{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:09:54Z","timestamp":1784545794494,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.fct.2009.08.007","type":"journal-article","created":{"date-parts":[[2009,8,19]],"date-time":"2009-08-19T04:33:08Z","timestamp":1250656388000},"page":"2742-2748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo"],"prefix":"10.1016","volume":"47","author":[{"given":"Eun-Jeon","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Zhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn-Chul","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hwan","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2009.08.007_bibins1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.fct.2009.08.007_bib1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1074\/jbc.272.1.217","article-title":"Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation","volume":"272","author":"Bae","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2009.08.007_bib2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0300-483X(03)00157-4","article-title":"Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients","volume":"189","author":"Basu","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2009.08.007_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-8741(02)00363-X","article-title":"IDN 5082, a standardized extract of Salvia miltiorrhiza, delays acquisition of alcohol drinking behavior in rats","volume":"85","author":"Brunetti","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2009.08.007_bib4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/ptr.1191","article-title":"Glycosmis arborea extract as a hepatoprotective agent","volume":"7","author":"Gomes","year":"2003","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fct.2009.08.007_bib5","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1152\/ajpgi.00001.2006","article-title":"Mechanisms of liver injury. III. Role of glutathione redox status in liver injury","volume":"291","author":"Han","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.fct.2009.08.007_bib6","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1248\/cpb.53.705","article-title":"Quantitative determination of four diterpenoids in Radix Salviae Miltiorrhiza using LC-MS-MS","volume":"53","author":"Hu","year":"2005","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.fct.2009.08.007_bib7","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/j.lfs.2005.09.024","article-title":"The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells","volume":"78","author":"Ikeda","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2009.08.007_bib8","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jhep.2004.06.033","article-title":"Japanese herbal medicine inchin-ko-to as a therapeutic drug for liver fibrosis","volume":"41","author":"Inao","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.fct.2009.08.007_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.04.044","article-title":"Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1\/2, p38 and JNK pathways","volume":"542","author":"Jang","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2009.08.007_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1055\/s-2006-960918","article-title":"Tert-butyl hydroperoxide-induced injury in isolated rat hepatocytes: a model for studying anti-hepatotoxic crude drugs","volume":"56","author":"Joyeux","year":"1990","journal-title":"Planta Med."},{"key":"10.1016\/j.fct.2009.08.007_bib11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1600-0773.2003.920410.x","article-title":"Induction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells","volume":"92","author":"Kim","year":"2003","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.fct.2009.08.007_bib12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/ptr.941","article-title":"Effects of tanshinone I isolated from Salvia miltiorrhiza bunge on arachidonic acid metabolism and in vivo inflammatory responses","volume":"16","author":"Kim","year":"2002","journal-title":"Phytother. Res."},{"key":"10.1016\/j.fct.2009.08.007_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1999.8757","article-title":"Protein S-thiolation can mediate the inhibition of protein synthesis induced by tert-butyl hydroperoxide in isolated rat hepatocytes","volume":"160","author":"Latour","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2009.08.007_bib14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1211\/jpp.58.5.0011","article-title":"Water-soluble extract of Salvia miltiorrhiza ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats","volume":"58","author":"Lee","year":"2006","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.fct.2009.08.007_bib15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2036.2004.01859.x","article-title":"Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial","volume":"19","author":"Madisch","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.fct.2009.08.007_bib16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1211\/0022357011775406","article-title":"Anti-fibrotic effects of a hot-water extract from Salvia miltiorrhiza roots on liver fibrosis induced by biliary obstruction in rats","volume":"53","author":"Nan","year":"2001","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.fct.2009.08.007_bib17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0024-3205(99)00642-6","article-title":"Antioxidative activity of natural products from plants","volume":"66","author":"Ng","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2009.08.007_bib18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jep.2004.06.004","article-title":"Effect of Oren-gedoku-to (Huanglian-Jie-Du-Tang) extract on disruption of hepatic antioxidant defense systems in rats treated with d-galactosamine","volume":"94","author":"Ohta","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2009.08.007_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1055\/s-2003-37027","article-title":"Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or d-galactosamine-induced toxicity in rat primary hepatocytes","volume":"69","author":"Park","year":"2003","journal-title":"Planta Med."},{"key":"10.1016\/j.fct.2009.08.007_bib20","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.fct.2007.04.005","article-title":"PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation","volume":"45","author":"Park","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2009.08.007_bib21","series-title":"Pharmacopoeia of the People\u2019s Republic of China","author":"Pharmacopoeia Commission of the People\u2019s Republic of China","year":"2000"},{"key":"10.1016\/j.fct.2009.08.007_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7258(89)90050-8","article-title":"Mechanism of carbon tetrachloride toxicity","volume":"43","author":"Recknagel","year":"1989","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fct.2009.08.007_bib23","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1016\/j.lfs.2004.11.016","article-title":"Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction","volume":"76","author":"Sun","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2009.08.007_bib24","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/emm.1999.28","article-title":"Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3","volume":"31","author":"Sung","year":"1999","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.fct.2009.08.007_bib25","first-page":"359","article-title":"Protective effect of S-adenosyl-l-methionine on bromobenzene- and d-galactosamine-induced toxicity to isolated rat hepatocytes","volume":"23","author":"Wu","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.fct.2009.08.007_bib26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jacc.2005.05.031","volume":"46","author":"Vogel","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.fct.2009.08.007_bib27","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jpba.2005.12.032","article-title":"Improved quality control method for Danshen products \u2013 consideration of both hydrophilic and lipophilic active components","volume":"41","author":"Zhou","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.fct.2009.08.007_bib28","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1177\/0091270005282630","article-title":"Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","volume":"45","author":"Zhou","year":"2005","journal-title":"J. Clin. Pharmacol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691509003792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691509003792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T20:50:41Z","timestamp":1759524641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691509003792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0278691509003792"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2009.08.007","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2009.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}