{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:02:02Z","timestamp":1778814122556,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.fct.2009.05.021","type":"journal-article","created":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T05:02:18Z","timestamp":1243486938000},"page":"2031-2036","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice"],"prefix":"10.1016","volume":"47","author":[{"given":"Chia-Fang","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wen","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Kang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Huei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Chieh","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Chyuan","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fung-Jou","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2009.05.021_bib1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0300-483X(03)00157-4","article-title":"Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients","volume":"189","author":"Basu","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2009.05.021_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0009-2797(97)03764-2","article-title":"Prevention of lipid peroxidation induced by ochratoxin A in Vero cells in culture by several agents","volume":"104","author":"Baudrimont","year":"1997","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2009.05.021_bib3","first-page":"524","article-title":"Strain differences in mice in carbon tetrachloride-induced liver injury","volume":"64","author":"Bhathal","year":"1983","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.fct.2009.05.021_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neulet.2009.02.016","article-title":"Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson\u2019s disease","volume":"453","author":"Fu","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.fct.2009.05.021_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1254\/fpj.97.1_13","article-title":"Studies on antinephritic effects of plant components in rats. (1) Effects of saikosaponins originaltype anti-GBM nephritis in rats and its mechanisms","volume":"97","author":"Hattori","year":"1991","journal-title":"Nippon Yakurigaku Zasshi"},{"key":"10.1016\/j.fct.2009.05.021_bib7","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1021\/jf021159t","article-title":"Antioxidative and hepatoprotective effects of Antrodia camphorata extract","volume":"51","author":"Hsiao","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2009.05.021_bib8","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1523-1755.2003.00118.x","article-title":"Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water","volume":"64","author":"Huang","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.fct.2009.05.021_bib9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.ki.5001576","article-title":"Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients","volume":"70","author":"Huang","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.fct.2009.05.021_bib10","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0891-5849(00)00198-2","article-title":"Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl4 poisoning? J","volume":"28","author":"Kadiska","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fct.2009.05.021_bib1a","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.nutres.2008.01.008","article-title":"Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance","volume":"28","author":"Kajiyama","year":"2008","journal-title":"Nutr. Res."},{"key":"10.1016\/j.fct.2009.05.021_bib11","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.lfs.2006.07.027","article-title":"Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice","volume":"79","author":"Kim","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2009.05.021_bib12","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1248\/bpb.30.234","article-title":"Preservative effect of electrolyzed reduced water on pancreatic \u03b2-cell mass in diabetic db\/db mice","volume":"30","author":"Kim","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.fct.2009.05.021_bib13","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","article-title":"Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis","volume":"1","author":"Knodell","year":"1981","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2009.05.021_bib14","first-page":"302","article-title":"Anticancer effect of alkaline reduced water","volume":"22","author":"Lee","year":"2004","journal-title":"J. ISLIS"},{"key":"10.1016\/j.fct.2009.05.021_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1385\/ABAB:135:2:133","article-title":"Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein","volume":"135","author":"Lee","year":"2006","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.fct.2009.05.021_bib16","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/j.fct.2007.05.010","article-title":"Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice","volume":"45","author":"Lee","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2009.05.021_bib17","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.fct.2008.01.017","article-title":"Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice","volume":"46","author":"Lee","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2009.05.021_bib18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.tox.2008.03.009","article-title":"Protective effect of caffeic acid phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice","volume":"248","author":"Lee","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2009.05.021_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1023\/A:1023936421448","article-title":"Protective mechanism of reduced water against alloxan-induced pancreatic \u03b2-cell damage: scavenging effect against reactive oxygen species","volume":"40","author":"Li","year":"2002","journal-title":"Cytotechnology"},{"key":"10.1016\/j.fct.2009.05.021_bib20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/npp.2008.95","article-title":"Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice","volume":"34","author":"Nagata","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.fct.2009.05.021_bib21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1478-3231.2007.01463.x","article-title":"Antioxidant and hepatoprotective effects of Ginkgo biloba phytosomes in carbon tetrachloride-induced liver injury in rodents","volume":"27","author":"Naik","year":"2007","journal-title":"Liver Int."},{"key":"10.1016\/j.fct.2009.05.021_bib22","unstructured":"Nakashima-Kamimura, N., Mori, T., Ohsawa, I., Asoh, S., Ohta, S., in press. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice. Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.fct.2009.05.021_bib23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0378-8741(02)00293-3","article-title":"Protective effect of Rhodiola sachalinensis extract on carbon tetrachloride-induced liver injury in rats","volume":"84","author":"Nan","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2009.05.021_bib1b","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.bbrc.2008.10.156","article-title":"Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice","volume":"377","author":"Ohsawa","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fct.2009.05.021_bib24","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/BF02253360","article-title":"Actions of melatonin in the reduction of oxidative stress","volume":"7","author":"Reiter","year":"2000","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.fct.2009.05.021_bib25","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.fct.2006.10.022","article-title":"Protective effects of Passiflora alata extract pretreatment on carbon tetrachloride induced oxidative damage in rats","volume":"45","author":"Rudnicki","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2009.05.021_bib26","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/hep.1840100509","article-title":"The integrated value of serum procollagen III peptide over time predicts hepatic hydroxyproline content and stainable collagen in a model of dietary cirrhosis in the rat","volume":"10","author":"Ruwart","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2009.05.021_bib27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/bbrc.1997.6622","article-title":"Electrolyzed-reduced water scavenge active oxygen species and protects DNA from oxidative damage","volume":"234","author":"Shirahata","year":"1997","journal-title":"Biochem. Biphys. Res. Commun."},{"key":"10.1016\/j.fct.2009.05.021_bib28","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1042\/bj1230823","article-title":"The stimulatory effects of carbon tetrachloride on peroxidative reactions in rat liver fractions in vitro. Inhibitory effects of free-radical scavengers and other agents","volume":"123","author":"Slater","year":"1971","journal-title":"Biochem. J."},{"key":"10.1016\/j.fct.2009.05.021_bib29","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.fct.2003.12.017","article-title":"Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats","volume":"42","author":"Taira","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2009.05.021_bib30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1271\/bbb.80413","article-title":"Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells by electrolyzed-reduced water and glutathione","volume":"73","author":"Tsai","year":"2009","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.fct.2009.05.021_bib31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/10408690490911701","article-title":"Dietary antioxidant compounds and liver health","volume":"44","author":"Vitaglione","year":"2004","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.fct.2009.05.021_bib32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.fct.2009.05.021_bib33","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1517\/13543784.8.5.585","article-title":"Toxicity of hepatotoxins: new insights into mechanisms and therapy","volume":"8","author":"Wu","year":"1999","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.fct.2009.05.021_bib34","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1271\/bbb.69.1985","article-title":"Electrolyzed hydrogen-saturated water for frinking use elicits an antioxidative effect: A feeding test with rats","volume":"69","author":"Yanagihara","year":"2005","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.fct.2009.05.021_bib35","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.fct.2007.08.016","article-title":"Protective effects of Pycnogenol\u00ae on carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats","volume":"46","author":"Yang","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2009.05.021_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1248\/bpb.31.19","article-title":"Inhibitory effect of electrolyzed reduced water on tumor angiogenesis","volume":"31","author":"Ye","year":"2008","journal-title":"Biol. Pharm. Bull."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691509002464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691509002464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:52:50Z","timestamp":1759524770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691509002464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["S0278691509002464"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2009.05.021","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2009.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}