{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:37:43Z","timestamp":1787920663258,"version":"build-2784847793"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T00:00:00Z","timestamp":1397606400000},"content-version":"vor","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.fct.2012.12.038","type":"journal-article","created":{"date-parts":[[2012,12,29]],"date-time":"2012-12-29T13:04:05Z","timestamp":1356786245000},"page":"48-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":127,"special_numbering":"C","title":["Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats"],"prefix":"10.1016","volume":"55","author":[{"given":"Guilherme Pires","family":"Amaral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson Rodrigues","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo Pillon","family":"Barcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Dobrachinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael de Lima","family":"Portella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Hinerasky","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Henrique","family":"Lugokenski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaecir Roseni Mundstock","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f4nia Cristina Almeida","family":"da Luz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Augusti","family":"Boligon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareth Linde","family":"Athayde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Antonio","family":"Villetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix Alexandre","family":"Antunes Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselei","family":"Fachinetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2012.12.038_b0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.fct.2012.12.038_b0010","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1021\/jf062610+","article-title":"Characterization of topical antiinflammatory compounds in Rosmarinus officinalis L","volume":"55","author":"Altinier","year":"2007","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.fct.2012.12.038_b0015","doi-asserted-by":"crossref","first-page":"697","DOI":"10.4103\/0250-474X.84577","article-title":"Evaluation of antiinflammatory activity of centratherum anthelminticum (L) kuntze seed","volume":"72","author":"Ashok","year":"2010","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.fct.2012.12.038_b0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jep.2007.10.039","article-title":"In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits","volume":"116","author":"Bakirel","year":"2008","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.fct.2012.12.038_b0025","article-title":"Theory and Practice of histological techniques","volume":"238","author":"Bancroft","year":"1977","journal-title":"The Journal of the American Medical Association"},{"key":"10.1016\/j.fct.2012.12.038_b0030","first-page":"65","article-title":"Observational survey of NSAID-related upper gastro-intestinal adverse events in Belgium","volume":"65","author":"Belaiche","year":"2002","journal-title":"Acta Gastroenterology"},{"key":"10.1016\/j.fct.2012.12.038_b0035","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.foodchem.2010.06.056","article-title":"Analysis of the anti-inflammatory properties of Rosmarinus officinalis L. in mice","volume":"124","author":"Beninc\u00e1","year":"2011","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fct.2012.12.038_b0040","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.fct.2012.12.038_b0045","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.fct.2008.10.026","article-title":"Protective effects of a polysaccharide from Hizikia fusiformis against ethanol toxicity in rats","volume":"47","author":"Choi","year":"2009","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.fct.2012.12.038_b0050","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1053\/j.gastro.2007.06.026","article-title":"Carcinogenesis of Helicobacter pylori","volume":"133","author":"Correa","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fct.2012.12.038_b0055","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.4315\/0362-028X-63.10.1359","article-title":"Antimicrobial effect of rosemary extracts","volume":"63","author":"Del Campo","year":"2000","journal-title":"Journal of Food Protection"},{"key":"10.1016\/j.fct.2012.12.038_b0060","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-8741(99)00133-6","article-title":"Antiulcerogenic activity of crude hydroalcoholic extract of Rosmarinus officinalis L","volume":"69","author":"Dias","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.fct.2012.12.038_b0065","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.foodchem.2008.01.058","article-title":"Antioxidant activities of rosemary (Rosmarinus officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol","volume":"110","author":"Erkan","year":"2008","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fct.2012.12.038_b0070","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1043-6618(02)00083-X","article-title":"Effects of paracetamol and propacetamol on gastric mucosal damage and gastric lipid peroxidation caused acetylsalicylic acid (ASA) in rats","volume":"46","author":"Galuska","year":"2002","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.fct.2012.12.038_b0075","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1590\/S0074-02761991000600031","article-title":"Inhibition of gastric-secretion by a water extract from Baccharis-triptera","volume":"86","author":"Gamberini","year":"1991","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz."},{"key":"10.1016\/j.fct.2012.12.038_b0080","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jep.2006.12.011","article-title":"Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents","volume":"111","author":"Gonz\u00e1lez-Trujano","year":"2007","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.fct.2012.12.038_b0085","first-page":"567","article-title":"Xanthine oxidase and neutrophil infiltration in intestinal ischemia","volume":"251","author":"Grisham","year":"1986","journal-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.fct.2012.12.038_b0090","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00213-006-0376-5","article-title":"Nitric oxide is involved in the memory facilitation induced by spermidine in rats","volume":"186","author":"Guerra","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.fct.2012.12.038_b0095","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0378-8741(00)00184-7","article-title":"Experimental diuretic effects of Rosmarinus officinalis and Centaurium erythraea","volume":"71","author":"Haloui","year":"2000","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.fct.2012.12.038_b0100","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jep.2006.05.035","article-title":"Ethnobotany and ethnopharmacology \u2013 interdisciplinary links with the historical sciences","volume":"107","author":"Heinrich","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.fct.2012.12.038_b0105","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A fluorometric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"Hissin","year":"1976","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.fct.2012.12.038_b0110","unstructured":"Hoogerwerf, W.A., Pasricha, P.J., 2001. Agents used for control of gastric acidity and treatment of peptic ulcer and gastro esophageal reflux disease. In: G.a.G.t.P.B.o. (Ed.). Therapeutics, 11th ed. McGraw Hill, New York, pp. 1005\u20131020."},{"key":"10.1016\/j.fct.2012.12.038_b0115","unstructured":"Hoogerwerf, W.A., Pasricha, P.J., 2001. Agents used for the Control of Gastric Acidity and Treatment of Peptic Ulcers and Gastrooesophageal Reflux Diseases."},{"key":"10.1016\/j.fct.2012.12.038_b0120","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1016\/j.fct.2008.06.007","article-title":"Diphenyl diselenide reverses gastric lesions in rats: involvement of oxidative stress","volume":"46","author":"Ineu","year":"2008","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.fct.2012.12.038_b0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0300-483X(02)00514-0","article-title":"The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions","volume":"183","author":"Kaharaman","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.fct.2012.12.038_b0230","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.foodchem.2012.09.028","article-title":"Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L","volume":"136","author":"Machado","year":"2013","journal-title":"Food Chemistry"},{"key":"10.1016\/j.fct.2012.12.038_b0135","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/niox.2000.0319","article-title":"A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite","volume":"5","author":"Miranda","year":"2001","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.fct.2012.12.038_b0140","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.fct.2012.12.038_b0145","unstructured":"Mulinaccia, N., Innocentia, M., Bellumoria, M., Giaccherinia, C., Martinib, V., Michelozzib, M., 2009. The Scientific Foundation for Herbal Medicinal Products, second ed. European on Phytotherapy Scientific Cooperative, pp. 429\u2013436."},{"key":"10.1016\/j.fct.2012.12.038_b0150","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.talanta.2011.03.050","article-title":"Storage method, drying processes and extraction procedures strongly affect the phenolic fraction of rosemary leaves: an HPLC\/DAD\/MS study","volume":"85","author":"Mulinaccia","year":"2011","journal-title":"Talanta"},{"key":"10.1016\/j.fct.2012.12.038_b0155","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0006-2952(03)00083-2","article-title":"Evaluation of the probes 2\u2032,7\u2032-dichlorofluorescin diacetate, luminol, and lucigenin as indicators of reactive species formation","volume":"65","author":"Myhre","year":"2003","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.fct.2012.12.038_b0160","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.phrs.2009.11.010","article-title":"Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals","volume":"61","author":"Nabekuraa","year":"2010","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.fct.2012.12.038_b0170","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.fct.2012.12.038_b0165","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00002800-200311000-00008","article-title":"Gastric ulcers and GERD: the new \u2018\u2018plagues\u201d of the 21st century update for the clinical nurse specialist","volume":"17","author":"O\u2019Malley","year":"2003","journal-title":"Clinical Nurse Specialist"},{"key":"10.1016\/j.fct.2012.12.038_b0175","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.phrs.2005.03.003","article-title":"Neurobehavioral and genotoxic aspects of rosmarinic acid","volume":"52","author":"Pereira","year":"2005","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.fct.2012.12.038_b0180","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.abb.2006.07.004","article-title":"Rosemary (Rosmarinus officinalis) diterpenes affect lipid polymorphism and fluidity in phospholipid membranes","volume":"453","author":"P\u00e9rez-Fons","year":"2006","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.fct.2012.12.038_b0185","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.neuint.2004.06.008","article-title":"S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats","volume":"45","author":"P\u00e9rez-Severiano","year":"2004","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.fct.2012.12.038_b0190","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.freeradbiomed.2012.09.001","article-title":"Nitroxides attenuate carrageenan-induced inflammation in rat paws by reducing neutrophil infiltration and the resulting myeloperoxidase-mediated damage","volume":"53","author":"Queiroz","year":"2012","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.fct.2012.12.038_b0195","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: how are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/j.fct.2012.12.038_b0200","first-page":"761","volume":"77","author":"Robert","year":"1979","journal-title":"Cytoprotection by Prostaglandins Gastroenterology"},{"key":"10.1016\/j.fct.2012.12.038_b0205","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.etap.2005.07.017","article-title":"Antisecretory and antiulcer effects of diphenyl diselenide","volume":"21","author":"Savegnago","year":"2006","journal-title":"Environmental Toxicology and Pharmacology"},{"key":"10.1016\/j.fct.2012.12.038_b0210","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1016\/j.fct.2010.07.007","article-title":"Anti-inflammatory and anti-ulcer activity of the extract from Alhagi maurorum (camelthorn)","volume":"48","author":"Shaker","year":"2010","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.fct.2012.12.038_b0215","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0378-8741(02)00090-9","article-title":"Evaluation of the effectiveness of Rosmarinus officinalis (Lamiaceae) in the alleviation of carbon tetrachloride-induced acute hepatotoxicity in the rat","volume":"81","author":"Sotelo-F\u00e9lix","year":"2002","journal-title":"Journal of Ethnopharmacology"},{"key":"10.1016\/j.fct.2012.12.038_b0220","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.nut.2004.09.016","article-title":"Testing various herbs for antithrombotic effect","volume":"21","author":"Yamamoto","year":"2005","journal-title":"Nutrition"},{"key":"10.1016\/j.fct.2012.12.038_b0225","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0014-2999(00)00278-8","article-title":"Intragastric administration of heparin enhances gastric ulcer healing through a nitric oxide-dependent mechanism in rats","volume":"399","author":"Yang","year":"2000","journal-title":"European Journal of Pharmacology"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691512009118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691512009118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:09:53Z","timestamp":1759525793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691512009118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":45,"alternative-id":["S0278691512009118"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2012.12.038","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective action of ethanolic extract of Rosmarinus officinalis L. in gastric ulcer prevention induced by ethanol in rats","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2012.12.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}