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(Lond)"},{"key":"10.1016\/j.fct.2007.09.101_bib106","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0003-9861(02)00030-9","article-title":"Activation and induction of glycine N-methyltransferase by retinoids are tissue- and gender-specific","volume":"401","author":"McMullen","year":"2002","journal-title":"Arch. Biochem. 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Influence of folate status on genomic DNA methylation in colonic mucosa of subjects without colorectal adenoma or cancer. Br J Cancer.","DOI":"10.1038\/sj.bjc.6602439"},{"key":"10.1016\/j.fct.2007.09.101_bib131","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/ajcn\/72.4.998","article-title":"Genomic DNA methylation decreases in response to moderate folate depletion in elderly women","volume":"72","author":"Rampersaud","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.fct.2007.09.101_bib132","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/35047554","article-title":"Genomic imprinting: parental influence on the genome","volume":"2","author":"Reik","year":"2001","journal-title":"Nat. Rev. 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