","first-page":"143","article-title":"The biological\/pharmacological activity of the Salvia genus","author":"Baricevic","year":"2000"},{"key":"10.1016\/j.fct.2006.09.009_bib8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0163-7258(01)00137-1","article-title":"Dietary agents in cancer prevention: flavonoids and isoflavonoids","volume":"90","author":"Birt","year":"2001","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fct.2006.09.009_bib9","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1016\/0006-2952(85)90355-7","article-title":"Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450","volume":"34","author":"Burke","year":"1985","journal-title":"Biochem. Pharmacol."},{"issue":"64\/65","key":"10.1016\/j.fct.2006.09.009_bib10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0378-4274(92)90244-E","article-title":"Problems and opportunities in toxicity testing arising from species differences in xenobiotic metabolism","author":"Caldwell","year":"1992","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2006.09.009_bib11","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1080\/15287390590967522","article-title":"Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications","volume":"68","author":"Chan","year":"2005","journal-title":"Journal of Toxicology and Environmental Health: Part A."},{"key":"10.1016\/j.fct.2006.09.009_bib12","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.taap.2003.08.006","article-title":"Differential metabolism of acrylonitrile to cyanide is responsible for the greater sensitivity of male vs female mice: role of CYP2E1 and epoxide hydrolases","volume":"193","author":"Chanas","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2006.09.009_bib13","first-page":"311","article-title":"Gender-related differences in expression of murine glutathione S-transferases and their induction by butylated hydroxyanisole","volume":"108","author":"Chaubey","year":"1994","journal-title":"Comp. Biochem. Physiol. C"},{"key":"10.1016\/j.fct.2006.09.009_bib14","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/ajcn\/80.3.742","article-title":"Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants","volume":"80","author":"Chen","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.fct.2006.09.009_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.taap.2004.11.004","article-title":"Comprehensive analysis of differential gene expression profiles on carbon tetrachloride-induced rat liver injury and regeneration","volume":"206","author":"Chung","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2006.09.009_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/20024091064264","article-title":"Review and evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry","volume":"32","author":"Clewell","year":"2002","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.fct.2006.09.009_bib17","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1021\/jf00039a012","article-title":"Antioxidant constituents in sage (Salvia officinalis)","volume":"42","author":"Cuvelier","year":"1994","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2006.09.009_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0278-6915(00)00117-4","article-title":"Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver","volume":"39","author":"Debersac","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2006.09.009_bib19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tox.2005.10.012","article-title":"The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (\u2212\/\u2212) mice","volume":"218","author":"Dwivedi","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2006.09.009_bib20","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/carcin\/14.6.1221","article-title":"Effects of anticarcinogenic monoterpenes on phase II hepatic metabolizing enzymes","volume":"14","author":"Elegbede","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2006.09.009_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tox.2004.01.035","article-title":"Dietary cancer and prevention using antimutagens","volume":"198","author":"Ferguson","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2006.09.009_bib22","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1093\/carcin\/12.12.2259","article-title":"Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration","volume":"12","author":"Forkert","year":"1991","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2006.09.009_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0163-7258(02)00298-X","article-title":"The biochemistry and medical significance of the flavonoids","volume":"96","author":"Havsteen","year":"2002","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fct.2006.09.009_bib24","doi-asserted-by":"crossref","first-page":"13480","DOI":"10.1074\/jbc.M212087200","article-title":"Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase","volume":"278","author":"Henderson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2006.09.009_bib25","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.2165\/00003495-200565090-00005","article-title":"Herb\u2013drug interactions \u2013 a literature review","volume":"65","author":"Hu","year":"2005","journal-title":"Drugs"},{"key":"10.1016\/j.fct.2006.09.009_bib26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/00498250210124147","article-title":"Pharmacokinetic interactions between herbal remedies and medicinal drugs","volume":"32","author":"Ioannides","year":"2002","journal-title":"Xenobiotica"},{"key":"10.1016\/j.fct.2006.09.009_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1472-8206.2004.00301.x","article-title":"Herb\u2013drug interactions: an overview of the clinical evidence","volume":"19","author":"Izzo","year":"2005","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.fct.2006.09.009_bib28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/toxsci\/65.2.166","article-title":"Forum \u2013 mechanisms of hepatotoxicity","volume":"65","author":"Jaeschke","year":"2002","journal-title":"Toxicol. Sci."},{"issue":"64\/65","key":"10.1016\/j.fct.2006.09.009_bib29","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0378-4274(92)90245-F","article-title":"Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity","author":"Kato","year":"1992","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2006.09.009_bib30","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.fct.2006.09.009_bib31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jep.2004.11.029","article-title":"The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats","volume":"97","author":"Lima","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2006.09.009_bib32","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tiv.2004.01.001","article-title":"Evaluation of toxic\/protective effects of the essential oil of Salvia officinalis on freshly isolated rat hepatocytes","volume":"18","author":"Lima","year":"2004","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.fct.2006.09.009_bib33","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.lfs.2006.06.042","article-title":"Phenolic compounds protect HepG2 cells from oxidative damage: Relevance of glutathione levels","volume":"79","author":"Lima","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2006.09.009_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0891-5849(02)01167-X","article-title":"Oxidative stress in viral and alcoholic hepatitis","volume":"34","author":"Loguercio","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fct.2006.09.009_bib35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2006.09.009_bib36","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1096\/fasebj.13.10.1169","article-title":"Regulation of hepatic glutathione synthesis: current concepts and controversies","volume":"13","author":"Lu","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.fct.2006.09.009_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0300-483X(00)00306-1","article-title":"Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology","volume":"153","author":"Mates","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2006.09.009_bib38","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2165\/00003088-200241050-00002","article-title":"How important are gender differences in pharmacokinetics?","volume":"41","author":"Meibohm","year":"2002","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.fct.2006.09.009_bib39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/abbi.1996.0294","article-title":"Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity","volume":"331","author":"Pearce","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.fct.2006.09.009_bib40","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/S0021-9258(19)73803-4","article-title":"Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies","volume":"237","author":"Phillips","year":"1962","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2006.09.009_bib41","series-title":"Principles and Methods of Toxicology","first-page":"407","article-title":"Detection and evaluation of chemically induced liver injury","author":"Plaa","year":"1982"},{"key":"10.1016\/j.fct.2006.09.009_bib42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/med.10033","article-title":"Flavonoids: promising anticancer agents","volume":"23","author":"Ren","year":"2003","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.fct.2006.09.009_bib43","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-2002-30104","article-title":"Herbal hepatotoxicity","volume":"22","author":"Stedman","year":"2002","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.fct.2006.09.009_bib44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1023\/B:BGEN.0000038024.58911.6e","article-title":"Age and gender differences in antioxidant enzyme activity: potential relationship to liver carcinogenesis in male mice","volume":"5","author":"Sverko","year":"2004","journal-title":"Biogerontology"},{"key":"10.1016\/j.fct.2006.09.009_bib45","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s00011-003-1186-4","article-title":"Some aspects of interindividual variations in the metabolism of xenobiotics","volume":"52","author":"Tamasi","year":"2003","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.fct.2006.09.009_bib46","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.76.9.4350","article-title":"Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications","volume":"76","author":"Towbin","year":"1979","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.fct.2006.09.009_bib47","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/10408690490911701","article-title":"Dietary antioxidant compounds and liver health","volume":"44","author":"Vitaglione","year":"2004","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fct.2006.09.009_bib48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.fct.2006.09.009_bib49","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.freeradbiomed.2004.01.001","article-title":"Flavonoids: antioxidants or signalling molecules?","volume":"36","author":"Williams","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fct.2006.09.009_bib50","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.taap.2005.01.057","article-title":"Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1","volume":"207","author":"Wu","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2006.09.009_bib51","first-page":"286","article-title":"Protective effects of luteolin-7-glucoside against liver injury caused by carbon tetrachloride in rats","volume":"59","author":"Zheng","year":"2004","journal-title":"Pharmazie"},{"key":"10.1016\/j.fct.2006.09.009_bib52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1081\/DMR-120018248","article-title":"Interactions of herbs with cytochrome P450","volume":"35","author":"Zhou","year":"2003","journal-title":"Drug Metab. Rev."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691506002729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691506002729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:39:32Z","timestamp":1759523972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691506002729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0278691506002729"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2006.09.009","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drinking of Salvia officinalis tea increases CCl4-induced hepatotoxicity in mice","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2006.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}