{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:41:00Z","timestamp":1768819260765,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.fct.2009.03.021","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T05:18:23Z","timestamp":1238044703000},"page":"1385-1392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats"],"prefix":"10.1016","volume":"47","author":[{"given":"Yu-Tang","family":"Tung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyh-Horng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Chang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Chi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suh-Ching","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Tzen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2009.03.021_bib1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/ptr.2146","article-title":"Ameliorative effects of pycnogenol on carbon tetrachloride-induced hepatic oxidative damage in rats","volume":"21","author":"Ahn","year":"2007","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fct.2009.03.021_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","article-title":"A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase","volume":"195","author":"Beers","year":"1952","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2009.03.021_bib3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1078\/1438-4639-00175","article-title":"2nd industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms","volume":"205","author":"Brautbar","year":"2002","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.fct.2009.03.021_bib4","doi-asserted-by":"crossref","unstructured":"Chang, C.Y., Chen, Y.L., Yang, S.C., Huang, G.C., Tsi, D., Huang, C.C., Chen, J.R., Li, J.S., 2009. Effect of schisandrin B and sesamin mixture on CCl4-induced hepatic oxidative stress in rats. Phytother. Res. 23, 251\u2013256.","DOI":"10.1002\/ptr.2602"},{"key":"10.1016\/j.fct.2009.03.021_bib5","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1021\/jf0100907","article-title":"Antioxidant activity of extracts from Acacia confusa bark and heartwood","volume":"49","author":"Chang","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2009.03.021_bib6","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1016\/j.fct.2008.07.010","article-title":"Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl4-induced oxidative damage in rats","volume":"46","author":"Gowri Shankar","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2009.03.021_bib7","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0140-6736(93)92876-U","article-title":"Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study","volume":"342","author":"Hertog","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.fct.2009.03.021_bib8","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1021\/jf021159t","article-title":"Antioxidative and hepatoprotective effects of Antrodia camphorata extract","volume":"51","author":"Hsiao","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2009.03.021_bib9","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.3748\/wjg.v11.i17.2603","article-title":"Effects of long-term ethanol consumption on jejunal lipase and disaccharidase activities in male and female rats","volume":"11","author":"Huang","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2009.03.021_bib10","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.fct.2006.03.009","article-title":"Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats","volume":"44","author":"Hung","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2009.03.021_bib11","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jep.2006.07.033","article-title":"Protective effect of Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats","volume":"109","author":"Jadon","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2009.03.021_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jep.2007.09.009","article-title":"Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of Momordica dioica Roxb","volume":"115","author":"Jain","year":"2008","journal-title":"Leaves. J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2009.03.021_bib13","series-title":"Manual of Medicinal Plants in Taiwan, vol. 2","first-page":"239","article-title":"Leguminosae","author":"Kan","year":"1978"},{"key":"10.1016\/j.fct.2009.03.021_bib14","first-page":"52","article-title":"Antioxidant activity of Aulosira fertilisima on CCl4 induced hepatotoxicity in rats","volume":"46","author":"Kuriakose","year":"2008","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.fct.2009.03.021_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1142\/S0192415X07004643","article-title":"Actinidia rubricaulis attenuates hepatic fibrosis induced by carbon tetrachloride in rats","volume":"35","author":"Liao","year":"2007","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.fct.2009.03.021_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-2006-961473","article-title":"Anti-oxidant activity of dibenzocyclooctene lignans isolated from schisandraceae","volume":"58","author":"Lu","year":"1992","journal-title":"Planta Med."},{"key":"10.1016\/j.fct.2009.03.021_bib17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1515\/bchm2.1977.358.1.141","article-title":"Mechanism of the stimulation of RNA synthesis in rat liver nuclei by silybin","volume":"358","author":"Machicao","year":"1997","journal-title":"Hoppe. Seylers. Z. Physiol. Chem."},{"key":"10.1016\/j.fct.2009.03.021_bib18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2009.03.021_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0009-3084(87)90063-6","article-title":"The role of lipid peroxidation in liver damage","volume":"45","author":"Poli","year":"1987","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.fct.2009.03.021_bib20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1034\/j.1600-0773.2001.088002053.x","article-title":"Biochemical changes induced in liver and serum of aflatoxin B1-treated male wistar rats: preventive effect of picroliv","volume":"88","author":"Rastogi","year":"2001","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.fct.2009.03.021_bib21","series-title":"Hepatotoxicology","first-page":"401","article-title":"Free radical damage and lipid peroxidation","author":"Reckengel","year":"1991"},{"key":"10.1016\/j.fct.2009.03.021_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanisms of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fct.2009.03.021_bib23","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.phytochem.2008.01.017","article-title":"Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators","volume":"69","author":"Shyur","year":"2008","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fct.2009.03.021_bib24","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1515\/bchm2.1976.357.2.1171","article-title":"Stimulation of RNA synthesis in rat liver and isolated hepatocytes by silybin, an antihepatotoxic agent from Silybum marianum L","volume":"357","author":"Sonnenbichler","year":"1976","journal-title":"Gaertn. Hoppe. Seylers. Z. Physiol. Chem."},{"key":"10.1016\/j.fct.2009.03.021_bib25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1211\/0022357021778303","article-title":"Inhibition of CYP3A-mediated oxidation in human hepatic microsomes by the dietary derived complex phenol, gallic acid","volume":"54","author":"Stupans","year":"2002","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.fct.2009.03.021_bib26","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.lfs.2005.09.025","article-title":"Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats","volume":"78","author":"Sugiyama","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2009.03.021_bib27","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2009.03.021_bib28","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.biortech.2008.01.001","article-title":"Antioxidant activities and phytochemical characteristics of extracts from Acacia confusa bark","volume":"100","author":"Tung","year":"2009","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.fct.2009.03.021_bib29","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.biortech.2006.04.017","article-title":"Antioxidant activities of natural phenolic compounds from Acacia confusa bark","volume":"98","author":"Tung","year":"2007","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.fct.2009.03.021_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jep.2006.01.031","article-title":"Protective effect of Lygodium flexuosum (L.) Sw. extract against carbon tetrachloride-induced acute liver injury in rats","volume":"107","author":"Wills","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2009.03.021_bib31","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1021\/jf050550m","article-title":"Phenolic antioxidants from the heartwood of Acacia confusa","volume":"53","author":"Wu","year":"2005","journal-title":"J. Agric. Food Chem."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869150900129X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869150900129X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:50:47Z","timestamp":1759524647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869150900129X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S027869150900129X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2009.03.021","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2009.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2009 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}