{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:18:26Z","timestamp":1777436306225,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Food and Chemical Toxicology"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.fct.2013.01.055","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T05:16:07Z","timestamp":1360818967000},"page":"69-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["\u03b1-Lipoic acid supplementation up-regulates antioxidant capacity in adults with G6PD deficiency"],"prefix":"10.1016","volume":"61","author":[{"given":"Kalliopi","family":"Georgakouli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chariklia K.","family":"Deli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Zalavras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis G.","family":"Fatouros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Kouretas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiannis","family":"Koutedakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios Z.","family":"Jamurtas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fct.2013.01.055_b0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.fct.2013.01.055_b0010","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1365-2141.2005.05834.x","article-title":"Red blood cells, platelets and polymorphonuclear neutrophils of patients with sickle cell disease exhibit oxidative stress that can be ameliorated by antioxidants","volume":"132","author":"Amer","year":"2006","journal-title":"Br. J. Haematol."},{"issue":"12","key":"10.1016\/j.fct.2013.01.055_b0015","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.clinbiochem.2009.05.009","article-title":"Increased oxidative\/nitrosative stress and decreased antioxidant enzyme activities in prostate cancer","volume":"42","author":"Arsova-Sarafinovska","year":"2009","journal-title":"Clin. Biochem."},{"issue":"3","key":"10.1016\/j.fct.2013.01.055_b0020","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0005-2760(88)90326-8","article-title":"Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation","volume":"963","author":"Bast","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fct.2013.01.055_b0200","series-title":"The Molecular Basis of Blood Disease","article-title":"The molecular biology of enzymes of erythrocyte metabolism","author":"Beutler","year":"1993"},{"key":"10.1016\/j.fct.2013.01.055_b0025","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613","article-title":"G6PD deficiency","volume":"84","author":"Beutler","year":"1994","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.fct.2013.01.055_b0205","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0306-3623(96)00474-0","article-title":"The pharmacology of the antioxidant lipoic acid","volume":"29","author":"Biewenga","year":"1997","journal-title":"Gen. Pharmacol."},{"issue":"2","key":"10.1016\/j.fct.2013.01.055_b0030","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0006-2952(95)00084-D","article-title":"Reduction and transport of lipoic acid by human erythrocytes","volume":"50","author":"Constantinescu","year":"1995","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.fct.2013.01.055_b0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.yrtph.2006.06.004","article-title":"Safety evaluation of alpha-lipoic acid (ALA)","volume":"46","author":"Cremer","year":"2006","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"4","key":"10.1016\/j.fct.2013.01.055_b0040","first-page":"163","article-title":"Regulation of cellular glutathione","volume":"257","author":"Deneke","year":"1989","journal-title":"Am. J. Physiol."},{"issue":"4","key":"10.1016\/j.fct.2013.01.055_b0045","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0022-3476(86)80833-2","article-title":"Improved erythrocyte survival with combined vitamin E and selenium therapy in children with glucose-6-phosphate dehydrogenase deficiency and mild chronic hemolysis","volume":"108","author":"Hafez","year":"1986","journal-title":"J. Pediatr."},{"issue":"5","key":"10.1016\/j.fct.2013.01.055_b0050","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1042\/BST0351147","article-title":"Biochemistry of oxidative stress","volume":"35","author":"Halliwell","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.fct.2013.01.055_b0055","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/biof.5520060303","article-title":"Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization","volume":"6","author":"Han","year":"1997","journal-title":"BioFactors"},{"issue":"3","key":"10.1016\/j.fct.2013.01.055_b0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1179\/135100007X200209","article-title":"Glucose-6-phosphate dehydrogenase \u2013 from oxidative stress to cellular functions and degenerative diseases","volume":"12","author":"Ho","year":"2007","journal-title":"Redox Rep."},{"issue":"6B","key":"10.1016\/j.fct.2013.01.055_b0065","first-page":"875","article-title":"Effect of exercise on oxidative stress in individuals with glucose-6-phosphate dehydrogenase deficiency","volume":"20","author":"Jamurtas","year":"2006","journal-title":"In Vivo"},{"key":"10.1016\/j.fct.2013.01.055_b0070","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/003655102317475498","article-title":"Assay of total antioxidant capacity: comparison of four methods as applied to human blood plasma","volume":"62","author":"Janaszewska","year":"2002","journal-title":"Scand. J. Clin. Lab. Invest."},{"issue":"1","key":"10.1016\/j.fct.2013.01.055_b0075","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0891-5849(02)00862-6","article-title":"Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells","volume":"33","author":"Jones","year":"2002","journal-title":"Free Radical Biol. Med."},{"issue":"8","key":"10.1016\/j.fct.2013.01.055_b0080","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0006-2952(92)90482-X","article-title":"Dihydrolipoic acid \u2013 a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals","volume":"44","author":"Kagan","year":"1992","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.fct.2013.01.055_b0085","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S0317167100052823","article-title":"Effect of corticosteroid therapy on serum and CSF malondialdehyde and antioxidant proteins in multiple sclerosis","volume":"28","author":"Keles","year":"2001","journal-title":"Can. J. Neurol. Sci."},{"issue":"3","key":"10.1016\/j.fct.2013.01.055_b0090","first-page":"155","article-title":"Glutathione: systemic protectant against oxidative and free radical damage","volume":"2","author":"Kidd","year":"1997","journal-title":"Alt. Med. Rev."},{"issue":"9\u201310","key":"10.1016\/j.fct.2013.01.055_b0095","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S0891-5849(99)00155-0","article-title":"Comparison of the effect of alpha-lipoic acidand alpha-tocopherol supplementation on measures of oxidative stress","volume":"27","author":"Marangon","year":"1999","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.fct.2013.01.055_b0100","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.clnu.2009.01.017","article-title":"Alpha-lipoic acid modifies oxidative stress parameters in sickle cell trait subjects and sickle cell patients","volume":"28","author":"Martins","year":"2009","journal-title":"Clin. Nut."},{"key":"10.1016\/j.fct.2013.01.055_b0105","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0981-9428(02)01407-9","article-title":"Lipoic acid: a unique antioxidant in the detoxification of activated oxygen species","volume":"40","author":"Navari-Izzo","year":"2002","journal-title":"Plant Physiol. Biochem."},{"issue":"8","key":"10.1016\/j.fct.2013.01.055_b0110","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1249\/01.mss.0000228938.24658.5f","article-title":"Exercise-induced oxidative stress in G6PD-deficient individuals","volume":"38","author":"Nikolaidis","year":"2006","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.fct.2013.01.055_b0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0891-5849(95)00017-R","article-title":"Alpha-lipoic acid as a biological antioxidant","volume":"19","author":"Packer","year":"1995","journal-title":"Free Radical Biol. Med."},{"issue":"1","key":"10.1016\/j.fct.2013.01.055_b0120","first-page":"22","article-title":"Sulfur in human nutrition and applications in medicine","volume":"7","author":"Parcell","year":"2002","journal-title":"Altern. Med. Rev."},{"issue":"2","key":"10.1016\/j.fct.2013.01.055_b0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neulet.2003.10.080","article-title":"Thiol redox state (TRS) and oxidative stress in the mose hippocampus after pentylenetetrazol-induced epileptic seizure","volume":"357","author":"Patsoukis","year":"2004","journal-title":"Neurosci. Lett."},{"issue":"10","key":"10.1016\/j.fct.2013.01.055_b0130","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.bbagen.2009.07.026","article-title":"Alpha-lipoic acid as a dietary supplement, molecular mechanisms and therapeutic potential","volume":"1790","author":"Petersen Shay","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fct.2013.01.055_b0135","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0006-2952(03)00504-5","article-title":"The changing faces of glutathione, a cellular protagonist","volume":"66","author":"Pompella","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fct.2013.01.055_b0140","first-page":"213","article-title":"Role of free radicals and antioxidants in tuberculosis patients","volume":"51","author":"Reddy","year":"2004","journal-title":"Indian J. Tuberc."},{"issue":"10","key":"10.1016\/j.fct.2013.01.055_b0145","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/ptr.1544","article-title":"Antioxidanteffect of EGb 761 on hydrogen peroxide-induced lipoperoxidation of G-6-PD deficient erythrocytes","volume":"18","author":"Sarik\u00e7io\u011flu","year":"2004","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.fct.2013.01.055_b0150","first-page":"343","article-title":"Antioxidant intake and status, and oxidative stress in relation to breast cancer risk: a case-control study","volume":"9","author":"Shahar","year":"2008","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"11","key":"10.1016\/j.fct.2013.01.055_b0155","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1753-4887.2008.00118.x","article-title":"Alpha-lipoic acid supplementation and diabetes","volume":"66","author":"Singh","year":"2008","journal-title":"Nutr. Rev."},{"issue":"1\/2","key":"10.1016\/j.fct.2013.01.055_b0160","first-page":"12","article-title":"Effects of vitamin E supplementation on some aspects of hematological variables in patients of hemolytic anemia with glucose 6 phosphate dehydrogenase (G6PD) deficiency","volume":"22","author":"Sultana","year":"2006","journal-title":"Bangladesh J. Physiol. Pharmacol."},{"issue":"6","key":"10.1016\/j.fct.2013.01.055_b0165","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1249\/MSS.0b013e3181c67ecd","article-title":"Comparison between glucose-6-phosphate dehydrogenase-deficient and normal individuals after eccentric exercise","volume":"42","author":"Theodorou","year":"2010","journal-title":"Med. Sci. Sports Exerc."},{"issue":"2","key":"10.1016\/j.fct.2013.01.055_b0170","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1385\/ENDO:19:2:191","article-title":"Decreased blood activity of glucose-6-phosphate dehydrogenase associates with increased risk for diabetes mellitus","volume":"19","author":"Wan","year":"2002","journal-title":"Endocrine"},{"issue":"6","key":"10.1016\/j.fct.2013.01.055_b0175","first-page":"601","article-title":"Glucose-6-phosphate dehydrogenase deficiency","volume":"67","author":"WHO Working Group","year":"1989","journal-title":"Bull. World Health Organ."},{"issue":"6","key":"10.1016\/j.fct.2013.01.055_b0180","doi-asserted-by":"crossref","first-page":"855","DOI":"10.33549\/physiolres.931590","article-title":"The comparison of antioxidant and hematological properties of N-acetylcysteine and alpha-lipoic acid in physically active males","volume":"58","author":"Zembron-Lacny","year":"2009","journal-title":"Physiol. Res."},{"issue":"5","key":"10.1016\/j.fct.2013.01.055_b0185","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4077\/CJP.2009.AMH026","article-title":"Effects of sulphur-containing compounds on plasma redox status in muscle-damaging exercise","volume":"52","author":"Zembron-Lacny","year":"2009","journal-title":"Chin. J. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.fct.2013.01.055_b0190","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jns.2007.01.039","article-title":"Vascularoxidative stressinAlzheimer disease","volume":"257","author":"Zhu","year":"2007","journal-title":"J. Neurol. Sci."},{"issue":"11","key":"10.1016\/j.fct.2013.01.055_b0195","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.2337\/dc06-1216","article-title":"Oral treatment with alpha-lipoic acidimproves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial","volume":"29","author":"Ziegler","year":"2006","journal-title":"Diabetes Care"}],"container-title":["Food and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691513001038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0278691513001038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T21:14:59Z","timestamp":1759526099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0278691513001038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":41,"alternative-id":["S0278691513001038"],"URL":"https:\/\/doi.org\/10.1016\/j.fct.2013.01.055","relation":{},"ISSN":["0278-6915"],"issn-type":[{"value":"0278-6915","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b1-Lipoic acid supplementation up-regulates antioxidant capacity in adults with G6PD deficiency","name":"articletitle","label":"Article Title"},{"value":"Food and Chemical Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fct.2013.01.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}