{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:14:29Z","timestamp":1772820869783,"version":"3.50.1"},"reference-count":14,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.fct.2009.06.003","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T04:42:27Z","timestamp":1244522547000},"page":"2183-2188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The use of nonregular fractional factorial designs in combination toxicity studies"],"prefix":"10.1016","volume":"47","author":[{"given":"Frederick K.H.","family":"Phoa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongquan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weng Kee","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2009.06.003_bib1","series-title":"Statistics for Experimenters: Design, Innovation, and Discovery","author":"Box","year":"2005"},{"key":"10.1016\/j.fct.2009.06.003_bib2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1198\/004017002317375127","article-title":"Design selection and classification for Hadamard matrices using generalized minimum aberration criteria","volume":"44","author":"Deng","year":"2002","journal-title":"Technometrics"},{"key":"10.1016\/j.fct.2009.06.003_bib3","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/444981a","article-title":"Animal experiments under fire for poor design","volume":"444","author":"Giles","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.fct.2009.06.003_bib4","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0278-6915(97)00078-1","article-title":"Use of factorial designs in combination toxicity studies","volume":"34","author":"Groten","year":"1996","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.fct.2009.06.003_bib5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/faat.1996.2281","article-title":"Subacute toxicity of a mixture of nine chemicals in rats: detecting interactive effects with a fractionated two-level factorial design","volume":"36","author":"Groten","year":"1997","journal-title":"Fundamental and Applied Toxicology"},{"key":"10.1016\/j.fct.2009.06.003_bib6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0278-6915(91)90022-Y","article-title":"Interaction of dietary Ca, P, Mg, Mn, Cu, Fe, Zn and Se with the accumulation and oral toxicity of cadmium in rats","volume":"29","author":"Groten","year":"1991","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.fct.2009.06.003_bib7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/00224065.1992.11979383","article-title":"Analysis of designed experiments with complex aliasing","volume":"24","author":"Hamada","year":"1992","journal-title":"Journal of Quality Technology"},{"key":"10.1016\/j.fct.2009.06.003_bib8","series-title":"Design and Analysis of Experiments","author":"Montgomery","year":"2009"},{"key":"10.1016\/j.fct.2009.06.003_bib9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/faat.1995.1125","article-title":"Non-additive developmental toxicity in mixtures of trichloroethylene, di(2-ethylhexyl)phthalate and heptachlor in a 5\u00d75\u00d75 design","volume":"27","author":"Narotsky","year":"1995","journal-title":"Fundamental and Applied Toxicology"},{"key":"10.1016\/j.fct.2009.06.003_bib10","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0300-483X(95)03238-B","article-title":"Mechanistic linkage between DNA adducts, mutations in oncogenes and tumorigenesis of carcinogenic environmental polycyclic aromatic hydrocarbons in strain A\/J mice","volume":"105","author":"Nesnow","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2009.06.003_bib11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/biomet\/33.4.305","article-title":"The design of optimum multifactorial experiments","volume":"33","author":"Plackett","year":"1946","journal-title":"Biometrika"},{"key":"10.1016\/j.fct.2009.06.003_bib12","series-title":"Toxicology of Chemical Mixtures","first-page":"599","article-title":"Statistical methods for the toxicological evaluation of the additivity assumption as used in the environmental protection agency chemical mixture risk assessment guideline","author":"Svensgaard","year":"1994"},{"key":"10.1016\/j.fct.2009.06.003_bib13","series-title":"Experiments: Planning, Analysis, and Parameter Design Optimization","author":"Wu","year":"2000"},{"key":"10.1016\/j.fct.2009.06.003_bib14","first-page":"1191","article-title":"Two-level nonregular designs from quaternary codes","volume":"17","author":"Xu","year":"2007","journal-title":"Statistica Sinica"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691509002701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691509002701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:48:23Z","timestamp":1759524503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691509002701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0278691509002701"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2009.06.003","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The use of nonregular fractional factorial designs in combination toxicity studies","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2009.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}