{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:10:54Z","timestamp":1781611854172,"version":"3.54.5"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004602","name":"Program for New Century Excellent Talents in University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31000757"],"award-info":[{"award-number":["31000757"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.fct.2012.11.048","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T19:24:59Z","timestamp":1354735499000},"page":"62-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells"],"prefix":"10.1016","volume":"53","author":[{"given":"Li","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2012.11.048_b0010","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0378-8741(98)00147-0","article-title":"Effect of isoorientin isolated from Arum palaestinum on uterine smooth muscle of rats and guinea pigs","volume":"65","author":"Afifi","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2012.11.048_b0005","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/j.bcp.2010.06.036","article-title":"Cancer chemoprevention by dietary polyphenols: promising role for epigenetics","volume":"80","author":"Alexander","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2012.11.048_b0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pharmthera.2010.01.009","article-title":"Dietary flavonoids in cancer therapy and prevention: substrates and inhibitors of cytochrome P450 CYP1 enzymes","volume":"126","author":"Androutsopoulos","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fct.2012.11.048_b0025","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0031-9422(02)00258-3","article-title":"Naphthalene glucoside and other phenolics from the shoot and callus cultures of Drosophyllum lusitanicum","volume":"61","author":"Budzianowski","year":"2002","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fct.2012.11.048_b0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/35065000","article-title":"Mammalian MAP kinase signalling cascades","volume":"410","author":"Chang","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.fct.2012.11.048_b0030","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1080\/01635581.2010.494821","article-title":"Anticancer activities of an anthocyanin-rich extract from black rice against breast cancer cells in vitro and in vivo","volume":"62","author":"Chang","year":"2010","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.fct.2012.11.048_b0045","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.toxicon.2010.01.024","article-title":"Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells","volume":"55","author":"Chen","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.fct.2012.11.048_b0040","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S1734-1140(11)70584-9","article-title":"No protective effect of curcumin on hydrogen peroxide-induced cytotoxicity in HepG2 cells","volume":"63","author":"Chen","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.fct.2012.11.048_b0050","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1021\/tx100248s","article-title":"Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways","volume":"24","author":"Chiang","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fct.2012.11.048_b0055","doi-asserted-by":"crossref","first-page":"580","DOI":"10.3181\/0707-RM-205","article-title":"Blockade of chronic high glucose\u2013induced endothelial apoptosis by sasa borealis bamboo extract","volume":"233","author":"Choi","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.fct.2012.11.048_b0060","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.fct.2012.11.048_b0065","first-page":"41","article-title":"Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy","volume":"12","author":"Decaudin","year":"1998","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.fct.2012.11.048_b0315","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10495-009-0421-z","article-title":"Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling","volume":"15","author":"El-Najjar","year":"2010","journal-title":"Apoptosis."},{"key":"10.1016\/j.fct.2012.11.048_b0070","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.fct.2012.11.048_b0075","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1021\/np200390x","article-title":"Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways","volume":"74","author":"Festa","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.fct.2012.11.048_b0080","series-title":"The Flavonoids \u2013 Advances in Research Since 1986","author":"Harborne","year":"1994"},{"key":"10.1016\/j.fct.2012.11.048_b0320","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/mnfr.201000005","article-title":"Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells","volume":"54","author":"Huang","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fct.2012.11.048_b0085","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1038\/sj.onc.1203129","article-title":"From receptors to stress-activated MAP kinases","volume":"18","author":"Ichijo","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.fct.2012.11.048_b0090","first-page":"69","article-title":"Global cancer statistics","volume":"261","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.fct.2012.11.048_b0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.0022-3042.2001.00678.x","article-title":"MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad","volume":"80","author":"Jin","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.fct.2012.11.048_b0100","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1074\/jbc.M107231200","article-title":"ERK-1\/2 and p38 kinase oppositely regulate nitric oxide-induced apoptosis of chondrocytes in association with p53, caspase-3, and differentiation status","volume":"277","author":"Kim","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2012.11.048_b0105","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1515\/znc-2004-11-1204","article-title":"Evaluation of in vivo biological activity profile of isoorientin","volume":"59c","author":"K\u00fcpeli","year":"2004","journal-title":"Z. Naturforsch."},{"key":"10.1016\/j.fct.2012.11.048_b0110","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1096\/fj.04-2285fje","article-title":"Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes","volume":"18","author":"Laethem","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.fct.2012.11.048_b0115","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1471-4159.2004.02191.x","article-title":"Mitogen-activated protein kinase\/extracellular signal-regulated kinase attenuates 3-hydroxykynurenine-induced neuronal cell death","volume":"88","author":"Lee","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.fct.2012.11.048_b0120","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.phytochem.2009.06.006","article-title":"Neural cell protective compounds isolated from Phoenix hanceana var. formosana","volume":"70","author":"Lin","year":"2010","journal-title":"Phytochemistry"},{"key":"10.1016\/j.fct.2012.11.048_b0130","doi-asserted-by":"crossref","first-page":"11851","DOI":"10.1158\/0008-5472.CAN-06-1377","article-title":"Sorafenib blocks the RAF\/MEK\/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC\/PRF\/5","volume":"66","author":"Liu","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2012.11.048_b0125","first-page":"152","article-title":"Flavonoids: recent advances as anticancer drugs","volume":"5","author":"Liu","year":"2010","journal-title":"Recent Pat. Anti-Cancer"},{"key":"10.1016\/j.fct.2012.11.048_b0135","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1016\/j.febslet.2010.08.014","article-title":"The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells","volume":"584","author":"Lu","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.fct.2012.11.048_b0140","doi-asserted-by":"crossref","first-page":"19245","DOI":"10.1074\/jbc.M208134200","article-title":"Sustained activation of JNK\/p38MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells","volume":"278","author":"Mansouri","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fct.2012.11.048_b0145","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nature01101","article-title":"Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c\/Apaf-1\/caspase-9 apoptosome","volume":"19","author":"Marsden","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.fct.2012.11.048_b0150","first-page":"811","article-title":"Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK\/AP-1 pathway","volume":"17","author":"Michela","year":"2006","journal-title":"Int. Mol. Med."},{"key":"10.1016\/j.fct.2012.11.048_b0155","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3136\/nskkk.49.119","article-title":"Changes in antioxidative activity and flavonoid composition of the extracts from aerial parts of buckwheat during growth period","volume":"49","author":"Mitsuru","year":"2002","journal-title":"Nippon Shokuhin Kagaku Kogaku Kaishi"},{"key":"10.1016\/j.fct.2012.11.048_b0160","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.taap.2010.07.025","article-title":"Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K\/Akt\/eNOS pathway","volume":"248","author":"Ou","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2012.11.048_b0165","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1021\/np100255u","article-title":"Spectroscopic characterization and antiproliferative activity on HepG2 human hepatoblastoma cells of flavonoid C-glycosides from Petrorhagia velutina","volume":"73","author":"Pacifico","year":"2010","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.fct.2012.11.048_b0170","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.chroma.2005.03.067","article-title":"Preparative separation of isovitexin and isoorientin from Patrinia villosa Juss by high-speed counter-current chromatography","volume":"1074","author":"Peng","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.fct.2012.11.048_b0175","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1002\/cbdv.200790241","article-title":"4\u2034-Acetylvitexin-2\u2033-O-rhamnoside, isoorientin, orientin, and 8-methoxykaempferol-3-O-glucoside as markers for the differentiation of Crataegus monogyna and Crataegus pentagyna from Crataegus laevigata","volume":"4","author":"Prinz","year":"2007","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.fct.2012.11.048_b0180","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0896-6273(03)00355-6","article-title":"JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis","volume":"38","author":"Putcha","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.fct.2012.11.048_b0185","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jep.2010.02.022","article-title":"Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells","volume":"128","author":"Qi","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2012.11.048_b0190","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2011.06.016","article-title":"Acetylsalicylic acid-induced oxidative stress, cell cycle arrest, apoptosis and mitochondrial dysfunction in human hepatoma HepG2 cells","volume":"668","author":"Raza","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fct.2012.11.048_b0195","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1258\/ebm.2012.011423","article-title":"Raf\/MEK\/ERK signaling inhibition enhances the ability of dequalinium to induce apoptosis in the human leukemic cell line K562","volume":"237","author":"Sancho","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.fct.2012.11.048_b0200","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/excr.2001.5262","article-title":"The role of ERK 1\/2 and p38 MAP-kinase pathways in taxol-induced apoptosis in human ovarian carcinoma cells","volume":"268","author":"Seidman","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.fct.2012.11.048_b0205","first-page":"1604","article-title":"Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular- signal-regulated protein kinases and p38 Kinase","volume":"61","author":"She","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2012.11.048_b0210","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.taap.2010.03.004","article-title":"Cr (VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells","volume":"245","author":"Son","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2012.11.048_b0215","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrc844","article-title":"Chemoprevention: an essential approach to controlling cancer","volume":"2","author":"Sporn","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.fct.2012.11.048_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/carcin\/bgh220","article-title":"Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1\/JNK-dependent signaling pathway in human leukemia HL-60 cells","volume":"26","author":"Su","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fct.2012.11.048_b0225","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.semcancer.2007.05.002","article-title":"Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?","volume":"17","author":"Thomas","year":"2007","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.fct.2012.11.048_b0230","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.288.5467.870","article-title":"Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway","volume":"288","author":"Tournier","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.fct.2012.11.048_b0235","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1038\/sj.emboj.7600194","article-title":"JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins","volume":"23","author":"Tsuruta","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.fct.2012.11.048_b0240","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jep.2006.10.024","article-title":"Antioxidant, anti-inflammatory, anti-nociceptive activities and composition of Lythrum salicaria L. extracts","volume":"110","author":"Tunalier","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fct.2012.11.048_b0245","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1158\/0008-5472.CAN-04-0866","article-title":"Blocking the Raf\/MEK\/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis","volume":"64","author":"Wu","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.fct.2012.11.048_b0255","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2010.07.004","article-title":"The role of p38 MAPK in valproic acid induced microglia apoptosis","volume":"482","author":"Xie","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.fct.2012.11.048_b0250","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ejps.2012.03.002","article-title":"The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells","volume":"46","author":"Xie","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.fct.2012.11.048_b0265","first-page":"261","article-title":"Enhancement of paclitaxel-induced apoptosis by inhibition of mitogen-activated protein kinase pathway in colon cancer cells","volume":"29","author":"Xu","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.fct.2012.11.048_b0260","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.fct.2012.01.002","article-title":"Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism","volume":"50","author":"Xu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fct.2012.11.048_b0270","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/taap.1999.8888","article-title":"Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK\/JNK activation","volume":"164","author":"Yang","year":"2000","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.fct.2012.11.048_b0275","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/0973-1296.93319","article-title":"A novel high-performance liquid chromatography fingerprint approach to discriminate Phyllostachys pubescens from China","volume":"8","author":"Yong-Chun","year":"2012","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.fct.2012.11.048_b0325","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.taap.2012.09.022","article-title":"Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K\/Akt signaling pathway in HepG2 cancer cells","volume":"265","author":"Yuan","year":"2012","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.fct.2012.11.048_b0285","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bcp.2004.03.030","article-title":"Aggravation of necrotic death of glucose-deprived cells by the MEK1 inhibitors U0126 and PD184161 through depletion of ATP","volume":"68","author":"Yung","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2012.11.048_b0300","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cbi.2010.03.035","article-title":"Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells","volume":"185","author":"Zhang","year":"2010","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.fct.2012.11.048_b0290","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.taap.2011.02.006","article-title":"The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K\/Akt pathway","volume":"252","author":"Zhang","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fct.2012.11.048_b0295","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1089\/ars.2010.3685","article-title":"Redox control of the survival of healthy and diseased cells","volume":"15","author":"Zhang","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.fct.2012.11.048_b0305","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s11101-009-9161-5","article-title":"Tricin-a potential multifunctional nutraceutical","volume":"9","author":"Zhou","year":"2010","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.fct.2012.11.048_b0310","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1158\/1078-0432.CCR-09-0661","article-title":"Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth","volume":"15","author":"Zhou","year":"2009","journal-title":"Clin. Cancer Res."}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691512008551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691512008551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:09:39Z","timestamp":1759525779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691512008551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":63,"alternative-id":["S0278691512008551"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2012.11.048","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2012.11.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2012 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}