{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:18:26Z","timestamp":1791181106692,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.fct.2009.02.006","type":"journal-article","created":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T20:21:22Z","timestamp":1234902082000},"page":"1168-1175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Propolis protection from reproductive toxicity caused by aluminium chloride in male rats"],"prefix":"10.1016","volume":"47","author":[{"given":"Mokhtar I.","family":"Yousef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrah F.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2009.02.006_bib1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1071\/RD9950659","article-title":"Free radicals, lipid peroxidation and sperm function","volume":"7","author":"Aitken","year":"1995","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.fct.2009.02.006_bib2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1177\/096032719801701008","article-title":"Assessment of aggressive, sexual behavior and fertility in adult male rat following long term ingestion of four industrial metals salts","volume":"17","author":"Bataineh","year":"1998","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.fct.2009.02.006_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/tcm.10011","article-title":"Protective action of propolis on the rat colon carcinogenesis","volume":"22","author":"Bazo","year":"2002","journal-title":"Teratog. Carcinog. Mutag."},{"key":"10.1016\/j.fct.2009.02.006_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0773.1999.tb01055.x","article-title":"Lack of protective effects of dietary silicon on aluminium-induced maternal and developmental toxicity in mice","volume":"85","author":"Belles","year":"1999","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.fct.2009.02.006_bib5","first-page":"882","article-title":"An improved method for the detection of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.fct.2009.02.006_bib6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0015-0282(16)30125-X","article-title":"A one-minute live\u2013dead sperm stain by means of eosinnigrosin","volume":"1","author":"Blom","year":"1950","journal-title":"J. Fertil. Steril."},{"key":"10.1016\/j.fct.2009.02.006_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0367-326X(02)00185-5","article-title":"Propolis, an old remedy used in modern medicine","volume":"73","author":"Castaldo","year":"2002","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fct.2009.02.006_bib9","first-page":"601","article-title":"Fetal\u2013placental\u2013maternal uptake of aluminium in mice following gestational exposure","volume":"7","author":"Cranmer","year":"1986","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.fct.2009.02.006_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02783337","article-title":"Comparison of sperm viability with seminal plasma metal levels","volume":"64","author":"Dawson","year":"1998","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fct.2009.02.006_bib11","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0163-7258(91)90029-L","article-title":"Glutathione metabolism and its role in hepatotoxicity","volume":"52","author":"DeLeve","year":"1991","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fct.2009.02.006_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/014850101753145915","article-title":"Inhibition of steroidogenesis in Leydig cells by exogenous nitric oxide occurs independently of steroidogenic acute regulatory protein (star) mRNA","volume":"47","author":"Dobashi","year":"2001","journal-title":"Arch. Androl."},{"key":"10.1016\/j.fct.2009.02.006_bib13","series-title":"Carleton\u2019s Histological Technique","author":"Drury","year":"1980"},{"key":"10.1016\/j.fct.2009.02.006_bib14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0076-6879(90)86134-H","article-title":"Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal","volume":"186","author":"Esterbauer","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.fct.2009.02.006_bib15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1357-4310(98)01209-X","article-title":"Does antiperspirant use increase the risk of aluminium-related disease, including Alzheimer\u2018s disease? Mol","volume":"4","author":"Exley","year":"1998","journal-title":"Med. Today"},{"key":"10.1016\/j.fct.2009.02.006_bib16","first-page":"319","article-title":"Aluminum induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA","volume":"134","author":"Flora","year":"2003","journal-title":"Comp. Biochem. Physiol. Part C"},{"key":"10.1016\/j.fct.2009.02.006_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.freeradbiomed.2004.10.009","article-title":"Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxident enzymes after melatonin administration","volume":"38","author":"Gomez","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fct.2009.02.006_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(96)03512-3","article-title":"The effect of age on aluminum retention in rats","volume":"16","author":"Gomez","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2009.02.006_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ptr.2650080408","article-title":"Hepatoprotective effects of propolis extract on paracetarnol induced liver damage in mice","volume":"8","author":"Gonzalez","year":"1994","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fct.2009.02.006_bib20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.etap.2004.11.007","article-title":"The influence of aluminum exposure on male reproduction and offspring in mice","volume":"20","author":"Guo","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2009.02.006_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.etap.2004.02.009","article-title":"Aluminium induced suppression of testosterone through nitric oxide production in male mice","volume":"19","author":"Guo","year":"2005","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fct.2009.02.006_bib22","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases: The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2009.02.006_bib23","first-page":"2249","article-title":"Oxidative stress contributes to the anti-proliferative effects of flavone acetic acid on endothelial cells","volume":"20","author":"Harris","year":"2000","journal-title":"Anticancer Res."},{"key":"10.1016\/j.fct.2009.02.006_bib24","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jep.2006.10.023","article-title":"In vivo study of propolis supplementation effects on antioxidative status and red blood cells","volume":"110","author":"Jasprica","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2009.02.006_bib25","first-page":"900","article-title":"Antioxidant effect of propolis against exposure to propetamphos in rats","volume":"72","author":"Kanbura","year":"2009","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"10.1016\/j.fct.2009.02.006_bib26","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1016\/S0021-9258(19)70665-6","article-title":"Purification of rat testicular microsomal 17-Ketosteroid reductase. Evidence that 17-ketosteroid reductase and 17-\u03b2-Hydroxysteroid dehydrogenase are distinct enzymes","volume":"255","author":"Katryna","year":"1980","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.fct.2009.02.006_bib27","first-page":"22","article-title":"Biological activity of bee propolis in health and disease","volume":"7","author":"Khalil","year":"2006","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.fct.2009.02.006_bib28","first-page":"63","article-title":"Histological and ultrastructural studies on the testis of rat after treatment with aluminium chloride","volume":"1","author":"Khattab","year":"2007","journal-title":"Austr. J. Basic Appl. Sci."},{"key":"10.1016\/j.fct.2009.02.006_bib29","first-page":"197","article-title":"Mechanisms involved in the anti-inflammatory effect of propolis extract","volume":"19","author":"Khayyal","year":"1993","journal-title":"Drugs Exp. Clin. Res."},{"key":"10.1016\/j.fct.2009.02.006_bib30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-2007-1016283","article-title":"Oxidation and the spermatozoa","volume":"16","author":"Kim","year":"1998","journal-title":"Semen. Reprod. Endocrinol."},{"key":"10.1016\/j.fct.2009.02.006_bib31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0960-0760(00)00185-0","article-title":"Inhibitory effects of stress-activated nitric oxide on antioxidant enzymes and testicular steroidogenesis","volume":"75","author":"Kostic","year":"2000","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"10.1016\/j.fct.2009.02.006_bib32","first-page":"47","article-title":"Experimental study of biological effects of leads and aluminum following oral administration","volume":"30","author":"Krasovskii","year":"1979","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fct.2009.02.006_bib33","doi-asserted-by":"crossref","first-page":"7203","DOI":"10.1021\/jf0345447","article-title":"Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate","volume":"51","author":"Lee","year":"2003","journal-title":"J. Agricul. Food Chem."},{"key":"10.1016\/j.fct.2009.02.006_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/faat.1995.1140","article-title":"Dibromoacetic acid affects reproductive competence and sperm quality in the male rats","volume":"28","author":"Linder","year":"1995","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.fct.2009.02.006_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/faat.1995.1038","article-title":"Reproductive toxicology of aluminum in male mice","volume":"25","author":"Llobet","year":"1995","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.fct.2009.02.006_bib36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2009.02.006_bib37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jep.2005.10.011","article-title":"Propolis: effect of different concentrations, extracts and intake period on seric biochemical variables","volume":"105","author":"Mani","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2009.02.006_bib38","first-page":"45","article-title":"Quality evaluation of propolis. 1. A comparative study on radical scavenging effects of propolis and vespae nidus","volume":"12","author":"Matsushige","year":"1995","journal-title":"J. Trad. Med."},{"key":"10.1016\/j.fct.2009.02.006_bib39","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/BF02975325","article-title":"Suppressive effects of propolis in rat adjuvant arthritis","volume":"22","author":"Park","year":"1999","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.fct.2009.02.006_bib40","first-page":"105","article-title":"Widespread aluminum deposition in extracerebral organ systems of patients with dialysis-associated encephalopathy","volume":"424","author":"Reusche","year":"1994","journal-title":"Virchows Arc."},{"key":"10.1016\/j.fct.2009.02.006_bib41","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.lfs.2004.10.085","article-title":"Propolis protects human spermatozoa from DNA damage caused by benzo[a]pyrene and exogenous reactive oxygen species","volume":"78","author":"Russo","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2009.02.006_bib42","first-page":"27","article-title":"Effect of sodium arsenate on spermatogenesis, plasma gonadotrophins and testosterone in rats","volume":"5","author":"Sarkar","year":"2003","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.fct.2009.02.006_bib43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0378-8741(00)00320-2","article-title":"Seasonal effect on Brazilian propolis antibacterial activity","volume":"73","author":"Sforcin","year":"2000","journal-title":"J. Ethnopharm."},{"key":"10.1016\/j.fct.2009.02.006_bib44","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1590\/S0104-79302002000100003","article-title":"Absence of seasonal effect on the immunomodulatory action of Brazilian propolis on natural killer activity","volume":"8","author":"Sforcin","year":"2002","journal-title":"J. Venom. Animals Toxins"},{"key":"10.1016\/j.fct.2009.02.006_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1155\/S1565363303000177","article-title":"Synthesis and characterization of some new aluminium derivatives of Schiff bases containing N, O and S donor atoms and the anti fertility activity of the derivative Al [SC6 H4 N: C (CH3)CH2 COCH3]3","volume":"1","author":"Sharma","year":"2003","journal-title":"J. Bioinorg. Chem. Appl."},{"key":"10.1016\/j.fct.2009.02.006_bib46","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1365-2265.1990.tb03916.x","article-title":"Intratesticular control of steroidogenesis","volume":"33","author":"Sharpe","year":"1990","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.fct.2009.02.006_bib47","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1021\/jf0612023","article-title":"Oxidant\/antioxidant properties of Croatian native propolis","volume":"54","author":"Sobocanec","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2009.02.006_bib48","doi-asserted-by":"crossref","first-page":"488","DOI":"10.2164\/jandrol.108.005132","article-title":"Oxidative stress: a common factor in testicular dysfunction","volume":"29","author":"Turner","year":"2008","journal-title":"J. Androl."},{"key":"10.1016\/j.fct.2009.02.006_bib49","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0162-0134(01)00206-9","article-title":"Aluminum speciation studies in biological fluids Part 7. A quantitative investigation of aluminum(III)\u2013malate complex equilibria and their potential implications for aluminum metabolism and toxicity","volume":"85","author":"Venturini-Soriano","year":"2001","journal-title":"J. Inorg. Bioch."},{"key":"10.1016\/j.fct.2009.02.006_bib50","first-page":"151","article-title":"Effect of vitamin E on human sperm motility and lipid peroxidation in vitro","volume":"1","author":"Verma","year":"1999","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.fct.2009.02.006_bib51","first-page":"73","article-title":"Determination of catalase activity and catalase inhibition by ultraviolet spectrophotometry","volume":"16","author":"Xu","year":"1997","journal-title":"Chin. Environ. Chem."},{"key":"10.1016\/j.fct.2009.02.006_bib52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tox.2004.02.014","article-title":"Aluminium-induced changes in hemato-biochemical parameters, lipid peroxidation and enzyme activities of male rabbits: Protective role of ascorbic acid","volume":"199","author":"Yousef","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2009.02.006_bib53","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1081\/PFC-120021666","article-title":"Protective role of isoflavones against the toxic effect of cypermethrin on semen quality and testosterone levels of rabbits","volume":"38","author":"Yousef","year":"2003","journal-title":"J. Environ. Sci. Health Part B"},{"key":"10.1016\/j.fct.2009.02.006_bib54","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0300-483X(03)00145-8","article-title":"Changes in some hematological and biochemical indices of rabbits induced by isoflavones and cypermethrin","volume":"189","author":"Yousef","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2009.02.006_bib55","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.tox.2005.06.025","article-title":"Aluminium induced deterioration in reproductive performance and seminal plasma biochemistry of male rabbits: protective role of ascorbic acid","volume":"215","author":"Yousef","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2009.02.006_bib56","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1081\/LESB-200030880","article-title":"Effect of isoflavones on reproductive performance, testosterone levels, lipid peroxidation and seminal plasma biochemistry of male rabbits","volume":"39","author":"Yousef","year":"2004","journal-title":"J. Environ. Sci. Health Part B"},{"key":"10.1016\/j.fct.2009.02.006_bib57","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.fct.2004.04.012","article-title":"Antioxidant activities and lipid lowering effects of isoflavone in male rabbits","volume":"42","author":"Yousef","year":"2004","journal-title":"Food Chem. Toxicol."},{"issue":"2007","key":"10.1016\/j.fct.2009.02.006_bib58","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tox.2007.07.011","article-title":"An in vitro study on reproductive toxicity of aluminium chloride on rabbit sperm: the protective role of some antioxidants","volume":"239","author":"Yousef","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2009.02.006_bib59","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1046\/j.1432-1033.2000.01328.x","article-title":"Effects of aluminum on activity of Krebs cycle enzymes and glutamate dehydrogenase in rat brain homogenate","volume":"267","author":"Zatta","year":"2000","journal-title":"Eur. J. Biochem."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691509000726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691509000726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:51:11Z","timestamp":1759524671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691509000726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0278691509000726"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2009.02.006","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Propolis protection from reproductive toxicity caused by aluminium chloride in male rats","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2009.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}