{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:37:23Z","timestamp":1791275843924,"version":"4.1.0"},"reference-count":107,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2007]]},"DOI":"10.1016\/j.fct.2007.09.053","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T11:48:04Z","timestamp":1195040884000},"page":"S428-S452","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"S1","title":["Fragrance material review on methyl salicylate"],"prefix":"10.1016","volume":"45","author":[{"given":"A.","family":"Lapczynski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"McGinty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.P.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.S.","family":"Letizia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Api","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2007.09.053_bib1","unstructured":"Abbott, D.D., Harrisson, J.W.E., 1978. Methyl salicylate: studies of osseous changes in the rat, reproduction in the rat and mouse, and liver and kidney effects in the dog. Unpublished report to the Flavor and Extract Manufacturers Association, Washington, DC. Report number 26000."},{"key":"10.1016\/j.fct.2007.09.053_bib2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1365-2133.1982.tb00356.x","article-title":"The relationship between exposure to fragrance materials and persistent light reaction in the photosensitivity dermatitis with actinic reticuloid syndrome","volume":"107","author":"Addo","year":"1982","journal-title":"British Journal of Dermatology"},{"key":"10.1016\/j.fct.2007.09.053_bib3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0165-1161(75)90046-1","article-title":"Methods for detecting carcinogens and mutagens with the Salmonella\/mammalian-microsome mutagenicity test","volume":"31","author":"Ames","year":"1975","journal-title":"Mutation Research"},{"key":"10.1016\/j.fct.2007.09.053_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0278-6915(92)90138-B","article-title":"Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens","volume":"30","author":"Basketter","year":"1992","journal-title":"Food and Chemical Toxicology"},{"issue":"1S1","key":"10.1016\/j.fct.2007.09.053_bib5","doi-asserted-by":"crossref","first-page":"S318","DOI":"10.1016\/j.fct.2007.09.066","article-title":"A toxicologic and dermatologic assessment of salicylates when used as fragrance ingredients","volume":"45","author":"Belsito","year":"2007","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib6","first-page":"443","article-title":"Teratogenic effect of methyl salicylate and hypoxia in combination","volume":"151","author":"Bertone","year":"1965","journal-title":"The Anatomical Record"},{"key":"10.1016\/j.fct.2007.09.053_bib7","first-page":"1655","article-title":"On the absorption and excretion of methyl salicylate administered by injection","volume":"28","author":"Beutner","year":"1943","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"10.1016\/j.fct.2007.09.053_bib8","first-page":"730","article-title":"Absorption from the human skin","volume":"37","author":"Bliss","year":"1935","journal-title":"Drug and Cosmetic Industry"},{"key":"10.1016\/j.fct.2007.09.053_bib9","first-page":"1155","article-title":"Characterization of esterase and alcohol dehydrogenase activity in skin. Metabolism of retinyl palmitate to retinol (vitamin A) during percutaneous absorption","volume":"11","author":"Boehnlein","year":"1994","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.fct.2007.09.053_bib10","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1042\/bj0321982","article-title":"CCLVII. Experiments on the chemotherapy of cancer. II. The effect of aldehydes and glucosides","volume":"32","author":"Boyland","year":"1938","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.fct.2007.09.053_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0022-3565(25)06061-6","article-title":"The absorption of methyl salicylate by the human skin","volume":"50","author":"Brown","year":"1934","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.fct.2007.09.053_bib12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0022-3565(25)07336-7","article-title":"The comparative absorption of certain salicylate esters by the human skin","volume":"50","author":"Brown","year":"1934","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.fct.2007.09.053_bib13","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/jps.2600820623","article-title":"Fragrance compounds and essential oils with sedative effects upon inhalation","volume":"82","author":"Buchbauer","year":"1993","journal-title":"Journal of Pharmaceutical Science"},{"key":"10.1016\/j.fct.2007.09.053_bib14","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/0002-9394(46)92032-6","article-title":"Chemical burns of the rabbit cornea","volume":"29","author":"Carpenter","year":"1946","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/j.fct.2007.09.053_bib15","first-page":"199","article-title":"Reproductive assessment by continuous breeding: Evolving study design and summaries of ninety studies","volume":"105","author":"Chapin","year":"1997","journal-title":"Environmental Health Perspectives"},{"key":"10.1016\/j.fct.2007.09.053_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1091581803022S203","volume":"22","author":"CIR (Cosmetic Ingredient Review Panel, Cosmetic, Toiletry and Fragrance Association)","year":"2003","journal-title":"International Journal of Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0041-008X(71)90227-4","article-title":"Effect of methyl salicylate on rat reproduction","volume":"18","author":"Collins","year":"1971","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.fct.2007.09.053_bib18","unstructured":"Council of Europe, 2000. Partial Agreement in the Social and Public Health Field. Chemically-defined Flavouring Substances. Group 9.5.13 esters of aromatic acids. salicylates, p. 407, number 433. Council of Europe Publishing, Strasbourg."},{"key":"10.1016\/j.fct.2007.09.053_bib19","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0140-6736(05)63324-7","article-title":";Is there tissue penetration after application of topical salicylate formulations?","volume":"350","author":"Cross","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.fct.2007.09.053_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1365-2125.1998.00045.x","article-title":"Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies","volume":"46","author":"Cross","year":"1998","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.fct.2007.09.053_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF00870985","article-title":"Effect of exercise and heat exposure on percutaneous absorption of methyl salicylate","volume":"31","author":"Danon","year":"1986","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1016\/j.fct.2007.09.053_bib22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0272-0590(88)90104-2","article-title":"Functional teratogens of the rat kidney. I. Colchicine, dinoseb, and methyl salicylate","volume":"11","author":"Daston","year":"1988","journal-title":"Fundamental and Applied Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.2042-7158.1981.tb11756.x","article-title":"Percutaneous absorption of methyl salicylate from polyethylene glycol vehicles","volume":"33","author":"Davis","year":"1981","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.fct.2007.09.053_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0022-3565(25)26029-3","article-title":"On the metabolism and toxicity of methyl salicylate","volume":"132","author":"Davison","year":"1961","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.fct.2007.09.053_bib25","first-page":"184","article-title":"Routine patch testing with fragrance chemicals in The Netherlands","volume":"42","author":"de Groot","year":"2000","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2007.09.053_bib26","unstructured":"Draize, J.H., 1959. Appraisal of the safety of chemicals in foods, drugs and cosmetics. Dermal toxicity. The Association of Food and Drug Officials of the United States, Texas State Department of Health, Austin. pp. 46\u201359."},{"key":"10.1016\/j.fct.2007.09.053_bib27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jat.838","article-title":"Site-specific percutaneous absorption of methyl salicylate and VX in domestic swine","volume":"22","author":"Duncan","year":"2002","journal-title":"Journal of Applied Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/jid.1969.12","article-title":"Percutaneous penetration of steroids in man","volume":"52","author":"Feldmann","year":"1969","journal-title":"Journal of Investigative Dermatology"},{"issue":"2, part 2","key":"10.1016\/j.fct.2007.09.053_bib29","first-page":"151","article-title":"Recent progress in the consideration of flavoring ingredients under the food additives amendment III. GRAS Substances","volume":"19","author":"FEMA (Flavor and Extract Manufacturers Association)","year":"1965","journal-title":"Food Technology"},{"key":"10.1016\/j.fct.2007.09.053_bib30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1600-0536.1984.tb00039.x","article-title":"Cinnamic aldehyde test concentrations. [Letter to the Editor]","volume":"10","author":"Ferguson","year":"1984","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2007.09.053_bib31","first-page":"1","article-title":"The subacute inhalation toxicity of 109 industrial chemicals","volume":"27","author":"Gage","year":"1970","journal-title":"British Journal of Industrial Medicine"},{"key":"10.1016\/j.fct.2007.09.053_bib32","first-page":"383","article-title":"Comparative toxicity of methyl diethylacetylsalicylate and methyl salicylate","volume":"14","author":"Giroux","year":"1954","journal-title":"Soci\u00e9t\u00e9 Pharmacie Montpellier"},{"key":"10.1016\/j.fct.2007.09.053_bib33","first-page":"131","article-title":"Psychophysical assessment of the chemical irritability of human skin","volume":"43","author":"Green","year":"1992","journal-title":"Journal of the Society of Cosmetic Chemists Japan"},{"key":"10.1016\/j.fct.2007.09.053_bib34","first-page":"43","article-title":"The excretion of salicyl after the administration of methyl salicylate to animals","volume":"14","author":"Hanzlik","year":"1920","journal-title":"Journal of Pharmacology"},{"key":"10.1016\/j.fct.2007.09.053_bib35","first-page":"554","article-title":"Salicylates and other hydroxybenzoates: effect upon osseous tissue of young rats","volume":"22","author":"Harrisson","year":"1963","journal-title":"Federation Proceedings"},{"key":"10.1016\/j.fct.2007.09.053_bib36","first-page":"302","article-title":"Percutaneous penetration and metabolism of salicylic acid derivatives across hairless mouse skin in diffusion cell in vitro","volume":"5","author":"Higo","year":"1995","journal-title":"STP Pharma Sciences"},{"issue":"1","key":"10.1016\/j.fct.2007.09.053_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/105172300242526","article-title":"Comparison of murine assays for the identification of chemical sensitizers","volume":"10","author":"Howell","year":"2000","journal-title":"Toxicology Methods"},{"key":"10.1016\/j.fct.2007.09.053_bib38","unstructured":"IFRA (International Fragrance Association), 2002. Use Level Survey, April 2002."},{"key":"10.1016\/j.fct.2007.09.053_bib39","unstructured":"Infurna, R., Beyer, B., Twitty, L., Koehler, G., Daughtrey, W., 1990. Evaluation of the dermal absorption and teratogenic potential of methyl salicylate in a petroleum based grease. Teratology 41, 566."},{"key":"10.1016\/j.fct.2007.09.053_bib40","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0278-6915(84)90271-0","article-title":"Primary mutagenicity screening of food additives currently used in Japan","volume":"22","author":"Ishidate","year":"1984","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib41","first-page":"230","article-title":"Closed epicutaneous test","volume":"28","author":"Ishihara","year":"1986","journal-title":"Skin Research"},{"key":"10.1016\/j.fct.2007.09.053_bib42","unstructured":"JECFA (Joint Expert Committee on Food Additives), 2001. Safety evaluation of certain food additives. Who Food Additives Series: 48. Prepared by the Fifty-seventh meeting of the Joint FAO\/WHO Expert Committee on Food Additives. World Health Organization, Geneva 2001."},{"key":"10.1016\/j.fct.2007.09.053_bib43","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0015-6264(64)80192-9","article-title":"Food flavorings and compounds of related structure. I. Acute oral toxicity","volume":"2","author":"Jenner","year":"1964","journal-title":"Food and Cosmetics Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib44","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/tera.1420260211","article-title":"An analysis of fetotoxicity using biochemical endpoints of organ differentiation","volume":"26","author":"Kavlock","year":"1982","journal-title":"Teratology"},{"key":"10.1016\/j.fct.2007.09.053_bib45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0378-4274(91)90135-S","article-title":"The murine local lymph node assay: results of an inter-laboratory trial","volume":"55","author":"Kimber","year":"1991","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.fct.2007.09.053_bib46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0300-483X(95)03114-U","article-title":"An international evaluation of the murine local lymph node assay and comparison of modified procedures","volume":"103","author":"Kimber","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib47","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/009841098159141","article-title":"Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: An interlaboratory evaluation","volume":"53","author":"Kimber","year":"1998","journal-title":"Journal of Toxicology and Environmental Health"},{"key":"10.1016\/j.fct.2007.09.053_bib48","unstructured":"Klecak, G., 1979. The open epicutaneous test (OET), a predictive test procedure in the guinea pig for estimation of allergenic properties of simple chemical compounds, their mixtures and of finished cosmetic preparations. International Federation Societies Cosmetic Chemists, 9\/18\/79."},{"key":"10.1016\/j.fct.2007.09.053_bib49","first-page":"152","article-title":"The Freund\u2019s complete adjuvant test and the open epicutaneous test","volume":"vol. 14","author":"Klecak","year":"1985"},{"key":"10.1016\/j.fct.2007.09.053_bib50","first-page":"53","article-title":"Screening of fragrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods","volume":"28","author":"Klecak","year":"1977","journal-title":"Journal of the Society of Cosmetic Chemists Japan"},{"key":"10.1016\/j.fct.2007.09.053_bib51","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2334\/josnusd1959.34.183","article-title":"Mutagenicity of analgesics, their derivatives, and anti-inflammatory drugs with S-9 mix of several animal species","volume":"34","author":"Kuboyama","year":"1992","journal-title":"Journal of Nihon University School of Dentistry"},{"key":"10.1016\/j.fct.2007.09.053_bib52","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/15376519509049116","article-title":"Comparison of 125-idodeoxyuridine (125IUdR) and [3H]thymidine ([3H]TdR) for assessing cell proliferation in the murine local lymph node assay","volume":"5","author":"Ladics","year":"1995","journal-title":"Toxicology Methods"},{"key":"10.1016\/j.fct.2007.09.053_bib53","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/jid.1969.42","article-title":"The identification of contact allergens by animal assay. The guinea pig maximization test","volume":"52","author":"Magnusson","year":"1969","journal-title":"Journal of Investigative Dermatology"},{"key":"10.1016\/j.fct.2007.09.053_bib54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0300-483X(80)90050-5","article-title":"The optimization test in the guinea pig in relation to other predictive sensitization methods","volume":"15","author":"Maurer","year":"1980","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib55","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.2042-7158.1995.tb03266.x","article-title":"Percutaneous absorption of salicylates from some commercially available topical products containing methyl salicylate or salicylate salts in rats","volume":"47","author":"Megwa","year":"1995","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.fct.2007.09.053_bib56","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1600-0536.1982.tb04242.x","article-title":"Results of standard patch tests with substances abandoned","volume":"8","author":"Mitchell","year":"1982","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2007.09.053_bib57","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2340\/00015555744550","article-title":"Experience with the murine local lymph node assay: Inability to discriminate between allergens and irritants","volume":"74","author":"Montelius","year":"1994","journal-title":"Acta Dermato-Venereologica"},{"key":"10.1016\/j.fct.2007.09.053_bib58","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1177\/106002809603000903","article-title":"Serum concentrations of salicylic acid following topically applied salicylate derivatives","volume":"30","author":"Morra","year":"1996","journal-title":"The Annals of Pharmacotherapy"},{"key":"10.1016\/j.fct.2007.09.053_bib59","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0272-0590(89)90332-1","article-title":"Results and evaluations of 48 continuous breeding reproduction studies conducted in mice","volume":"13","author":"Morrissey","year":"1989","journal-title":"Fundamental and Applied Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/em.2860080802","article-title":"Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals","volume":"8","author":"Mortelmans","year":"1986","journal-title":"Environmental Mutagenesis"},{"key":"10.1016\/j.fct.2007.09.053_bib61","unstructured":"National Toxicology Program (NTP), 1984a. Methyl salicylate: Reproduction and fertility assessment in CD-1 mice when administered by gavage. August. NTP-84-156; PB84-241140."},{"key":"10.1016\/j.fct.2007.09.053_bib62","unstructured":"National Toxicology Program (NTP), 1984b. Methyl salicylate: Reproduction and fertility assessment in CD-1 mice when administered by gavage. Final Report, November. NTP-85-022; PB85-164283."},{"key":"10.1016\/j.fct.2007.09.053_bib63","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0190-9622(89)70165-1","article-title":"A review of 79 cases of eyelid dermatitis","volume":"21","author":"Nethercott","year":"1989","journal-title":"Journal of the American Academy of Dermatology"},{"key":"10.1016\/j.fct.2007.09.053_bib64","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1248\/cpb.16.389","article-title":"Studies on absorption and excretion of drugs. IX. Relation between chemical structure and absorption rate. Effects of the number and the position of OH-groups on the intestinal absorption rate of benzoyl derivatives","volume":"16","author":"Nogami","year":"1968","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.fct.2007.09.053_bib65","first-page":"177","article-title":"Mutagenicity of food flavors in bacteria","volume":"9","author":"Oda","year":"1978","journal-title":"Shokuhin Eisei Hen"},{"key":"10.1016\/j.fct.2007.09.053_bib66","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.2504\/kds.38.1064","article-title":"A study on acute toxicities of essential oils used in endodontic treatment","volume":"38","author":"Ohsumi","year":"1984","journal-title":"Journal Kyushu Dental Society"},{"key":"10.1016\/j.fct.2007.09.053_bib67","first-page":"476","article-title":"Hindlimb metabolism in dogs intoxicated with methyl salicylate","volume":"48","author":"Ojiambo","year":"1972","journal-title":"East African Medical Journal"},{"key":"10.1016\/j.fct.2007.09.053_bib68","first-page":"499","article-title":"Comparative dose\u2013response analysis of the teratogenic effects of methyl salicylate applied orally or topically to hamsters","volume":"190","author":"Overman","year":"1978","journal-title":"The Anatomical Record"},{"key":"10.1016\/j.fct.2007.09.053_bib69","first-page":"42A","article-title":"Percutaneous administration of teratogens: effects of treatment with methyl salicylate and dimethyl sulfoxide in the hamster","volume":"19","author":"Overman","year":"1979","journal-title":"Teratology"},{"key":"10.1016\/j.fct.2007.09.053_bib70","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/tera.1420280313","article-title":"Comparative teratogenic effects of methyl salicylate applied orally or topically to hamsters","volume":"28","author":"Overman","year":"1983","journal-title":"Teratology"},{"key":"10.1016\/j.fct.2007.09.053_bib71","first-page":"62","article-title":"Chronic oral toxicity of oil sweet birch (methyl salicylate)","volume":"3","author":"Packman","year":"1961","journal-title":"The Pharmacologist"},{"key":"10.1016\/j.fct.2007.09.053_bib72","first-page":"499","article-title":"Interspecies differences in sensitivity to inflammatory mediators modify dose response and time course of chemically induced skin irritation","volume":"86","author":"Patrick","year":"1986","journal-title":"Journal of Investigative Dermatology"},{"key":"10.1016\/j.fct.2007.09.053_bib73","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/0041-008X(85)90419-3","article-title":"Mechanisms of chemically induced skin irritation","volume":"81","author":"Patrick","year":"1985","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.fct.2007.09.053_bib74","doi-asserted-by":"crossref","first-page":"24s","DOI":"10.1111\/1523-1747.ep12468907","article-title":"Recent investigations of mechanisms of chemically induced skin irritation in laboratory mice","volume":"88","author":"Patrick","year":"1987","journal-title":"Journal of Investigative Dermatology"},{"key":"10.1016\/j.fct.2007.09.053_bib75","first-page":"185","article-title":"Pharmacokinetic study of percutaneous absorption of salicylic acid from baths with salicylate methyl ester and salicylic acid","volume":"49","author":"Pratzel","year":"1990","journal-title":"Zeltschrift F\u00fcr Rheumatologie"},{"key":"10.1016\/j.fct.2007.09.053_bib76","first-page":"151","article-title":"Use of methyl salicylate as a stimulant to predict the percutaneous absorption of sulfur mustard","volume":"54","author":"Riviere","year":"2000","journal-title":"The Toxicologist"},{"key":"10.1016\/j.fct.2007.09.053_bib77","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jat.718","article-title":"Use of methyl salicylate as a stimulant to predict the percutaneous absorption of sulfur mustard","volume":"21","author":"Riviere","year":"2001","journal-title":"Journal of Applied Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib78","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 1963. Report on Eye irritation study of methyl salicylate in rabbits. Unpublished report from IFF Incorporated, 29 November. Report number 12616 (RIFM, Woodcliff Lake, NJ, USA)."},{"key":"10.1016\/j.fct.2007.09.053_bib79","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 1964. Repeated insult patch test of methyl salicylate in human subjects. Unpublished report from IFF Incorporated, 3 April. Report number 12617 (RIFM, Woodcliff Lake, NJ, USA)."},{"key":"10.1016\/j.fct.2007.09.053_bib80","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 1973a. Acute toxicity studies on rats and rabbits. RIFM report number 2021, November 12 (RIFM, Woodcliff Lake, NJ, USA)."},{"key":"10.1016\/j.fct.2007.09.053_bib81","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 1973b. Report on human maximization studies. RIFM report number 1803, November 26 (RIFM, Woodcliff Lake, NJ, USA)."},{"key":"10.1016\/j.fct.2007.09.053_bib82","unstructured":"RIFM (Research Institute for Fragrance Material, Inc.), 1976a. Report on human maximization studies. RIFM report number 1796, July 23 (RIFM, Woodcliff Lake, NJ, USA."},{"key":"10.1016\/j.fct.2007.09.053_bib83","unstructured":"RIFM (Research Institute for Fragrance Material, Inc.), 1976b. Phototoxicity and irritation studies on fragrance materials in guinea pigs and mice. RIFM report number 2039, July 20 (RIFM, Woodcliff Lake, NJ, USA)."},{"key":"10.1016\/j.fct.2007.09.053_bib84","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 1981. Guinea pig skin sensitization test with methyl salicylate. Unpublished report from Quest Incorporated, 12 November. RIFM report number 46937 (RIFM, Woodcliff Lake, NJ, USA)."},{"key":"10.1016\/j.fct.2007.09.053_bib85","unstructured":"RIFM (Research Institute for Fragrance Materials, Inc.), 1982. Acute toxicity studies. Unpublished report from Givaudan Incorporated, 27 September. Report number 1786 (RIFM, Woodcliff Lake, NJ, USA)."},{"key":"10.1016\/j.fct.2007.09.053_bib86","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1445-5994.1982.tb02485.x","article-title":"Topical bioavailability of methyl salicylate","volume":"12","author":"Roberts","year":"1982","journal-title":"Australian and New Zealand Journal of Medicine"},{"key":"10.1016\/j.fct.2007.09.053_bib87","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1600-0536.1980.tb04954.x","article-title":"Statistical and comparative study of 4600 patients tested in Barcelona (1973\u20131977)","volume":"6","author":"Romaguera","year":"1980","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2007.09.053_bib88","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0536.1977.tb03649.x","article-title":"North American group results","volume":"3","author":"Rudner","year":"1977","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2007.09.053_bib89","first-page":"53","article-title":"Patch test results of the North American Contact Dermatitis Group","volume":"93","author":"Rudner","year":"1978","journal-title":"Cosmetics and Toiletries"},{"key":"10.1016\/j.fct.2007.09.053_bib90","first-page":"209","article-title":"Fetal toxicity and hypocalcemia induced by acetylsalicylic acid analogues","volume":"38","author":"Saito","year":"1982","journal-title":"Research Communications in Chemical Pathology and Pharmacology"},{"key":"10.1016\/j.fct.2007.09.053_bib91","first-page":"181","article-title":"pH-Effects on salicylate absorption through the intact rat skin","volume":"40","author":"Siddiqi","year":"1972","journal-title":"Scientia Pharmaceutica"},{"key":"10.1016\/j.fct.2007.09.053_bib92","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-0536.1995.tb00540.x","article-title":"Occupational hand dermatitis in hospital environments","volume":"33","author":"Stingeni","year":"1995","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.fct.2007.09.053_bib93","first-page":"3069","article-title":"Test for carcinogenicity of food additives and chemotherapeutic agents by the pulmonary tumor response in strain A mice","volume":"33","author":"Stoner","year":"1973","journal-title":"Cancer Research"},{"key":"10.1016\/j.fct.2007.09.053_bib94","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1002\/jps.2600631141","article-title":"Gastric irritation and bleeding after drug administration [Letter to the Editor]","volume":"63","author":"Strom","year":"1974","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.fct.2007.09.053_bib95","first-page":"546","article-title":"The effect of oil of wintergreen on the incidence of spontaneous carcinoma in mice. IV. Effect on growth rate and survival time after onset of malignancy","volume":"4","author":"Strong","year":"1932","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.fct.2007.09.053_bib96","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3181\/00379727-30-6494","article-title":"Possible effect of oil of Gaultheria in diet of mice susceptible to spontaneous carcinoma of the breast. I. A suggestion","volume":"30","author":"Strong","year":"1932","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"key":"10.1016\/j.fct.2007.09.053_bib97","first-page":"313","article-title":"Fundamental studies of safe compound perfumes for cosmetics. Part 1. The primary irritation of compound materials to the skin","author":"Takenaka","year":"1986","journal-title":"Unknown Source"},{"key":"10.1016\/j.fct.2007.09.053_bib98","first-page":"315","article-title":"Experimental production of congenital malformations in rats by salicylate poisoning","volume":"35","author":"Warkany","year":"1959","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.fct.2007.09.053_bib99","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1467-2494.1992.tb00059.x","article-title":"Prediction of the percutaneous penetration of ultra-violet filters used in sunscreen formulations","volume":"14","author":"Watkinson","year":"1992","journal-title":"International Journal Cosmetic Science"},{"key":"10.1016\/j.fct.2007.09.053_bib100","first-page":"255","article-title":"Chronic and subacute toxicology and pathology of methyl salicylate in dogs, rats and rabbits","volume":"21","author":"Webb","year":"1962","journal-title":"Federation Proceedings"},{"key":"10.1016\/j.fct.2007.09.053_bib101","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/0041-008X(63)90003-6","article-title":"Chronic and subacute toxicology and pathology of methyl salicylate in dogs, rats and rabbits","volume":"5","author":"Webb","year":"1963","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.fct.2007.09.053_bib102","first-page":"355","article-title":"Plasma salicylate from methyl salicylate cream compared to oil of wintergreen","volume":"41","author":"Wolowich","year":"2003","journal-title":"Journal of Toxicology: Clinical Toxicology"},{"key":"10.1016\/j.fct.2007.09.053_bib103","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/tera.1420060210","article-title":"\u201cApparent hydronephrosis\u201d as a normal aspect of renal development in late gestation of rats: the effect of methyl salicylate","volume":"6","author":"Woo","year":"1972","journal-title":"Teratology"},{"key":"10.1016\/j.fct.2007.09.053_bib104","series-title":"Advances in Biology of Skin","first-page":"511","article-title":"The effects of various vehicles on absorption rates in skin","volume":"vol. 12","author":"Yankell","year":"1972"},{"key":"10.1016\/j.fct.2007.09.053_bib105","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0024-3205(86)90195-5","article-title":"Skin permeability of various non-steroidal anti-inflammatory drugs in man","volume":"39","author":"Yano","year":"1986","journal-title":"Life Sciences"},{"key":"10.1016\/j.fct.2007.09.053_bib106","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1248\/bpb1978.14.663","article-title":"Effects of l-menthol and dl-camphor on the penetration and hydrolysis of methyl salicylate in hairless mouse skin","volume":"14","author":"Yano","year":"1991","journal-title":"Journal of Pharmacobio-Dynamics"},{"key":"10.1016\/j.fct.2007.09.053_bib107","first-page":"153","article-title":"Comparison of the effect of allergen and irritant treatment on proliferation and subpopulation of the draining lymph node cells in mice and guinea pigs","volume":"54","author":"Yoshida","year":"2000","journal-title":"The Toxicologist"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691507003900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691507003900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:42:04Z","timestamp":1759524124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691507003900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":107,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007]]}},"alternative-id":["S0278691507003900"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2007.09.053","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2007]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fragrance material review on methyl salicylate","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2007.09.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}