{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:45:52Z","timestamp":1775673952104,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.fct.2007.09.110","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T07:31:00Z","timestamp":1191310260000},"page":"752-760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolome"],"prefix":"10.1016","volume":"46","author":[{"given":"M.","family":"Hansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Baunsgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Autrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.B.","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lindecrona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wallin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.E.","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Loft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.O.","family":"Dragsted","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.fct.2007.09.110_bib1","first-page":"233","article-title":"Biomarkers for exposure to ambient air pollution--comparison of carcinogen-DNA adduct levels with other exposure markers and markers for oxidative stress","volume":"107","author":"Autrup","year":"1999","journal-title":"Environ. Health Perspect"},{"issue":"12","key":"10.1016\/j.fct.2007.09.110_bib2","first-page":"1011","article-title":"Colorectal epithelial cell proliferative kinetics and risk factors for colon cancer in sporadic adenoma patients","volume":"6","author":"Bostick","year":"1997","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"12","key":"10.1016\/j.fct.2007.09.110_bib3","first-page":"1271","article-title":"Possible mechanisms relating diet and risk of colon cancer","volume":"9","author":"Bruce","year":"2000","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"2","key":"10.1016\/j.fct.2007.09.110_bib4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/01635589609514440","article-title":"Dietary sucrose, glucose, fructose, and starches affect colonic functions in rats","volume":"25","author":"Caderni","year":"1996","journal-title":"Nutr. Cancer"},{"issue":"8234","key":"10.1016\/j.fct.2007.09.110_bib5","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/S0140-6736(81)92547-2","article-title":"Schistosomiasis and colon cancer","volume":"1","author":"Cheever","year":"1981","journal-title":"Lancet"},{"issue":"1\u20132","key":"10.1016\/j.fct.2007.09.110_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0027-5107(00)00125-1","article-title":"Differential mutation of transgenic and endogenous loci in vivo","volume":"454","author":"Cosentino","year":"2000","journal-title":"Mutat. Res."},{"issue":"4","key":"10.1016\/j.fct.2007.09.110_bib7","doi-asserted-by":"crossref","first-page":"865S","DOI":"10.1093\/ajcn\/78.4.865S","article-title":"Sugars, insulin sensitivity, and the postprandial state","volume":"78","author":"Daly","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.fct.2007.09.110_bib8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/135475097231841","article-title":"Gamma-Glutamyl semialdehyde and 2-amino-adipic semiladehyde: biomarkers of oxidative damage to protein","volume":"2","author":"Daneshvar","year":"1997","journal-title":"Biomarkers"},{"issue":"15","key":"10.1016\/j.fct.2007.09.110_bib9","first-page":"4339","article-title":"A sucrose-rich diet induces mutations in the rat colon","volume":"62","author":"Dragsted","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2007.09.110_bib10","unstructured":"Fagt, S., Trolle, E. 2001, Forsyningen af f\u00f8devarer 1955\u20131999. udviklingen i danskernes kost - forbrug indk\u00f8b og vaner. F\u00f8devarestyrelse, S\u00f8borg."},{"issue":"8","key":"10.1016\/j.fct.2007.09.110_bib11","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.fct.2004.03.009","article-title":"Commonly consumed and naturally occurring dietary substances affect biomarkers of oxidative stress and DNA damage in healthy rats","volume":"42","author":"Farombi","year":"2004","journal-title":"Food Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.fct.2007.09.110_bib12","doi-asserted-by":"crossref","first-page":"873S","DOI":"10.1093\/ajcn\/78.4.873S","article-title":"Sugars, hypertriglyceridemia, and cardiovascular disease","volume":"78","author":"Fried","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"issue":"Suppl. 11","key":"10.1016\/j.fct.2007.09.110_bib13","doi-asserted-by":"crossref","first-page":"3109S","DOI":"10.1093\/jn\/131.11.3109S","article-title":"Insulin, insulin-like growth factors and colon cancer: a review of the evidence","volume":"131","author":"Giovannucci","year":"2001","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.fct.2007.09.110_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/01635589309514266","article-title":"Correlations of colon cancer mortality with dietary factors, serum markers, and schistosomiasis in China","volume":"20","author":"Guo","year":"1993","journal-title":"Nutr. Cancer"},{"issue":"1\u20132","key":"10.1016\/j.fct.2007.09.110_bib15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.mrfmmm.2004.05.002","article-title":"Sucrose and IQ induced mutations in rat colon by independent mechanism","volume":"554","author":"Hansen","year":"2004","journal-title":"Mutat. Res."},{"issue":"4","key":"10.1016\/j.fct.2007.09.110_bib16","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3748\/wjg.v9.i4.771","article-title":"Influence of methionine\/valine-depleted enteral nutrition on nucleic acid and protein metabolism in tumor-bearing rats","volume":"9","author":"He","year":"2003","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.fct.2007.09.110_bib17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1079\/BJN2003782","article-title":"Influences of dietary adaptation and source of resistant starch on short-chain fatty acids in the hindgut of rats","volume":"89","author":"Henningsson","year":"2003","journal-title":"Br. J. Nutr."},{"issue":"2","key":"10.1016\/j.fct.2007.09.110_bib18","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1462-8902.2004.00323.x","article-title":"The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats","volume":"6","author":"Huang","year":"2004","journal-title":"Diabetes Obes. Metab."},{"issue":"8","key":"10.1016\/j.fct.2007.09.110_bib19","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/carcin\/bgg098","article-title":"Effect of resistant starch on genotoxin-induced apoptosis, colonic epithelium, and lumenal contents in rats","volume":"24","author":"Le Leu","year":"2003","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.fct.2007.09.110_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.canlet.2003.12.008","article-title":"Effects of sucrose and cornstarch on 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced colon and liver carcinogenesis in F344 rats","volume":"209","author":"Lindecrona","year":"2004","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.fct.2007.09.110_bib21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/01635589609514441","article-title":"Effects of repeated boluses of sucrose on proliferation and on AOM- induced aberrant crypt foci in rat colon","volume":"25","author":"Luceri","year":"1996","journal-title":"Nutr. Cancer"},{"issue":"1","key":"10.1016\/j.fct.2007.09.110_bib22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000186698","article-title":"Estimation of renal tubular secretion in man, in health and disease, using endogenous N-1-methylnicotinamide","volume":"60","author":"Maiza","year":"1992","journal-title":"Nephron"},{"key":"10.1016\/j.fct.2007.09.110_bib23","series-title":"Multivariate Calibration","author":"Martens","year":"1993"},{"issue":"1","key":"10.1016\/j.fct.2007.09.110_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1079\/PHN2002361","article-title":"Size makes a difference","volume":"6","author":"Matthiessen","year":"2003","journal-title":"Public Health Nutr."},{"key":"10.1016\/j.fct.2007.09.110_bib25","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1063\/1.1716296","article-title":"Review modified spin-echo method for measuring nuclear relaxation times","volume":"29","author":"Meiboom","year":"1958","journal-title":"Rev. Sci. Instrum."},{"issue":"2","key":"10.1016\/j.fct.2007.09.110_bib26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/pmed.1998.0399","article-title":"Comparison of risk estimates for selected diseases and causes of death","volume":"28","author":"Merrill","year":"1999","journal-title":"Prev. Med."},{"issue":"3","key":"10.1016\/j.fct.2007.09.110_bib27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1258\/002367782780891705","article-title":"The influence of minerals and protein on the nephrocalcinosis potential for rats of semisynthetic diets","volume":"16","author":"Meyer","year":"1982","journal-title":"Lab. Anim."},{"issue":"4","key":"10.1016\/j.fct.2007.09.110_bib28","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/ki.1997.160","article-title":"Implication of an increased oxidative stress in the formation of advanced glycation end products in patients with end-stage renal failure","volume":"51","author":"Miyata","year":"1997","journal-title":"Kidney Int."},{"issue":"1\u20132","key":"10.1016\/j.fct.2007.09.110_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0027-5107(03)00058-7","article-title":"Dietary low-dose sucrose modulation of IQ-induced genotoxicity in the colon and liver of Big Blue rats","volume":"527","author":"Moller","year":"2003","journal-title":"Mutat. Res."},{"issue":"8","key":"10.1016\/j.fct.2007.09.110_bib30","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/carcin\/23.8.1379","article-title":"Mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in colon and liver of Big Blue rats: role of DNA adducts, strand breaks, DNA repair and oxidative stress","volume":"23","author":"Moller","year":"2002","journal-title":"Carcinogenesis"},{"issue":"12","key":"10.1016\/j.fct.2007.09.110_bib31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1348-0421.2003.tb03469.x","article-title":"Effects of high amylose maize starch and Clostridium butyricum on metabolism in colonic microbiota and formation of azoxymethane-induced aberrant crypt foci in the rat colon","volume":"47","author":"Nakanishi","year":"2003","journal-title":"Microbiol. Immunol."},{"issue":"5","key":"10.1016\/j.fct.2007.09.110_bib32","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/ac00101a004","article-title":"750MHz 1H and 1H 13C NMR spectroscopy of human blood plasma","volume":"67","author":"Nicholson","year":"1995","journal-title":"Anal. Chem."},{"issue":"3","key":"10.1016\/j.fct.2007.09.110_bib33","doi-asserted-by":"crossref","first-page":"E561","DOI":"10.1152\/ajpendo.00042.2003","article-title":"Insulin effects on acetate metabolism","volume":"285","author":"Piloquet","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.fct.2007.09.110_bib34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-3835(01)00487-6","article-title":"The influence of simple sugars and starch given during pre- or post- initiation on aberrant crypt foci in rat colon","volume":"167","author":"Poulsen","year":"2001","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.fct.2007.09.110_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1179\/136485905X19883","article-title":"A matched, case-control study of the association between Schistosoma japonicum and liver and colon cancers, in rural China","volume":"99","author":"Qiu","year":"2005","journal-title":"Ann. Trop. Med. Parasitol."},{"issue":"12","key":"10.1016\/j.fct.2007.09.110_bib36","doi-asserted-by":"crossref","first-page":"8416","DOI":"10.1074\/jbc.275.12.8416","volume":"275","author":"Taghibiglou","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.fct.2007.09.110_bib37","first-page":"251","article-title":"Determination of polycyclic aromatic hydrocarbons (PAHs) in Brazilian sugar","volume":"197","author":"Tfouni","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.fct.2007.09.110_bib38","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/ajcn\/49.6.1155","article-title":"Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats","volume":"49","author":"Thorburn","year":"1989","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.fct.2007.09.110_bib39","doi-asserted-by":"crossref","first-page":"R1334","DOI":"10.1152\/ajpregu.2000.279.4.R1334","article-title":"Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance","volume":"279","author":"Thresher","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"12","key":"10.1016\/j.fct.2007.09.110_bib40","first-page":"1013","article-title":"Insulin promotion of colon tumors in rats","volume":"5","author":"Tran","year":"1996","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.fct.2007.09.110_bib41","doi-asserted-by":"crossref","unstructured":"Trygg, J., Wold, S., 2002. Orthogonal projections to latent structures, O-PLS. J. Chemom. 16 (Ref Type: Generic).","DOI":"10.1002\/cem.695"},{"issue":"9","key":"10.1016\/j.fct.2007.09.110_bib42","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1080\/1071576031000150779","article-title":"Effect of increased intake of dietary animal fat and fat energy on oxidative damage, mutation frequency, DNA adduct level and DNA repair in rat colon and liver","volume":"37","author":"Vogel","year":"2003","journal-title":"Free Radic. Res."},{"issue":"34","key":"10.1016\/j.fct.2007.09.110_bib43","doi-asserted-by":"crossref","first-page":"12676","DOI":"10.1073\/pnas.0404878101","article-title":"Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification","volume":"101","author":"Wang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.fct.2007.09.110_bib44","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1039\/a707497b","article-title":"Determination of anions in soil solutions by capillary zone electrophoresis","volume":"123","author":"Westergaard","year":"1998","journal-title":"Analyst"},{"issue":"3","key":"10.1016\/j.fct.2007.09.110_bib45","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jpba.2005.01.013","article-title":"A combined 1H NMR and HPLC-MS-based metabonomic study of urine from obese (fa\/fa) Zucker and normal Wistar-derived rats","volume":"38","author":"Williams","year":"2005","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.fct.2007.09.110_bib46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0169-7439(87)80084-9","article-title":"Principal Component Analysis","volume":"2","author":"Wold","year":"1987","journal-title":"Chemom. Chemom. Intell. Lab. Syst."},{"issue":"3","key":"10.1016\/j.fct.2007.09.110_bib47","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/ijc.2910340305","article-title":"Schistosoma japonicum and colorectal cancer: an epidemiological study in the People\u2019s Republic of China","volume":"34","author":"Xu","year":"1984","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.fct.2007.09.110_bib48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0021-9150(96)06006-6","article-title":"Effect of long-term exogenous hyperinsulinemia and fructose or glucose supplementation on triglyceride turnover in rats","volume":"129","author":"Yoshino","year":"1997","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.fct.2007.09.110_bib49","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1093\/jn\/133.11.3509","article-title":"Acetate and butyrate are the major substrates for de novo lipogenesis in rat colonic epithelial cells","volume":"133","author":"Zambell","year":"2003","journal-title":"J. Nutr."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691507004589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691507004589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:45:13Z","timestamp":1759524313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691507004589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0278691507004589"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2007.09.110","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1099232.555451","asserted-by":"object"}]},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolome","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2007.09.110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}