{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:17:08Z","timestamp":1779002228919,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["III 43004"],"award-info":[{"award-number":["III 43004"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.fct.2012.10.034","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T18:01:44Z","timestamp":1352484104000},"page":"83-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats"],"prefix":"10.1016","volume":"52","author":[{"given":"Vladimir","family":"Mihailovi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjana","family":"Mihailovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Uskokovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Aramba\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danijela","family":"Mi\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Stankovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Katani\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Mladenovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slavica","family":"Soluji\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Mati\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2012.10.034_b0005","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/j.1478-3231.2010.02295.x","article-title":"Resveratrol and liver disease: from bench to bedside and community","volume":"30","author":"Bishayee","year":"2010","journal-title":"Liver Int."},{"key":"10.1016\/j.fct.2012.10.034_b0010","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.taap.2012.01.015","article-title":"Mangiferin exerts hepatoprotective activity against d-galactosamine induced acute toxicity and oxidative\/nitrosative stress via Nrf2\u2013NF\u03baB pathways","volume":"260","author":"Das","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2012.10.034_b0015","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.fct.2011.10.063","article-title":"Hepatoprotective potential of polyphenol rich extract of Murraya koenigii L.: An in vivo study","volume":"50","author":"Desai","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2012.10.034_b0020","first-page":"45","article-title":"In vitro multiplication of willow getian (Gentiana asclepiadea L.) and the production of gentiopicrine and mangiferin","volume":"46","author":"Devi\u0107","year":"2006","journal-title":"Phyton"},{"key":"10.1016\/j.fct.2012.10.034_b0025","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulphydryl group","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.fct.2012.10.034_b0030","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0009-8981(91)90067-M","article-title":"A simple method for determination of serum catalase activity and revision of reference range","volume":"196","author":"G\u00f3th","year":"1991","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.fct.2012.10.034_b0035","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1159\/000239478","article-title":"Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone","volume":"42","author":"Guha","year":"1996","journal-title":"Chemotherapy"},{"key":"10.1016\/j.fct.2012.10.034_b0040","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-4274(96)03847-7","article-title":"The contribution of cytotoxicity to DNA effects in the single cell gel test (Comet assay)","volume":"90","author":"Hartmann","year":"1997","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fct.2012.10.034_b0045","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jep.2010.06.029","article-title":"Hepatoprotective and antioxidant effects of the methanolic extract from Halenia elliptica","volume":"131","author":"Huang","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2012.10.034_b0050","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.fct.2011.12.009","article-title":"Hepatoprotective effects of total saponins isolated from Taraphochlamys affinis against carbon tetrachloride induced liver injury in rats","volume":"50","author":"Huang","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2012.10.034_b0055","first-page":"21","article-title":"Cytotoxic and genotoxic effect of methanolic flower extract from Gentiana asclepiadea on Cos1 cells","volume":"31","author":"Hudecova","year":"2010","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.fct.2012.10.034_b0060","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/cbf.1822","article-title":"Gentiana asclepiadea protects human cells against oxidation DNA lesions","volume":"30","author":"Hudecova","year":"2012","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.fct.2012.10.034_b0065","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4149\/neo_2012_01_008","article-title":"Gentiana asclepiadea and Armoracia rusticana can modulate the adaptive response induced by zeocin in human lymphocytes","volume":"59","author":"Hudecova","year":"2012","journal-title":"Neoplasma"},{"key":"10.1016\/j.fct.2012.10.034_b0070","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1016\/j.fct.2012.06.017","article-title":"Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage","volume":"50","author":"Hudecov\u00e1","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2012.10.034_b0075","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1248\/bpb.21.1389","article-title":"New antidiabetic compounds, mangiferin and its glucoside","volume":"21","author":"Ichiki","year":"1998","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.fct.2012.10.034_b0080","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jep.2010.04.019","article-title":"Antioxidant and hepatoprotective effect of swertiamarin from Enicostemm axillare against d-galactosamine induced acute liver damage in rats","volume":"130","author":"Jaishree","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2012.10.034_b0085","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.foodchem.2010.09.062","article-title":"Hepatoprotective effects of almond oil against carbon tetrachloride induced liver injury in rats","volume":"125","author":"Jia","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2012.10.034_b0090","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0031-9422(92)80080-X","article-title":"A naphthodipyranodione from Gentiana asclepiadea","volume":"31","author":"Kitanov","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fct.2012.10.034_b0095","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1055\/s-2006-959521","article-title":"Suppression of chemically and immunologically induced hepatic injuries by gentiopicroside in mice","volume":"60","author":"Kondo","year":"1993","journal-title":"Planta Med."},{"key":"10.1016\/j.fct.2012.10.034_b0100","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.fct.2006.11.007","article-title":"Hepatoprotection of tea seed oil (Camellia oleifera Abel.) against CCl4-induced oxidative damage in rats","volume":"45","author":"Lee","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2012.10.034_b0105","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.intimp.2004.03.002","article-title":"Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin","volume":"4","author":"Leiro","year":"2004","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fct.2012.10.034_b0110","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.fct.2012.02.025","article-title":"Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-kB bioluminescent imaging-guided transcriptomic analysis","volume":"50","author":"Li","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2012.10.034_b0115","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cbi.2010.06.004","article-title":"Anti-apoptotic activity of gentiopicroside in d-galactosamine\/ipopolysaccharide-induced murine fulminant hepatic failure","volume":"188","author":"Lian","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fct.2012.10.034_b0120","doi-asserted-by":"crossref","first-page":"13013","DOI":"10.1021\/jf103976y","article-title":"Gentiana manshurica Kitagawa reverses acute alcohol-induced liver steatosis through blocking sterol regulatory element-binding protein-1 maturation","volume":"58","author":"Lian","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fct.2012.10.034_b0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2012.10.034_b0130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jep.2010.09.008","article-title":"Ethnobotanical study on traditional uses of wild medicinal plants in Prokletije Mountains (Montenegro)","volume":"133","author":"Menkovi\u0107","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2012.10.034_b0135","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the auto-oxidation of epinephrine and simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2012.10.034_b0140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1078\/0944-7113-00009","article-title":"Antidiabetic activity of a xanthone compound, mangiferin","volume":"8","author":"Miura","year":"2001","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fct.2012.10.034_b0145","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1248\/bpb.24.201","article-title":"Release of intermediate reactive hydrogen peroxide by macrophage cells activated by natural products","volume":"24","author":"Moreira","year":"2001","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.fct.2012.10.034_b0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1055\/s-2006-962394","article-title":"6\u2032-O-\u03b2-d-Glucosyl gentiopicroside: a new secoiridoid from Gentiana asclepiadea","volume":"54","author":"Mpondo","year":"1988","journal-title":"Planta Med."},{"key":"10.1016\/j.fct.2012.10.034_b0155","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1016\/j.fct.2010.08.007","article-title":"Antioxidant activity of selected plant species; potential new sources of natural antioxidants","volume":"48","author":"Ni\u0107iforovi\u0107","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2012.10.034_b0160","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0024-3205(03)00117-6","article-title":"Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle","volume":"72","author":"Orhan","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.fct.2012.10.034_b0165","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fct.2012.10.034_b0170","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S2221-1691(11)60078-6","article-title":"Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa","volume":"1","author":"Ravikumar","year":"2011","journal-title":"Asian. Pac. J. Trop. Biomed."},{"key":"10.1016\/j.fct.2012.10.034_b0175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/10408447309082019","article-title":"Carbon tetrachloride hepatotoxicity. An example of lethal cleavage","volume":"2","author":"Recknagel","year":"1973","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.fct.2012.10.034_b0180","series-title":"Medicinal Plants of SR Serbia","author":"Sari\u0107","year":"1989"},{"key":"10.1016\/j.fct.2012.10.034_b0185","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3923\/ijp.2005.226.233","article-title":"Antioxidants: their role in health and disease","volume":"1","author":"Saeed","year":"2005","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.fct.2012.10.034_b0190","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.fct.2012.10.034_b0195","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.foodchem.2009.05.014","article-title":"Hepatoprotective effect of the root extract of Decalepis hamiltonii against carbon tetrachloride-induced oxidative stress in rats","volume":"118","author":"Srivastava","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.fct.2012.10.034_b0200","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0014-4800(03)00097-2","article-title":"Oxidative stress, toxic hepatitis, and antioxidants with particular emphasis on zinc","volume":"75","author":"Stehbens","year":"2003","journal-title":"Exp. Mol. Pathol."},{"issue":"Suppl.","key":"10.1016\/j.fct.2012.10.034_b0205","doi-asserted-by":"crossref","first-page":"S-19","DOI":"10.1007\/BF02494108","article-title":"Comparative analysis of the underground parts of Gentiana species by HPLC with diode-array and mass spectrometric detection","volume":"56","author":"Sz\u00fccs","year":"2002","journal-title":"Chromatographia"},{"key":"10.1016\/j.fct.2012.10.034_b0210","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3748\/wjg.v16.i3.384","article-title":"Gentiana manshurica Kitagawa prevents acetaminophen induced acute hepatic injury in mice via inhibiting JNK\/ERK MAPK pathway","volume":"21","author":"Wang","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fct.2012.10.034_b0215","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1021\/np50095a004","article-title":"Search for bitter principles in Chironia species by LC-MS and isolation of a new secoiridoid diglycoside from Chironia krebsii","volume":"56","author":"Wolfender","year":"1993","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.fct.2012.10.034_b0220","first-page":"649","article-title":"Phytochemicals and biological activities of Gentiana species","volume":"5","author":"Yang","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.fct.2012.10.034_b0225","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3835(00)00678-9","article-title":"The inhibitory effects of mangiferin, a naturally occurring glucosylxanthone, in bowel carcinogenesis of male F344 rats","volume":"163","author":"Yoshimi","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fct.2012.10.034_b0230","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jep.2010.07.051","article-title":"Identification of medicinal plants used as Tibetan Traditional Medicine Jie-Ji","volume":"132","author":"Zhao","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2012.10.034_b0235","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jep.2010.03.016","article-title":"Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching","volume":"129","author":"Zhou","year":"2010","journal-title":"J. Ethnopharmacol."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869151200779X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027869151200779X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:09:07Z","timestamp":1759525747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027869151200779X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":47,"alternative-id":["S027869151200779X"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2012.10.034","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2012.10.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}